1C3RA

Crystal structure of an hdac homolog complexed with trichostatin a
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
372
structure length
372
Chain Sequence
KKVKLIGTLDYGKYRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNVAFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKKGFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPEKLNNKAKELLKSIDFEEFDDEVDRSYMLETLKDPWRGGEVRKEVKDTLEKAKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
pubmed doi rcsb
molecule tags Lyase
source organism Aquifex aeolicus
molecule keywords HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
total genus 133
structure length 372
sequence length 372
chains with identical sequence B
ec nomenclature
pdb deposition date 1999-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1c3rA00
4BZ8A 3F0RA 3F06A 5G1AA 5G10A 4LY1A 5DC7A 5G1CA 5LI3A 3C0YA 3MAXA 3Q9FA 4ZUMA 5A2SA 5EEMA 5G11A 5G0IA 4QA3A 3MZ6A 3RQDA 2VQWG 3Q9EA 4QA4A 4BKXB 5THVA 2VQOA 5FUEA 1ZZ1A 4RN0A 5EFGA 5G0YA 1ZZ0A 3MZ4A 1W22A 3Q9CA 5EFKB 2GH6A 3EW8A 5G13A 4QA1A 4QA6A 4RN1A 4BZ7A 5BWZA 4ZURA 2V5XA 5EFBD 5EFJD 2VQJA 1C3SA 5EF8A 3MZ7A 4CQFA 5G0HA 3C10A 3MZ3A 1VKGA 5D1BA 4BZ5A 5IX0A 5DC5A 3ZNRA 5THSA 2VQVA 1T67A 5D1DA 4ZUPA 4QA0A 5G3WA 3Q9BA 3SFHA 4CBYA 2VQMA 5THUA 3MENA 5EEIA 4RN2A 1T69A 4A69A 5EFNA 3F07A 4QA7A 4CBTA 5EEFA 2VQQA 5IWGA 5EFHA 5G0XA 5EEKA 5DC6A 4BZ6A 5G12A 5EF7A 3C0ZA 5G0GA 4QA2A 5DC8A 5G17A 2V5WA 1C3RA 2VCGA 1C3PA 1ZZ3A 5FCWA 4ZUOA 5D1CA 1T64A 3SFFA 5G1BA 5G0JA 4ZUQA 5JI5A 3EWFA 4QA5A 5THTA 5EENA 4LXZA 4BZ9A 3EZTA 3ZNSA 4ZUNA 3EZPA 5ICNB
chains in the Genus database with same CATH superfamily
4BZ8A 1R1OA 1RLAA 2PHOA 3F0RA 3F06A 1WVBA 4GWDA 3TF3A 2A0MA 5G1AA 3LHLA 5G10A 4LY1A 5DC7A 3GN0A 4Q3VA 3C0YA 5G1CA 5LI3A 3MAXA 2ZAVA 3Q9FA 4ZUMA 5A2SA 1HQXA 4Q3UA 1P8OA 5EEMA 5G11A 4DZ4A 5G0IA 4QA3A 3MZ6A 4FCKA 3RQDA 3THJA 2VQWG 3Q9EA 3CEVA 5HJAA 4QA4A 3SKKA 4BKXB 5THVA 1TA1A 4IU5A 2VQOA 5FUEA 1ZZ1A 1PQ3A 1T5FA 1ZPEA 4RN0A 4GSMA 5EFGA 1ZZ0A 3MZ4A 5G0YA 1W22A 3Q9CA 4IE3A 4RHQA 5EFKB 3THHA 4Q41A 5CEVA 3E6KA 1T4PA 2GH6A 1GQ6A 1P8RA 3EW8A 4MYFA 5G13A 4QA1A 1P8QA 4QA6A 4IU0A 3E9BA 1GQ7A 4RN1A 4RLAA 4BZ7A 5BWZA 4Q42A 4IU1A 1TBJA 4ZURA 2V5XA 2EF5A 2EF4A 3E8QA 5EFBD 5EFJD 2VQJA 4RHLA 1C3SA 5EF8A 5RLAA 3MZ7A 4Q3QA 4CQFA 4MXRA 3GMZA 1HQ5A 4IU4A 5G0HA 3E6VA 3C10A 1T4SA 3MZ3A 1VKGA 3LP7A 3MFWA 5D1BA 5HJ9A 1ZPGA 1TBLA 5IX0A 4BZ5A 5DC5A 3ZNRA 4Q3PA 5THSA 2VQVA 3SL0A 3THEA 4MYLA 1P8SA 3DJ8A 3KV2A 1P8MA 4ITYA 1T67A 4IXUA 1WVAA 1XFKA 4IXVA 5D1DA 4ZUPA 1T4RA 4QA0A 4GSZA 5G3WA 3Q9BA 3SFHA 4CBYA 2VQMA 1D3VA 5THUA 3E8ZA 4RHIA 1WOHA 3MENA 5EEIA 2CEVA 4RN2A 1T69A 3LP4A 4A69A 3SL1A 5EFNA 2EIVA 1HQFA 3F07A 4QA7A 4CBTA 5EEFA 3F80A 1TBHA 4MYNA 2VQQA 5IWGA 5EFHA 5G0XA 5EEKA 5DC6A 4BZ6A 2PLLA 5G12A 5EF7A 4I06A 1P8PA 3C0ZA 4RHJA 5G0GA 3SJTA 2PHAA 4QA2A 5DC8A 5G17A 3NIPA 4GSVA 2V5WA 2AEBA 3MFVA 4Q3RC 1C3RA 4IE1A 4MYKA 1P8NA 2VCGA 1HQHA 1C3PA 1ZZ3A 1T4TA 4Q3TA 4CEVA 1HQGA 5FCWA 4HZEA 4GWCA 4ZUOA 5D1CA 3M1RA 1T64A 3PZLA 3SFFA 5G1BA 4FCIA 5G0JA 4ZUQA 4G3HA 5JI5A 3EWFA 4IE2A 4QA5A 5THTA 4HXQA 5EENA 4HWWA 4Q3SA 4RHKA 1CEVA 4LXZA 4Q3RA 3NIQA 3NIOA 2RLAA 4RHMA 3TH7A 3EZTA 3MJLA 4BZ9A 4Q40A 3MMRA 3ZNSA 1WOGA 1T5GA 4ZUNA 3EZPA 1WOIA 5ICNB 3RLAA
chains in the Genus database with same CATH topology
4BZ8A 3F0RA 3F06A 5G1AA 5G10A 4LY1A 5DC7A 5G1CA 5LI3A 3C0YA 3MAXA 3Q9FA 4ZUMA 5A2SA 5EEMA 5G11A 5G0IA 4QA3A 3MZ6A 3RQDA 2VQWG 3Q9EA 4QA4A 4BKXB 5THVA 2VQOA 5FUEA 1ZZ1A 4RN0A 5EFGA 5G0YA 1ZZ0A 3MZ4A 1W22A 3Q9CA 5EFKB 2GH6A 3EW8A 5G13A 4QA1A 4QA6A 4RN1A 4BZ7A 5BWZA 4ZURA 2V5XA 5EFBD 5EFJD 2VQJA 1C3SA 5EF8A 3MZ7A 4CQFA 5G0HA 3C10A 3MZ3A 1VKGA 5D1BA 4BZ5A 5IX0A 5DC5A 3ZNRA 5THSA 2VQVA 1T67A 5D1DA 4ZUPA 4QA0A 5G3WA 3Q9BA 3SFHA 4CBYA 2VQMA 5THUA 3MENA 5EEIA 4RN2A 1T69A 4A69A 5EFNA 3F07A 4QA7A 4CBTA 5EEFA 2VQQA 5IWGA 5EFHA 5G0XA 5EEKA 5DC6A 4BZ6A 5G12A 5EF7A 3C0ZA 5G0GA 4QA2A 5DC8A 5G17A 2V5WA 1C3RA 2VCGA 1C3PA 1ZZ3A 5FCWA 4ZUOA 5D1CA 1T64A 3SFFA 5G1BA 5G0JA 4ZUQA 5JI5A 3EWFA 4QA5A 5THTA 5EENA 4LXZA 4BZ9A 3EZTA 3ZNSA 4ZUNA 3EZPA 5ICNB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BZ8 A;  3F0R A;  3F06 A;  5G1A A;  5G10 A;  4LY1 A;  5DC7 A;  5G1C A;  5LI3 A;  3C0Y A;  3MAX A;  3Q9F A;  4ZUM A;  5A2S A;  5EEM A;  5G11 A;  5G0I A;  4QA3 A;  3MZ6 A;  3RQD A;  2VQW G;  3Q9E A;  4QA4 A;  4BKX B;  5THV A;  2VQO A;  5FUE A;  1ZZ1 A;  4RN0 A;  5EFG A;  5G0Y A;  1ZZ0 A;  3MZ4 A;  1W22 A;  3Q9C A;  5EFK B;  2GH6 A;  3EW8 A;  5G13 A;  4QA1 A;  4QA6 A;  4RN1 A;  4BZ7 A;  5BWZ A;  4ZUR A;  2V5X A;  5EFB D;  5EFJ D;  2VQJ A;  1C3S A;  5EF8 A;  3MZ7 A;  4CQF A;  5G0H A;  3C10 A;  3MZ3 A;  1VKG A;  5D1B A;  4BZ5 A;  5IX0 A;  5DC5 A;  3ZNR A;  5THS A;  2VQV A;  1T67 A;  5D1D A;  4ZUP A;  4QA0 A;  5G3W A;  3Q9B A;  3SFH A;  4CBY A;  2VQM A;  5THU A;  3MEN A;  5EEI A;  4RN2 A;  1T69 A;  4A69 A;  5EFN A;  3F07 A;  4QA7 A;  4CBT A;  5EEF A;  2VQQ A;  5IWG A;  5EFH A;  5G0X A;  5EEK A;  5DC6 A;  4BZ6 A;  5G12 A;  5EF7 A;  3C0Z A;  5G0G A;  4QA2 A;  5DC8 A;  5G17 A;  2V5W A;  1C3R A;  2VCG A;  1C3P A;  1ZZ3 A;  5FCW A;  4ZUO A;  5D1C A;  1T64 A;  3SFF A;  5G1B A;  5G0J A;  4ZUQ A;  5JI5 A;  3EWF A;  4QA5 A;  5THT A;  5EEN A;  4LXZ A;  4BZ9 A;  3EZT A;  3ZNS A;  4ZUN A;  3EZP A;  5ICN B; 
#chains in the Genus database with same CATH topology
 4BZ8 A;  1R1O A;  1RLA A;  2PHO A;  3F0R A;  3F06 A;  1WVB A;  4GWD A;  3TF3 A;  2A0M A;  5G1A A;  3LHL A;  5G10 A;  4LY1 A;  5DC7 A;  3GN0 A;  4Q3V A;  3C0Y A;  5G1C A;  5LI3 A;  3MAX A;  2ZAV A;  3Q9F A;  4ZUM A;  5A2S A;  1HQX A;  4Q3U A;  1P8O A;  5EEM A;  5G11 A;  4DZ4 A;  5G0I A;  4QA3 A;  3MZ6 A;  4FCK A;  3RQD A;  3THJ A;  2VQW G;  3Q9E A;  3CEV A;  5HJA A;  4QA4 A;  3SKK A;  4BKX B;  5THV A;  1TA1 A;  4IU5 A;  2VQO A;  5FUE A;  1ZZ1 A;  1PQ3 A;  1T5F A;  1ZPE A;  4RN0 A;  4GSM A;  5EFG A;  1ZZ0 A;  3MZ4 A;  5G0Y A;  1W22 A;  3Q9C A;  4IE3 A;  4RHQ A;  5EFK B;  3THH A;  4Q41 A;  5CEV A;  3E6K A;  1T4P A;  2GH6 A;  1GQ6 A;  1P8R A;  3EW8 A;  4MYF A;  5G13 A;  4QA1 A;  1P8Q A;  4QA6 A;  4IU0 A;  3E9B A;  1GQ7 A;  4RN1 A;  4RLA A;  4BZ7 A;  5BWZ A;  4Q42 A;  4IU1 A;  1TBJ A;  4ZUR A;  2V5X A;  2EF5 A;  2EF4 A;  3E8Q A;  5EFB D;  5EFJ D;  2VQJ A;  4RHL A;  1C3S A;  5EF8 A;  5RLA A;  3MZ7 A;  4Q3Q A;  4CQF A;  4MXR A;  3GMZ A;  1HQ5 A;  4IU4 A;  5G0H A;  3E6V A;  3C10 A;  1T4S A;  3MZ3 A;  1VKG A;  3LP7 A;  3MFW A;  5D1B A;  5HJ9 A;  1ZPG A;  1TBL A;  5IX0 A;  4BZ5 A;  5DC5 A;  3ZNR A;  4Q3P A;  5THS A;  2VQV A;  3SL0 A;  3THE A;  4MYL A;  1P8S A;  3DJ8 A;  3KV2 A;  1P8M A;  4ITY A;  1T67 A;  4IXU A;  1WVA A;  1XFK A;  4IXV A;  5D1D A;  4ZUP A;  1T4R A;  4QA0 A;  4GSZ A;  5G3W A;  3Q9B A;  3SFH A;  4CBY A;  2VQM A;  1D3V A;  5THU A;  3E8Z A;  4RHI A;  1WOH A;  3MEN A;  5EEI A;  2CEV A;  4RN2 A;  1T69 A;  3LP4 A;  4A69 A;  3SL1 A;  5EFN A;  2EIV A;  1HQF A;  3F07 A;  4QA7 A;  4CBT A;  5EEF A;  3F80 A;  1TBH A;  4MYN A;  2VQQ A;  5IWG A;  5EFH A;  5G0X A;  5EEK A;  5DC6 A;  4BZ6 A;  2PLL A;  5G12 A;  5EF7 A;  4I06 A;  1P8P A;  3C0Z A;  4RHJ A;  5G0G A;  3SJT A;  2PHA A;  4QA2 A;  5DC8 A;  5G17 A;  3NIP A;  4GSV A;  2V5W A;  2AEB A;  3MFV A;  4Q3R C;  1C3R A;  4IE1 A;  4MYK A;  1P8N A;  2VCG A;  1HQH A;  1C3P A;  1ZZ3 A;  1T4T A;  4Q3T A;  4CEV A;  1HQG A;  5FCW A;  4HZE A;  4GWC A;  4ZUO A;  5D1C A;  3M1R A;  1T64 A;  3PZL A;  3SFF A;  5G1B A;  4FCI A;  5G0J A;  4ZUQ A;  4G3H A;  5JI5 A;  3EWF A;  4IE2 A;  4QA5 A;  5THT A;  4HXQ A;  5EEN A;  4HWW A;  4Q3S A;  4RHK A;  1CEV A;  4LXZ A;  4Q3R A;  3NIQ A;  3NIO A;  2RLA A;  4RHM A;  3TH7 A;  3EZT A;  3MJL A;  4BZ9 A;  4Q40 A;  3MMR A;  3ZNS A;  1WOG A;  1T5G A;  4ZUN A;  3EZP A;  1WOI A;  5ICN B;  3RLA A; 
#chains in the Genus database with same CATH homology
 4BZ8 A;  3F0R A;  3F06 A;  5G1A A;  5G10 A;  4LY1 A;  5DC7 A;  5G1C A;  5LI3 A;  3C0Y A;  3MAX A;  3Q9F A;  4ZUM A;  5A2S A;  5EEM A;  5G11 A;  5G0I A;  4QA3 A;  3MZ6 A;  3RQD A;  2VQW G;  3Q9E A;  4QA4 A;  4BKX B;  5THV A;  2VQO A;  5FUE A;  1ZZ1 A;  4RN0 A;  5EFG A;  5G0Y A;  1ZZ0 A;  3MZ4 A;  1W22 A;  3Q9C A;  5EFK B;  2GH6 A;  3EW8 A;  5G13 A;  4QA1 A;  4QA6 A;  4RN1 A;  4BZ7 A;  5BWZ A;  4ZUR A;  2V5X A;  5EFB D;  5EFJ D;  2VQJ A;  1C3S A;  5EF8 A;  3MZ7 A;  4CQF A;  5G0H A;  3C10 A;  3MZ3 A;  1VKG A;  5D1B A;  4BZ5 A;  5IX0 A;  5DC5 A;  3ZNR A;  5THS A;  2VQV A;  1T67 A;  5D1D A;  4ZUP A;  4QA0 A;  5G3W A;  3Q9B A;  3SFH A;  4CBY A;  2VQM A;  5THU A;  3MEN A;  5EEI A;  4RN2 A;  1T69 A;  4A69 A;  5EFN A;  3F07 A;  4QA7 A;  4CBT A;  5EEF A;  2VQQ A;  5IWG A;  5EFH A;  5G0X A;  5EEK A;  5DC6 A;  4BZ6 A;  5G12 A;  5EF7 A;  3C0Z A;  5G0G A;  4QA2 A;  5DC8 A;  5G17 A;  2V5W A;  1C3R A;  2VCG A;  1C3P A;  1ZZ3 A;  5FCW A;  4ZUO A;  5D1C A;  1T64 A;  3SFF A;  5G1B A;  5G0J A;  4ZUQ A;  5JI5 A;  3EWF A;  4QA5 A;  5THT A;  5EEN A;  4LXZ A;  4BZ9 A;  3EZT A;  3ZNS A;  4ZUN A;  3EZP A;  5ICN B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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