1C3SA

Crystal structure of an hdac homolog complexed with saha
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
372
structure length
372
Chain Sequence
KKVKLIGTLDYGKYRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNVAFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKKGFKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVREVFGEGVYLGGGGYHPYALARAWTLIWCELSGREVPEKLNNKAKELLKSIDFEEFDDEVDRSYMLETLKDPWRGGEVRKEVKDTLEKAKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
pubmed doi rcsb
molecule tags Lyase
source organism Aquifex aeolicus
molecule keywords HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)
total genus 125
structure length 372
sequence length 372
ec nomenclature
pdb deposition date 1999-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 1c3sA00
5G0JA 1VKGA 5G1AA 3EZTA 2VQOA 5D1CA 5EFKB 5G17A 4BZ8A 3ZNRA 4ZUMA 4ZUPA 5DC5A 5IX0A 4BZ7A 3MZ3A 4ZUNA 4ZUOA 1T69A 1ZZ1A 2V5XA 4QA3A 2VQMA 5BWZA 3RQDA 4CBTA 1T64A 4LXZA 1ZZ0A 5EEIA 5EENA 5FUEA 3EW8A 5D1DA 4QA2A 5G0GA 5G3WA 4A69A 5EEMA 5THTA 1T67A 3ZNSA 5EFBD 5DC7A 3C0YA 5EFGA 3EZPA 5FCWA 5EFHA 3SFFA 4QA4A 5G10A 1C3SA 5D1BA 3Q9FA 1W22A 3MZ6A 4QA7A 5EFNA 5THSA 5A2SA 4BZ6A 4LY1A 4RN0A 3MENA 1ZZ3A 5G0IA 5G11A 3MZ7A 5EFJD 5EEFA 4QA6A 5EF7A 3EWFA 5IWGA 4BZ5A 5G13A 3Q9EA 5G12A 3F07A 4RN2A 3SFHA 2V5WA 3MAXA 5DC8A 4RN1A 4BZ9A 5EF8A 3Q9BA 3MZ4A 1C3PA 4CQFA 5G0YA 5JI5A 2VCGA 4QA0A 2GH6A 5G1BA 4QA5A 5THUA 5EEKA 5THVA 4ZURA 1C3RA 5LI3A 3C10A 3F06A 2VQVA 5G0HA 4BKXB 5G1CA 4QA1A 3F0RA 2VQWG 4ZUQA 5ICNB 2VQQA 2VQJA 3C0ZA 5DC6A 5G0XA 3Q9CA 4CBYA
chains in the Genus database with same CATH superfamily
3SJTA 2EIVA 1WOIA 5G0JA 4RHJA 1VKGA 2ZAVA 4IU5A 3EZTA 2VQOA 5D1CA 5EFKB 5G1AA 5G17A 4IU1A 5RLAA 4BZ8A 3ZNRA 4ZUMA 3GN0A 4IE3A 5DC5A 4Q3QA 4ZUPA 5HJAA 5IX0A 4BZ7A 3MZ3A 3SL0A 3MMRA 1T4RA 4ZUNA 4ZUOA 1T69A 1ZZ1A 3E9BA 2V5XA 1TBLA 4IXVA 4Q3RC 1TA1A 4FCIA 4QA3A 2VQMA 5BWZA 3RQDA 1P8MA 4I06A 4CBTA 1HQFA 5CEVA 1RLAA 3NIPA 1T64A 4LXZA 4MYNA 4RHLA 1R1OA 3E8QA 4RHQA 1ZZ0A 1HQGA 5EEIA 5EENA 5FUEA 3TH7A 3EW8A 1WOHA 5D1DA 4QA2A 4Q3TA 5G0GA 5G3WA 3MFWA 4Q3PA 4A69A 3LP7A 5EEMA 3E8ZA 5THTA 2EF4A 4G3HA 1T67A 3ZNSA 1D3VA 1TBJA 5EFBD 5DC7A 1TBHA 3C0YA 4GSZA 3EZPA 1T5GA 1P8NA 4RHMA 5EFGA 5FCWA 1GQ7A 3RLAA 3LHLA 5EFHA 1PQ3A 1P8SA 1HQHA 3SFFA 4QA4A 5G10A 1C3SA 4DZ4A 5D1BA 3MFVA 2CEVA 1W22A 3Q9FA 4Q3VA 3MZ6A 4QA7A 1GQ6A 3GMZA 5EFNA 5THSA 4CEVA 5A2SA 4BZ6A 4LY1A 1T4PA 4RN0A 3MJLA 4Q3UA 4BZ5A 1ZZ3A 3MENA 3PZLA 1P8OA 4HWWA 5G0IA 4MYFA 5G11A 3MZ7A 3KV2A 4GSMA 3TF3A 4FCKA 5EFJD 5EEFA 4QA6A 5EF7A 2EF5A 3EWFA 3CEVA 1CEVA 4IE2A 5G13A 3DJ8A 3LP4A 3Q9EA 5G12A 1WVAA 3F07A 3NIQA 5HJ9A 4GWCA 4MXRA 1HQ5A 1ZPGA 4RN2A 3SL1A 1P8RA 2PHOA 2V5WA 3SFHA 3MAXA 5DC8A 4RN1A 4Q42A 4BZ9A 5EF8A 3THEA 3Q9BA 3MZ4A 1C3PA 4HZEA 5G0YA 3M1RA 4IE1A 1P8PA 3THHA 4CQFA 5JI5A 2VCGA 4QA0A 2GH6A 5G1BA 4QA5A 5THUA 4RHKA 1T5FA 1HQXA 1XFKA 5EEKA 5THVA 4ZURA 1C3RA 5LI3A 4HXQA 3C10A 3F06A 4IXUA 4MYLA 2VQVA 4IU0A 1T4SA 1WOGA 5G0HA 2PHAA 3E6KA 3SKKA 2RLAA 4Q41A 4RHIA 4BKXB 2AEBA 3F80A 5IWGA 2A0MA 1P8QA 5G1CA 4QA1A 3E6VA 3F0RA 4MYKA 4Q3SA 2VQWG 4IU4A 1T4TA 4Q3RA 4ZUQA 5ICNB 4Q40A 4GWDA 2VQQA 2VQJA 3THJA 3C0ZA 5DC6A 1WVBA 4ITYA 3NIOA 4GSVA 5G0XA 3Q9CA 4RLAA 1ZPEA 4CBYA 2PLLA
chains in the Genus database with same CATH topology
5G0JA 1VKGA 5G1AA 3EZTA 2VQOA 5D1CA 5EFKB 5G17A 4BZ8A 3ZNRA 4ZUMA 4ZUPA 5DC5A 5IX0A 4BZ7A 3MZ3A 4ZUNA 4ZUOA 1T69A 1ZZ1A 2V5XA 4QA3A 2VQMA 5BWZA 3RQDA 4CBTA 1T64A 4LXZA 1ZZ0A 5EEIA 5EENA 5FUEA 3EW8A 5D1DA 4QA2A 5G0GA 5G3WA 4A69A 5EEMA 5THTA 1T67A 3ZNSA 5EFBD 5DC7A 3C0YA 5EFGA 3EZPA 5FCWA 5EFHA 3SFFA 4QA4A 5G10A 1C3SA 5D1BA 3Q9FA 1W22A 3MZ6A 4QA7A 5EFNA 5THSA 5A2SA 4BZ6A 4LY1A 4RN0A 3MENA 1ZZ3A 5G0IA 5G11A 3MZ7A 5EFJD 5EEFA 4QA6A 5EF7A 3EWFA 5IWGA 4BZ5A 5G13A 3Q9EA 5G12A 3F07A 4RN2A 3SFHA 2V5WA 3MAXA 5DC8A 4RN1A 4BZ9A 5EF8A 3Q9BA 3MZ4A 1C3PA 4CQFA 5G0YA 5JI5A 2VCGA 4QA0A 2GH6A 5G1BA 4QA5A 5THUA 5EEKA 5THVA 4ZURA 1C3RA 5LI3A 3C10A 3F06A 2VQVA 5G0HA 4BKXB 5G1CA 4QA1A 3F0RA 2VQWG 4ZUQA 5ICNB 2VQQA 2VQJA 3C0ZA 5DC6A 5G0XA 3Q9CA 4CBYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G0J A;  1VKG A;  5G1A A;  3EZT A;  2VQO A;  5D1C A;  5EFK B;  5G17 A;  4BZ8 A;  3ZNR A;  4ZUM A;  4ZUP A;  5DC5 A;  5IX0 A;  4BZ7 A;  3MZ3 A;  4ZUN A;  4ZUO A;  1T69 A;  1ZZ1 A;  2V5X A;  4QA3 A;  2VQM A;  5BWZ A;  3RQD A;  4CBT A;  1T64 A;  4LXZ A;  1ZZ0 A;  5EEI A;  5EEN A;  5FUE A;  3EW8 A;  5D1D A;  4QA2 A;  5G0G A;  5G3W A;  4A69 A;  5EEM A;  5THT A;  1T67 A;  3ZNS A;  5EFB D;  5DC7 A;  3C0Y A;  5EFG A;  3EZP A;  5FCW A;  5EFH A;  3SFF A;  4QA4 A;  5G10 A;  1C3S A;  5D1B A;  3Q9F A;  1W22 A;  3MZ6 A;  4QA7 A;  5EFN A;  5THS A;  5A2S A;  4BZ6 A;  4LY1 A;  4RN0 A;  3MEN A;  1ZZ3 A;  5G0I A;  5G11 A;  3MZ7 A;  5EFJ D;  5EEF A;  4QA6 A;  5EF7 A;  3EWF A;  5IWG A;  4BZ5 A;  5G13 A;  3Q9E A;  5G12 A;  3F07 A;  4RN2 A;  3SFH A;  2V5W A;  3MAX A;  5DC8 A;  4RN1 A;  4BZ9 A;  5EF8 A;  3Q9B A;  3MZ4 A;  1C3P A;  4CQF A;  5G0Y A;  5JI5 A;  2VCG A;  4QA0 A;  2GH6 A;  5G1B A;  4QA5 A;  5THU A;  5EEK A;  5THV A;  4ZUR A;  1C3R A;  5LI3 A;  3C10 A;  3F06 A;  2VQV A;  5G0H A;  4BKX B;  5G1C A;  4QA1 A;  3F0R A;  2VQW G;  4ZUQ A;  5ICN B;  2VQQ A;  2VQJ A;  3C0Z A;  5DC6 A;  5G0X A;  3Q9C A;  4CBY A; 
#chains in the Genus database with same CATH topology
 3SJT A;  2EIV A;  1WOI A;  5G0J A;  4RHJ A;  1VKG A;  2ZAV A;  4IU5 A;  3EZT A;  2VQO A;  5D1C A;  5EFK B;  5G1A A;  5G17 A;  4IU1 A;  5RLA A;  4BZ8 A;  3ZNR A;  4ZUM A;  3GN0 A;  4IE3 A;  5DC5 A;  4Q3Q A;  4ZUP A;  5HJA A;  5IX0 A;  4BZ7 A;  3MZ3 A;  3SL0 A;  3MMR A;  1T4R A;  4ZUN A;  4ZUO A;  1T69 A;  1ZZ1 A;  3E9B A;  2V5X A;  1TBL A;  4IXV A;  4Q3R C;  1TA1 A;  4FCI A;  4QA3 A;  2VQM A;  5BWZ A;  3RQD A;  1P8M A;  4I06 A;  4CBT A;  1HQF A;  5CEV A;  1RLA A;  3NIP A;  1T64 A;  4LXZ A;  4MYN A;  4RHL A;  1R1O A;  3E8Q A;  4RHQ A;  1ZZ0 A;  1HQG A;  5EEI A;  5EEN A;  5FUE A;  3TH7 A;  3EW8 A;  1WOH A;  5D1D A;  4QA2 A;  4Q3T A;  5G0G A;  5G3W A;  3MFW A;  4Q3P A;  4A69 A;  3LP7 A;  5EEM A;  3E8Z A;  5THT A;  2EF4 A;  4G3H A;  1T67 A;  3ZNS A;  1D3V A;  1TBJ A;  5EFB D;  5DC7 A;  1TBH A;  3C0Y A;  4GSZ A;  3EZP A;  1T5G A;  1P8N A;  4RHM A;  5EFG A;  5FCW A;  1GQ7 A;  3RLA A;  3LHL A;  5EFH A;  1PQ3 A;  1P8S A;  1HQH A;  3SFF A;  4QA4 A;  5G10 A;  1C3S A;  4DZ4 A;  5D1B A;  3MFV A;  2CEV A;  1W22 A;  3Q9F A;  4Q3V A;  3MZ6 A;  4QA7 A;  1GQ6 A;  3GMZ A;  5EFN A;  5THS A;  4CEV A;  5A2S A;  4BZ6 A;  4LY1 A;  1T4P A;  4RN0 A;  3MJL A;  4Q3U A;  4BZ5 A;  1ZZ3 A;  3MEN A;  3PZL A;  1P8O A;  4HWW A;  5G0I A;  4MYF A;  5G11 A;  3MZ7 A;  3KV2 A;  4GSM A;  3TF3 A;  4FCK A;  5EFJ D;  5EEF A;  4QA6 A;  5EF7 A;  2EF5 A;  3EWF A;  3CEV A;  1CEV A;  4IE2 A;  5G13 A;  3DJ8 A;  3LP4 A;  3Q9E A;  5G12 A;  1WVA A;  3F07 A;  3NIQ A;  5HJ9 A;  4GWC A;  4MXR A;  1HQ5 A;  1ZPG A;  4RN2 A;  3SL1 A;  1P8R A;  2PHO A;  2V5W A;  3SFH A;  3MAX A;  5DC8 A;  4RN1 A;  4Q42 A;  4BZ9 A;  5EF8 A;  3THE A;  3Q9B A;  3MZ4 A;  1C3P A;  4HZE A;  5G0Y A;  3M1R A;  4IE1 A;  1P8P A;  3THH A;  4CQF A;  5JI5 A;  2VCG A;  4QA0 A;  2GH6 A;  5G1B A;  4QA5 A;  5THU A;  4RHK A;  1T5F A;  1HQX A;  1XFK A;  5EEK A;  5THV A;  4ZUR A;  1C3R A;  5LI3 A;  4HXQ A;  3C10 A;  3F06 A;  4IXU A;  4MYL A;  2VQV A;  4IU0 A;  1T4S A;  1WOG A;  5G0H A;  2PHA A;  3E6K A;  3SKK A;  2RLA A;  4Q41 A;  4RHI A;  4BKX B;  2AEB A;  3F80 A;  5IWG A;  2A0M A;  1P8Q A;  5G1C A;  4QA1 A;  3E6V A;  3F0R A;  4MYK A;  4Q3S A;  2VQW G;  4IU4 A;  1T4T A;  4Q3R A;  4ZUQ A;  5ICN B;  4Q40 A;  4GWD A;  2VQQ A;  2VQJ A;  3THJ A;  3C0Z A;  5DC6 A;  1WVB A;  4ITY A;  3NIO A;  4GSV A;  5G0X A;  3Q9C A;  4RLA A;  1ZPE A;  4CBY A;  2PLL A; 
#chains in the Genus database with same CATH homology
 5G0J A;  1VKG A;  5G1A A;  3EZT A;  2VQO A;  5D1C A;  5EFK B;  5G17 A;  4BZ8 A;  3ZNR A;  4ZUM A;  4ZUP A;  5DC5 A;  5IX0 A;  4BZ7 A;  3MZ3 A;  4ZUN A;  4ZUO A;  1T69 A;  1ZZ1 A;  2V5X A;  4QA3 A;  2VQM A;  5BWZ A;  3RQD A;  4CBT A;  1T64 A;  4LXZ A;  1ZZ0 A;  5EEI A;  5EEN A;  5FUE A;  3EW8 A;  5D1D A;  4QA2 A;  5G0G A;  5G3W A;  4A69 A;  5EEM A;  5THT A;  1T67 A;  3ZNS A;  5EFB D;  5DC7 A;  3C0Y A;  5EFG A;  3EZP A;  5FCW A;  5EFH A;  3SFF A;  4QA4 A;  5G10 A;  1C3S A;  5D1B A;  3Q9F A;  1W22 A;  3MZ6 A;  4QA7 A;  5EFN A;  5THS A;  5A2S A;  4BZ6 A;  4LY1 A;  4RN0 A;  3MEN A;  1ZZ3 A;  5G0I A;  5G11 A;  3MZ7 A;  5EFJ D;  5EEF A;  4QA6 A;  5EF7 A;  3EWF A;  5IWG A;  4BZ5 A;  5G13 A;  3Q9E A;  5G12 A;  3F07 A;  4RN2 A;  3SFH A;  2V5W A;  3MAX A;  5DC8 A;  4RN1 A;  4BZ9 A;  5EF8 A;  3Q9B A;  3MZ4 A;  1C3P A;  4CQF A;  5G0Y A;  5JI5 A;  2VCG A;  4QA0 A;  2GH6 A;  5G1B A;  4QA5 A;  5THU A;  5EEK A;  5THV A;  4ZUR A;  1C3R A;  5LI3 A;  3C10 A;  3F06 A;  2VQV A;  5G0H A;  4BKX B;  5G1C A;  4QA1 A;  3F0R A;  2VQW G;  4ZUQ A;  5ICN B;  2VQQ A;  2VQJ A;  3C0Z A;  5DC6 A;  5G0X A;  3Q9C A;  4CBY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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