1HQFA

Crystal structure of the binuclear manganese metalloenzyme arginase complexed with n-hydroxy-l-arginine
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE 1
total genus 106
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hqfA00
1T4PA 3THEA 1WOHA 4RHIA 1WVBA 1D3VA 3THHA 3RLAA 2A0MA 1ZPEA 1WOIA 4IXVA 3MFWA 4GSVA 4FCIA 1WVAA 1TA1A 3TH7A 4HWWA 1T4TA 4DZ4A 1HQFA 1T5GA 3DJ8A 3LP4A 4GWDA 3MMRA 4Q42A 1CEVA 2PHOA 3TF3A 3E8ZA 1P8RA 5HJ9A 4GSMA 3MJLA 4RHKA 4IU0A 4Q3SA 4Q40A 3NIQA 1P8MA 2CEVA 5CEVA 3LHLA 2RLAA 4IE1A 4Q3UA 1GQ6A 1TBJA 2AEBA 5HJAA 3SKKA 1RLAA 3KV2A 1GQ7A 4IU5A 3NIPA 4Q3TA 5RLAA 4RHQA 1R1OA 3E6VA 3E9BA 3E8QA 3THJA 1P8SA 1T4SA 4G3HA 4CEVA 3LP7A 2ZAVA 3SJTA 3GN0A 4MXRA 1HQGA 4GWCA 1P8NA 3CEVA 4GSZA 4HXQA 3F80A 1P8PA 3NIOA 2PLLA 4I06A 2EIVA 3SL0A 3GMZA 4MYLA 4IE2A 4IU4A 1WOGA 4Q3QA 4RHLA 2PHAA 4RLAA 4Q3RC 3M1RA 4ITYA 1HQ5A 1HQHA 2EF5A 4HZEA 1ZPGA 1PQ3A 1TBLA 1XFKA 4IXUA 3SL1A 4MYNA 1P8OA 4MYKA 4RHJA 4Q41A 4Q3RA 1T4RA 4RHMA 1HQXA 4Q3PA 4IU1A 1TBHA 3E6KA 1T5FA 4MYFA 1P8QA 3PZLA 4IE3A 4Q3VA 3MFVA 4FCKA 2EF4A
chains in the Genus database with same CATH superfamily
5EEKA 1T4PA 3F07A 4ZURA 3THEA 1WOHA 4RHIA 3Q9FA 5DC7A 5EFGA 5G0JA 1WVBA 1D3VA 3RQDA 4BZ7A 3THHA 3RLAA 3C0YA 2A0MA 5IX0A 1T67A 1ZPEA 5BWZA 4CBYA 1WOIA 4IXVA 5G13A 3MFWA 4GSVA 4FCIA 1WVAA 5EFHA 3SFHA 1TA1A 3TH7A 4HWWA 1T4TA 5G0XA 4DZ4A 4QA5A 1HQFA 5EF7A 1T5GA 3DJ8A 1T69A 3LP4A 3SFFA 4ZUQA 5THUA 4GWDA 5G0IA 3MMRA 4Q42A 5THSA 1CEVA 2PHOA 3TF3A 2VQWG 3E8ZA 3Q9BA 1P8RA 5HJ9A 4GSMA 4ZUOA 2VQJA 3ZNRA 3MJLA 3EZTA 4RHKA 4IU0A 4Q3SA 4Q40A 3NIQA 4QA3A 4QA2A 1P8MA 2CEVA 4A69A 4LY1A 5EEIA 5EFKB 5CEVA 5A2SA 4CBTA 3LHLA 4BZ5A 5G11A 2RLAA 1W22A 2VCGA 4IE1A 3MZ4A 4Q3UA 5G10A 1GQ6A 5THTA 4ZUNA 3EW8A 1TBJA 5HJAA 4BKXB 3F0RA 3SKKA 1RLAA 3F06A 3KV2A 1GQ7A 5DC6A 4BZ8A 4IU5A 4RN2A 5ICNB 1ZZ1A 3NIPA 5FCWA 2VQQA 1ZZ3A 2GH6A 4Q3TA 5RLAA 4CQFA 3C10A 4RHQA 1R1OA 5G1BA 4BZ9A 3E6VA 5G1CA 3E9BA 1T64A 3E8QA 5D1CA 5FUEA 1P8SA 1T4SA 4G3HA 5DC5A 3LP7A 5EFNA 5G0YA 2ZAVA 5G0HA 4CEVA 1C3SA 3MFVA 3SJTA 2VQVA 3C0ZA 3GN0A 4MXRA 4BZ6A 1HQGA 2V5WA 4GWCA 1P8NA 5D1BA 3CEVA 4GSZA 4QA7A 5G1AA 4HXQA 5DC8A 3F80A 1P8PA 3Q9CA 3NIOA 1ZZ0A 5JI5A 2PLLA 4I06A 2EIVA 3SL0A 4RN0A 3GMZA 5G17A 4MYLA 4IE2A 4IU4A 1WOGA 4Q3QA 5EEMA 4QA6A 3ZNSA 4RHLA 2PHAA 4RLAA 4Q3RC 5EFBD 3M1RA 4ITYA 1HQ5A 5G0GA 3Q9EA 1HQHA 4QA4A 5EFJD 5EENA 4QA0A 2EF5A 1VKGA 1ZPGA 4HZEA 1PQ3A 1TBLA 5G3WA 1XFKA 4IXUA 4RN1A 3EZPA 3SL1A 4MYNA 3MZ6A 4ZUPA 1P8OA 3MZ3A 4LXZA 4MYKA 4RHJA 4Q3RA 5D1DA 4Q41A 1T4RA 3MAXA 3MZ7A 4RHMA 1HQXA 4Q3PA 5G12A 2VQOA 5IWGA 4IU1A 1TBHA 3E6KA 1C3PA 1T5FA 4MYFA 5EF8A 3MENA 1C3RA 1P8QA 4QA1A 3THJA 3EWFA 3PZLA 5EEFA 4ZUMA 5THVA 2V5XA 5LI3A 4IE3A 2VQMA 4Q3VA 2AEBA 4FCKA 2EF4A
chains in the Genus database with same CATH topology
1T4PA 3THEA 1WOHA 4RHIA 1WVBA 1D3VA 3THHA 3RLAA 2A0MA 1ZPEA 1WOIA 4IXVA 3MFWA 4GSVA 4FCIA 1WVAA 1TA1A 3TH7A 4HWWA 1T4TA 4DZ4A 1HQFA 1T5GA 3DJ8A 3LP4A 4GWDA 3MMRA 4Q42A 1CEVA 2PHOA 3TF3A 3E8ZA 1P8RA 5HJ9A 4GSMA 3MJLA 4RHKA 4IU0A 4Q3SA 4Q40A 3NIQA 1P8MA 2CEVA 5CEVA 3LHLA 2RLAA 4IE1A 4Q3UA 1GQ6A 1TBJA 2AEBA 5HJAA 3SKKA 1RLAA 3KV2A 1GQ7A 4IU5A 3NIPA 4Q3TA 5RLAA 4RHQA 1R1OA 3E6VA 3E9BA 3E8QA 3THJA 1P8SA 1T4SA 4G3HA 4CEVA 3LP7A 2ZAVA 3SJTA 3GN0A 4MXRA 1HQGA 4GWCA 1P8NA 3CEVA 4GSZA 4HXQA 3F80A 1P8PA 3NIOA 2PLLA 4I06A 2EIVA 3SL0A 3GMZA 4MYLA 4IE2A 4IU4A 1WOGA 4Q3QA 4RHLA 2PHAA 4RLAA 4Q3RC 3M1RA 4ITYA 1HQ5A 1HQHA 2EF5A 4HZEA 1ZPGA 1PQ3A 1TBLA 1XFKA 4IXUA 3SL1A 4MYNA 1P8OA 4MYKA 4RHJA 4Q41A 4Q3RA 1T4RA 4RHMA 1HQXA 4Q3PA 4IU1A 1TBHA 3E6KA 1T5FA 4MYFA 1P8QA 3PZLA 4IE3A 4Q3VA 3MFVA 4FCKA 2EF4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T4P A;  3THE A;  1WOH A;  4RHI A;  1WVB A;  1D3V A;  3THH A;  3RLA A;  2A0M A;  1ZPE A;  1WOI A;  4IXV A;  3MFW A;  4GSV A;  4FCI A;  1WVA A;  1TA1 A;  3TH7 A;  4HWW A;  1T4T A;  4DZ4 A;  1HQF A;  1T5G A;  3DJ8 A;  3LP4 A;  4GWD A;  3MMR A;  4Q42 A;  1CEV A;  2PHO A;  3TF3 A;  3E8Z A;  1P8R A;  5HJ9 A;  4GSM A;  3MJL A;  4RHK A;  4IU0 A;  4Q3S A;  4Q40 A;  3NIQ A;  1P8M A;  2CEV A;  5CEV A;  3LHL A;  2RLA A;  4IE1 A;  4Q3U A;  1GQ6 A;  1TBJ A;  2AEB A;  5HJA A;  3SKK A;  1RLA A;  3KV2 A;  1GQ7 A;  4IU5 A;  3NIP A;  4Q3T A;  5RLA A;  4RHQ A;  1R1O A;  3E6V A;  3E9B A;  3E8Q A;  3THJ A;  1P8S A;  1T4S A;  4G3H A;  4CEV A;  3LP7 A;  2ZAV A;  3SJT A;  3GN0 A;  4MXR A;  1HQG A;  4GWC A;  1P8N A;  3CEV A;  4GSZ A;  4HXQ A;  3F80 A;  1P8P A;  3NIO A;  2PLL A;  4I06 A;  2EIV A;  3SL0 A;  3GMZ A;  4MYL A;  4IE2 A;  4IU4 A;  1WOG A;  4Q3Q A;  4RHL A;  2PHA A;  4RLA A;  4Q3R C;  3M1R A;  4ITY A;  1HQ5 A;  1HQH A;  2EF5 A;  4HZE A;  1ZPG A;  1PQ3 A;  1TBL A;  1XFK A;  4IXU A;  3SL1 A;  4MYN A;  1P8O A;  4MYK A;  4RHJ A;  4Q41 A;  4Q3R A;  1T4R A;  4RHM A;  1HQX A;  4Q3P A;  4IU1 A;  1TBH A;  3E6K A;  1T5F A;  4MYF A;  1P8Q A;  3PZL A;  4IE3 A;  4Q3V A;  3MFV A;  4FCK A;  2EF4 A; 
#chains in the Genus database with same CATH topology
 5EEK A;  1T4P A;  3F07 A;  4ZUR A;  3THE A;  1WOH A;  4RHI A;  3Q9F A;  5DC7 A;  5EFG A;  5G0J A;  1WVB A;  1D3V A;  3RQD A;  4BZ7 A;  3THH A;  3RLA A;  3C0Y A;  2A0M A;  5IX0 A;  1T67 A;  1ZPE A;  5BWZ A;  4CBY A;  1WOI A;  4IXV A;  5G13 A;  3MFW A;  4GSV A;  4FCI A;  1WVA A;  5EFH A;  3SFH A;  1TA1 A;  3TH7 A;  4HWW A;  1T4T A;  5G0X A;  4DZ4 A;  4QA5 A;  1HQF A;  5EF7 A;  1T5G A;  3DJ8 A;  1T69 A;  3LP4 A;  3SFF A;  4ZUQ A;  5THU A;  4GWD A;  5G0I A;  3MMR A;  4Q42 A;  5THS A;  1CEV A;  2PHO A;  3TF3 A;  2VQW G;  3E8Z A;  3Q9B A;  1P8R A;  5HJ9 A;  4GSM A;  4ZUO A;  2VQJ A;  3ZNR A;  3MJL A;  3EZT A;  4RHK A;  4IU0 A;  4Q3S A;  4Q40 A;  3NIQ A;  4QA3 A;  4QA2 A;  1P8M A;  2CEV A;  4A69 A;  4LY1 A;  5EEI A;  5EFK B;  5CEV A;  5A2S A;  4CBT A;  3LHL A;  4BZ5 A;  5G11 A;  2RLA A;  1W22 A;  2VCG A;  4IE1 A;  3MZ4 A;  4Q3U A;  5G10 A;  1GQ6 A;  5THT A;  4ZUN A;  3EW8 A;  1TBJ A;  5HJA A;  4BKX B;  3F0R A;  3SKK A;  1RLA A;  3F06 A;  3KV2 A;  1GQ7 A;  5DC6 A;  4BZ8 A;  4IU5 A;  4RN2 A;  5ICN B;  1ZZ1 A;  3NIP A;  5FCW A;  2VQQ A;  1ZZ3 A;  2GH6 A;  4Q3T A;  5RLA A;  4CQF A;  3C10 A;  4RHQ A;  1R1O A;  5G1B A;  4BZ9 A;  3E6V A;  5G1C A;  3E9B A;  1T64 A;  3E8Q A;  5D1C A;  5FUE A;  1P8S A;  1T4S A;  4G3H A;  5DC5 A;  3LP7 A;  5EFN A;  5G0Y A;  2ZAV A;  5G0H A;  4CEV A;  1C3S A;  3MFV A;  3SJT A;  2VQV A;  3C0Z A;  3GN0 A;  4MXR A;  4BZ6 A;  1HQG A;  2V5W A;  4GWC A;  1P8N A;  5D1B A;  3CEV A;  4GSZ A;  4QA7 A;  5G1A A;  4HXQ A;  5DC8 A;  3F80 A;  1P8P A;  3Q9C A;  3NIO A;  1ZZ0 A;  5JI5 A;  2PLL A;  4I06 A;  2EIV A;  3SL0 A;  4RN0 A;  3GMZ A;  5G17 A;  4MYL A;  4IE2 A;  4IU4 A;  1WOG A;  4Q3Q A;  5EEM A;  4QA6 A;  3ZNS A;  4RHL A;  2PHA A;  4RLA A;  4Q3R C;  5EFB D;  3M1R A;  4ITY A;  1HQ5 A;  5G0G A;  3Q9E A;  1HQH A;  4QA4 A;  5EFJ D;  5EEN A;  4QA0 A;  2EF5 A;  1VKG A;  1ZPG A;  4HZE A;  1PQ3 A;  1TBL A;  5G3W A;  1XFK A;  4IXU A;  4RN1 A;  3EZP A;  3SL1 A;  4MYN A;  3MZ6 A;  4ZUP A;  1P8O A;  3MZ3 A;  4LXZ A;  4MYK A;  4RHJ A;  4Q3R A;  5D1D A;  4Q41 A;  1T4R A;  3MAX A;  3MZ7 A;  4RHM A;  1HQX A;  4Q3P A;  5G12 A;  2VQO A;  5IWG A;  4IU1 A;  1TBH A;  3E6K A;  1C3P A;  1T5F A;  4MYF A;  5EF8 A;  3MEN A;  1C3R A;  1P8Q A;  4QA1 A;  3THJ A;  3EWF A;  3PZL A;  5EEF A;  4ZUM A;  5THV A;  2V5X A;  5LI3 A;  4IE3 A;  2VQM A;  4Q3V A;  2AEB A;  4FCK A;  2EF4 A; 
#chains in the Genus database with same CATH homology
 1T4P A;  3THE A;  1WOH A;  4RHI A;  1WVB A;  1D3V A;  3THH A;  3RLA A;  2A0M A;  1ZPE A;  1WOI A;  4IXV A;  3MFW A;  4GSV A;  4FCI A;  1WVA A;  1TA1 A;  3TH7 A;  4HWW A;  1T4T A;  4DZ4 A;  1HQF A;  1T5G A;  3DJ8 A;  3LP4 A;  4GWD A;  3MMR A;  4Q42 A;  1CEV A;  2PHO A;  3TF3 A;  3E8Z A;  1P8R A;  5HJ9 A;  4GSM A;  3MJL A;  4RHK A;  4IU0 A;  4Q3S A;  4Q40 A;  3NIQ A;  1P8M A;  2CEV A;  5CEV A;  3LHL A;  2RLA A;  4IE1 A;  4Q3U A;  1GQ6 A;  1TBJ A;  2AEB A;  5HJA A;  3SKK A;  1RLA A;  3KV2 A;  1GQ7 A;  4IU5 A;  3NIP A;  4Q3T A;  5RLA A;  4RHQ A;  1R1O A;  3E6V A;  3E9B A;  3E8Q A;  3THJ A;  1P8S A;  1T4S A;  4G3H A;  4CEV A;  3LP7 A;  2ZAV A;  3SJT A;  3GN0 A;  4MXR A;  1HQG A;  4GWC A;  1P8N A;  3CEV A;  4GSZ A;  4HXQ A;  3F80 A;  1P8P A;  3NIO A;  2PLL A;  4I06 A;  2EIV A;  3SL0 A;  3GMZ A;  4MYL A;  4IE2 A;  4IU4 A;  1WOG A;  4Q3Q A;  4RHL A;  2PHA A;  4RLA A;  4Q3R C;  3M1R A;  4ITY A;  1HQ5 A;  1HQH A;  2EF5 A;  4HZE A;  1ZPG A;  1PQ3 A;  1TBL A;  1XFK A;  4IXU A;  3SL1 A;  4MYN A;  1P8O A;  4MYK A;  4RHJ A;  4Q41 A;  4Q3R A;  1T4R A;  4RHM A;  1HQX A;  4Q3P A;  4IU1 A;  1TBH A;  3E6K A;  1T5F A;  4MYF A;  1P8Q A;  3PZL A;  4IE3 A;  4Q3V A;  3MFV A;  4FCK A;  2EF4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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