1HQXA

R308k arginase variant
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKKEGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
pubmed rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 112
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2000-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1hqxA00
4Q3PA 1P8NA 1P8OA 2RLAA 3E8QA 3LP7A 3TF3A 4GSZA 3NIOA 4RHKA 1WVAA 4HWWA 3SKKA 2AEBA 1CEVA 1T4RA 4Q41A 5RLAA 2PLLA 4Q3RC 4MXRA 1TA1A 4GSVA 3THEA 4I06A 3LP4A 4Q3UA 4Q3RA 3MJLA 4GSMA 2EF4A 3NIPA 4G3HA 4FCIA 5HJAA 4MYFA 3NIQA 4Q3SA 3MFVA 3M1RA 1HQFA 3DJ8A 4RHJA 2A0MA 4RLAA 1WVBA 1D3VA 4Q42A 3MMRA 2PHOA 4CEVA 3E8ZA 1T4TA 1RLAA 3E9BA 4IXUA 4IU1A 1WOHA 4IE3A 1P8MA 1WOGA 3E6VA 1HQ5A 3SJTA 4IU4A 4IXVA 1XFKA 4GWCA 1ZPGA 4ITYA 1T4PA 4Q40A 5HJ9A 2EF5A 1P8RA 5CEVA 4GWDA 1T4SA 1PQ3A 2ZAVA 3KV2A 4Q3VA 3SL0A 3GMZA 1R1OA 1GQ6A 3LHLA 1TBLA 1P8QA 4MYKA 4Q3QA 4MYLA 3TH7A 1GQ7A 3MFWA 4RHIA 2PHAA 4RHQA 1ZPEA 3GN0A 4RHMA 4Q3TA 1TBJA 1HQGA 1HQXA 3F80A 1T5FA 1P8PA 1P8SA 3PZLA 3E6KA 1WOIA 1HQHA 4HXQA 4IE1A 2EIVA 4HZEA 4DZ4A 4IE2A 3RLAA 3THHA 4MYNA 3THJA 4FCKA 3CEVA 4IU5A 1T5GA 4RHLA 1TBHA 3SL1A 2CEVA 4IU0A
chains in the Genus database with same CATH superfamily
4ZUQA 5EFHA 3EZTA 4Q3PA 5EEFA 5G1AA 1P8NA 4QA7A 1P8OA 2RLAA 5THUA 4CBYA 3E8QA 3LP7A 3TF3A 5BWZA 4GSZA 3SFHA 5THTA 4QA1A 4QA4A 3NIOA 4RHKA 1WVAA 2VQJA 4HWWA 3SKKA 2AEBA 5G1CA 5G13A 1CEVA 1T4RA 1ZZ1A 5RLAA 1T69A 4Q41A 2PLLA 4RN2A 4Q3RC 5DC5A 4BKXB 1C3PA 5G3WA 3F06A 4MXRA 1TA1A 4QA2A 4GSVA 3THEA 4I06A 5THVA 3LP4A 4Q3UA 5DC7A 5ICNB 5EEIA 5JI5A 3MZ6A 4QA5A 1T67A 3C10A 4Q3RA 5FCWA 3MJLA 4GSMA 3C0YA 1C3SA 5DC6A 5EFNA 2EF4A 3NIPA 4G3HA 4FCIA 5HJAA 4MYFA 3NIQA 5IWGA 4BZ6A 5EF8A 3EWFA 4Q3SA 3F0RA 3MFVA 4ZUMA 5EF7A 3M1RA 1HQFA 3DJ8A 4BZ7A 1ZZ3A 4RHJA 2A0MA 4RLAA 1C3RA 5EFJD 4BZ8A 2VQQA 1WVBA 1D3VA 4Q42A 2VQWG 3MMRA 4LY1A 5A2SA 4BZ9A 2PHOA 4CEVA 4ZUOA 3E8ZA 1T4TA 1RLAA 3E9BA 3MZ4A 4ZUPA 3RQDA 4IXUA 5EEMA 4IU1A 1WOHA 4IE3A 1P8MA 5EENA 5G0IA 4ZURA 3Q9EA 1WOGA 5D1CA 3E6VA 5G0HA 1HQ5A 3SJTA 3MAXA 4IU4A 3MENA 4IXVA 1XFKA 4GWCA 1ZPGA 3F07A 4ITYA 1T4PA 4Q40A 4QA3A 5EFKB 5HJ9A 5IX0A 5THSA 2EF5A 5G0GA 1P8RA 5CEVA 1ZZ0A 1W22A 3Q9BA 4GWDA 3ZNRA 4A69A 1T4SA 3MZ7A 5G12A 3EZPA 3C0ZA 1PQ3A 4RN0A 1T64A 2ZAVA 3KV2A 4Q3VA 5G1BA 5D1DA 5G17A 3SL0A 4CBTA 3GMZA 1R1OA 1GQ6A 3LHLA 3SFFA 2VQVA 1TBLA 5EFGA 1P8QA 4MYKA 4Q3QA 4MYLA 5D1BA 5DC8A 5G0YA 3TH7A 2VQOA 3ZNSA 3MZ3A 5FUEA 1GQ7A 3MFWA 4RHIA 2PHAA 4RHQA 5EEKA 5G0XA 1ZPEA 3GN0A 4RHMA 4Q3TA 4RN1A 1TBJA 1HQGA 5EFBD 1HQXA 2GH6A 2V5XA 5G0JA 4ZUNA 2VCGA 3F80A 1T5FA 4CQFA 1P8PA 1P8SA 3PZLA 2V5WA 5G11A 3E6KA 1WOIA 4QA0A 1HQHA 4HXQA 4IE1A 5LI3A 2EIVA 4BZ5A 4HZEA 4DZ4A 4IE2A 3RLAA 3THHA 2VQMA 4MYNA 3THJA 1VKGA 4QA6A 4FCKA 3Q9FA 3CEVA 4IU5A 4LXZA 1T5GA 4RHLA 1TBHA 3EW8A 3SL1A 3Q9CA 5G10A 2CEVA 4IU0A
chains in the Genus database with same CATH topology
4Q3PA 1P8NA 1P8OA 2RLAA 3E8QA 3LP7A 3TF3A 4GSZA 3NIOA 4RHKA 1WVAA 4HWWA 3SKKA 2AEBA 1CEVA 1T4RA 4Q41A 5RLAA 2PLLA 4Q3RC 4MXRA 1TA1A 4GSVA 3THEA 4I06A 3LP4A 4Q3UA 4Q3RA 3MJLA 4GSMA 2EF4A 3NIPA 4G3HA 4FCIA 5HJAA 4MYFA 3NIQA 4Q3SA 3MFVA 3M1RA 1HQFA 3DJ8A 4RHJA 2A0MA 4RLAA 1WVBA 1D3VA 4Q42A 3MMRA 2PHOA 4CEVA 3E8ZA 1T4TA 1RLAA 3E9BA 4IXUA 4IU1A 1WOHA 4IE3A 1P8MA 1WOGA 3E6VA 1HQ5A 3SJTA 4IU4A 4IXVA 1XFKA 4GWCA 1ZPGA 4ITYA 1T4PA 4Q40A 5HJ9A 2EF5A 1P8RA 5CEVA 4GWDA 1T4SA 1PQ3A 2ZAVA 3KV2A 4Q3VA 3SL0A 3GMZA 1R1OA 1GQ6A 3LHLA 1TBLA 1P8QA 4MYKA 4Q3QA 4MYLA 3TH7A 1GQ7A 3MFWA 4RHIA 2PHAA 4RHQA 1ZPEA 3GN0A 4RHMA 4Q3TA 1TBJA 1HQGA 1HQXA 3F80A 1T5FA 1P8PA 1P8SA 3PZLA 3E6KA 1WOIA 1HQHA 4HXQA 4IE1A 2EIVA 4HZEA 4DZ4A 4IE2A 3RLAA 3THHA 4MYNA 3THJA 4FCKA 3CEVA 4IU5A 1T5GA 4RHLA 1TBHA 3SL1A 2CEVA 4IU0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q3P A;  1P8N A;  1P8O A;  2RLA A;  3E8Q A;  3LP7 A;  3TF3 A;  4GSZ A;  3NIO A;  4RHK A;  1WVA A;  4HWW A;  3SKK A;  2AEB A;  1CEV A;  1T4R A;  4Q41 A;  5RLA A;  2PLL A;  4Q3R C;  4MXR A;  1TA1 A;  4GSV A;  3THE A;  4I06 A;  3LP4 A;  4Q3U A;  4Q3R A;  3MJL A;  4GSM A;  2EF4 A;  3NIP A;  4G3H A;  4FCI A;  5HJA A;  4MYF A;  3NIQ A;  4Q3S A;  3MFV A;  3M1R A;  1HQF A;  3DJ8 A;  4RHJ A;  2A0M A;  4RLA A;  1WVB A;  1D3V A;  4Q42 A;  3MMR A;  2PHO A;  4CEV A;  3E8Z A;  1T4T A;  1RLA A;  3E9B A;  4IXU A;  4IU1 A;  1WOH A;  4IE3 A;  1P8M A;  1WOG A;  3E6V A;  1HQ5 A;  3SJT A;  4IU4 A;  4IXV A;  1XFK A;  4GWC A;  1ZPG A;  4ITY A;  1T4P A;  4Q40 A;  5HJ9 A;  2EF5 A;  1P8R A;  5CEV A;  4GWD A;  1T4S A;  1PQ3 A;  2ZAV A;  3KV2 A;  4Q3V A;  3SL0 A;  3GMZ A;  1R1O A;  1GQ6 A;  3LHL A;  1TBL A;  1P8Q A;  4MYK A;  4Q3Q A;  4MYL A;  3TH7 A;  1GQ7 A;  3MFW A;  4RHI A;  2PHA A;  4RHQ A;  1ZPE A;  3GN0 A;  4RHM A;  4Q3T A;  1TBJ A;  1HQG A;  1HQX A;  3F80 A;  1T5F A;  1P8P A;  1P8S A;  3PZL A;  3E6K A;  1WOI A;  1HQH A;  4HXQ A;  4IE1 A;  2EIV A;  4HZE A;  4DZ4 A;  4IE2 A;  3RLA A;  3THH A;  4MYN A;  3THJ A;  4FCK A;  3CEV A;  4IU5 A;  1T5G A;  4RHL A;  1TBH A;  3SL1 A;  2CEV A;  4IU0 A; 
#chains in the Genus database with same CATH topology
 4ZUQ A;  5EFH A;  3EZT A;  4Q3P A;  5EEF A;  5G1A A;  1P8N A;  4QA7 A;  1P8O A;  2RLA A;  5THU A;  4CBY A;  3E8Q A;  3LP7 A;  3TF3 A;  5BWZ A;  4GSZ A;  3SFH A;  5THT A;  4QA1 A;  4QA4 A;  3NIO A;  4RHK A;  1WVA A;  2VQJ A;  4HWW A;  3SKK A;  2AEB A;  5G1C A;  5G13 A;  1CEV A;  1T4R A;  1ZZ1 A;  5RLA A;  1T69 A;  4Q41 A;  2PLL A;  4RN2 A;  4Q3R C;  5DC5 A;  4BKX B;  1C3P A;  5G3W A;  3F06 A;  4MXR A;  1TA1 A;  4QA2 A;  4GSV A;  3THE A;  4I06 A;  5THV A;  3LP4 A;  4Q3U A;  5DC7 A;  5ICN B;  5EEI A;  5JI5 A;  3MZ6 A;  4QA5 A;  1T67 A;  3C10 A;  4Q3R A;  5FCW A;  3MJL A;  4GSM A;  3C0Y A;  1C3S A;  5DC6 A;  5EFN A;  2EF4 A;  3NIP A;  4G3H A;  4FCI A;  5HJA A;  4MYF A;  3NIQ A;  5IWG A;  4BZ6 A;  5EF8 A;  3EWF A;  4Q3S A;  3F0R A;  3MFV A;  4ZUM A;  5EF7 A;  3M1R A;  1HQF A;  3DJ8 A;  4BZ7 A;  1ZZ3 A;  4RHJ A;  2A0M A;  4RLA A;  1C3R A;  5EFJ D;  4BZ8 A;  2VQQ A;  1WVB A;  1D3V A;  4Q42 A;  2VQW G;  3MMR A;  4LY1 A;  5A2S A;  4BZ9 A;  2PHO A;  4CEV A;  4ZUO A;  3E8Z A;  1T4T A;  1RLA A;  3E9B A;  3MZ4 A;  4ZUP A;  3RQD A;  4IXU A;  5EEM A;  4IU1 A;  1WOH A;  4IE3 A;  1P8M A;  5EEN A;  5G0I A;  4ZUR A;  3Q9E A;  1WOG A;  5D1C A;  3E6V A;  5G0H A;  1HQ5 A;  3SJT A;  3MAX A;  4IU4 A;  3MEN A;  4IXV A;  1XFK A;  4GWC A;  1ZPG A;  3F07 A;  4ITY A;  1T4P A;  4Q40 A;  4QA3 A;  5EFK B;  5HJ9 A;  5IX0 A;  5THS A;  2EF5 A;  5G0G A;  1P8R A;  5CEV A;  1ZZ0 A;  1W22 A;  3Q9B A;  4GWD A;  3ZNR A;  4A69 A;  1T4S A;  3MZ7 A;  5G12 A;  3EZP A;  3C0Z A;  1PQ3 A;  4RN0 A;  1T64 A;  2ZAV A;  3KV2 A;  4Q3V A;  5G1B A;  5D1D A;  5G17 A;  3SL0 A;  4CBT A;  3GMZ A;  1R1O A;  1GQ6 A;  3LHL A;  3SFF A;  2VQV A;  1TBL A;  5EFG A;  1P8Q A;  4MYK A;  4Q3Q A;  4MYL A;  5D1B A;  5DC8 A;  5G0Y A;  3TH7 A;  2VQO A;  3ZNS A;  3MZ3 A;  5FUE A;  1GQ7 A;  3MFW A;  4RHI A;  2PHA A;  4RHQ A;  5EEK A;  5G0X A;  1ZPE A;  3GN0 A;  4RHM A;  4Q3T A;  4RN1 A;  1TBJ A;  1HQG A;  5EFB D;  1HQX A;  2GH6 A;  2V5X A;  5G0J A;  4ZUN A;  2VCG A;  3F80 A;  1T5F A;  4CQF A;  1P8P A;  1P8S A;  3PZL A;  2V5W A;  5G11 A;  3E6K A;  1WOI A;  4QA0 A;  1HQH A;  4HXQ A;  4IE1 A;  5LI3 A;  2EIV A;  4BZ5 A;  4HZE A;  4DZ4 A;  4IE2 A;  3RLA A;  3THH A;  2VQM A;  4MYN A;  3THJ A;  1VKG A;  4QA6 A;  4FCK A;  3Q9F A;  3CEV A;  4IU5 A;  4LXZ A;  1T5G A;  4RHL A;  1TBH A;  3EW8 A;  3SL1 A;  3Q9C A;  5G10 A;  2CEV A;  4IU0 A; 
#chains in the Genus database with same CATH homology
 4Q3P A;  1P8N A;  1P8O A;  2RLA A;  3E8Q A;  3LP7 A;  3TF3 A;  4GSZ A;  3NIO A;  4RHK A;  1WVA A;  4HWW A;  3SKK A;  2AEB A;  1CEV A;  1T4R A;  4Q41 A;  5RLA A;  2PLL A;  4Q3R C;  4MXR A;  1TA1 A;  4GSV A;  3THE A;  4I06 A;  3LP4 A;  4Q3U A;  4Q3R A;  3MJL A;  4GSM A;  2EF4 A;  3NIP A;  4G3H A;  4FCI A;  5HJA A;  4MYF A;  3NIQ A;  4Q3S A;  3MFV A;  3M1R A;  1HQF A;  3DJ8 A;  4RHJ A;  2A0M A;  4RLA A;  1WVB A;  1D3V A;  4Q42 A;  3MMR A;  2PHO A;  4CEV A;  3E8Z A;  1T4T A;  1RLA A;  3E9B A;  4IXU A;  4IU1 A;  1WOH A;  4IE3 A;  1P8M A;  1WOG A;  3E6V A;  1HQ5 A;  3SJT A;  4IU4 A;  4IXV A;  1XFK A;  4GWC A;  1ZPG A;  4ITY A;  1T4P A;  4Q40 A;  5HJ9 A;  2EF5 A;  1P8R A;  5CEV A;  4GWD A;  1T4S A;  1PQ3 A;  2ZAV A;  3KV2 A;  4Q3V A;  3SL0 A;  3GMZ A;  1R1O A;  1GQ6 A;  3LHL A;  1TBL A;  1P8Q A;  4MYK A;  4Q3Q A;  4MYL A;  3TH7 A;  1GQ7 A;  3MFW A;  4RHI A;  2PHA A;  4RHQ A;  1ZPE A;  3GN0 A;  4RHM A;  4Q3T A;  1TBJ A;  1HQG A;  1HQX A;  3F80 A;  1T5F A;  1P8P A;  1P8S A;  3PZL A;  3E6K A;  1WOI A;  1HQH A;  4HXQ A;  4IE1 A;  2EIV A;  4HZE A;  4DZ4 A;  4IE2 A;  3RLA A;  3THH A;  4MYN A;  3THJ A;  4FCK A;  3CEV A;  4IU5 A;  1T5G A;  4RHL A;  1TBH A;  3SL1 A;  2CEV A;  4IU0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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