1P8PA

Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase i.
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords Arginase 1
total genus 105
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2003-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 1p8pA00
4IU0A 3KV2A 1GQ7A 1GQ6A 1P8MA 1P8QA 4RLAA 2PLLA 3MFVA 1P8RA 3THEA 1HQFA 1HQGA 3SKKA 4GSMA 4RHIA 1P8PA 3NIOA 3F80A 4Q3RC 3TF3A 1P8NA 4Q42A 5HJAA 5HJ9A 3GMZA 3GN0A 4Q3UA 3M1RA 4FCKA 4IXVA 2PHOA 3DJ8A 3THJA 4IXUA 4FCIA 1P8OA 1TA1A 4ITYA 1TBJA 4RHJA 1P8SA 4IU4A 3SL1A 2CEVA 2EIVA 4GWCA 3NIQA 3NIPA 1T4TA 3E6VA 1T4PA 4MYLA 1T4SA 1R1OA 1ZPGA 3E8ZA 4HXQA 2AEBA 1ZPEA 1TBLA 4I06A 1CEVA 5RLAA 1RLAA 4Q40A 3SL0A 1D3VA 1WOGA 4GSZA 4Q3PA 4MYNA 1XFKA 4IE3A 1WOIA 1PQ3A 4IE2A 4RHMA 4MYFA 4IU1A 1HQHA 1T5GA 1HQ5A 3MMRA 4GWDA 3LP7A 3E9BA 3SJTA 3LHLA 4Q3SA 3LP4A 4MXRA 1WVBA 4DZ4A 1WVAA 4GSVA 1T5FA 4RHLA 4RHKA 1T4RA 3MJLA 4IU5A 4CEVA 1TBHA 3E8QA 2ZAVA 2RLAA 4HWWA 3CEVA 4MYKA 1HQXA 4HZEA 4Q3TA 3RLAA 4RHQA 2EF4A 1WOHA 4IE1A 5CEVA 3PZLA 4Q41A 2A0MA 4Q3RA 2EF5A 3THHA 3E6KA 3MFWA 4G3HA 4Q3VA 2PHAA 4Q3QA 3TH7A
chains in the Genus database with same CATH superfamily
4IU0A 3KV2A 4LY1A 1GQ7A 1GQ6A 1P8MA 5G0HA 5G1CA 1P8QA 4RLAA 5THVA 2PLLA 4A69A 5DC6A 3MFVA 3F06A 1P8RA 3THEA 3C0YA 5EENA 1T64A 5G10A 1C3RA 1HQFA 3MAXA 1HQGA 5THSA 3SKKA 4GSMA 4RHIA 1P8PA 5EEFA 4QA4A 3NIOA 3F80A 4Q3RC 4RN1A 3TF3A 1P8NA 3Q9FA 3SFFA 4CBTA 4Q42A 4QA2A 5HJAA 5HJ9A 4BKXB 3GMZA 3GN0A 4Q3UA 5D1BA 5G12A 4BZ8A 3M1RA 4FCKA 2VQWG 4IXVA 5JI5A 5G13A 2PHOA 3DJ8A 5EFBD 5G0YA 5G0IA 3THJA 3MENA 4IXUA 4BZ9A 3MZ4A 1C3SA 4FCIA 1P8OA 1TA1A 4QA5A 4ITYA 4ZURA 5EF7A 2GH6A 5DC5A 1VKGA 1TBJA 4RHJA 1P8SA 3EWFA 4IU4A 5G0GA 3SL1A 1T69A 2VQOA 3EZPA 2V5WA 2CEVA 4QA1A 1ZZ3A 3C0ZA 2EIVA 4GWCA 3NIQA 3NIPA 4BZ5A 1T4TA 3E6VA 1T4PA 4MYLA 1T4SA 5EFGA 3ZNSA 1R1OA 1ZPGA 3F0RA 5EFHA 3E8ZA 4HXQA 2AEBA 4RN2A 5EFNA 5LI3A 1ZPEA 2VQQA 1TBLA 3F07A 4I06A 5G0JA 1CEVA 5G1BA 5RLAA 4BZ7A 3C10A 3ZNRA 1RLAA 4ZUMA 5DC7A 1ZZ0A 4Q40A 5THTA 5IWGA 4ZUQA 5G17A 3SL0A 1D3VA 1WOGA 4GSZA 4QA3A 4Q3PA 4MYNA 1XFKA 4IE3A 1WOIA 1PQ3A 4IE2A 4RHMA 3Q9BA 5G11A 2VQJA 5FUEA 4MYFA 4IU1A 5EEKA 1C3PA 1HQHA 1T5GA 1HQ5A 3MZ3A 5FCWA 3MMRA 2VQVA 4QA0A 4GWDA 3LP7A 3E9BA 3EZTA 5D1CA 3SJTA 5BWZA 3LHLA 4Q3SA 3LP4A 4MXRA 1WVBA 4QA6A 5EF8A 4DZ4A 1WVAA 5G3WA 4GSVA 1T5FA 4RHLA 3Q9EA 4ZUNA 5EFKB 1W22A 3Q9CA 4RHKA 5ICNB 1T4RA 2VCGA 5EEMA 3MJLA 4IU5A 4CEVA 3RQDA 1TBHA 3E8QA 2ZAVA 2RLAA 5G1AA 4HWWA 3CEVA 4MYKA 4CQFA 1HQXA 4HZEA 4Q3TA 5EFJD 3RLAA 4RHQA 3MZ7A 4ZUPA 2EF4A 4QA7A 5G0XA 4LXZA 1WOHA 5IX0A 4IE1A 4ZUOA 5EEIA 4CBYA 1ZZ1A 2V5XA 5CEVA 3PZLA 4Q41A 2VQMA 2A0MA 5THUA 3EW8A 3MZ6A 4Q3RA 1T67A 2EF5A 3E6KA 4RN0A 5D1DA 3SFHA 3THHA 4BZ6A 3MFWA 4G3HA 4Q3VA 5DC8A 5A2SA 2PHAA 4Q3QA 3TH7A
chains in the Genus database with same CATH topology
4IU0A 3KV2A 1GQ7A 1GQ6A 1P8MA 1P8QA 4RLAA 2PLLA 3MFVA 1P8RA 3THEA 1HQFA 1HQGA 3SKKA 4GSMA 4RHIA 1P8PA 3NIOA 3F80A 4Q3RC 3TF3A 1P8NA 4Q42A 5HJAA 5HJ9A 3GMZA 3GN0A 4Q3UA 3M1RA 4FCKA 4IXVA 2PHOA 3DJ8A 3THJA 4IXUA 4FCIA 1P8OA 1TA1A 4ITYA 1TBJA 4RHJA 1P8SA 4IU4A 3SL1A 2CEVA 2EIVA 4GWCA 3NIQA 3NIPA 1T4TA 3E6VA 1T4PA 4MYLA 1T4SA 1R1OA 1ZPGA 3E8ZA 4HXQA 2AEBA 1ZPEA 1TBLA 4I06A 1CEVA 5RLAA 1RLAA 4Q40A 3SL0A 1D3VA 1WOGA 4GSZA 4Q3PA 4MYNA 1XFKA 4IE3A 1WOIA 1PQ3A 4IE2A 4RHMA 4MYFA 4IU1A 1HQHA 1T5GA 1HQ5A 3MMRA 4GWDA 3LP7A 3E9BA 3SJTA 3LHLA 4Q3SA 3LP4A 4MXRA 1WVBA 4DZ4A 1WVAA 4GSVA 1T5FA 4RHLA 4RHKA 1T4RA 3MJLA 4IU5A 4CEVA 1TBHA 3E8QA 2ZAVA 2RLAA 4HWWA 3CEVA 4MYKA 1HQXA 4HZEA 4Q3TA 3RLAA 4RHQA 2EF4A 1WOHA 4IE1A 5CEVA 3PZLA 4Q41A 2A0MA 4Q3RA 2EF5A 3THHA 3E6KA 3MFWA 4G3HA 4Q3VA 2PHAA 4Q3QA 3TH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IU0 A;  3KV2 A;  1GQ7 A;  1GQ6 A;  1P8M A;  1P8Q A;  4RLA A;  2PLL A;  3MFV A;  1P8R A;  3THE A;  1HQF A;  1HQG A;  3SKK A;  4GSM A;  4RHI A;  1P8P A;  3NIO A;  3F80 A;  4Q3R C;  3TF3 A;  1P8N A;  4Q42 A;  5HJA A;  5HJ9 A;  3GMZ A;  3GN0 A;  4Q3U A;  3M1R A;  4FCK A;  4IXV A;  2PHO A;  3DJ8 A;  3THJ A;  4IXU A;  4FCI A;  1P8O A;  1TA1 A;  4ITY A;  1TBJ A;  4RHJ A;  1P8S A;  4IU4 A;  3SL1 A;  2CEV A;  2EIV A;  4GWC A;  3NIQ A;  3NIP A;  1T4T A;  3E6V A;  1T4P A;  4MYL A;  1T4S A;  1R1O A;  1ZPG A;  3E8Z A;  4HXQ A;  2AEB A;  1ZPE A;  1TBL A;  4I06 A;  1CEV A;  5RLA A;  1RLA A;  4Q40 A;  3SL0 A;  1D3V A;  1WOG A;  4GSZ A;  4Q3P A;  4MYN A;  1XFK A;  4IE3 A;  1WOI A;  1PQ3 A;  4IE2 A;  4RHM A;  4MYF A;  4IU1 A;  1HQH A;  1T5G A;  1HQ5 A;  3MMR A;  4GWD A;  3LP7 A;  3E9B A;  3SJT A;  3LHL A;  4Q3S A;  3LP4 A;  4MXR A;  1WVB A;  4DZ4 A;  1WVA A;  4GSV A;  1T5F A;  4RHL A;  4RHK A;  1T4R A;  3MJL A;  4IU5 A;  4CEV A;  1TBH A;  3E8Q A;  2ZAV A;  2RLA A;  4HWW A;  3CEV A;  4MYK A;  1HQX A;  4HZE A;  4Q3T A;  3RLA A;  4RHQ A;  2EF4 A;  1WOH A;  4IE1 A;  5CEV A;  3PZL A;  4Q41 A;  2A0M A;  4Q3R A;  2EF5 A;  3THH A;  3E6K A;  3MFW A;  4G3H A;  4Q3V A;  2PHA A;  4Q3Q A;  3TH7 A; 
#chains in the Genus database with same CATH topology
 4IU0 A;  3KV2 A;  4LY1 A;  1GQ7 A;  1GQ6 A;  1P8M A;  5G0H A;  5G1C A;  1P8Q A;  4RLA A;  5THV A;  2PLL A;  4A69 A;  5DC6 A;  3MFV A;  3F06 A;  1P8R A;  3THE A;  3C0Y A;  5EEN A;  1T64 A;  5G10 A;  1C3R A;  1HQF A;  3MAX A;  1HQG A;  5THS A;  3SKK A;  4GSM A;  4RHI A;  1P8P A;  5EEF A;  4QA4 A;  3NIO A;  3F80 A;  4Q3R C;  4RN1 A;  3TF3 A;  1P8N A;  3Q9F A;  3SFF A;  4CBT A;  4Q42 A;  4QA2 A;  5HJA A;  5HJ9 A;  4BKX B;  3GMZ A;  3GN0 A;  4Q3U A;  5D1B A;  5G12 A;  4BZ8 A;  3M1R A;  4FCK A;  2VQW G;  4IXV A;  5JI5 A;  5G13 A;  2PHO A;  3DJ8 A;  5EFB D;  5G0Y A;  5G0I A;  3THJ A;  3MEN A;  4IXU A;  4BZ9 A;  3MZ4 A;  1C3S A;  4FCI A;  1P8O A;  1TA1 A;  4QA5 A;  4ITY A;  4ZUR A;  5EF7 A;  2GH6 A;  5DC5 A;  1VKG A;  1TBJ A;  4RHJ A;  1P8S A;  3EWF A;  4IU4 A;  5G0G A;  3SL1 A;  1T69 A;  2VQO A;  3EZP A;  2V5W A;  2CEV A;  4QA1 A;  1ZZ3 A;  3C0Z A;  2EIV A;  4GWC A;  3NIQ A;  3NIP A;  4BZ5 A;  1T4T A;  3E6V A;  1T4P A;  4MYL A;  1T4S A;  5EFG A;  3ZNS A;  1R1O A;  1ZPG A;  3F0R A;  5EFH A;  3E8Z A;  4HXQ A;  2AEB A;  4RN2 A;  5EFN A;  5LI3 A;  1ZPE A;  2VQQ A;  1TBL A;  3F07 A;  4I06 A;  5G0J A;  1CEV A;  5G1B A;  5RLA A;  4BZ7 A;  3C10 A;  3ZNR A;  1RLA A;  4ZUM A;  5DC7 A;  1ZZ0 A;  4Q40 A;  5THT A;  5IWG A;  4ZUQ A;  5G17 A;  3SL0 A;  1D3V A;  1WOG A;  4GSZ A;  4QA3 A;  4Q3P A;  4MYN A;  1XFK A;  4IE3 A;  1WOI A;  1PQ3 A;  4IE2 A;  4RHM A;  3Q9B A;  5G11 A;  2VQJ A;  5FUE A;  4MYF A;  4IU1 A;  5EEK A;  1C3P A;  1HQH A;  1T5G A;  1HQ5 A;  3MZ3 A;  5FCW A;  3MMR A;  2VQV A;  4QA0 A;  4GWD A;  3LP7 A;  3E9B A;  3EZT A;  5D1C A;  3SJT A;  5BWZ A;  3LHL A;  4Q3S A;  3LP4 A;  4MXR A;  1WVB A;  4QA6 A;  5EF8 A;  4DZ4 A;  1WVA A;  5G3W A;  4GSV A;  1T5F A;  4RHL A;  3Q9E A;  4ZUN A;  5EFK B;  1W22 A;  3Q9C A;  4RHK A;  5ICN B;  1T4R A;  2VCG A;  5EEM A;  3MJL A;  4IU5 A;  4CEV A;  3RQD A;  1TBH A;  3E8Q A;  2ZAV A;  2RLA A;  5G1A A;  4HWW A;  3CEV A;  4MYK A;  4CQF A;  1HQX A;  4HZE A;  4Q3T A;  5EFJ D;  3RLA A;  4RHQ A;  3MZ7 A;  4ZUP A;  2EF4 A;  4QA7 A;  5G0X A;  4LXZ A;  1WOH A;  5IX0 A;  4IE1 A;  4ZUO A;  5EEI A;  4CBY A;  1ZZ1 A;  2V5X A;  5CEV A;  3PZL A;  4Q41 A;  2VQM A;  2A0M A;  5THU A;  3EW8 A;  3MZ6 A;  4Q3R A;  1T67 A;  2EF5 A;  3E6K A;  4RN0 A;  5D1D A;  3SFH A;  3THH A;  4BZ6 A;  3MFW A;  4G3H A;  4Q3V A;  5DC8 A;  5A2S A;  2PHA A;  4Q3Q A;  3TH7 A; 
#chains in the Genus database with same CATH homology
 4IU0 A;  3KV2 A;  1GQ7 A;  1GQ6 A;  1P8M A;  1P8Q A;  4RLA A;  2PLL A;  3MFV A;  1P8R A;  3THE A;  1HQF A;  1HQG A;  3SKK A;  4GSM A;  4RHI A;  1P8P A;  3NIO A;  3F80 A;  4Q3R C;  3TF3 A;  1P8N A;  4Q42 A;  5HJA A;  5HJ9 A;  3GMZ A;  3GN0 A;  4Q3U A;  3M1R A;  4FCK A;  4IXV A;  2PHO A;  3DJ8 A;  3THJ A;  4IXU A;  4FCI A;  1P8O A;  1TA1 A;  4ITY A;  1TBJ A;  4RHJ A;  1P8S A;  4IU4 A;  3SL1 A;  2CEV A;  2EIV A;  4GWC A;  3NIQ A;  3NIP A;  1T4T A;  3E6V A;  1T4P A;  4MYL A;  1T4S A;  1R1O A;  1ZPG A;  3E8Z A;  4HXQ A;  2AEB A;  1ZPE A;  1TBL A;  4I06 A;  1CEV A;  5RLA A;  1RLA A;  4Q40 A;  3SL0 A;  1D3V A;  1WOG A;  4GSZ A;  4Q3P A;  4MYN A;  1XFK A;  4IE3 A;  1WOI A;  1PQ3 A;  4IE2 A;  4RHM A;  4MYF A;  4IU1 A;  1HQH A;  1T5G A;  1HQ5 A;  3MMR A;  4GWD A;  3LP7 A;  3E9B A;  3SJT A;  3LHL A;  4Q3S A;  3LP4 A;  4MXR A;  1WVB A;  4DZ4 A;  1WVA A;  4GSV A;  1T5F A;  4RHL A;  4RHK A;  1T4R A;  3MJL A;  4IU5 A;  4CEV A;  1TBH A;  3E8Q A;  2ZAV A;  2RLA A;  4HWW A;  3CEV A;  4MYK A;  1HQX A;  4HZE A;  4Q3T A;  3RLA A;  4RHQ A;  2EF4 A;  1WOH A;  4IE1 A;  5CEV A;  3PZL A;  4Q41 A;  2A0M A;  4Q3R A;  2EF5 A;  3THH A;  3E6K A;  3MFW A;  4G3H A;  4Q3V A;  2PHA A;  4Q3Q A;  3TH7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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