2CEVA

Arginase from bacillus caldevelox, native structure at ph 8.5
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
298
structure length
298
Chain Sequence
KPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIPIGKAERLHEQGDSRLRNLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGHPALTQIGGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLKERTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERNKTASVAVALMGSLFGEKLM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of Bacillus caldovelox arginase in complex with substrate and inhibitors reveal new insights into activation, inhibition and catalysis in the arginase superfamily.
pubmed doi rcsb
molecule tags Hydrolase
source organism Bacillus caldovelox
molecule keywords PROTEIN (ARGINASE)
total genus 117
structure length 298
sequence length 298
chains with identical sequence B, C, D, E, F
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1999-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2cevA00
4IU4A 1T5GA 3MJLA 4IU1A 3M1RA 4RHQA 2RLAA 4RHLA 3KV2A 1R1OA 1TBJA 1P8RA 1WVBA 5HJAA 3THJA 2PHOA 3NIPA 4IXVA 1P8PA 1T4SA 3MFWA 4IU0A 3GMZA 4HZEA 4DZ4A 4GSVA 4MYFA 4MYNA 1P8SA 1GQ7A 1TA1A 4Q3QA 1TBHA 3THEA 4IU5A 3GN0A 5RLAA 4HWWA 4IXUA 3LHLA 4RHJA 3PZLA 4GWDA 1RLAA 3E8ZA 2EIVA 4G3HA 1PQ3A 4FCKA 1D3VA 1CEVA 3NIQA 1WOIA 4MYLA 1P8NA 3SL1A 3E9BA 4GSMA 1ZPGA 4IE2A 2A0MA 3NIOA 1WVAA 2EF5A 2PHAA 1XFKA 2CEVA 1T4PA 3E6KA 1P8OA 2AEBA 1T5FA 5CEVA 4MYKA 4RHIA 4FCIA 3F80A 1P8MA 1HQFA 4Q41A 3CEVA 4Q42A 4ITYA 1P8QA 1GQ6A 1WOGA 4Q40A 4HXQA 4IE3A 4RHMA 1WOHA 1HQXA 4Q3TA 4Q3PA 3MFVA 4Q3UA 4IE1A 2EF4A 3TH7A 1ZPEA 5HJ9A 4CEVA 3DJ8A 1HQHA 4RLAA 3THHA 1HQ5A 1TBLA 4Q3RC 4Q3RA 3SKKA 2ZAVA 3TF3A 3E8QA 3SL0A 2PLLA 3RLAA 3E6VA 4GWCA 1T4TA 4RHKA 3SJTA 4I06A 3LP4A 4GSZA 1HQGA 4MXRA 3MMRA 3LP7A 4Q3SA 4Q3VA 1T4RA
chains in the Genus database with same CATH superfamily
3MENA 1T5GA 3MJLA 4IU1A 4IU4A 5FUEA 1T4RA 3M1RA 4RHQA 5EFGA 4BZ8A 2RLAA 4RHLA 3KV2A 1R1OA 4QA0A 5G1AA 2GH6A 4ZUMA 1TBJA 1P8RA 1WVBA 5HJAA 3THJA 1T69A 3F06A 2PHOA 1W22A 3NIPA 1P8PA 1T4SA 4IXVA 5THUA 5EFNA 3MFWA 1C3SA 3GMZA 4HZEA 4IU0A 2V5XA 5D1CA 5EENA 5EFKB 4DZ4A 2VQOA 4GSVA 3F07A 3EW8A 4MYFA 4MYNA 1P8SA 3EZPA 1GQ7A 1TA1A 5DC6A 4Q3QA 1TBHA 3THEA 4IU5A 5THVA 5ICNB 4QA7A 3C0ZA 3GN0A 5D1BA 3MZ7A 1T64A 3ZNSA 5BWZA 3Q9BA 5EFJD 5RLAA 4HWWA 4IXUA 4QA2A 4QA3A 5EF8A 3LHLA 4RHJA 3PZLA 4GWDA 1RLAA 3E8ZA 2EIVA 4G3HA 1PQ3A 4FCKA 4CBTA 1CEVA 1D3VA 3NIQA 5G3WA 1WOIA 4QA5A 4ZUNA 5G13A 4MYLA 1P8NA 4ZUPA 3SL1A 3E9BA 5D1DA 4GSMA 1ZPGA 4IE2A 5G0HA 2A0MA 3NIOA 3F0RA 1WVAA 3Q9FA 5EEIA 4A69A 2EF5A 2PHAA 1XFKA 4LXZA 2CEVA 1T4PA 5DC7A 3MZ6A 3E6KA 1P8OA 1ZZ1A 2AEBA 1T5FA 2VQMA 5CEVA 4CQFA 4MYKA 5IWGA 4RHIA 3C0YA 4FCIA 3Q9EA 5THTA 3F80A 1P8MA 5DC5A 2VCGA 4BZ6A 1HQFA 4Q41A 3CEVA 4BZ5A 4Q42A 5A2SA 4BZ9A 4ITYA 5JI5A 1P8QA 2VQVA 1GQ6A 1WOGA 1ZZ3A 4Q40A 4HXQA 4RN2A 4IE3A 4RHMA 1WOHA 1HQXA 4Q3TA 3MZ4A 4RN1A 5FCWA 5G0XA 4BKXB 1C3PA 3MFVA 4Q3PA 5EFBD 4Q3UA 5G1BA 5G12A 3MAXA 4IE1A 2EF4A 3TH7A 5LI3A 3EWFA 1ZPEA 5HJ9A 4CEVA 5EF7A 3EZTA 3DJ8A 1VKGA 3Q9CA 1HQHA 1ZZ0A 4QA1A 5G17A 1T67A 4RLAA 1C3RA 5G0JA 3THHA 5EEKA 4RN0A 5EEMA 5G11A 1HQ5A 1TBLA 4Q3RC 4Q3RA 5THSA 2ZAVA 2VQQA 3E8QA 3C10A 3RQDA 3SKKA 5G0GA 3SFHA 3TF3A 5G0IA 3SL0A 4BZ7A 2PLLA 5IX0A 3RLAA 2VQJA 3E6VA 5EFHA 4GWCA 1T4TA 5G0YA 4RHKA 3SFFA 3MZ3A 3SJTA 4I06A 4QA6A 3LP4A 5DC8A 4ZUQA 3ZNRA 4ZURA 5EEFA 4GSZA 5G10A 1HQGA 4CBYA 4QA4A 5G1CA 4MXRA 3MMRA 2V5WA 4ZUOA 3LP7A 4Q3SA 4LY1A 4Q3VA 2VQWG
chains in the Genus database with same CATH topology
4IU4A 1T5GA 3MJLA 4IU1A 3M1RA 4RHQA 2RLAA 4RHLA 3KV2A 1R1OA 1TBJA 1P8RA 1WVBA 5HJAA 3THJA 2PHOA 3NIPA 4IXVA 1P8PA 1T4SA 3MFWA 4IU0A 3GMZA 4HZEA 4DZ4A 4GSVA 4MYFA 4MYNA 1P8SA 1GQ7A 1TA1A 4Q3QA 1TBHA 3THEA 4IU5A 3GN0A 5RLAA 4HWWA 4IXUA 3LHLA 4RHJA 3PZLA 4GWDA 1RLAA 3E8ZA 2EIVA 4G3HA 1PQ3A 4FCKA 1D3VA 1CEVA 3NIQA 1WOIA 4MYLA 1P8NA 3SL1A 3E9BA 4GSMA 1ZPGA 4IE2A 2A0MA 3NIOA 1WVAA 2EF5A 2PHAA 1XFKA 2CEVA 1T4PA 3E6KA 1P8OA 2AEBA 1T5FA 5CEVA 4MYKA 4RHIA 4FCIA 3F80A 1P8MA 1HQFA 4Q41A 3CEVA 4Q42A 4ITYA 1P8QA 1GQ6A 1WOGA 4Q40A 4HXQA 4IE3A 4RHMA 1WOHA 1HQXA 4Q3TA 4Q3PA 3MFVA 4Q3UA 4IE1A 2EF4A 3TH7A 1ZPEA 5HJ9A 4CEVA 3DJ8A 1HQHA 4RLAA 3THHA 1HQ5A 1TBLA 4Q3RC 4Q3RA 3SKKA 2ZAVA 3TF3A 3E8QA 3SL0A 2PLLA 3RLAA 3E6VA 4GWCA 1T4TA 4RHKA 3SJTA 4I06A 3LP4A 4GSZA 1HQGA 4MXRA 3MMRA 3LP7A 4Q3SA 4Q3VA 1T4RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IU4 A;  1T5G A;  3MJL A;  4IU1 A;  3M1R A;  4RHQ A;  2RLA A;  4RHL A;  3KV2 A;  1R1O A;  1TBJ A;  1P8R A;  1WVB A;  5HJA A;  3THJ A;  2PHO A;  3NIP A;  4IXV A;  1P8P A;  1T4S A;  3MFW A;  4IU0 A;  3GMZ A;  4HZE A;  4DZ4 A;  4GSV A;  4MYF A;  4MYN A;  1P8S A;  1GQ7 A;  1TA1 A;  4Q3Q A;  1TBH A;  3THE A;  4IU5 A;  3GN0 A;  5RLA A;  4HWW A;  4IXU A;  3LHL A;  4RHJ A;  3PZL A;  4GWD A;  1RLA A;  3E8Z A;  2EIV A;  4G3H A;  1PQ3 A;  4FCK A;  1D3V A;  1CEV A;  3NIQ A;  1WOI A;  4MYL A;  1P8N A;  3SL1 A;  3E9B A;  4GSM A;  1ZPG A;  4IE2 A;  2A0M A;  3NIO A;  1WVA A;  2EF5 A;  2PHA A;  1XFK A;  2CEV A;  1T4P A;  3E6K A;  1P8O A;  2AEB A;  1T5F A;  5CEV A;  4MYK A;  4RHI A;  4FCI A;  3F80 A;  1P8M A;  1HQF A;  4Q41 A;  3CEV A;  4Q42 A;  4ITY A;  1P8Q A;  1GQ6 A;  1WOG A;  4Q40 A;  4HXQ A;  4IE3 A;  4RHM A;  1WOH A;  1HQX A;  4Q3T A;  4Q3P A;  3MFV A;  4Q3U A;  4IE1 A;  2EF4 A;  3TH7 A;  1ZPE A;  5HJ9 A;  4CEV A;  3DJ8 A;  1HQH A;  4RLA A;  3THH A;  1HQ5 A;  1TBL A;  4Q3R C;  4Q3R A;  3SKK A;  2ZAV A;  3TF3 A;  3E8Q A;  3SL0 A;  2PLL A;  3RLA A;  3E6V A;  4GWC A;  1T4T A;  4RHK A;  3SJT A;  4I06 A;  3LP4 A;  4GSZ A;  1HQG A;  4MXR A;  3MMR A;  3LP7 A;  4Q3S A;  4Q3V A;  1T4R A; 
#chains in the Genus database with same CATH topology
 3MEN A;  1T5G A;  3MJL A;  4IU1 A;  4IU4 A;  5FUE A;  1T4R A;  3M1R A;  4RHQ A;  5EFG A;  4BZ8 A;  2RLA A;  4RHL A;  3KV2 A;  1R1O A;  4QA0 A;  5G1A A;  2GH6 A;  4ZUM A;  1TBJ A;  1P8R A;  1WVB A;  5HJA A;  3THJ A;  1T69 A;  3F06 A;  2PHO A;  1W22 A;  3NIP A;  1P8P A;  1T4S A;  4IXV A;  5THU A;  5EFN A;  3MFW A;  1C3S A;  3GMZ A;  4HZE A;  4IU0 A;  2V5X A;  5D1C A;  5EEN A;  5EFK B;  4DZ4 A;  2VQO A;  4GSV A;  3F07 A;  3EW8 A;  4MYF A;  4MYN A;  1P8S A;  3EZP A;  1GQ7 A;  1TA1 A;  5DC6 A;  4Q3Q A;  1TBH A;  3THE A;  4IU5 A;  5THV A;  5ICN B;  4QA7 A;  3C0Z A;  3GN0 A;  5D1B A;  3MZ7 A;  1T64 A;  3ZNS A;  5BWZ A;  3Q9B A;  5EFJ D;  5RLA A;  4HWW A;  4IXU A;  4QA2 A;  4QA3 A;  5EF8 A;  3LHL A;  4RHJ A;  3PZL A;  4GWD A;  1RLA A;  3E8Z A;  2EIV A;  4G3H A;  1PQ3 A;  4FCK A;  4CBT A;  1CEV A;  1D3V A;  3NIQ A;  5G3W A;  1WOI A;  4QA5 A;  4ZUN A;  5G13 A;  4MYL A;  1P8N A;  4ZUP A;  3SL1 A;  3E9B A;  5D1D A;  4GSM A;  1ZPG A;  4IE2 A;  5G0H A;  2A0M A;  3NIO A;  3F0R A;  1WVA A;  3Q9F A;  5EEI A;  4A69 A;  2EF5 A;  2PHA A;  1XFK A;  4LXZ A;  2CEV A;  1T4P A;  5DC7 A;  3MZ6 A;  3E6K A;  1P8O A;  1ZZ1 A;  2AEB A;  1T5F A;  2VQM A;  5CEV A;  4CQF A;  4MYK A;  5IWG A;  4RHI A;  3C0Y A;  4FCI A;  3Q9E A;  5THT A;  3F80 A;  1P8M A;  5DC5 A;  2VCG A;  4BZ6 A;  1HQF A;  4Q41 A;  3CEV A;  4BZ5 A;  4Q42 A;  5A2S A;  4BZ9 A;  4ITY A;  5JI5 A;  1P8Q A;  2VQV A;  1GQ6 A;  1WOG A;  1ZZ3 A;  4Q40 A;  4HXQ A;  4RN2 A;  4IE3 A;  4RHM A;  1WOH A;  1HQX A;  4Q3T A;  3MZ4 A;  4RN1 A;  5FCW A;  5G0X A;  4BKX B;  1C3P A;  3MFV A;  4Q3P A;  5EFB D;  4Q3U A;  5G1B A;  5G12 A;  3MAX A;  4IE1 A;  2EF4 A;  3TH7 A;  5LI3 A;  3EWF A;  1ZPE A;  5HJ9 A;  4CEV A;  5EF7 A;  3EZT A;  3DJ8 A;  1VKG A;  3Q9C A;  1HQH A;  1ZZ0 A;  4QA1 A;  5G17 A;  1T67 A;  4RLA A;  1C3R A;  5G0J A;  3THH A;  5EEK A;  4RN0 A;  5EEM A;  5G11 A;  1HQ5 A;  1TBL A;  4Q3R C;  4Q3R A;  5THS A;  2ZAV A;  2VQQ A;  3E8Q A;  3C10 A;  3RQD A;  3SKK A;  5G0G A;  3SFH A;  3TF3 A;  5G0I A;  3SL0 A;  4BZ7 A;  2PLL A;  5IX0 A;  3RLA A;  2VQJ A;  3E6V A;  5EFH A;  4GWC A;  1T4T A;  5G0Y A;  4RHK A;  3SFF A;  3MZ3 A;  3SJT A;  4I06 A;  4QA6 A;  3LP4 A;  5DC8 A;  4ZUQ A;  3ZNR A;  4ZUR A;  5EEF A;  4GSZ A;  5G10 A;  1HQG A;  4CBY A;  4QA4 A;  5G1C A;  4MXR A;  3MMR A;  2V5W A;  4ZUO A;  3LP7 A;  4Q3S A;  4LY1 A;  4Q3V A;  2VQW G; 
#chains in the Genus database with same CATH homology
 4IU4 A;  1T5G A;  3MJL A;  4IU1 A;  3M1R A;  4RHQ A;  2RLA A;  4RHL A;  3KV2 A;  1R1O A;  1TBJ A;  1P8R A;  1WVB A;  5HJA A;  3THJ A;  2PHO A;  3NIP A;  4IXV A;  1P8P A;  1T4S A;  3MFW A;  4IU0 A;  3GMZ A;  4HZE A;  4DZ4 A;  4GSV A;  4MYF A;  4MYN A;  1P8S A;  1GQ7 A;  1TA1 A;  4Q3Q A;  1TBH A;  3THE A;  4IU5 A;  3GN0 A;  5RLA A;  4HWW A;  4IXU A;  3LHL A;  4RHJ A;  3PZL A;  4GWD A;  1RLA A;  3E8Z A;  2EIV A;  4G3H A;  1PQ3 A;  4FCK A;  1D3V A;  1CEV A;  3NIQ A;  1WOI A;  4MYL A;  1P8N A;  3SL1 A;  3E9B A;  4GSM A;  1ZPG A;  4IE2 A;  2A0M A;  3NIO A;  1WVA A;  2EF5 A;  2PHA A;  1XFK A;  2CEV A;  1T4P A;  3E6K A;  1P8O A;  2AEB A;  1T5F A;  5CEV A;  4MYK A;  4RHI A;  4FCI A;  3F80 A;  1P8M A;  1HQF A;  4Q41 A;  3CEV A;  4Q42 A;  4ITY A;  1P8Q A;  1GQ6 A;  1WOG A;  4Q40 A;  4HXQ A;  4IE3 A;  4RHM A;  1WOH A;  1HQX A;  4Q3T A;  4Q3P A;  3MFV A;  4Q3U A;  4IE1 A;  2EF4 A;  3TH7 A;  1ZPE A;  5HJ9 A;  4CEV A;  3DJ8 A;  1HQH A;  4RLA A;  3THH A;  1HQ5 A;  1TBL A;  4Q3R C;  4Q3R A;  3SKK A;  2ZAV A;  3TF3 A;  3E8Q A;  3SL0 A;  2PLL A;  3RLA A;  3E6V A;  4GWC A;  1T4T A;  4RHK A;  3SJT A;  4I06 A;  3LP4 A;  4GSZ A;  1HQG A;  4MXR A;  3MMR A;  3LP7 A;  4Q3S A;  4Q3V A;  1T4R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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