2PHAA

Crystal structure of native, unliganded human arginase at 1.90 resolution
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
314
structure length
314
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase-1
total genus 107
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2phaA00
1WVAA 2ZAVA 4MYKA 1HQ5A 1P8SA 3LHLA 1RLAA 2EF4A 5RLAA 2AEBA 1XFKA 3E8QA 4RHIA 4RLAA 3NIPA 2PLLA 4GSVA 4DZ4A 4Q3RC 3GN0A 3TF3A 1TBHA 2PHOA 4IXVA 3THJA 5CEVA 3F80A 4FCKA 4IU4A 1WOHA 4IE2A 4IU5A 4Q42A 4MYFA 4MYNA 3MJLA 3E8ZA 4GWCA 1P8PA 2EF5A 4HZEA 1GQ6A 2PHAA 3SL0A 3SKKA 3THHA 1TBLA 4MYLA 3E6VA 4MXRA 1T4PA 4IE3A 1T4TA 4Q41A 4Q3SA 1ZPEA 4RHQA 2RLAA 3E9BA 1D3VA 1TBJA 1ZPGA 4G3HA 4IU1A 4CEVA 1P8MA 2CEVA 3MFVA 3PZLA 1T4SA 1WOGA 1HQFA 5HJ9A 3DJ8A 3E6KA 4Q3UA 1HQHA 3GMZA 4GWDA 4IXUA 4Q3TA 4Q3VA 3RLAA 1HQXA 1P8OA 3CEVA 5HJAA 3M1RA 1T4RA 3NIOA 4RHMA 3TH7A 1P8QA 4GSZA 4HWWA 4Q3RA 4RHLA 3SL1A 4RHKA 3KV2A 2EIVA 1T5GA 1TA1A 4GSMA 3MMRA 1P8RA 1HQGA 1P8NA 4FCIA 3MFWA 1PQ3A 4ITYA 4Q40A 1T5FA 4IE1A 4RHJA 3NIQA 3SJTA 4HXQA 2A0MA 1GQ7A 4IU0A 3THEA 1WVBA 3LP7A 1R1OA 1CEVA 4I06A 4Q3QA 3LP4A 1WOIA 4Q3PA
chains in the Genus database with same CATH superfamily
5EFJD 1WVAA 2ZAVA 4MYKA 2VQOA 4BKXB 2VQQA 5EEIA 1HQ5A 4BZ6A 3EZPA 4A69A 1P8SA 4BZ9A 3LHLA 1RLAA 2EF4A 4QA6A 1T69A 5BWZA 5RLAA 3F06A 2AEBA 3Q9CA 1XFKA 3C0ZA 3E8QA 4RHIA 4RLAA 3NIPA 5DC6A 2PLLA 4GSVA 3ZNRA 4DZ4A 4ZUOA 5LI3A 5G0IA 5G17A 4Q3RC 5D1DA 5D1CA 3EW8A 3GN0A 5G1AA 3TF3A 1TBHA 2PHOA 4QA2A 3MZ4A 4QA0A 4ZURA 4IXVA 3THJA 3F07A 5CEVA 3F80A 3Q9EA 5G1CA 5G0HA 1C3PA 4FCKA 4QA5A 5THSA 2VQJA 4IU4A 1WOHA 4IE2A 4IU5A 4Q42A 4BZ8A 4MYFA 4MYNA 4BZ5A 3MJLA 3E8ZA 4GWCA 5EENA 1P8PA 5DC7A 2EF5A 4ZUPA 4HZEA 1GQ6A 2PHAA 4QA7A 3SL0A 3SKKA 3THHA 1ZZ1A 3EWFA 5EEKA 1TBLA 3Q9FA 4MYLA 5EFNA 5G13A 5G0YA 4ZUQA 4CBTA 3E6VA 4MXRA 1T4PA 4IE3A 2VQWG 1T4TA 5D1BA 1C3RA 4Q41A 4Q3SA 5G1BA 1ZPEA 4LXZA 5G0GA 3ZNSA 4RHQA 4RN2A 5IWGA 2RLAA 3E9BA 1D3VA 1TBJA 1ZPGA 4G3HA 4IU1A 2V5XA 1T67A 2V5WA 5THTA 1P8MA 2VCGA 4CBYA 2CEVA 4QA1A 3MFVA 3PZLA 4RN1A 4CQFA 1T4SA 1WOGA 5THVA 3MZ6A 3MZ3A 1HQFA 5HJ9A 5IX0A 5G12A 3DJ8A 3E6KA 5FUEA 4Q3UA 1HQHA 3GMZA 5A2SA 4GWDA 1ZZ0A 4IXUA 4Q3TA 3MZ7A 3EZTA 3SFHA 4Q3VA 4BZ7A 2VQVA 4LY1A 4ZUNA 5G10A 3RLAA 1HQXA 5JI5A 1P8OA 3CEVA 3Q9BA 5HJAA 3M1RA 1T4RA 3NIOA 4RHMA 3TH7A 1P8QA 4GSZA 4RN0A 3MENA 4HWWA 4Q3RA 4RHLA 5EFBD 5FCWA 4RHKA 5DC5A 3SL1A 3KV2A 5G0JA 2EIVA 1T5GA 1TA1A 3C10A 4GSMA 4QA3A 5G11A 3MMRA 1P8RA 1HQGA 4ZUMA 5G3WA 1P8NA 4FCIA 5EF7A 3RQDA 4CEVA 3MFWA 5EF8A 1PQ3A 4ITYA 4Q40A 1ZZ3A 5DC8A 1T5FA 2GH6A 4QA4A 5EFHA 4IE1A 5EFKB 4RHJA 2VQMA 3NIQA 3C0YA 1VKGA 3SJTA 4HXQA 2A0MA 3SFFA 3MAXA 1GQ7A 4IU0A 5G0XA 3THEA 1WVBA 3LP7A 1C3SA 5EFGA 5EEFA 5THUA 1R1OA 1CEVA 3F0RA 1W22A 4I06A 5EEMA 5ICNB 4Q3QA 3LP4A 1WOIA 1T64A 4Q3PA
chains in the Genus database with same CATH topology
1WVAA 2ZAVA 4MYKA 1HQ5A 1P8SA 3LHLA 1RLAA 2EF4A 5RLAA 2AEBA 1XFKA 3E8QA 4RHIA 4RLAA 3NIPA 2PLLA 4GSVA 4DZ4A 4Q3RC 3GN0A 3TF3A 1TBHA 2PHOA 4IXVA 3THJA 5CEVA 3F80A 4FCKA 4IU4A 1WOHA 4IE2A 4IU5A 4Q42A 4MYFA 4MYNA 3MJLA 3E8ZA 4GWCA 1P8PA 2EF5A 4HZEA 1GQ6A 2PHAA 3SL0A 3SKKA 3THHA 1TBLA 4MYLA 3E6VA 4MXRA 1T4PA 4IE3A 1T4TA 4Q41A 4Q3SA 1ZPEA 4RHQA 2RLAA 3E9BA 1D3VA 1TBJA 1ZPGA 4G3HA 4IU1A 4CEVA 1P8MA 2CEVA 3MFVA 3PZLA 1T4SA 1WOGA 1HQFA 5HJ9A 3DJ8A 3E6KA 4Q3UA 1HQHA 3GMZA 4GWDA 4IXUA 4Q3TA 4Q3VA 3RLAA 1HQXA 1P8OA 3CEVA 5HJAA 3M1RA 1T4RA 3NIOA 4RHMA 3TH7A 1P8QA 4GSZA 4HWWA 4Q3RA 4RHLA 3SL1A 4RHKA 3KV2A 2EIVA 1T5GA 1TA1A 4GSMA 3MMRA 1P8RA 1HQGA 1P8NA 4FCIA 3MFWA 1PQ3A 4ITYA 4Q40A 1T5FA 4IE1A 4RHJA 3NIQA 3SJTA 4HXQA 2A0MA 1GQ7A 4IU0A 3THEA 1WVBA 3LP7A 1R1OA 1CEVA 4I06A 4Q3QA 3LP4A 1WOIA 4Q3PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WVA A;  2ZAV A;  4MYK A;  1HQ5 A;  1P8S A;  3LHL A;  1RLA A;  2EF4 A;  5RLA A;  2AEB A;  1XFK A;  3E8Q A;  4RHI A;  4RLA A;  3NIP A;  2PLL A;  4GSV A;  4DZ4 A;  4Q3R C;  3GN0 A;  3TF3 A;  1TBH A;  2PHO A;  4IXV A;  3THJ A;  5CEV A;  3F80 A;  4FCK A;  4IU4 A;  1WOH A;  4IE2 A;  4IU5 A;  4Q42 A;  4MYF A;  4MYN A;  3MJL A;  3E8Z A;  4GWC A;  1P8P A;  2EF5 A;  4HZE A;  1GQ6 A;  2PHA A;  3SL0 A;  3SKK A;  3THH A;  1TBL A;  4MYL A;  3E6V A;  4MXR A;  1T4P A;  4IE3 A;  1T4T A;  4Q41 A;  4Q3S A;  1ZPE A;  4RHQ A;  2RLA A;  3E9B A;  1D3V A;  1TBJ A;  1ZPG A;  4G3H A;  4IU1 A;  4CEV A;  1P8M A;  2CEV A;  3MFV A;  3PZL A;  1T4S A;  1WOG A;  1HQF A;  5HJ9 A;  3DJ8 A;  3E6K A;  4Q3U A;  1HQH A;  3GMZ A;  4GWD A;  4IXU A;  4Q3T A;  4Q3V A;  3RLA A;  1HQX A;  1P8O A;  3CEV A;  5HJA A;  3M1R A;  1T4R A;  3NIO A;  4RHM A;  3TH7 A;  1P8Q A;  4GSZ A;  4HWW A;  4Q3R A;  4RHL A;  3SL1 A;  4RHK A;  3KV2 A;  2EIV A;  1T5G A;  1TA1 A;  4GSM A;  3MMR A;  1P8R A;  1HQG A;  1P8N A;  4FCI A;  3MFW A;  1PQ3 A;  4ITY A;  4Q40 A;  1T5F A;  4IE1 A;  4RHJ A;  3NIQ A;  3SJT A;  4HXQ A;  2A0M A;  1GQ7 A;  4IU0 A;  3THE A;  1WVB A;  3LP7 A;  1R1O A;  1CEV A;  4I06 A;  4Q3Q A;  3LP4 A;  1WOI A;  4Q3P A; 
#chains in the Genus database with same CATH topology
 5EFJ D;  1WVA A;  2ZAV A;  4MYK A;  2VQO A;  4BKX B;  2VQQ A;  5EEI A;  1HQ5 A;  4BZ6 A;  3EZP A;  4A69 A;  1P8S A;  4BZ9 A;  3LHL A;  1RLA A;  2EF4 A;  4QA6 A;  1T69 A;  5BWZ A;  5RLA A;  3F06 A;  2AEB A;  3Q9C A;  1XFK A;  3C0Z A;  3E8Q A;  4RHI A;  4RLA A;  3NIP A;  5DC6 A;  2PLL A;  4GSV A;  3ZNR A;  4DZ4 A;  4ZUO A;  5LI3 A;  5G0I A;  5G17 A;  4Q3R C;  5D1D A;  5D1C A;  3EW8 A;  3GN0 A;  5G1A A;  3TF3 A;  1TBH A;  2PHO A;  4QA2 A;  3MZ4 A;  4QA0 A;  4ZUR A;  4IXV A;  3THJ A;  3F07 A;  5CEV A;  3F80 A;  3Q9E A;  5G1C A;  5G0H A;  1C3P A;  4FCK A;  4QA5 A;  5THS A;  2VQJ A;  4IU4 A;  1WOH A;  4IE2 A;  4IU5 A;  4Q42 A;  4BZ8 A;  4MYF A;  4MYN A;  4BZ5 A;  3MJL A;  3E8Z A;  4GWC A;  5EEN A;  1P8P A;  5DC7 A;  2EF5 A;  4ZUP A;  4HZE A;  1GQ6 A;  2PHA A;  4QA7 A;  3SL0 A;  3SKK A;  3THH A;  1ZZ1 A;  3EWF A;  5EEK A;  1TBL A;  3Q9F A;  4MYL A;  5EFN A;  5G13 A;  5G0Y A;  4ZUQ A;  4CBT A;  3E6V A;  4MXR A;  1T4P A;  4IE3 A;  2VQW G;  1T4T A;  5D1B A;  1C3R A;  4Q41 A;  4Q3S A;  5G1B A;  1ZPE A;  4LXZ A;  5G0G A;  3ZNS A;  4RHQ A;  4RN2 A;  5IWG A;  2RLA A;  3E9B A;  1D3V A;  1TBJ A;  1ZPG A;  4G3H A;  4IU1 A;  2V5X A;  1T67 A;  2V5W A;  5THT A;  1P8M A;  2VCG A;  4CBY A;  2CEV A;  4QA1 A;  3MFV A;  3PZL A;  4RN1 A;  4CQF A;  1T4S A;  1WOG A;  5THV A;  3MZ6 A;  3MZ3 A;  1HQF A;  5HJ9 A;  5IX0 A;  5G12 A;  3DJ8 A;  3E6K A;  5FUE A;  4Q3U A;  1HQH A;  3GMZ A;  5A2S A;  4GWD A;  1ZZ0 A;  4IXU A;  4Q3T A;  3MZ7 A;  3EZT A;  3SFH A;  4Q3V A;  4BZ7 A;  2VQV A;  4LY1 A;  4ZUN A;  5G10 A;  3RLA A;  1HQX A;  5JI5 A;  1P8O A;  3CEV A;  3Q9B A;  5HJA A;  3M1R A;  1T4R A;  3NIO A;  4RHM A;  3TH7 A;  1P8Q A;  4GSZ A;  4RN0 A;  3MEN A;  4HWW A;  4Q3R A;  4RHL A;  5EFB D;  5FCW A;  4RHK A;  5DC5 A;  3SL1 A;  3KV2 A;  5G0J A;  2EIV A;  1T5G A;  1TA1 A;  3C10 A;  4GSM A;  4QA3 A;  5G11 A;  3MMR A;  1P8R A;  1HQG A;  4ZUM A;  5G3W A;  1P8N A;  4FCI A;  5EF7 A;  3RQD A;  4CEV A;  3MFW A;  5EF8 A;  1PQ3 A;  4ITY A;  4Q40 A;  1ZZ3 A;  5DC8 A;  1T5F A;  2GH6 A;  4QA4 A;  5EFH A;  4IE1 A;  5EFK B;  4RHJ A;  2VQM A;  3NIQ A;  3C0Y A;  1VKG A;  3SJT A;  4HXQ A;  2A0M A;  3SFF A;  3MAX A;  1GQ7 A;  4IU0 A;  5G0X A;  3THE A;  1WVB A;  3LP7 A;  1C3S A;  5EFG A;  5EEF A;  5THU A;  1R1O A;  1CEV A;  3F0R A;  1W22 A;  4I06 A;  5EEM A;  5ICN B;  4Q3Q A;  3LP4 A;  1WOI A;  1T64 A;  4Q3P A; 
#chains in the Genus database with same CATH homology
 1WVA A;  2ZAV A;  4MYK A;  1HQ5 A;  1P8S A;  3LHL A;  1RLA A;  2EF4 A;  5RLA A;  2AEB A;  1XFK A;  3E8Q A;  4RHI A;  4RLA A;  3NIP A;  2PLL A;  4GSV A;  4DZ4 A;  4Q3R C;  3GN0 A;  3TF3 A;  1TBH A;  2PHO A;  4IXV A;  3THJ A;  5CEV A;  3F80 A;  4FCK A;  4IU4 A;  1WOH A;  4IE2 A;  4IU5 A;  4Q42 A;  4MYF A;  4MYN A;  3MJL A;  3E8Z A;  4GWC A;  1P8P A;  2EF5 A;  4HZE A;  1GQ6 A;  2PHA A;  3SL0 A;  3SKK A;  3THH A;  1TBL A;  4MYL A;  3E6V A;  4MXR A;  1T4P A;  4IE3 A;  1T4T A;  4Q41 A;  4Q3S A;  1ZPE A;  4RHQ A;  2RLA A;  3E9B A;  1D3V A;  1TBJ A;  1ZPG A;  4G3H A;  4IU1 A;  4CEV A;  1P8M A;  2CEV A;  3MFV A;  3PZL A;  1T4S A;  1WOG A;  1HQF A;  5HJ9 A;  3DJ8 A;  3E6K A;  4Q3U A;  1HQH A;  3GMZ A;  4GWD A;  4IXU A;  4Q3T A;  4Q3V A;  3RLA A;  1HQX A;  1P8O A;  3CEV A;  5HJA A;  3M1R A;  1T4R A;  3NIO A;  4RHM A;  3TH7 A;  1P8Q A;  4GSZ A;  4HWW A;  4Q3R A;  4RHL A;  3SL1 A;  4RHK A;  3KV2 A;  2EIV A;  1T5G A;  1TA1 A;  4GSM A;  3MMR A;  1P8R A;  1HQG A;  1P8N A;  4FCI A;  3MFW A;  1PQ3 A;  4ITY A;  4Q40 A;  1T5F A;  4IE1 A;  4RHJ A;  3NIQ A;  3SJT A;  4HXQ A;  2A0M A;  1GQ7 A;  4IU0 A;  3THE A;  1WVB A;  3LP7 A;  1R1O A;  1CEV A;  4I06 A;  4Q3Q A;  3LP4 A;  1WOI A;  4Q3P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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