2PHOA

Crystal structure of human arginase i complexed with thiosemicarbazide at 1.95 resolution
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
313
structure length
313
Chain Sequence
RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase-1
total genus 108
structure length 313
sequence length 313
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2007-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2phoA00
1R1OA 3CEVA 1P8OA 1HQHA 1T4SA 1TBLA 3E8QA 3RLAA 4HWWA 4CEVA 1CEVA 4Q3QA 2EF4A 3SL1A 4IE1A 4HXQA 1HQFA 4G3HA 1P8PA 4FCKA 1WVBA 1T4RA 4Q41A 1WVAA 4IE2A 1ZPGA 4IXVA 4Q3PA 3MJLA 4RHJA 1ZPEA 4ITYA 1P8NA 2A0MA 3THHA 1GQ6A 1PQ3A 2EF5A 3MFWA 4MXRA 3KV2A 1P8RA 4GSMA 4Q3UA 3NIQA 2EIVA 3MFVA 3LP7A 2RLAA 3DJ8A 3SKKA 1TBJA 3TF3A 2AEBA 1HQGA 4MYNA 4MYKA 4Q40A 4FCIA 3TH7A 1HQXA 4MYFA 4RHLA 4GSVA 3E8ZA 4I06A 5HJAA 1P8QA 1T4PA 4IU1A 1TBHA 1T5GA 2CEVA 3F80A 4GWCA 1WOGA 4GWDA 4Q3RC 2PHAA 3NIOA 4RHMA 4RLAA 1XFKA 1GQ7A 4Q42A 2ZAVA 3MMRA 3LP4A 5HJ9A 4IXUA 1HQ5A 4MYLA 1RLAA 4IE3A 5CEVA 4Q3VA 3GN0A 4Q3SA 1T4TA 4RHIA 1WOHA 4IU0A 3NIPA 1P8SA 3LHLA 3E9BA 4Q3TA 1WOIA 4DZ4A 3SJTA 3SL0A 4RHQA 1T5FA 3THEA 3PZLA 3GMZA 4Q3RA 4RHKA 2PHOA 2PLLA 1P8MA 5RLAA 4HZEA 3E6KA 3E6VA 4IU4A 1D3VA 4GSZA 3M1RA 3THJA 1TA1A 4IU5A
chains in the Genus database with same CATH superfamily
1R1OA 3CEVA 1P8OA 1HQHA 1T4SA 1TBLA 2V5XA 3E8QA 3ZNSA 3RLAA 3C0YA 4LXZA 4QA1A 1ZZ0A 5G13A 4ZUQA 3C0ZA 4HWWA 4CQFA 3EW8A 4CEVA 1CEVA 4Q3QA 2EF4A 5G12A 4IE1A 5FCWA 4HXQA 5G17A 1HQFA 4RN0A 4ZUPA 5DC7A 5EEIA 5D1CA 4G3HA 1P8PA 3SFHA 5EFKB 4FCKA 4BKXB 1WVBA 1T4RA 3RQDA 4Q41A 1WVAA 4IE2A 4LY1A 5EEMA 1ZPGA 5ICNB 4IXVA 4Q3PA 3MAXA 5THSA 3MJLA 4RHJA 1ZPEA 5DC8A 4ITYA 5G0GA 4QA7A 1P8NA 2A0MA 3THHA 1GQ6A 1PQ3A 2EF5A 3MFWA 4MXRA 2VCGA 1P8RA 3C10A 3KV2A 4GSMA 5EFGA 5G3WA 4Q3UA 3NIQA 5THVA 2EIVA 5EENA 5DC6A 5A2SA 4BZ5A 3MZ7A 3MFVA 3LP7A 1T67A 2RLAA 5DC5A 3ZNRA 3DJ8A 2VQOA 4ZUMA 3SKKA 1TBJA 5JI5A 5LI3A 3TF3A 2AEBA 1HQGA 5EF8A 4MYNA 4MYKA 4Q40A 4FCIA 5EEFA 3TH7A 1HQXA 5EEKA 5G11A 5G0IA 5THUA 2VQJA 2VQQA 4MYFA 4RHLA 3EZTA 4GSVA 3E8ZA 4QA6A 4QA3A 4I06A 3Q9FA 5D1DA 3MZ4A 5HJAA 1P8QA 1T4PA 4BZ7A 4IU1A 1TBHA 2VQMA 1T5GA 2CEVA 5G0HA 3F80A 4GWCA 1WOGA 3F07A 1C3RA 2PHAA 3NIOA 3EWFA 4GWDA 4Q3RC 4RHMA 4RLAA 1W22A 5IX0A 4CBYA 3MENA 3SFFA 1XFKA 1GQ7A 4Q42A 5EFNA 2ZAVA 3MZ6A 3MMRA 3Q9CA 3LP4A 5HJ9A 1ZZ3A 4IXUA 3Q9EA 5G0YA 5G1CA 1ZZ1A 1HQ5A 5EFJD 4MYLA 2GH6A 1RLAA 4IE3A 5CEVA 4Q3VA 3GN0A 5G10A 4BZ8A 3EZPA 4Q3SA 4QA5A 5EFBD 1T4TA 4RHIA 5D1BA 1WOHA 4A69A 4IU0A 3NIPA 3F06A 1T64A 4QA0A 1P8SA 4BZ6A 3LHLA 3E9BA 3F0RA 4RN2A 4Q3TA 1WOIA 4ZUNA 5G1AA 4DZ4A 5BWZA 5G0XA 1C3PA 5IWGA 2VQWG 5THTA 3SJTA 4BZ9A 4CBTA 3SL0A 4RHQA 4QA4A 4RN1A 1T5FA 5EF7A 3PZLA 3THEA 3GMZA 4Q3RA 4RHKA 4ZURA 3SL1A 2V5WA 2PHOA 4ZUOA 4IU5A 5G1BA 4QA2A 2VQVA 5FUEA 2PLLA 1C3SA 1P8MA 5RLAA 4HZEA 3E6KA 1VKGA 3E6VA 1D3VA 3MZ3A 4GSZA 4IU4A 5EFHA 3M1RA 1T69A 3THJA 5G0JA 1TA1A 3Q9BA
chains in the Genus database with same CATH topology
1R1OA 3CEVA 1P8OA 1HQHA 1T4SA 1TBLA 3E8QA 3RLAA 4HWWA 4CEVA 1CEVA 4Q3QA 2EF4A 3SL1A 4IE1A 4HXQA 1HQFA 4G3HA 1P8PA 4FCKA 1WVBA 1T4RA 4Q41A 1WVAA 4IE2A 1ZPGA 4IXVA 4Q3PA 3MJLA 4RHJA 1ZPEA 4ITYA 1P8NA 2A0MA 3THHA 1GQ6A 1PQ3A 2EF5A 3MFWA 4MXRA 3KV2A 1P8RA 4GSMA 4Q3UA 3NIQA 2EIVA 3MFVA 3LP7A 2RLAA 3DJ8A 3SKKA 1TBJA 3TF3A 2AEBA 1HQGA 4MYNA 4MYKA 4Q40A 4FCIA 3TH7A 1HQXA 4MYFA 4RHLA 4GSVA 3E8ZA 4I06A 5HJAA 1P8QA 1T4PA 4IU1A 1TBHA 1T5GA 2CEVA 3F80A 4GWCA 1WOGA 4GWDA 4Q3RC 2PHAA 3NIOA 4RHMA 4RLAA 1XFKA 1GQ7A 4Q42A 2ZAVA 3MMRA 3LP4A 5HJ9A 4IXUA 1HQ5A 4MYLA 1RLAA 4IE3A 5CEVA 4Q3VA 3GN0A 4Q3SA 1T4TA 4RHIA 1WOHA 4IU0A 3NIPA 1P8SA 3LHLA 3E9BA 4Q3TA 1WOIA 4DZ4A 3SJTA 3SL0A 4RHQA 1T5FA 3THEA 3PZLA 3GMZA 4Q3RA 4RHKA 2PHOA 2PLLA 1P8MA 5RLAA 4HZEA 3E6KA 3E6VA 4IU4A 1D3VA 4GSZA 3M1RA 3THJA 1TA1A 4IU5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R1O A;  3CEV A;  1P8O A;  1HQH A;  1T4S A;  1TBL A;  3E8Q A;  3RLA A;  4HWW A;  4CEV A;  1CEV A;  4Q3Q A;  2EF4 A;  3SL1 A;  4IE1 A;  4HXQ A;  1HQF A;  4G3H A;  1P8P A;  4FCK A;  1WVB A;  1T4R A;  4Q41 A;  1WVA A;  4IE2 A;  1ZPG A;  4IXV A;  4Q3P A;  3MJL A;  4RHJ A;  1ZPE A;  4ITY A;  1P8N A;  2A0M A;  3THH A;  1GQ6 A;  1PQ3 A;  2EF5 A;  3MFW A;  4MXR A;  3KV2 A;  1P8R A;  4GSM A;  4Q3U A;  3NIQ A;  2EIV A;  3MFV A;  3LP7 A;  2RLA A;  3DJ8 A;  3SKK A;  1TBJ A;  3TF3 A;  2AEB A;  1HQG A;  4MYN A;  4MYK A;  4Q40 A;  4FCI A;  3TH7 A;  1HQX A;  4MYF A;  4RHL A;  4GSV A;  3E8Z A;  4I06 A;  5HJA A;  1P8Q A;  1T4P A;  4IU1 A;  1TBH A;  1T5G A;  2CEV A;  3F80 A;  4GWC A;  1WOG A;  4GWD A;  4Q3R C;  2PHA A;  3NIO A;  4RHM A;  4RLA A;  1XFK A;  1GQ7 A;  4Q42 A;  2ZAV A;  3MMR A;  3LP4 A;  5HJ9 A;  4IXU A;  1HQ5 A;  4MYL A;  1RLA A;  4IE3 A;  5CEV A;  4Q3V A;  3GN0 A;  4Q3S A;  1T4T A;  4RHI A;  1WOH A;  4IU0 A;  3NIP A;  1P8S A;  3LHL A;  3E9B A;  4Q3T A;  1WOI A;  4DZ4 A;  3SJT A;  3SL0 A;  4RHQ A;  1T5F A;  3THE A;  3PZL A;  3GMZ A;  4Q3R A;  4RHK A;  2PHO A;  2PLL A;  1P8M A;  5RLA A;  4HZE A;  3E6K A;  3E6V A;  4IU4 A;  1D3V A;  4GSZ A;  3M1R A;  3THJ A;  1TA1 A;  4IU5 A; 
#chains in the Genus database with same CATH topology
 1R1O A;  3CEV A;  1P8O A;  1HQH A;  1T4S A;  1TBL A;  2V5X A;  3E8Q A;  3ZNS A;  3RLA A;  3C0Y A;  4LXZ A;  4QA1 A;  1ZZ0 A;  5G13 A;  4ZUQ A;  3C0Z A;  4HWW A;  4CQF A;  3EW8 A;  4CEV A;  1CEV A;  4Q3Q A;  2EF4 A;  5G12 A;  4IE1 A;  5FCW A;  4HXQ A;  5G17 A;  1HQF A;  4RN0 A;  4ZUP A;  5DC7 A;  5EEI A;  5D1C A;  4G3H A;  1P8P A;  3SFH A;  5EFK B;  4FCK A;  4BKX B;  1WVB A;  1T4R A;  3RQD A;  4Q41 A;  1WVA A;  4IE2 A;  4LY1 A;  5EEM A;  1ZPG A;  5ICN B;  4IXV A;  4Q3P A;  3MAX A;  5THS A;  3MJL A;  4RHJ A;  1ZPE A;  5DC8 A;  4ITY A;  5G0G A;  4QA7 A;  1P8N A;  2A0M A;  3THH A;  1GQ6 A;  1PQ3 A;  2EF5 A;  3MFW A;  4MXR A;  2VCG A;  1P8R A;  3C10 A;  3KV2 A;  4GSM A;  5EFG A;  5G3W A;  4Q3U A;  3NIQ A;  5THV A;  2EIV A;  5EEN A;  5DC6 A;  5A2S A;  4BZ5 A;  3MZ7 A;  3MFV A;  3LP7 A;  1T67 A;  2RLA A;  5DC5 A;  3ZNR A;  3DJ8 A;  2VQO A;  4ZUM A;  3SKK A;  1TBJ A;  5JI5 A;  5LI3 A;  3TF3 A;  2AEB A;  1HQG A;  5EF8 A;  4MYN A;  4MYK A;  4Q40 A;  4FCI A;  5EEF A;  3TH7 A;  1HQX A;  5EEK A;  5G11 A;  5G0I A;  5THU A;  2VQJ A;  2VQQ A;  4MYF A;  4RHL A;  3EZT A;  4GSV A;  3E8Z A;  4QA6 A;  4QA3 A;  4I06 A;  3Q9F A;  5D1D A;  3MZ4 A;  5HJA A;  1P8Q A;  1T4P A;  4BZ7 A;  4IU1 A;  1TBH A;  2VQM A;  1T5G A;  2CEV A;  5G0H A;  3F80 A;  4GWC A;  1WOG A;  3F07 A;  1C3R A;  2PHA A;  3NIO A;  3EWF A;  4GWD A;  4Q3R C;  4RHM A;  4RLA A;  1W22 A;  5IX0 A;  4CBY A;  3MEN A;  3SFF A;  1XFK A;  1GQ7 A;  4Q42 A;  5EFN A;  2ZAV A;  3MZ6 A;  3MMR A;  3Q9C A;  3LP4 A;  5HJ9 A;  1ZZ3 A;  4IXU A;  3Q9E A;  5G0Y A;  5G1C A;  1ZZ1 A;  1HQ5 A;  5EFJ D;  4MYL A;  2GH6 A;  1RLA A;  4IE3 A;  5CEV A;  4Q3V A;  3GN0 A;  5G10 A;  4BZ8 A;  3EZP A;  4Q3S A;  4QA5 A;  5EFB D;  1T4T A;  4RHI A;  5D1B A;  1WOH A;  4A69 A;  4IU0 A;  3NIP A;  3F06 A;  1T64 A;  4QA0 A;  1P8S A;  4BZ6 A;  3LHL A;  3E9B A;  3F0R A;  4RN2 A;  4Q3T A;  1WOI A;  4ZUN A;  5G1A A;  4DZ4 A;  5BWZ A;  5G0X A;  1C3P A;  5IWG A;  2VQW G;  5THT A;  3SJT A;  4BZ9 A;  4CBT A;  3SL0 A;  4RHQ A;  4QA4 A;  4RN1 A;  1T5F A;  5EF7 A;  3PZL A;  3THE A;  3GMZ A;  4Q3R A;  4RHK A;  4ZUR A;  3SL1 A;  2V5W A;  2PHO A;  4ZUO A;  4IU5 A;  5G1B A;  4QA2 A;  2VQV A;  5FUE A;  2PLL A;  1C3S A;  1P8M A;  5RLA A;  4HZE A;  3E6K A;  1VKG A;  3E6V A;  1D3V A;  3MZ3 A;  4GSZ A;  4IU4 A;  5EFH A;  3M1R A;  1T69 A;  3THJ A;  5G0J A;  1TA1 A;  3Q9B A; 
#chains in the Genus database with same CATH homology
 1R1O A;  3CEV A;  1P8O A;  1HQH A;  1T4S A;  1TBL A;  3E8Q A;  3RLA A;  4HWW A;  4CEV A;  1CEV A;  4Q3Q A;  2EF4 A;  3SL1 A;  4IE1 A;  4HXQ A;  1HQF A;  4G3H A;  1P8P A;  4FCK A;  1WVB A;  1T4R A;  4Q41 A;  1WVA A;  4IE2 A;  1ZPG A;  4IXV A;  4Q3P A;  3MJL A;  4RHJ A;  1ZPE A;  4ITY A;  1P8N A;  2A0M A;  3THH A;  1GQ6 A;  1PQ3 A;  2EF5 A;  3MFW A;  4MXR A;  3KV2 A;  1P8R A;  4GSM A;  4Q3U A;  3NIQ A;  2EIV A;  3MFV A;  3LP7 A;  2RLA A;  3DJ8 A;  3SKK A;  1TBJ A;  3TF3 A;  2AEB A;  1HQG A;  4MYN A;  4MYK A;  4Q40 A;  4FCI A;  3TH7 A;  1HQX A;  4MYF A;  4RHL A;  4GSV A;  3E8Z A;  4I06 A;  5HJA A;  1P8Q A;  1T4P A;  4IU1 A;  1TBH A;  1T5G A;  2CEV A;  3F80 A;  4GWC A;  1WOG A;  4GWD A;  4Q3R C;  2PHA A;  3NIO A;  4RHM A;  4RLA A;  1XFK A;  1GQ7 A;  4Q42 A;  2ZAV A;  3MMR A;  3LP4 A;  5HJ9 A;  4IXU A;  1HQ5 A;  4MYL A;  1RLA A;  4IE3 A;  5CEV A;  4Q3V A;  3GN0 A;  4Q3S A;  1T4T A;  4RHI A;  1WOH A;  4IU0 A;  3NIP A;  1P8S A;  3LHL A;  3E9B A;  4Q3T A;  1WOI A;  4DZ4 A;  3SJT A;  3SL0 A;  4RHQ A;  1T5F A;  3THE A;  3PZL A;  3GMZ A;  4Q3R A;  4RHK A;  2PHO A;  2PLL A;  1P8M A;  5RLA A;  4HZE A;  3E6K A;  3E6V A;  4IU4 A;  1D3V A;  4GSZ A;  3M1R A;  3THJ A;  1TA1 A;  4IU5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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