2VQQA

Structure of hdac4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor
Total Genus 132
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
399
structure length
361
Chain Sequence
RFTTGLVYDTLMLKHQHAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQTVHSEAHTLLYGTNPLVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (10-13)AH3 (73-80)3H1 (16-18)EMPTYTII2 (292-295)AH1 (37-48)3H2 (50-53)AH4 (117-143)S2 (55-57)AH2 (64-68)TI1 (68-71)TVIII4 (280-283)TI2 (113-116)S3 (148-151)TI'1 (166-169)TVIII2 (144-147)3H4 (239-241)AH5 (173-185)AH6 (201-207)TI3 (157-160)TIV1 (161-164)O1 (171-173)O2 (199-201)TIV2 (252-255)TIV3 (254-257)TI4 (207-210)S4 (190-194)AH9 (334-349)S8 (324-328)AH7 (260-278)S5 (213-220)3H5 (320-322)3H3 (222-224)TII1 (241-244)S7 (282-287)S6 (245-250)TI7 (289-292)AH8 (306-318)TIV4 (296-299)TIV5 (297-300)TIV6 (298-301)O4 (322-324)AH10 (358-362)TVIII1 (19-22)TI6 (232-235)TVIa1 (226-229)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
pubmed doi rcsb
molecule keywords HISTONE DEACETYLASE 4
total genus 132
structure length 361
sequence length 399
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-03-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 2vqqA00
4BZ8A 4LY1A 5A2SA 5G11A 4A69A 2VQJA 4CQFA 5EFHA 4BZ9A 1ZZ3A 3C0ZA 4QA0A 4BZ6A 5G10A 5G13A 5EFJD 5EFGA 3MZ7A 3MAXA 4CBYA 1C3RA 5G0HA 4CBTA 3F06A 5G17A 5D1DA 1ZZ1A 5DC5A 1T64A 3C10A 5EFKB 4RN1A 4ZUOA 5EEMA 3SFFA 4LXZA 5G0XA 2VQWG 4ZUMA 5EF7A 2V5XA 5THTA 4BKXB 3EZPA 5G3WA 1C3SA 1W22A 2VQVA 3MZ6A 2V5WA 5LI3A 3Q9CA 2VQOA 3MZ4A 3ZNSA 5G0IA 5EENA 2VQQA 4QA4A 5G1AA 3SFHA 5EFNA 3ZNRA 5EEKA 5DC6A 3Q9EA 3F07A 5EEFA 5IWGA 2VCGA 5G0YA 3EW8A 5EEIA 4RN2A 4QA5A 2GH6A 3MENA 5G0JA 4BZ7A 5G0GA 5THVA 1ZZ0A 5DC8A 4QA6A 2VQMA 5G1CA 1C3PA 5THUA 4ZUPA 4QA3A 4QA1A 3EWFA 3Q9BA 5ICNB 5JI5A 4RN0A 3F0RA 3Q9FA 5FUEA 5IX0A 3RQDA 4QA2A 4ZURA 5D1BA 5THSA 1T69A 4ZUQA 5DC7A 5EF8A 4ZUNA 1VKGA 5D1CA 4BZ5A 3EZTA 4QA7A 5G12A 5FCWA 5BWZA 3C0YA 1T67A 3MZ3A 5G1BA 5EFBD
chains in the Genus database with same CATH superfamily
2ZAVA 1RLAA 4Q3TA 4Q3SA 4BZ8A 1R1OA 4RHJA 4LY1A 5A2SA 1GQ6A 3LHLA 5G11A 1WVAA 4A69A 2VQJA 4IXUA 4CQFA 5EFHA 2A0MA 1ZZ3A 4MYNA 4BZ9A 3C0ZA 3THJA 1P8PA 3SL1A 4QA0A 2RLAA 3MFWA 4BZ6A 1T5FA 5G10A 5G13A 4HZEA 1P8RA 5EFGA 5EFJD 3MZ7A 3MFVA 3MAXA 4IXVA 1C3RA 1P8QA 5G0HA 4CBTA 4Q3PA 4CBYA 4IU5A 3F06A 3TH7A 2AEBA 5G17A 5D1DA 1ZZ1A 5DC5A 1P8MA 1T64A 3C10A 5EFKB 4FCKA 1HQFA 4MXRA 2PLLA 3E9BA 4RN1A 4I06A 4ZUOA 1TBLA 5EEMA 4G3HA 3SFFA 1TBHA 4RHIA 1XFKA 4LXZA 5G0XA 2VQWG 1HQ5A 1PQ3A 3F80A 4RHQA 1HQXA 4ZUMA 2PHOA 5EF7A 4Q3UA 2V5XA 3E8ZA 5THTA 4BKXB 1P8NA 3EZPA 4IU0A 5G3WA 4MYKA 4IE2A 4FCIA 4MYFA 5HJ9A 5HJAA 3LP4A 3NIPA 1C3SA 4Q3RA 1W22A 4Q41A 2VQVA 1P8SA 1HQHA 3MZ6A 2V5WA 1WOHA 3THEA 3GMZA 3Q9CA 5LI3A 4IE1A 4IU4A 3KV2A 2VQOA 3MZ4A 3ZNSA 4GWCA 1T4RA 5G0IA 5EENA 3SL0A 3DJ8A 2VQQA 4QA4A 5G1AA 1T5GA 2CEVA 3E6KA 3SFHA 5EFNA 3ZNRA 4IU1A 5EEKA 3GN0A 5DC6A 3Q9EA 3PZLA 2EF4A 3F07A 5EEFA 3M1RA 5IWGA 2VCGA 5G0YA 3EW8A 3MMRA 5EEIA 4HXQA 4RN2A 4QA5A 3LP7A 3SKKA 2GH6A 3CEVA 1GQ7A 3MENA 1HQGA 1WOIA 5G0JA 4BZ7A 1WOGA 3NIQA 5G0GA 5THVA 1ZZ0A 5DC8A 1TBJA 4QA6A 2EIVA 3TF3A 2VQMA 4IE3A 5G1CA 1C3PA 5THUA 4ZUPA 4QA3A 3E8QA 3EWFA 3Q9BA 4QA1A 4Q3VA 1T4SA 3MJLA 3THHA 5ICNB 4Q40A 4Q3QA 5JI5A 5CEVA 4GSVA 1T4TA 1WVBA 4RN0A 5RLAA 4HWWA 3F0RA 3NIOA 1P8OA 2EF5A 3Q9FA 5FUEA 1TA1A 4Q3RC 5IX0A 3RQDA 4QA2A 4ZURA 1ZPGA 5D1BA 5THSA 2PHAA 1T69A 4MYLA 1D3VA 4RHLA 4ZUQA 4GSZA 1ZPEA 4GSMA 5DC7A 5EF8A 5EFBD 1T4PA 4ZUNA 1VKGA 4GWDA 5D1CA 4BZ5A 3EZTA 4QA7A 3RLAA 4ITYA 4RHMA 5G12A 5FCWA 4DZ4A 3SJTA 4Q42A 5BWZA 3C0YA 4CEVA 4RLAA 1T67A 3MZ3A 4RHKA 5G1BA 1CEVA 3E6VA
chains in the Genus database with same CATH topology
4BZ8A 4LY1A 5A2SA 5G11A 4A69A 2VQJA 4CQFA 5EFHA 4BZ9A 1ZZ3A 3C0ZA 4QA0A 4BZ6A 5G10A 5G13A 5EFJD 5EFGA 3MZ7A 3MAXA 4CBYA 1C3RA 5G0HA 4CBTA 3F06A 5G17A 5D1DA 1ZZ1A 5DC5A 1T64A 3C10A 5EFKB 4RN1A 4ZUOA 5EEMA 3SFFA 4LXZA 5G0XA 2VQWG 4ZUMA 5EF7A 2V5XA 5THTA 4BKXB 3EZPA 5G3WA 1C3SA 1W22A 2VQVA 3MZ6A 2V5WA 5LI3A 3Q9CA 2VQOA 3MZ4A 3ZNSA 5G0IA 5EENA 2VQQA 4QA4A 5G1AA 3SFHA 5EFNA 3ZNRA 5EEKA 5DC6A 3Q9EA 3F07A 5EEFA 5IWGA 2VCGA 5G0YA 3EW8A 5EEIA 4RN2A 4QA5A 2GH6A 3MENA 5G0JA 4BZ7A 5G0GA 5THVA 1ZZ0A 5DC8A 4QA6A 2VQMA 5G1CA 1C3PA 5THUA 4ZUPA 4QA3A 4QA1A 3EWFA 3Q9BA 5ICNB 5JI5A 4RN0A 3F0RA 3Q9FA 5FUEA 5IX0A 3RQDA 4QA2A 4ZURA 5D1BA 5THSA 1T69A 4ZUQA 5DC7A 5EF8A 4ZUNA 1VKGA 5D1CA 4BZ5A 3EZTA 4QA7A 5G12A 5FCWA 5BWZA 3C0YA 1T67A 3MZ3A 5G1BA 5EFBD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BZ8 A;  4LY1 A;  5A2S A;  5G11 A;  4A69 A;  2VQJ A;  4CQF A;  5EFH A;  4BZ9 A;  1ZZ3 A;  3C0Z A;  4QA0 A;  4BZ6 A;  5G10 A;  5G13 A;  5EFJ D;  5EFG A;  3MZ7 A;  3MAX A;  4CBY A;  1C3R A;  5G0H A;  4CBT A;  3F06 A;  5G17 A;  5D1D A;  1ZZ1 A;  5DC5 A;  1T64 A;  3C10 A;  5EFK B;  4RN1 A;  4ZUO A;  5EEM A;  3SFF A;  4LXZ A;  5G0X A;  2VQW G;  4ZUM A;  5EF7 A;  2V5X A;  5THT A;  4BKX B;  3EZP A;  5G3W A;  1C3S A;  1W22 A;  2VQV A;  3MZ6 A;  2V5W A;  5LI3 A;  3Q9C A;  2VQO A;  3MZ4 A;  3ZNS A;  5G0I A;  5EEN A;  2VQQ A;  4QA4 A;  5G1A A;  3SFH A;  5EFN A;  3ZNR A;  5EEK A;  5DC6 A;  3Q9E A;  3F07 A;  5EEF A;  5IWG A;  2VCG A;  5G0Y A;  3EW8 A;  5EEI A;  4RN2 A;  4QA5 A;  2GH6 A;  3MEN A;  5G0J A;  4BZ7 A;  5G0G A;  5THV A;  1ZZ0 A;  5DC8 A;  4QA6 A;  2VQM A;  5G1C A;  1C3P A;  5THU A;  4ZUP A;  4QA3 A;  4QA1 A;  3EWF A;  3Q9B A;  5ICN B;  5JI5 A;  4RN0 A;  3F0R A;  3Q9F A;  5FUE A;  5IX0 A;  3RQD A;  4QA2 A;  4ZUR A;  5D1B A;  5THS A;  1T69 A;  4ZUQ A;  5DC7 A;  5EF8 A;  4ZUN A;  1VKG A;  5D1C A;  4BZ5 A;  3EZT A;  4QA7 A;  5G12 A;  5FCW A;  5BWZ A;  3C0Y A;  1T67 A;  3MZ3 A;  5G1B A;  5EFB D; 
#chains in the Genus database with same CATH topology
 2ZAV A;  1RLA A;  4Q3T A;  4Q3S A;  4BZ8 A;  1R1O A;  4RHJ A;  4LY1 A;  5A2S A;  1GQ6 A;  3LHL A;  5G11 A;  1WVA A;  4A69 A;  2VQJ A;  4IXU A;  4CQF A;  5EFH A;  2A0M A;  1ZZ3 A;  4MYN A;  4BZ9 A;  3C0Z A;  3THJ A;  1P8P A;  3SL1 A;  4QA0 A;  2RLA A;  3MFW A;  4BZ6 A;  1T5F A;  5G10 A;  5G13 A;  4HZE A;  1P8R A;  5EFG A;  5EFJ D;  3MZ7 A;  3MFV A;  3MAX A;  4IXV A;  1C3R A;  1P8Q A;  5G0H A;  4CBT A;  4Q3P A;  4CBY A;  4IU5 A;  3F06 A;  3TH7 A;  2AEB A;  5G17 A;  5D1D A;  1ZZ1 A;  5DC5 A;  1P8M A;  1T64 A;  3C10 A;  5EFK B;  4FCK A;  1HQF A;  4MXR A;  2PLL A;  3E9B A;  4RN1 A;  4I06 A;  4ZUO A;  1TBL A;  5EEM A;  4G3H A;  3SFF A;  1TBH A;  4RHI A;  1XFK A;  4LXZ A;  5G0X A;  2VQW G;  1HQ5 A;  1PQ3 A;  3F80 A;  4RHQ A;  1HQX A;  4ZUM A;  2PHO A;  5EF7 A;  4Q3U A;  2V5X A;  3E8Z A;  5THT A;  4BKX B;  1P8N A;  3EZP A;  4IU0 A;  5G3W A;  4MYK A;  4IE2 A;  4FCI A;  4MYF A;  5HJ9 A;  5HJA A;  3LP4 A;  3NIP A;  1C3S A;  4Q3R A;  1W22 A;  4Q41 A;  2VQV A;  1P8S A;  1HQH A;  3MZ6 A;  2V5W A;  1WOH A;  3THE A;  3GMZ A;  3Q9C A;  5LI3 A;  4IE1 A;  4IU4 A;  3KV2 A;  2VQO A;  3MZ4 A;  3ZNS A;  4GWC A;  1T4R A;  5G0I A;  5EEN A;  3SL0 A;  3DJ8 A;  2VQQ A;  4QA4 A;  5G1A A;  1T5G A;  2CEV A;  3E6K A;  3SFH A;  5EFN A;  3ZNR A;  4IU1 A;  5EEK A;  3GN0 A;  5DC6 A;  3Q9E A;  3PZL A;  2EF4 A;  3F07 A;  5EEF A;  3M1R A;  5IWG A;  2VCG A;  5G0Y A;  3EW8 A;  3MMR A;  5EEI A;  4HXQ A;  4RN2 A;  4QA5 A;  3LP7 A;  3SKK A;  2GH6 A;  3CEV A;  1GQ7 A;  3MEN A;  1HQG A;  1WOI A;  5G0J A;  4BZ7 A;  1WOG A;  3NIQ A;  5G0G A;  5THV A;  1ZZ0 A;  5DC8 A;  1TBJ A;  4QA6 A;  2EIV A;  3TF3 A;  2VQM A;  4IE3 A;  5G1C A;  1C3P A;  5THU A;  4ZUP A;  4QA3 A;  3E8Q A;  3EWF A;  3Q9B A;  4QA1 A;  4Q3V A;  1T4S A;  3MJL A;  3THH A;  5ICN B;  4Q40 A;  4Q3Q A;  5JI5 A;  5CEV A;  4GSV A;  1T4T A;  1WVB A;  4RN0 A;  5RLA A;  4HWW A;  3F0R A;  3NIO A;  1P8O A;  2EF5 A;  3Q9F A;  5FUE A;  1TA1 A;  4Q3R C;  5IX0 A;  3RQD A;  4QA2 A;  4ZUR A;  1ZPG A;  5D1B A;  5THS A;  2PHA A;  1T69 A;  4MYL A;  1D3V A;  4RHL A;  4ZUQ A;  4GSZ A;  1ZPE A;  4GSM A;  5DC7 A;  5EF8 A;  5EFB D;  1T4P A;  4ZUN A;  1VKG A;  4GWD A;  5D1C A;  4BZ5 A;  3EZT A;  4QA7 A;  3RLA A;  4ITY A;  4RHM A;  5G12 A;  5FCW A;  4DZ4 A;  3SJT A;  4Q42 A;  5BWZ A;  3C0Y A;  4CEV A;  4RLA A;  1T67 A;  3MZ3 A;  4RHK A;  5G1B A;  1CEV A;  3E6V A; 
#chains in the Genus database with same CATH homology
 4BZ8 A;  4LY1 A;  5A2S A;  5G11 A;  4A69 A;  2VQJ A;  4CQF A;  5EFH A;  4BZ9 A;  1ZZ3 A;  3C0Z A;  4QA0 A;  4BZ6 A;  5G10 A;  5G13 A;  5EFJ D;  5EFG A;  3MZ7 A;  3MAX A;  4CBY A;  1C3R A;  5G0H A;  4CBT A;  3F06 A;  5G17 A;  5D1D A;  1ZZ1 A;  5DC5 A;  1T64 A;  3C10 A;  5EFK B;  4RN1 A;  4ZUO A;  5EEM A;  3SFF A;  4LXZ A;  5G0X A;  2VQW G;  4ZUM A;  5EF7 A;  2V5X A;  5THT A;  4BKX B;  3EZP A;  5G3W A;  1C3S A;  1W22 A;  2VQV A;  3MZ6 A;  2V5W A;  5LI3 A;  3Q9C A;  2VQO A;  3MZ4 A;  3ZNS A;  5G0I A;  5EEN A;  2VQQ A;  4QA4 A;  5G1A A;  3SFH A;  5EFN A;  3ZNR A;  5EEK A;  5DC6 A;  3Q9E A;  3F07 A;  5EEF A;  5IWG A;  2VCG A;  5G0Y A;  3EW8 A;  5EEI A;  4RN2 A;  4QA5 A;  2GH6 A;  3MEN A;  5G0J A;  4BZ7 A;  5G0G A;  5THV A;  1ZZ0 A;  5DC8 A;  4QA6 A;  2VQM A;  5G1C A;  1C3P A;  5THU A;  4ZUP A;  4QA3 A;  4QA1 A;  3EWF A;  3Q9B A;  5ICN B;  5JI5 A;  4RN0 A;  3F0R A;  3Q9F A;  5FUE A;  5IX0 A;  3RQD A;  4QA2 A;  4ZUR A;  5D1B A;  5THS A;  1T69 A;  4ZUQ A;  5DC7 A;  5EF8 A;  4ZUN A;  1VKG A;  5D1C A;  4BZ5 A;  3EZT A;  4QA7 A;  5G12 A;  5FCW A;  5BWZ A;  3C0Y A;  1T67 A;  3MZ3 A;  5G1B A;  5EFB D; 
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