2PHAA

Crystal structure of native, unliganded human arginase at 1.90 resolution
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
314
structure length
314
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase-1
total genus 107
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2007-04-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2phaA00
4IU0A 4Q3TA 3E8ZA 4HZEA 4Q3RC 2PLLA 3GN0A 3TH7A 1HQ5A 5HJ9A 4RHKA 1ZPEA 2CEVA 3KV2A 4IU1A 1P8PA 4IE2A 4GWCA 1TA1A 1P8RA 1T4RA 1P8QA 1GQ6A 1CEVA 4GWDA 3THJA 1GQ7A 1ZPGA 3DJ8A 2ZAVA 3MFWA 4Q42A 2A0MA 1T5FA 4IXUA 4MXRA 4IE1A 1PQ3A 4IE3A 3TF3A 3LHLA 4G3HA 4MYNA 3M1RA 3SL0A 4Q3PA 3E6KA 3NIOA 3CEVA 4RHMA 4RLAA 4DZ4A 4Q3VA 5CEVA 2EIVA 4RHIA 1T4SA 1D3VA 1TBLA 1WOHA 4RHLA 2EF4A 2AEBA 3MJLA 3THHA 1HQHA 1WOGA 3SL1A 4Q3RA 3SJTA 1TBJA 3E8QA 4IXVA 4GSVA 3MFVA 1P8OA 3NIQA 1T4PA 3PZLA 4MYLA 4Q3SA 3SKKA 4Q40A 2PHAA 4MYKA 1P8MA 4HXQA 2RLAA 4RHJA 4IU5A 4HWWA 3F80A 1T4TA 4IU4A 4FCKA 1RLAA 1P8NA 3E6VA 3MMRA 1HQFA 4Q3UA 1HQGA 3GMZA 3NIPA 4GSMA 4GSZA 1WVBA 4I06A 1XFKA 1P8SA 3RLAA 3LP4A 4MYFA 4CEVA 5HJAA 3E9BA 3LP7A 4Q41A 1TBHA 1WVAA 5RLAA 2EF5A 4FCIA 4RHQA 4ITYA 3THEA 4Q3QA 1WOIA 1T5GA 2PHOA 1HQXA 1R1OA
chains in the Genus database with same CATH superfamily
4IU0A 4Q3TA 2VQQA 3E8ZA 4HZEA 5G0YA 4Q3RC 5THVA 1T67A 2PLLA 3GN0A 5G0IA 5LI3A 5DC7A 5G13A 3TH7A 5D1DA 5G11A 1HQ5A 4LY1A 4BZ7A 2GH6A 5HJ9A 4RHKA 1ZPEA 2CEVA 3KV2A 3TF3A 4IU1A 5G0XA 5G1BA 1P8PA 2VQJA 5EEFA 4IE2A 1VKGA 4GWCA 1TA1A 4RN2A 1P8RA 5EEIA 1T4RA 4LXZA 5FUEA 4A69A 1P8QA 1GQ6A 1CEVA 4RN0A 3Q9CA 1ZZ0A 4GWDA 3THJA 5THTA 4BZ5A 4QA1A 4ZUNA 3F07A 1GQ7A 1ZPGA 3DJ8A 2ZAVA 3F0RA 3MFWA 4Q42A 2A0MA 5G12A 5D1BA 5G1CA 1T5FA 1ZZ3A 2VQOA 4IXUA 4IE1A 1PQ3A 4IE3A 4MXRA 4QA7A 5EEKA 4ZURA 3LHLA 1W22A 1C3RA 4G3HA 4MYNA 3M1RA 3SL0A 4BZ9A 4Q3PA 3EW8A 3MZ7A 3E6KA 3NIOA 3CEVA 4RHMA 1C3PA 4RLAA 4DZ4A 4Q3VA 5CEVA 5G0JA 2EIVA 4RHIA 1T4SA 4CQFA 4BZ8A 3MENA 5ICNB 1D3VA 1TBLA 1WOHA 4RHLA 2EF4A 5EF8A 2V5WA 5G0HA 2AEBA 3MJLA 5EEMA 3THHA 5G3WA 1HQHA 5IX0A 1WOGA 2V5XA 3Q9BA 5DC5A 3Q9FA 3SL1A 4Q3RA 3ZNRA 3SJTA 1TBJA 3C0ZA 3E8QA 3C0YA 4IXVA 3EZTA 5EF7A 4GSVA 1T64A 3RQDA 4CBTA 3MFVA 1P8OA 4QA0A 3NIQA 1T4PA 3PZLA 4CBYA 3SFFA 4MYLA 5THUA 4BKXB 3EZPA 4Q3SA 4Q40A 2PHAA 4MYKA 1P8MA 4HXQA 2RLAA 4RHJA 3SKKA 2VQMA 4ZUQA 4IU5A 4HWWA 3F80A 5EFHA 4ZUMA 5EFGA 1T4TA 4QA3A 4IU4A 4FCKA 3MZ3A 5D1CA 1RLAA 1P8NA 3EWFA 4BZ6A 3E6VA 5G1AA 3MMRA 5THSA 1HQFA 5A2SA 4Q3UA 4QA2A 1HQGA 3GMZA 3NIPA 4RN1A 4QA4A 4ZUOA 5EENA 4GSMA 4GSZA 5EFBD 1WVBA 4I06A 1XFKA 4QA5A 1P8SA 2VCGA 3RLAA 3LP4A 5EFKB 4MYFA 5DC8A 1C3SA 4CEVA 3ZNSA 5HJAA 5G0GA 4ZUPA 2VQWG 3E9BA 3LP7A 1TBHA 1WVAA 5EFJD 5IWGA 5RLAA 4Q41A 5JI5A 2EF5A 5EFNA 1T69A 4QA6A 5G17A 4FCIA 3C10A 4RHQA 4ITYA 2VQVA 5FCWA 5BWZA 3THEA 3F06A 3MZ4A 4Q3QA 3SFHA 1WOIA 1ZZ1A 3MAXA 5G10A 1T5GA 2PHOA 1HQXA 5DC6A 1R1OA 3MZ6A 3Q9EA
chains in the Genus database with same CATH topology
4IU0A 4Q3TA 3E8ZA 4HZEA 4Q3RC 2PLLA 3GN0A 3TH7A 1HQ5A 5HJ9A 4RHKA 1ZPEA 2CEVA 3KV2A 4IU1A 1P8PA 4IE2A 4GWCA 1TA1A 1P8RA 1T4RA 1P8QA 1GQ6A 1CEVA 4GWDA 3THJA 1GQ7A 1ZPGA 3DJ8A 2ZAVA 3MFWA 4Q42A 2A0MA 1T5FA 4IXUA 4MXRA 4IE1A 1PQ3A 4IE3A 3TF3A 3LHLA 4G3HA 4MYNA 3M1RA 3SL0A 4Q3PA 3E6KA 3NIOA 3CEVA 4RHMA 4RLAA 4DZ4A 4Q3VA 5CEVA 2EIVA 4RHIA 1T4SA 1D3VA 1TBLA 1WOHA 4RHLA 2EF4A 2AEBA 3MJLA 3THHA 1HQHA 1WOGA 3SL1A 4Q3RA 3SJTA 1TBJA 3E8QA 4IXVA 4GSVA 3MFVA 1P8OA 3NIQA 1T4PA 3PZLA 4MYLA 4Q3SA 3SKKA 4Q40A 2PHAA 4MYKA 1P8MA 4HXQA 2RLAA 4RHJA 4IU5A 4HWWA 3F80A 1T4TA 4IU4A 4FCKA 1RLAA 1P8NA 3E6VA 3MMRA 1HQFA 4Q3UA 1HQGA 3GMZA 3NIPA 4GSMA 4GSZA 1WVBA 4I06A 1XFKA 1P8SA 3RLAA 3LP4A 4MYFA 4CEVA 5HJAA 3E9BA 3LP7A 4Q41A 1TBHA 1WVAA 5RLAA 2EF5A 4FCIA 4RHQA 4ITYA 3THEA 4Q3QA 1WOIA 1T5GA 2PHOA 1HQXA 1R1OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IU0 A;  4Q3T A;  3E8Z A;  4HZE A;  4Q3R C;  2PLL A;  3GN0 A;  3TH7 A;  1HQ5 A;  5HJ9 A;  4RHK A;  1ZPE A;  2CEV A;  3KV2 A;  4IU1 A;  1P8P A;  4IE2 A;  4GWC A;  1TA1 A;  1P8R A;  1T4R A;  1P8Q A;  1GQ6 A;  1CEV A;  4GWD A;  3THJ A;  1GQ7 A;  1ZPG A;  3DJ8 A;  2ZAV A;  3MFW A;  4Q42 A;  2A0M A;  1T5F A;  4IXU A;  4MXR A;  4IE1 A;  1PQ3 A;  4IE3 A;  3TF3 A;  3LHL A;  4G3H A;  4MYN A;  3M1R A;  3SL0 A;  4Q3P A;  3E6K A;  3NIO A;  3CEV A;  4RHM A;  4RLA A;  4DZ4 A;  4Q3V A;  5CEV A;  2EIV A;  4RHI A;  1T4S A;  1D3V A;  1TBL A;  1WOH A;  4RHL A;  2EF4 A;  2AEB A;  3MJL A;  3THH A;  1HQH A;  1WOG A;  3SL1 A;  4Q3R A;  3SJT A;  1TBJ A;  3E8Q A;  4IXV A;  4GSV A;  3MFV A;  1P8O A;  3NIQ A;  1T4P A;  3PZL A;  4MYL A;  4Q3S A;  3SKK A;  4Q40 A;  2PHA A;  4MYK A;  1P8M A;  4HXQ A;  2RLA A;  4RHJ A;  4IU5 A;  4HWW A;  3F80 A;  1T4T A;  4IU4 A;  4FCK A;  1RLA A;  1P8N A;  3E6V A;  3MMR A;  1HQF A;  4Q3U A;  1HQG A;  3GMZ A;  3NIP A;  4GSM A;  4GSZ A;  1WVB A;  4I06 A;  1XFK A;  1P8S A;  3RLA A;  3LP4 A;  4MYF A;  4CEV A;  5HJA A;  3E9B A;  3LP7 A;  4Q41 A;  1TBH A;  1WVA A;  5RLA A;  2EF5 A;  4FCI A;  4RHQ A;  4ITY A;  3THE A;  4Q3Q A;  1WOI A;  1T5G A;  2PHO A;  1HQX A;  1R1O A; 
#chains in the Genus database with same CATH topology
 4IU0 A;  4Q3T A;  2VQQ A;  3E8Z A;  4HZE A;  5G0Y A;  4Q3R C;  5THV A;  1T67 A;  2PLL A;  3GN0 A;  5G0I A;  5LI3 A;  5DC7 A;  5G13 A;  3TH7 A;  5D1D A;  5G11 A;  1HQ5 A;  4LY1 A;  4BZ7 A;  2GH6 A;  5HJ9 A;  4RHK A;  1ZPE A;  2CEV A;  3KV2 A;  3TF3 A;  4IU1 A;  5G0X A;  5G1B A;  1P8P A;  2VQJ A;  5EEF A;  4IE2 A;  1VKG A;  4GWC A;  1TA1 A;  4RN2 A;  1P8R A;  5EEI A;  1T4R A;  4LXZ A;  5FUE A;  4A69 A;  1P8Q A;  1GQ6 A;  1CEV A;  4RN0 A;  3Q9C A;  1ZZ0 A;  4GWD A;  3THJ A;  5THT A;  4BZ5 A;  4QA1 A;  4ZUN A;  3F07 A;  1GQ7 A;  1ZPG A;  3DJ8 A;  2ZAV A;  3F0R A;  3MFW A;  4Q42 A;  2A0M A;  5G12 A;  5D1B A;  5G1C A;  1T5F A;  1ZZ3 A;  2VQO A;  4IXU A;  4IE1 A;  1PQ3 A;  4IE3 A;  4MXR A;  4QA7 A;  5EEK A;  4ZUR A;  3LHL A;  1W22 A;  1C3R A;  4G3H A;  4MYN A;  3M1R A;  3SL0 A;  4BZ9 A;  4Q3P A;  3EW8 A;  3MZ7 A;  3E6K A;  3NIO A;  3CEV A;  4RHM A;  1C3P A;  4RLA A;  4DZ4 A;  4Q3V A;  5CEV A;  5G0J A;  2EIV A;  4RHI A;  1T4S A;  4CQF A;  4BZ8 A;  3MEN A;  5ICN B;  1D3V A;  1TBL A;  1WOH A;  4RHL A;  2EF4 A;  5EF8 A;  2V5W A;  5G0H A;  2AEB A;  3MJL A;  5EEM A;  3THH A;  5G3W A;  1HQH A;  5IX0 A;  1WOG A;  2V5X A;  3Q9B A;  5DC5 A;  3Q9F A;  3SL1 A;  4Q3R A;  3ZNR A;  3SJT A;  1TBJ A;  3C0Z A;  3E8Q A;  3C0Y A;  4IXV A;  3EZT A;  5EF7 A;  4GSV A;  1T64 A;  3RQD A;  4CBT A;  3MFV A;  1P8O A;  4QA0 A;  3NIQ A;  1T4P A;  3PZL A;  4CBY A;  3SFF A;  4MYL A;  5THU A;  4BKX B;  3EZP A;  4Q3S A;  4Q40 A;  2PHA A;  4MYK A;  1P8M A;  4HXQ A;  2RLA A;  4RHJ A;  3SKK A;  2VQM A;  4ZUQ A;  4IU5 A;  4HWW A;  3F80 A;  5EFH A;  4ZUM A;  5EFG A;  1T4T A;  4QA3 A;  4IU4 A;  4FCK A;  3MZ3 A;  5D1C A;  1RLA A;  1P8N A;  3EWF A;  4BZ6 A;  3E6V A;  5G1A A;  3MMR A;  5THS A;  1HQF A;  5A2S A;  4Q3U A;  4QA2 A;  1HQG A;  3GMZ A;  3NIP A;  4RN1 A;  4QA4 A;  4ZUO A;  5EEN A;  4GSM A;  4GSZ A;  5EFB D;  1WVB A;  4I06 A;  1XFK A;  4QA5 A;  1P8S A;  2VCG A;  3RLA A;  3LP4 A;  5EFK B;  4MYF A;  5DC8 A;  1C3S A;  4CEV A;  3ZNS A;  5HJA A;  5G0G A;  4ZUP A;  2VQW G;  3E9B A;  3LP7 A;  1TBH A;  1WVA A;  5EFJ D;  5IWG A;  5RLA A;  4Q41 A;  5JI5 A;  2EF5 A;  5EFN A;  1T69 A;  4QA6 A;  5G17 A;  4FCI A;  3C10 A;  4RHQ A;  4ITY A;  2VQV A;  5FCW A;  5BWZ A;  3THE A;  3F06 A;  3MZ4 A;  4Q3Q A;  3SFH A;  1WOI A;  1ZZ1 A;  3MAX A;  5G10 A;  1T5G A;  2PHO A;  1HQX A;  5DC6 A;  1R1O A;  3MZ6 A;  3Q9E A; 
#chains in the Genus database with same CATH homology
 4IU0 A;  4Q3T A;  3E8Z A;  4HZE A;  4Q3R C;  2PLL A;  3GN0 A;  3TH7 A;  1HQ5 A;  5HJ9 A;  4RHK A;  1ZPE A;  2CEV A;  3KV2 A;  4IU1 A;  1P8P A;  4IE2 A;  4GWC A;  1TA1 A;  1P8R A;  1T4R A;  1P8Q A;  1GQ6 A;  1CEV A;  4GWD A;  3THJ A;  1GQ7 A;  1ZPG A;  3DJ8 A;  2ZAV A;  3MFW A;  4Q42 A;  2A0M A;  1T5F A;  4IXU A;  4MXR A;  4IE1 A;  1PQ3 A;  4IE3 A;  3TF3 A;  3LHL A;  4G3H A;  4MYN A;  3M1R A;  3SL0 A;  4Q3P A;  3E6K A;  3NIO A;  3CEV A;  4RHM A;  4RLA A;  4DZ4 A;  4Q3V A;  5CEV A;  2EIV A;  4RHI A;  1T4S A;  1D3V A;  1TBL A;  1WOH A;  4RHL A;  2EF4 A;  2AEB A;  3MJL A;  3THH A;  1HQH A;  1WOG A;  3SL1 A;  4Q3R A;  3SJT A;  1TBJ A;  3E8Q A;  4IXV A;  4GSV A;  3MFV A;  1P8O A;  3NIQ A;  1T4P A;  3PZL A;  4MYL A;  4Q3S A;  3SKK A;  4Q40 A;  2PHA A;  4MYK A;  1P8M A;  4HXQ A;  2RLA A;  4RHJ A;  4IU5 A;  4HWW A;  3F80 A;  1T4T A;  4IU4 A;  4FCK A;  1RLA A;  1P8N A;  3E6V A;  3MMR A;  1HQF A;  4Q3U A;  1HQG A;  3GMZ A;  3NIP A;  4GSM A;  4GSZ A;  1WVB A;  4I06 A;  1XFK A;  1P8S A;  3RLA A;  3LP4 A;  4MYF A;  4CEV A;  5HJA A;  3E9B A;  3LP7 A;  4Q41 A;  1TBH A;  1WVA A;  5RLA A;  2EF5 A;  4FCI A;  4RHQ A;  4ITY A;  3THE A;  4Q3Q A;  1WOI A;  1T5G A;  2PHO A;  1HQX A;  1R1O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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