2PHOA

Crystal structure of human arginase i complexed with thiosemicarbazide at 1.95 resolution
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
313
structure length
313
Chain Sequence
RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase-1
total genus 108
structure length 313
sequence length 313
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2007-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2phoA00
1TBHA 1T4PA 3MFVA 4RHLA 3M1RA 2AEBA 2EF5A 1T4RA 4MYKA 1WOIA 1ZPGA 4HWWA 4Q41A 1TBJA 3E8QA 3TH7A 1GQ7A 1HQXA 4IE3A 1T4TA 3F80A 5CEVA 3RLAA 3GN0A 2EIVA 4Q3TA 4RHIA 3SL1A 4Q3VA 2RLAA 1P8QA 1P8MA 4RHMA 3LP4A 4Q3UA 5HJ9A 4Q3QA 4HXQA 1D3VA 3MJLA 1T5FA 1T5GA 4HZEA 1HQHA 3KV2A 4CEVA 4IXVA 4RHJA 2PLLA 2EF4A 2A0MA 4RHQA 4I06A 4ITYA 4MXRA 1HQFA 3NIOA 3NIPA 3THHA 4Q3RC 1XFKA 4GWCA 4IE2A 1WOHA 3LP7A 4FCIA 4Q3PA 4Q3RA 1R1OA 3SKKA 1GQ6A 3TF3A 1TA1A 3E8ZA 5HJAA 4RLAA 1P8OA 4RHKA 4IXUA 4GSMA 1TBLA 2ZAVA 1P8SA 3E6KA 1PQ3A 2PHAA 4FCKA 3E9BA 3LHLA 3MFWA 1RLAA 2CEVA 3E6VA 3GMZA 4GSVA 4IE1A 1HQGA 4IU4A 4MYLA 1CEVA 3SJTA 1P8NA 4IU1A 1WOGA 1P8PA 3SL0A 4Q3SA 4IU5A 1T4SA 3PZLA 3THEA 4GSZA 3THJA 1WVBA 1WVAA 5RLAA 1P8RA 4MYNA 4IU0A 4G3HA 2PHOA 3CEVA 4Q42A 4Q40A 3NIQA 3MMRA 4GWDA 4DZ4A 3DJ8A 1HQ5A 4MYFA 1ZPEA
chains in the Genus database with same CATH superfamily
1TBHA 1T4PA 3EZTA 3MFVA 3M1RA 4RHLA 5THVA 2AEBA 2EF5A 5EFNA 2VQWG 1T4RA 4QA1A 5EFGA 4MYKA 2VQJA 1WOIA 5ICNB 1ZPGA 5G0YA 5G1AA 5DC7A 4QA2A 3SFHA 2GH6A 5D1CA 5BWZA 3F0RA 1ZZ0A 3MZ6A 1C3PA 4HWWA 4QA4A 4CQFA 2VQQA 4Q41A 3EW8A 1TBJA 5THUA 3E8QA 3TH7A 1GQ7A 1HQXA 4IE3A 1T4TA 4LXZA 2VQMA 1VKGA 2VQOA 4CBTA 3MZ7A 3F80A 2VQVA 5CEVA 3RQDA 3RLAA 3GN0A 2EIVA 4Q3TA 4RHIA 5G12A 4Q3VA 2RLAA 5DC5A 3SL1A 5THTA 2VCGA 1P8QA 1P8MA 4RHMA 5EENA 3LP4A 5G3WA 4Q3UA 5HJ9A 4Q3QA 4HXQA 4ZUPA 1D3VA 3MJLA 5G0GA 5G1CA 1T5FA 1T5GA 4HZEA 5G10A 4QA6A 1HQHA 5G13A 3KV2A 4CEVA 4IXVA 3C10A 4RHJA 5FUEA 2PLLA 2EF4A 2A0MA 3MZ4A 4QA7A 3C0ZA 4I06A 4RHQA 4ITYA 4MXRA 1HQFA 3NIOA 5G11A 3NIPA 3THHA 4Q3RC 1T69A 2V5XA 5G0JA 1XFKA 4GWCA 4IE2A 3SFFA 1WOHA 1T67A 5IX0A 3Q9FA 3LP7A 4FCIA 4Q3PA 5DC6A 3F06A 4ZURA 1C3SA 3Q9EA 4Q3RA 1R1OA 4LY1A 5EF7A 5EF8A 4BZ8A 3MZ3A 5D1BA 5G0HA 4QA0A 5EFHA 3SKKA 1GQ6A 5THSA 4BKXB 4CBYA 3TF3A 1W22A 5EEFA 1TA1A 1ZZ1A 3E8ZA 5EFKB 4RLAA 5HJAA 1P8OA 4RHKA 4IXUA 2V5WA 3EWFA 4GSMA 1TBLA 4QA3A 5EFJD 2ZAVA 5EEKA 3ZNSA 1P8SA 3E6KA 1PQ3A 2PHAA 4ZUOA 4FCKA 5EEMA 3E9BA 5G17A 3LHLA 3MFWA 1RLAA 2CEVA 3E6VA 3C0YA 1ZZ3A 4QA5A 3GMZA 4GSVA 4BZ7A 4BZ9A 1C3RA 4IE1A 5EFBD 1HQGA 4RN2A 5IWGA 4ZUQA 4IU4A 5D1DA 4MYLA 1CEVA 4BZ5A 5A2SA 3SJTA 3Q9BA 5G1BA 4RN1A 1P8NA 4RN0A 4IU1A 1WOGA 1P8PA 3SL0A 4Q3SA 4IU5A 3MENA 5EEIA 5FCWA 4ZUMA 1T4SA 3Q9CA 3EZPA 3PZLA 3THEA 4GSZA 3THJA 5DC8A 1WVBA 4BZ6A 1WVAA 5RLAA 1P8RA 3ZNRA 4MYNA 5G0IA 1T64A 4ZUNA 4IU0A 2PHOA 3CEVA 4G3HA 4Q42A 4Q40A 5G0XA 4A69A 5JI5A 3MAXA 3MMRA 3NIQA 3F07A 4GWDA 4DZ4A 5LI3A 3DJ8A 1HQ5A 4MYFA 1ZPEA
chains in the Genus database with same CATH topology
1TBHA 1T4PA 3MFVA 4RHLA 3M1RA 2AEBA 2EF5A 1T4RA 4MYKA 1WOIA 1ZPGA 4HWWA 4Q41A 1TBJA 3E8QA 3TH7A 1GQ7A 1HQXA 4IE3A 1T4TA 3F80A 5CEVA 3RLAA 3GN0A 2EIVA 4Q3TA 4RHIA 3SL1A 4Q3VA 2RLAA 1P8QA 1P8MA 4RHMA 3LP4A 4Q3UA 5HJ9A 4Q3QA 4HXQA 1D3VA 3MJLA 1T5FA 1T5GA 4HZEA 1HQHA 3KV2A 4CEVA 4IXVA 4RHJA 2PLLA 2EF4A 2A0MA 4RHQA 4I06A 4ITYA 4MXRA 1HQFA 3NIOA 3NIPA 3THHA 4Q3RC 1XFKA 4GWCA 4IE2A 1WOHA 3LP7A 4FCIA 4Q3PA 4Q3RA 1R1OA 3SKKA 1GQ6A 3TF3A 1TA1A 3E8ZA 5HJAA 4RLAA 1P8OA 4RHKA 4IXUA 4GSMA 1TBLA 2ZAVA 1P8SA 3E6KA 1PQ3A 2PHAA 4FCKA 3E9BA 3LHLA 3MFWA 1RLAA 2CEVA 3E6VA 3GMZA 4GSVA 4IE1A 1HQGA 4IU4A 4MYLA 1CEVA 3SJTA 1P8NA 4IU1A 1WOGA 1P8PA 3SL0A 4Q3SA 4IU5A 1T4SA 3PZLA 3THEA 4GSZA 3THJA 1WVBA 1WVAA 5RLAA 1P8RA 4MYNA 4IU0A 4G3HA 2PHOA 3CEVA 4Q42A 4Q40A 3NIQA 3MMRA 4GWDA 4DZ4A 3DJ8A 1HQ5A 4MYFA 1ZPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBH A;  1T4P A;  3MFV A;  4RHL A;  3M1R A;  2AEB A;  2EF5 A;  1T4R A;  4MYK A;  1WOI A;  1ZPG A;  4HWW A;  4Q41 A;  1TBJ A;  3E8Q A;  3TH7 A;  1GQ7 A;  1HQX A;  4IE3 A;  1T4T A;  3F80 A;  5CEV A;  3RLA A;  3GN0 A;  2EIV A;  4Q3T A;  4RHI A;  3SL1 A;  4Q3V A;  2RLA A;  1P8Q A;  1P8M A;  4RHM A;  3LP4 A;  4Q3U A;  5HJ9 A;  4Q3Q A;  4HXQ A;  1D3V A;  3MJL A;  1T5F A;  1T5G A;  4HZE A;  1HQH A;  3KV2 A;  4CEV A;  4IXV A;  4RHJ A;  2PLL A;  2EF4 A;  2A0M A;  4RHQ A;  4I06 A;  4ITY A;  4MXR A;  1HQF A;  3NIO A;  3NIP A;  3THH A;  4Q3R C;  1XFK A;  4GWC A;  4IE2 A;  1WOH A;  3LP7 A;  4FCI A;  4Q3P A;  4Q3R A;  1R1O A;  3SKK A;  1GQ6 A;  3TF3 A;  1TA1 A;  3E8Z A;  5HJA A;  4RLA A;  1P8O A;  4RHK A;  4IXU A;  4GSM A;  1TBL A;  2ZAV A;  1P8S A;  3E6K A;  1PQ3 A;  2PHA A;  4FCK A;  3E9B A;  3LHL A;  3MFW A;  1RLA A;  2CEV A;  3E6V A;  3GMZ A;  4GSV A;  4IE1 A;  1HQG A;  4IU4 A;  4MYL A;  1CEV A;  3SJT A;  1P8N A;  4IU1 A;  1WOG A;  1P8P A;  3SL0 A;  4Q3S A;  4IU5 A;  1T4S A;  3PZL A;  3THE A;  4GSZ A;  3THJ A;  1WVB A;  1WVA A;  5RLA A;  1P8R A;  4MYN A;  4IU0 A;  4G3H A;  2PHO A;  3CEV A;  4Q42 A;  4Q40 A;  3NIQ A;  3MMR A;  4GWD A;  4DZ4 A;  3DJ8 A;  1HQ5 A;  4MYF A;  1ZPE A; 
#chains in the Genus database with same CATH topology
 1TBH A;  1T4P A;  3EZT A;  3MFV A;  3M1R A;  4RHL A;  5THV A;  2AEB A;  2EF5 A;  5EFN A;  2VQW G;  1T4R A;  4QA1 A;  5EFG A;  4MYK A;  2VQJ A;  1WOI A;  5ICN B;  1ZPG A;  5G0Y A;  5G1A A;  5DC7 A;  4QA2 A;  3SFH A;  2GH6 A;  5D1C A;  5BWZ A;  3F0R A;  1ZZ0 A;  3MZ6 A;  1C3P A;  4HWW A;  4QA4 A;  4CQF A;  2VQQ A;  4Q41 A;  3EW8 A;  1TBJ A;  5THU A;  3E8Q A;  3TH7 A;  1GQ7 A;  1HQX A;  4IE3 A;  1T4T A;  4LXZ A;  2VQM A;  1VKG A;  2VQO A;  4CBT A;  3MZ7 A;  3F80 A;  2VQV A;  5CEV A;  3RQD A;  3RLA A;  3GN0 A;  2EIV A;  4Q3T A;  4RHI A;  5G12 A;  4Q3V A;  2RLA A;  5DC5 A;  3SL1 A;  5THT A;  2VCG A;  1P8Q A;  1P8M A;  4RHM A;  5EEN A;  3LP4 A;  5G3W A;  4Q3U A;  5HJ9 A;  4Q3Q A;  4HXQ A;  4ZUP A;  1D3V A;  3MJL A;  5G0G A;  5G1C A;  1T5F A;  1T5G A;  4HZE A;  5G10 A;  4QA6 A;  1HQH A;  5G13 A;  3KV2 A;  4CEV A;  4IXV A;  3C10 A;  4RHJ A;  5FUE A;  2PLL A;  2EF4 A;  2A0M A;  3MZ4 A;  4QA7 A;  3C0Z A;  4I06 A;  4RHQ A;  4ITY A;  4MXR A;  1HQF A;  3NIO A;  5G11 A;  3NIP A;  3THH A;  4Q3R C;  1T69 A;  2V5X A;  5G0J A;  1XFK A;  4GWC A;  4IE2 A;  3SFF A;  1WOH A;  1T67 A;  5IX0 A;  3Q9F A;  3LP7 A;  4FCI A;  4Q3P A;  5DC6 A;  3F06 A;  4ZUR A;  1C3S A;  3Q9E A;  4Q3R A;  1R1O A;  4LY1 A;  5EF7 A;  5EF8 A;  4BZ8 A;  3MZ3 A;  5D1B A;  5G0H A;  4QA0 A;  5EFH A;  3SKK A;  1GQ6 A;  5THS A;  4BKX B;  4CBY A;  3TF3 A;  1W22 A;  5EEF A;  1TA1 A;  1ZZ1 A;  3E8Z A;  5EFK B;  4RLA A;  5HJA A;  1P8O A;  4RHK A;  4IXU A;  2V5W A;  3EWF A;  4GSM A;  1TBL A;  4QA3 A;  5EFJ D;  2ZAV A;  5EEK A;  3ZNS A;  1P8S A;  3E6K A;  1PQ3 A;  2PHA A;  4ZUO A;  4FCK A;  5EEM A;  3E9B A;  5G17 A;  3LHL A;  3MFW A;  1RLA A;  2CEV A;  3E6V A;  3C0Y A;  1ZZ3 A;  4QA5 A;  3GMZ A;  4GSV A;  4BZ7 A;  4BZ9 A;  1C3R A;  4IE1 A;  5EFB D;  1HQG A;  4RN2 A;  5IWG A;  4ZUQ A;  4IU4 A;  5D1D A;  4MYL A;  1CEV A;  4BZ5 A;  5A2S A;  3SJT A;  3Q9B A;  5G1B A;  4RN1 A;  1P8N A;  4RN0 A;  4IU1 A;  1WOG A;  1P8P A;  3SL0 A;  4Q3S A;  4IU5 A;  3MEN A;  5EEI A;  5FCW A;  4ZUM A;  1T4S A;  3Q9C A;  3EZP A;  3PZL A;  3THE A;  4GSZ A;  3THJ A;  5DC8 A;  1WVB A;  4BZ6 A;  1WVA A;  5RLA A;  1P8R A;  3ZNR A;  4MYN A;  5G0I A;  1T64 A;  4ZUN A;  4IU0 A;  2PHO A;  3CEV A;  4G3H A;  4Q42 A;  4Q40 A;  5G0X A;  4A69 A;  5JI5 A;  3MAX A;  3MMR A;  3NIQ A;  3F07 A;  4GWD A;  4DZ4 A;  5LI3 A;  3DJ8 A;  1HQ5 A;  4MYF A;  1ZPE A; 
#chains in the Genus database with same CATH homology
 1TBH A;  1T4P A;  3MFV A;  4RHL A;  3M1R A;  2AEB A;  2EF5 A;  1T4R A;  4MYK A;  1WOI A;  1ZPG A;  4HWW A;  4Q41 A;  1TBJ A;  3E8Q A;  3TH7 A;  1GQ7 A;  1HQX A;  4IE3 A;  1T4T A;  3F80 A;  5CEV A;  3RLA A;  3GN0 A;  2EIV A;  4Q3T A;  4RHI A;  3SL1 A;  4Q3V A;  2RLA A;  1P8Q A;  1P8M A;  4RHM A;  3LP4 A;  4Q3U A;  5HJ9 A;  4Q3Q A;  4HXQ A;  1D3V A;  3MJL A;  1T5F A;  1T5G A;  4HZE A;  1HQH A;  3KV2 A;  4CEV A;  4IXV A;  4RHJ A;  2PLL A;  2EF4 A;  2A0M A;  4RHQ A;  4I06 A;  4ITY A;  4MXR A;  1HQF A;  3NIO A;  3NIP A;  3THH A;  4Q3R C;  1XFK A;  4GWC A;  4IE2 A;  1WOH A;  3LP7 A;  4FCI A;  4Q3P A;  4Q3R A;  1R1O A;  3SKK A;  1GQ6 A;  3TF3 A;  1TA1 A;  3E8Z A;  5HJA A;  4RLA A;  1P8O A;  4RHK A;  4IXU A;  4GSM A;  1TBL A;  2ZAV A;  1P8S A;  3E6K A;  1PQ3 A;  2PHA A;  4FCK A;  3E9B A;  3LHL A;  3MFW A;  1RLA A;  2CEV A;  3E6V A;  3GMZ A;  4GSV A;  4IE1 A;  1HQG A;  4IU4 A;  4MYL A;  1CEV A;  3SJT A;  1P8N A;  4IU1 A;  1WOG A;  1P8P A;  3SL0 A;  4Q3S A;  4IU5 A;  1T4S A;  3PZL A;  3THE A;  4GSZ A;  3THJ A;  1WVB A;  1WVA A;  5RLA A;  1P8R A;  4MYN A;  4IU0 A;  4G3H A;  2PHO A;  3CEV A;  4Q42 A;  4Q40 A;  3NIQ A;  3MMR A;  4GWD A;  4DZ4 A;  3DJ8 A;  1HQ5 A;  4MYF A;  1ZPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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