2RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
303
structure length
303
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVPLTLSCFGTKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ARGINASE
total genus 98
structure length 303
sequence length 303
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 2rlaA00
2EF4A 4RHMA 1T4SA 4IU0A 3THHA 3SJTA 1WVAA 4Q3RA 3NIQA 4MYNA 3F80A 4IXVA 1RLAA 3LP7A 3E8ZA 4GSVA 1XFKA 1T4TA 3MFWA 4FCKA 5CEVA 1HQFA 4HXQA 3E6VA 3M1RA 3SL0A 4CEVA 2PHAA 5HJAA 1WOIA 3GN0A 2RLAA 1P8PA 1WOHA 1P8SA 2CEVA 4IE1A 1TA1A 5RLAA 3GMZA 2AEBA 1WOGA 4Q40A 3MFVA 2ZAVA 4RHQA 3KV2A 1PQ3A 3PZLA 4MYFA 1T4PA 4Q3PA 3TH7A 1T5FA 4IE3A 3THJA 4Q42A 1TBJA 4IE2A 1P8NA 4GWDA 4HZEA 1D3VA 3DJ8A 1TBHA 3E9BA 2PLLA 3CEVA 4MYKA 4Q3UA 1ZPEA 4ITYA 4Q3SA 4MYLA 1R1OA 3TF3A 3THEA 4DZ4A 4IU4A 3LP4A 4MXRA 4RHJA 1TBLA 4IU1A 4GSZA 2PHOA 3MJLA 1ZPGA 4RHIA 3LHLA 4Q3TA 1CEVA 1HQXA 1HQ5A 1T4RA 4HWWA 4IXUA 1P8QA 2EF5A 3NIPA 3RLAA 2EIVA 3NIOA 4RHLA 4RLAA 4Q3RC 4Q41A 4RHKA 1P8MA 4IU5A 4Q3VA 3E6KA 1P8RA 1GQ7A 1HQHA 3SL1A 1T5GA 3SKKA 1P8OA 2A0MA 3E8QA 4GSMA 4G3HA 1WVBA 4GWCA 1HQGA 4FCIA 4Q3QA 4I06A 3MMRA 5HJ9A 1GQ6A
chains in the Genus database with same CATH superfamily
1W22A 2EF4A 3MZ7A 4BKXB 4RHMA 1T4SA 5EEMA 4IU0A 5G12A 3THHA 3SJTA 4QA5A 5EF8A 5G1CA 1WVAA 4Q3RA 3SL1A 3C10A 3F06A 5BWZA 3NIQA 4MYNA 4RN0A 2V5XA 3Q9CA 3F80A 4CBYA 4IXVA 1RLAA 3LP7A 3E8ZA 1XFKA 4GSVA 1T4TA 3MFWA 4FCKA 4BZ9A 2GH6A 5CEVA 2V5WA 1HQFA 4HXQA 3ZNSA 2VCGA 3E6VA 1C3SA 3M1RA 3SFFA 3MZ4A 2PHAA 3SL0A 5EFJD 3MAXA 4CEVA 5HJAA 4QA4A 1WOIA 3EZPA 3GN0A 2RLAA 5DC8A 1P8PA 1WOHA 5EFBD 4A69A 1P8SA 2CEVA 4IE1A 3C0YA 5FUEA 1TA1A 5THVA 5D1DA 5DC7A 5G0XA 5RLAA 3GMZA 3Q9BA 5A2SA 4LY1A 3F07A 2AEBA 1WOGA 4Q40A 5G11A 5EFGA 5G0HA 5EFKB 3SFHA 3MFVA 2VQWG 2ZAVA 3EW8A 4RHQA 5EENA 3KV2A 1PQ3A 3PZLA 4ZUMA 4MYFA 5ICNB 1T4PA 4Q3PA 4ZURA 1T5FA 3TH7A 5JI5A 4IE3A 3F0RA 3THJA 4Q42A 5EFHA 3EZTA 1T64A 1TBJA 4CBTA 4IE2A 1P8NA 5DC5A 4QA6A 4GWDA 4HZEA 1D3VA 4QA7A 5G0GA 3DJ8A 5G17A 1TBHA 3E9BA 5EEFA 2PLLA 3CEVA 5D1BA 4MYKA 4Q3UA 5G0JA 4BZ8A 1ZPEA 4ITYA 4Q3SA 4QA3A 4MYLA 1R1OA 3C0ZA 4RN2A 5DC6A 3THEA 3TF3A 1T67A 4DZ4A 5G1BA 4IU4A 3LP4A 5EEKA 4MXRA 3MZ6A 3EWFA 4RHJA 1TBLA 4IU1A 4GSZA 4ZUPA 2PHOA 3MENA 5IWGA 3MJLA 5EEIA 1ZPGA 4RHIA 4BZ7A 5THTA 3ZNRA 3LHLA 4Q3TA 1CEVA 5THUA 4LXZA 1HQXA 1HQ5A 1T4RA 4BZ5A 4HWWA 4IXUA 1P8QA 2EF5A 3NIPA 2VQMA 5IX0A 3RLAA 1ZZ3A 2EIVA 4QA0A 3NIOA 5EF7A 4RHLA 4RLAA 4ZUOA 4Q3RC 5G0IA 4Q41A 3Q9EA 1ZZ1A 5G13A 1C3PA 4RHKA 4BZ6A 4ZUQA 1P8MA 2VQQA 4IU5A 4Q3VA 3E6KA 1P8RA 1GQ7A 1HQHA 3MZ3A 4ZUNA 1T5GA 2VQOA 3RQDA 4QA1A 2VQVA 3SKKA 1ZZ0A 1C3RA 1P8OA 1VKGA 2A0MA 3E8QA 4GSMA 1WVBA 4G3HA 4GWCA 5G10A 5G3WA 1T69A 5G0YA 3Q9FA 4CQFA 5D1CA 1HQGA 4FCIA 5LI3A 4Q3QA 4I06A 5FCWA 5EFNA 3MMRA 4RN1A 4QA2A 5HJ9A 5THSA 2VQJA 5G1AA 1GQ6A
chains in the Genus database with same CATH topology
2EF4A 4RHMA 1T4SA 4IU0A 3THHA 3SJTA 1WVAA 4Q3RA 3NIQA 4MYNA 3F80A 4IXVA 1RLAA 3LP7A 3E8ZA 4GSVA 1XFKA 1T4TA 3MFWA 4FCKA 5CEVA 1HQFA 4HXQA 3E6VA 3M1RA 3SL0A 4CEVA 2PHAA 5HJAA 1WOIA 3GN0A 2RLAA 1P8PA 1WOHA 1P8SA 2CEVA 4IE1A 1TA1A 5RLAA 3GMZA 2AEBA 1WOGA 4Q40A 3MFVA 2ZAVA 4RHQA 3KV2A 1PQ3A 3PZLA 4MYFA 1T4PA 4Q3PA 3TH7A 1T5FA 4IE3A 3THJA 4Q42A 1TBJA 4IE2A 1P8NA 4GWDA 4HZEA 1D3VA 3DJ8A 1TBHA 3E9BA 2PLLA 3CEVA 4MYKA 4Q3UA 1ZPEA 4ITYA 4Q3SA 4MYLA 1R1OA 3TF3A 3THEA 4DZ4A 4IU4A 3LP4A 4MXRA 4RHJA 1TBLA 4IU1A 4GSZA 2PHOA 3MJLA 1ZPGA 4RHIA 3LHLA 4Q3TA 1CEVA 1HQXA 1HQ5A 1T4RA 4HWWA 4IXUA 1P8QA 2EF5A 3NIPA 3RLAA 2EIVA 3NIOA 4RHLA 4RLAA 4Q3RC 4Q41A 4RHKA 1P8MA 4IU5A 4Q3VA 3E6KA 1P8RA 1GQ7A 1HQHA 3SL1A 1T5GA 3SKKA 1P8OA 2A0MA 3E8QA 4GSMA 4G3HA 1WVBA 4GWCA 1HQGA 4FCIA 4Q3QA 4I06A 3MMRA 5HJ9A 1GQ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EF4 A;  4RHM A;  1T4S A;  4IU0 A;  3THH A;  3SJT A;  1WVA A;  4Q3R A;  3NIQ A;  4MYN A;  3F80 A;  4IXV A;  1RLA A;  3LP7 A;  3E8Z A;  4GSV A;  1XFK A;  1T4T A;  3MFW A;  4FCK A;  5CEV A;  1HQF A;  4HXQ A;  3E6V A;  3M1R A;  3SL0 A;  4CEV A;  2PHA A;  5HJA A;  1WOI A;  3GN0 A;  2RLA A;  1P8P A;  1WOH A;  1P8S A;  2CEV A;  4IE1 A;  1TA1 A;  5RLA A;  3GMZ A;  2AEB A;  1WOG A;  4Q40 A;  3MFV A;  2ZAV A;  4RHQ A;  3KV2 A;  1PQ3 A;  3PZL A;  4MYF A;  1T4P A;  4Q3P A;  3TH7 A;  1T5F A;  4IE3 A;  3THJ A;  4Q42 A;  1TBJ A;  4IE2 A;  1P8N A;  4GWD A;  4HZE A;  1D3V A;  3DJ8 A;  1TBH A;  3E9B A;  2PLL A;  3CEV A;  4MYK A;  4Q3U A;  1ZPE A;  4ITY A;  4Q3S A;  4MYL A;  1R1O A;  3TF3 A;  3THE A;  4DZ4 A;  4IU4 A;  3LP4 A;  4MXR A;  4RHJ A;  1TBL A;  4IU1 A;  4GSZ A;  2PHO A;  3MJL A;  1ZPG A;  4RHI A;  3LHL A;  4Q3T A;  1CEV A;  1HQX A;  1HQ5 A;  1T4R A;  4HWW A;  4IXU A;  1P8Q A;  2EF5 A;  3NIP A;  3RLA A;  2EIV A;  3NIO A;  4RHL A;  4RLA A;  4Q3R C;  4Q41 A;  4RHK A;  1P8M A;  4IU5 A;  4Q3V A;  3E6K A;  1P8R A;  1GQ7 A;  1HQH A;  3SL1 A;  1T5G A;  3SKK A;  1P8O A;  2A0M A;  3E8Q A;  4GSM A;  4G3H A;  1WVB A;  4GWC A;  1HQG A;  4FCI A;  4Q3Q A;  4I06 A;  3MMR A;  5HJ9 A;  1GQ6 A; 
#chains in the Genus database with same CATH topology
 1W22 A;  2EF4 A;  3MZ7 A;  4BKX B;  4RHM A;  1T4S A;  5EEM A;  4IU0 A;  5G12 A;  3THH A;  3SJT A;  4QA5 A;  5EF8 A;  5G1C A;  1WVA A;  4Q3R A;  3SL1 A;  3C10 A;  3F06 A;  5BWZ A;  3NIQ A;  4MYN A;  4RN0 A;  2V5X A;  3Q9C A;  3F80 A;  4CBY A;  4IXV A;  1RLA A;  3LP7 A;  3E8Z A;  1XFK A;  4GSV A;  1T4T A;  3MFW A;  4FCK A;  4BZ9 A;  2GH6 A;  5CEV A;  2V5W A;  1HQF A;  4HXQ A;  3ZNS A;  2VCG A;  3E6V A;  1C3S A;  3M1R A;  3SFF A;  3MZ4 A;  2PHA A;  3SL0 A;  5EFJ D;  3MAX A;  4CEV A;  5HJA A;  4QA4 A;  1WOI A;  3EZP A;  3GN0 A;  2RLA A;  5DC8 A;  1P8P A;  1WOH A;  5EFB D;  4A69 A;  1P8S A;  2CEV A;  4IE1 A;  3C0Y A;  5FUE A;  1TA1 A;  5THV A;  5D1D A;  5DC7 A;  5G0X A;  5RLA A;  3GMZ A;  3Q9B A;  5A2S A;  4LY1 A;  3F07 A;  2AEB A;  1WOG A;  4Q40 A;  5G11 A;  5EFG A;  5G0H A;  5EFK B;  3SFH A;  3MFV A;  2VQW G;  2ZAV A;  3EW8 A;  4RHQ A;  5EEN A;  3KV2 A;  1PQ3 A;  3PZL A;  4ZUM A;  4MYF A;  5ICN B;  1T4P A;  4Q3P A;  4ZUR A;  1T5F A;  3TH7 A;  5JI5 A;  4IE3 A;  3F0R A;  3THJ A;  4Q42 A;  5EFH A;  3EZT A;  1T64 A;  1TBJ A;  4CBT A;  4IE2 A;  1P8N A;  5DC5 A;  4QA6 A;  4GWD A;  4HZE A;  1D3V A;  4QA7 A;  5G0G A;  3DJ8 A;  5G17 A;  1TBH A;  3E9B A;  5EEF A;  2PLL A;  3CEV A;  5D1B A;  4MYK A;  4Q3U A;  5G0J A;  4BZ8 A;  1ZPE A;  4ITY A;  4Q3S A;  4QA3 A;  4MYL A;  1R1O A;  3C0Z A;  4RN2 A;  5DC6 A;  3THE A;  3TF3 A;  1T67 A;  4DZ4 A;  5G1B A;  4IU4 A;  3LP4 A;  5EEK A;  4MXR A;  3MZ6 A;  3EWF A;  4RHJ A;  1TBL A;  4IU1 A;  4GSZ A;  4ZUP A;  2PHO A;  3MEN A;  5IWG A;  3MJL A;  5EEI A;  1ZPG A;  4RHI A;  4BZ7 A;  5THT A;  3ZNR A;  3LHL A;  4Q3T A;  1CEV A;  5THU A;  4LXZ A;  1HQX A;  1HQ5 A;  1T4R A;  4BZ5 A;  4HWW A;  4IXU A;  1P8Q A;  2EF5 A;  3NIP A;  2VQM A;  5IX0 A;  3RLA A;  1ZZ3 A;  2EIV A;  4QA0 A;  3NIO A;  5EF7 A;  4RHL A;  4RLA A;  4ZUO A;  4Q3R C;  5G0I A;  4Q41 A;  3Q9E A;  1ZZ1 A;  5G13 A;  1C3P A;  4RHK A;  4BZ6 A;  4ZUQ A;  1P8M A;  2VQQ A;  4IU5 A;  4Q3V A;  3E6K A;  1P8R A;  1GQ7 A;  1HQH A;  3MZ3 A;  4ZUN A;  1T5G A;  2VQO A;  3RQD A;  4QA1 A;  2VQV A;  3SKK A;  1ZZ0 A;  1C3R A;  1P8O A;  1VKG A;  2A0M A;  3E8Q A;  4GSM A;  1WVB A;  4G3H A;  4GWC A;  5G10 A;  5G3W A;  1T69 A;  5G0Y A;  3Q9F A;  4CQF A;  5D1C A;  1HQG A;  4FCI A;  5LI3 A;  4Q3Q A;  4I06 A;  5FCW A;  5EFN A;  3MMR A;  4RN1 A;  4QA2 A;  5HJ9 A;  5THS A;  2VQJ A;  5G1A A;  1GQ6 A; 
#chains in the Genus database with same CATH homology
 2EF4 A;  4RHM A;  1T4S A;  4IU0 A;  3THH A;  3SJT A;  1WVA A;  4Q3R A;  3NIQ A;  4MYN A;  3F80 A;  4IXV A;  1RLA A;  3LP7 A;  3E8Z A;  4GSV A;  1XFK A;  1T4T A;  3MFW A;  4FCK A;  5CEV A;  1HQF A;  4HXQ A;  3E6V A;  3M1R A;  3SL0 A;  4CEV A;  2PHA A;  5HJA A;  1WOI A;  3GN0 A;  2RLA A;  1P8P A;  1WOH A;  1P8S A;  2CEV A;  4IE1 A;  1TA1 A;  5RLA A;  3GMZ A;  2AEB A;  1WOG A;  4Q40 A;  3MFV A;  2ZAV A;  4RHQ A;  3KV2 A;  1PQ3 A;  3PZL A;  4MYF A;  1T4P A;  4Q3P A;  3TH7 A;  1T5F A;  4IE3 A;  3THJ A;  4Q42 A;  1TBJ A;  4IE2 A;  1P8N A;  4GWD A;  4HZE A;  1D3V A;  3DJ8 A;  1TBH A;  3E9B A;  2PLL A;  3CEV A;  4MYK A;  4Q3U A;  1ZPE A;  4ITY A;  4Q3S A;  4MYL A;  1R1O A;  3TF3 A;  3THE A;  4DZ4 A;  4IU4 A;  3LP4 A;  4MXR A;  4RHJ A;  1TBL A;  4IU1 A;  4GSZ A;  2PHO A;  3MJL A;  1ZPG A;  4RHI A;  3LHL A;  4Q3T A;  1CEV A;  1HQX A;  1HQ5 A;  1T4R A;  4HWW A;  4IXU A;  1P8Q A;  2EF5 A;  3NIP A;  3RLA A;  2EIV A;  3NIO A;  4RHL A;  4RLA A;  4Q3R C;  4Q41 A;  4RHK A;  1P8M A;  4IU5 A;  4Q3V A;  3E6K A;  1P8R A;  1GQ7 A;  1HQH A;  3SL1 A;  1T5G A;  3SKK A;  1P8O A;  2A0M A;  3E8Q A;  4GSM A;  4G3H A;  1WVB A;  4GWC A;  1HQG A;  4FCI A;  4Q3Q A;  4I06 A;  3MMR A;  5HJ9 A;  1GQ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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