3KV2A

High resolution structure of human arginase i in complex with the strong inhibitor n(omega)-hydroxy-nor-l-arginine (nor-noha)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
313
structure length
313
Chain Sequence
RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of human arginase I by substrate and product analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Arginase-1
total genus 116
structure length 313
sequence length 313
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2009-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3kv2A00
3RLAA 4DZ4A 3GN0A 4MYNA 5RLAA 3MMRA 3SKKA 1P8SA 2A0MA 4GWDA 3NIPA 4Q40A 4MYLA 2RLAA 1P8RA 1T4PA 1P8QA 3SL0A 3LHLA 2CEVA 5CEVA 4G3HA 4Q42A 4IU0A 2EIVA 2PHOA 1WVBA 4HZEA 1T5FA 4FCKA 3KV2A 3E6VA 4GWCA 4MXRA 4IU1A 4I06A 3GMZA 4GSVA 4HWWA 3M1RA 1T4SA 1R1OA 1T5GA 3E9BA 4GSMA 1GQ6A 3THHA 3MJLA 2PHAA 1D3VA 2EF4A 4MYKA 3SL1A 3E8ZA 1HQ5A 3SJTA 3MFWA 1RLAA 3E8QA 4RHIA 4Q3RA 1WOGA 1WOHA 4MYFA 1T4TA 3TF3A 1P8PA 3E6KA 1HQGA 1PQ3A 2AEBA 3DJ8A 1HQXA 4RHLA 1P8MA 3CEVA 1P8OA 3NIOA 1TA1A 1XFKA 4Q3SA 1P8NA 2EF5A 4IU4A 4Q3PA 4IE2A 1ZPEA 4IXVA 4IU5A 4Q41A 3PZLA 4GSZA 4RHQA 1WOIA 3LP4A 4RHJA 2ZAVA 4IE3A 4HXQA 1HQHA 4ITYA 4Q3RC 4RHKA 5HJAA 4RHMA 1TBJA 4Q3QA 3F80A 4Q3TA 3THEA 5HJ9A 3MFVA 1T4RA 2PLLA 1TBLA 1TBHA 3NIQA 4FCIA 4IXUA 4Q3VA 4RLAA 1WVAA 4Q3UA 1ZPGA 1HQFA 1CEVA 3LP7A 1GQ7A 3TH7A 4IE1A 3THJA 4CEVA
chains in the Genus database with same CATH superfamily
3RLAA 3MENA 4DZ4A 4CBTA 3GN0A 4MYNA 5RLAA 4QA6A 5G0XA 3F0RA 3MMRA 4BZ9A 5EFBD 3SKKA 1P8SA 2A0MA 5IX0A 4GWDA 2VQQA 4LXZA 5G3WA 3C0YA 5G17A 5G0IA 3NIPA 3RQDA 4Q40A 4MYLA 2RLAA 1P8RA 1T4PA 3EW8A 5D1BA 1P8QA 3SL0A 3LHLA 2CEVA 3Q9BA 5EFGA 5A2SA 5CEVA 3EZTA 5G1AA 4G3HA 4Q42A 4BZ8A 5G10A 4IU0A 2EIVA 2PHOA 5BWZA 3MZ6A 3MAXA 1WVBA 4HZEA 1T5FA 4ZURA 2VCGA 4FCKA 4RN1A 5G12A 5ICNB 4BZ5A 3KV2A 3E6VA 4QA1A 4QA4A 5D1DA 5THUA 5THTA 5G0GA 1C3SA 4GWCA 4MXRA 4IU1A 4I06A 5THSA 3C0ZA 1C3RA 3F06A 3GMZA 4GSVA 2VQJA 3M1RA 2VQWG 4HWWA 1T4SA 1R1OA 1ZZ0A 1T5GA 3E9BA 5DC7A 1ZZ3A 1VKGA 5EF8A 1ZZ1A 4GSMA 5EEMA 1GQ6A 3THHA 3MJLA 2PHAA 1D3VA 2VQOA 3F07A 2GH6A 2EF4A 4MYKA 3SL1A 3E8ZA 5EFJD 5EENA 4RN0A 1HQ5A 3C10A 5FCWA 3SJTA 3MFWA 4CQFA 1RLAA 3E8QA 4RHIA 4Q3RA 1WOGA 3SFFA 1WOHA 4MYFA 2V5WA 5FUEA 3ZNRA 3Q9EA 1T4TA 4QA5A 5G0HA 1P8PA 3E6KA 3TF3A 4A69A 2VQMA 1HQGA 4RN2A 5D1CA 2V5XA 5IWGA 1PQ3A 2AEBA 4LY1A 3DJ8A 1HQXA 4RHLA 5EFKB 4QA7A 5EFHA 1P8MA 3CEVA 1P8OA 3NIOA 1TA1A 1XFKA 5LI3A 4Q3SA 1P8NA 2EF5A 4IU4A 4Q3PA 4CBYA 4IE2A 1ZPEA 3MZ7A 4IXVA 4IU5A 4Q41A 4QA2A 3PZLA 4GSZA 4RHQA 1WOIA 3LP4A 3EWFA 4BKXB 1W22A 4RHJA 2ZAVA 4IE3A 4ZUPA 4HXQA 4ZUMA 1HQHA 3MZ3A 4ITYA 4Q3RC 4RHKA 5HJAA 1C3PA 4RHMA 5DC6A 5G1CA 1TBJA 4Q3QA 5G0YA 3EZPA 5G1BA 3F80A 3Q9CA 4Q3TA 5EEFA 3THEA 4ZUQA 4ZUOA 5HJ9A 3MFVA 4BZ6A 4ZUNA 1T4RA 5G0JA 2PLLA 5EEKA 1TBLA 1TBHA 3NIQA 4FCIA 4IXUA 4Q3VA 5EEIA 3ZNSA 5JI5A 5DC5A 4RLAA 4QA3A 5EFNA 1T64A 1WVAA 4Q3UA 5THVA 5EF7A 2VQVA 1ZPGA 1T69A 3MZ4A 4BZ7A 1HQFA 1CEVA 1T67A 5DC8A 3LP7A 5G11A 1GQ7A 4QA0A 3SFHA 3TH7A 5G13A 3Q9FA 4IE1A 3THJA 4CEVA
chains in the Genus database with same CATH topology
3RLAA 4DZ4A 3GN0A 4MYNA 5RLAA 3MMRA 3SKKA 1P8SA 2A0MA 4GWDA 3NIPA 4Q40A 4MYLA 2RLAA 1P8RA 1T4PA 1P8QA 3SL0A 3LHLA 2CEVA 5CEVA 4G3HA 4Q42A 4IU0A 2EIVA 2PHOA 1WVBA 4HZEA 1T5FA 4FCKA 3KV2A 3E6VA 4GWCA 4MXRA 4IU1A 4I06A 3GMZA 4GSVA 4HWWA 3M1RA 1T4SA 1R1OA 1T5GA 3E9BA 4GSMA 1GQ6A 3THHA 3MJLA 2PHAA 1D3VA 2EF4A 4MYKA 3SL1A 3E8ZA 1HQ5A 3SJTA 3MFWA 1RLAA 3E8QA 4RHIA 4Q3RA 1WOGA 1WOHA 4MYFA 1T4TA 3TF3A 1P8PA 3E6KA 1HQGA 1PQ3A 2AEBA 3DJ8A 1HQXA 4RHLA 1P8MA 3CEVA 1P8OA 3NIOA 1TA1A 1XFKA 4Q3SA 1P8NA 2EF5A 4IU4A 4Q3PA 4IE2A 1ZPEA 4IXVA 4IU5A 4Q41A 3PZLA 4GSZA 4RHQA 1WOIA 3LP4A 4RHJA 2ZAVA 4IE3A 4HXQA 1HQHA 4ITYA 4Q3RC 4RHKA 5HJAA 4RHMA 1TBJA 4Q3QA 3F80A 4Q3TA 3THEA 5HJ9A 3MFVA 1T4RA 2PLLA 1TBLA 1TBHA 3NIQA 4FCIA 4IXUA 4Q3VA 4RLAA 1WVAA 4Q3UA 1ZPGA 1HQFA 1CEVA 3LP7A 1GQ7A 3TH7A 4IE1A 3THJA 4CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RLA A;  4DZ4 A;  3GN0 A;  4MYN A;  5RLA A;  3MMR A;  3SKK A;  1P8S A;  2A0M A;  4GWD A;  3NIP A;  4Q40 A;  4MYL A;  2RLA A;  1P8R A;  1T4P A;  1P8Q A;  3SL0 A;  3LHL A;  2CEV A;  5CEV A;  4G3H A;  4Q42 A;  4IU0 A;  2EIV A;  2PHO A;  1WVB A;  4HZE A;  1T5F A;  4FCK A;  3KV2 A;  3E6V A;  4GWC A;  4MXR A;  4IU1 A;  4I06 A;  3GMZ A;  4GSV A;  4HWW A;  3M1R A;  1T4S A;  1R1O A;  1T5G A;  3E9B A;  4GSM A;  1GQ6 A;  3THH A;  3MJL A;  2PHA A;  1D3V A;  2EF4 A;  4MYK A;  3SL1 A;  3E8Z A;  1HQ5 A;  3SJT A;  3MFW A;  1RLA A;  3E8Q A;  4RHI A;  4Q3R A;  1WOG A;  1WOH A;  4MYF A;  1T4T A;  3TF3 A;  1P8P A;  3E6K A;  1HQG A;  1PQ3 A;  2AEB A;  3DJ8 A;  1HQX A;  4RHL A;  1P8M A;  3CEV A;  1P8O A;  3NIO A;  1TA1 A;  1XFK A;  4Q3S A;  1P8N A;  2EF5 A;  4IU4 A;  4Q3P A;  4IE2 A;  1ZPE A;  4IXV A;  4IU5 A;  4Q41 A;  3PZL A;  4GSZ A;  4RHQ A;  1WOI A;  3LP4 A;  4RHJ A;  2ZAV A;  4IE3 A;  4HXQ A;  1HQH A;  4ITY A;  4Q3R C;  4RHK A;  5HJA A;  4RHM A;  1TBJ A;  4Q3Q A;  3F80 A;  4Q3T A;  3THE A;  5HJ9 A;  3MFV A;  1T4R A;  2PLL A;  1TBL A;  1TBH A;  3NIQ A;  4FCI A;  4IXU A;  4Q3V A;  4RLA A;  1WVA A;  4Q3U A;  1ZPG A;  1HQF A;  1CEV A;  3LP7 A;  1GQ7 A;  3TH7 A;  4IE1 A;  3THJ A;  4CEV A; 
#chains in the Genus database with same CATH topology
 3RLA A;  3MEN A;  4DZ4 A;  4CBT A;  3GN0 A;  4MYN A;  5RLA A;  4QA6 A;  5G0X A;  3F0R A;  3MMR A;  4BZ9 A;  5EFB D;  3SKK A;  1P8S A;  2A0M A;  5IX0 A;  4GWD A;  2VQQ A;  4LXZ A;  5G3W A;  3C0Y A;  5G17 A;  5G0I A;  3NIP A;  3RQD A;  4Q40 A;  4MYL A;  2RLA A;  1P8R A;  1T4P A;  3EW8 A;  5D1B A;  1P8Q A;  3SL0 A;  3LHL A;  2CEV A;  3Q9B A;  5EFG A;  5A2S A;  5CEV A;  3EZT A;  5G1A A;  4G3H A;  4Q42 A;  4BZ8 A;  5G10 A;  4IU0 A;  2EIV A;  2PHO A;  5BWZ A;  3MZ6 A;  3MAX A;  1WVB A;  4HZE A;  1T5F A;  4ZUR A;  2VCG A;  4FCK A;  4RN1 A;  5G12 A;  5ICN B;  4BZ5 A;  3KV2 A;  3E6V A;  4QA1 A;  4QA4 A;  5D1D A;  5THU A;  5THT A;  5G0G A;  1C3S A;  4GWC A;  4MXR A;  4IU1 A;  4I06 A;  5THS A;  3C0Z A;  1C3R A;  3F06 A;  3GMZ A;  4GSV A;  2VQJ A;  3M1R A;  2VQW G;  4HWW A;  1T4S A;  1R1O A;  1ZZ0 A;  1T5G A;  3E9B A;  5DC7 A;  1ZZ3 A;  1VKG A;  5EF8 A;  1ZZ1 A;  4GSM A;  5EEM A;  1GQ6 A;  3THH A;  3MJL A;  2PHA A;  1D3V A;  2VQO A;  3F07 A;  2GH6 A;  2EF4 A;  4MYK A;  3SL1 A;  3E8Z A;  5EFJ D;  5EEN A;  4RN0 A;  1HQ5 A;  3C10 A;  5FCW A;  3SJT A;  3MFW A;  4CQF A;  1RLA A;  3E8Q A;  4RHI A;  4Q3R A;  1WOG A;  3SFF A;  1WOH A;  4MYF A;  2V5W A;  5FUE A;  3ZNR A;  3Q9E A;  1T4T A;  4QA5 A;  5G0H A;  1P8P A;  3E6K A;  3TF3 A;  4A69 A;  2VQM A;  1HQG A;  4RN2 A;  5D1C A;  2V5X A;  5IWG A;  1PQ3 A;  2AEB A;  4LY1 A;  3DJ8 A;  1HQX A;  4RHL A;  5EFK B;  4QA7 A;  5EFH A;  1P8M A;  3CEV A;  1P8O A;  3NIO A;  1TA1 A;  1XFK A;  5LI3 A;  4Q3S A;  1P8N A;  2EF5 A;  4IU4 A;  4Q3P A;  4CBY A;  4IE2 A;  1ZPE A;  3MZ7 A;  4IXV A;  4IU5 A;  4Q41 A;  4QA2 A;  3PZL A;  4GSZ A;  4RHQ A;  1WOI A;  3LP4 A;  3EWF A;  4BKX B;  1W22 A;  4RHJ A;  2ZAV A;  4IE3 A;  4ZUP A;  4HXQ A;  4ZUM A;  1HQH A;  3MZ3 A;  4ITY A;  4Q3R C;  4RHK A;  5HJA A;  1C3P A;  4RHM A;  5DC6 A;  5G1C A;  1TBJ A;  4Q3Q A;  5G0Y A;  3EZP A;  5G1B A;  3F80 A;  3Q9C A;  4Q3T A;  5EEF A;  3THE A;  4ZUQ A;  4ZUO A;  5HJ9 A;  3MFV A;  4BZ6 A;  4ZUN A;  1T4R A;  5G0J A;  2PLL A;  5EEK A;  1TBL A;  1TBH A;  3NIQ A;  4FCI A;  4IXU A;  4Q3V A;  5EEI A;  3ZNS A;  5JI5 A;  5DC5 A;  4RLA A;  4QA3 A;  5EFN A;  1T64 A;  1WVA A;  4Q3U A;  5THV A;  5EF7 A;  2VQV A;  1ZPG A;  1T69 A;  3MZ4 A;  4BZ7 A;  1HQF A;  1CEV A;  1T67 A;  5DC8 A;  3LP7 A;  5G11 A;  1GQ7 A;  4QA0 A;  3SFH A;  3TH7 A;  5G13 A;  3Q9F A;  4IE1 A;  3THJ A;  4CEV A; 
#chains in the Genus database with same CATH homology
 3RLA A;  4DZ4 A;  3GN0 A;  4MYN A;  5RLA A;  3MMR A;  3SKK A;  1P8S A;  2A0M A;  4GWD A;  3NIP A;  4Q40 A;  4MYL A;  2RLA A;  1P8R A;  1T4P A;  1P8Q A;  3SL0 A;  3LHL A;  2CEV A;  5CEV A;  4G3H A;  4Q42 A;  4IU0 A;  2EIV A;  2PHO A;  1WVB A;  4HZE A;  1T5F A;  4FCK A;  3KV2 A;  3E6V A;  4GWC A;  4MXR A;  4IU1 A;  4I06 A;  3GMZ A;  4GSV A;  4HWW A;  3M1R A;  1T4S A;  1R1O A;  1T5G A;  3E9B A;  4GSM A;  1GQ6 A;  3THH A;  3MJL A;  2PHA A;  1D3V A;  2EF4 A;  4MYK A;  3SL1 A;  3E8Z A;  1HQ5 A;  3SJT A;  3MFW A;  1RLA A;  3E8Q A;  4RHI A;  4Q3R A;  1WOG A;  1WOH A;  4MYF A;  1T4T A;  3TF3 A;  1P8P A;  3E6K A;  1HQG A;  1PQ3 A;  2AEB A;  3DJ8 A;  1HQX A;  4RHL A;  1P8M A;  3CEV A;  1P8O A;  3NIO A;  1TA1 A;  1XFK A;  4Q3S A;  1P8N A;  2EF5 A;  4IU4 A;  4Q3P A;  4IE2 A;  1ZPE A;  4IXV A;  4IU5 A;  4Q41 A;  3PZL A;  4GSZ A;  4RHQ A;  1WOI A;  3LP4 A;  4RHJ A;  2ZAV A;  4IE3 A;  4HXQ A;  1HQH A;  4ITY A;  4Q3R C;  4RHK A;  5HJA A;  4RHM A;  1TBJ A;  4Q3Q A;  3F80 A;  4Q3T A;  3THE A;  5HJ9 A;  3MFV A;  1T4R A;  2PLL A;  1TBL A;  1TBH A;  3NIQ A;  4FCI A;  4IXU A;  4Q3V A;  4RLA A;  1WVA A;  4Q3U A;  1ZPG A;  1HQF A;  1CEV A;  3LP7 A;  1GQ7 A;  3TH7 A;  4IE1 A;  3THJ A;  4CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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