3RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 106
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3rlaA00
4IXUA 2PHAA 1P8MA 1GQ7A 4MXRA 4IU1A 4GSVA 4GWCA 3E6KA 1WVBA 4RLAA 2EIVA 4GSZA 2PHOA 4MYNA 5CEVA 4IU5A 2AEBA 4Q3PA 4ITYA 3MFVA 3E8QA 3LP7A 3M1RA 2EF5A 3CEVA 3DJ8A 5RLAA 4MYFA 4Q40A 4Q3UA 1R1OA 1T4RA 4GSMA 2A0MA 3TF3A 3SL1A 3E8ZA 1GQ6A 1T4PA 1WOHA 1TBLA 1P8PA 1HQXA 1T4SA 2CEVA 1WOGA 1WVAA 3F80A 4IE1A 4IE3A 4Q3VA 1HQFA 3KV2A 1T5FA 1WOIA 1TBHA 1PQ3A 3RLAA 4DZ4A 4G3HA 4FCKA 5HJ9A 3MMRA 1ZPGA 1XFKA 1ZPEA 1TBJA 4HXQA 4HWWA 3SL0A 3NIOA 4FCIA 4Q3TA 3THJA 1P8NA 2RLAA 3NIPA 2ZAVA 1P8OA 4IE2A 1P8RA 3SJTA 3THEA 1TA1A 4MYLA 3MFWA 4IU4A 1HQ5A 4IXVA 4RHLA 4IU0A 3PZLA 2PLLA 4RHIA 4GWDA 4Q3SA 4MYKA 3GN0A 3LHLA 3SKKA 3THHA 1P8SA 3MJLA 1CEVA 2EF4A 3NIQA 4RHJA 5HJAA 4RHMA 1P8QA 4I06A 4RHQA 4RHKA 4Q41A 1T5GA 3GMZA 3LP4A 1D3VA 4Q42A 1T4TA 3TH7A 3E6VA 4Q3QA 4CEVA 1HQGA 1HQHA 4Q3RC 3E9BA 1RLAA 4Q3RA 4HZEA
chains in the Genus database with same CATH superfamily
4IXUA 3MZ6A 4BZ8A 2PHAA 1P8MA 1GQ7A 4QA2A 4MXRA 5EFNA 5EENA 4IU1A 5G3WA 4GSVA 4GWCA 3E6KA 5G17A 1WVBA 4RLAA 5JI5A 1ZZ1A 2EIVA 2VQMA 5D1CA 5THVA 1C3RA 4GSZA 2PHOA 4MYNA 5CEVA 4IU5A 5EEIA 5G0HA 2AEBA 3EZTA 4Q3PA 4RN2A 4ITYA 3MFVA 5EFHA 3E8QA 3LP7A 3M1RA 2EF5A 3CEVA 2VQWG 3DJ8A 5RLAA 4MYFA 5EFGA 4Q40A 3Q9FA 4Q3UA 1R1OA 1VKGA 1T4RA 4GSMA 2A0MA 4QA6A 3SFHA 3TF3A 4LY1A 3SL1A 3E8ZA 1GQ6A 1T4PA 1WOHA 1TBLA 5G1AA 5DC7A 1P8PA 3SFFA 3MZ4A 1C3SA 5BWZA 1HQXA 1T4SA 2CEVA 4BZ9A 1WOGA 1WVAA 1T64A 3F80A 5G0GA 5G0IA 4IE1A 3EWFA 4IE3A 3MZ7A 5G0JA 2VQVA 4Q3VA 5D1BA 5G0XA 5EF8A 2VQJA 3EW8A 3MAXA 4ZUNA 1HQFA 3KV2A 5G11A 3C0YA 1T5FA 5D1DA 1WOIA 1TBHA 1PQ3A 5G1CA 3EZPA 3RLAA 4DZ4A 4G3HA 4FCKA 5FCWA 5HJ9A 3F06A 5THTA 3MMRA 5DC8A 4RN0A 1ZPGA 1XFKA 1ZPEA 1TBJA 4HXQA 4HWWA 4ZUPA 5FUEA 3SL0A 3NIOA 3MZ3A 3Q9EA 4FCIA 4Q3TA 5EFJD 3RQDA 4ZUQA 5EFBD 1T67A 1ZZ3A 5A2SA 3THJA 1P8NA 1ZZ0A 2RLAA 3Q9BA 3NIPA 5THUA 2ZAVA 4BZ7A 1P8OA 4IE2A 1P8RA 5IX0A 5EFKB 3SJTA 3THEA 5DC6A 1TA1A 3C0ZA 4MYLA 5G1BA 4A69A 3MFWA 4IU4A 1HQ5A 4IXVA 4RHLA 4IU0A 5G0YA 2VCGA 3PZLA 2PLLA 4RHIA 5G12A 4GWDA 4Q3SA 1T69A 5EEKA 4QA7A 2VQQA 3MENA 4QA1A 3C10A 5LI3A 4MYKA 3GN0A 3F07A 3LHLA 3SKKA 5DC5A 3THHA 4BZ5A 4CBYA 4ZUOA 4LXZA 1P8SA 3MJLA 1CEVA 2EF4A 3NIQA 4RHJA 5HJAA 4QA0A 4RHMA 1P8QA 4I06A 4RHQA 5G13A 4RHKA 4Q41A 2VQOA 5EEMA 3ZNSA 4ZURA 1T5GA 3GMZA 2V5XA 1D3VA 3LP4A 4ZUMA 5IWGA 3ZNRA 4Q42A 1T4TA 4QA5A 1C3PA 3E6VA 4QA4A 3TH7A 4BZ6A 4RN1A 4CQFA 5ICNB 2GH6A 3Q9CA 5EEFA 4Q3QA 4CBTA 5THSA 5EF7A 4CEVA 5G10A 1HQGA 1HQHA 4Q3RC 4BKXB 3F0RA 3E9BA 1RLAA 4Q3RA 4HZEA 2V5WA 4QA3A 1W22A
chains in the Genus database with same CATH topology
4IXUA 2PHAA 1P8MA 1GQ7A 4MXRA 4IU1A 4GSVA 4GWCA 3E6KA 1WVBA 4RLAA 2EIVA 4GSZA 2PHOA 4MYNA 5CEVA 4IU5A 2AEBA 4Q3PA 4ITYA 3MFVA 3E8QA 3LP7A 3M1RA 2EF5A 3CEVA 3DJ8A 5RLAA 4MYFA 4Q40A 4Q3UA 1R1OA 1T4RA 4GSMA 2A0MA 3TF3A 3SL1A 3E8ZA 1GQ6A 1T4PA 1WOHA 1TBLA 1P8PA 1HQXA 1T4SA 2CEVA 1WOGA 1WVAA 3F80A 4IE1A 4IE3A 4Q3VA 1HQFA 3KV2A 1T5FA 1WOIA 1TBHA 1PQ3A 3RLAA 4DZ4A 4G3HA 4FCKA 5HJ9A 3MMRA 1ZPGA 1XFKA 1ZPEA 1TBJA 4HXQA 4HWWA 3SL0A 3NIOA 4FCIA 4Q3TA 3THJA 1P8NA 2RLAA 3NIPA 2ZAVA 1P8OA 4IE2A 1P8RA 3SJTA 3THEA 1TA1A 4MYLA 3MFWA 4IU4A 1HQ5A 4IXVA 4RHLA 4IU0A 3PZLA 2PLLA 4RHIA 4GWDA 4Q3SA 4MYKA 3GN0A 3LHLA 3SKKA 3THHA 1P8SA 3MJLA 1CEVA 2EF4A 3NIQA 4RHJA 5HJAA 4RHMA 1P8QA 4I06A 4RHQA 4RHKA 4Q41A 1T5GA 3GMZA 3LP4A 1D3VA 4Q42A 1T4TA 3TH7A 3E6VA 4Q3QA 4CEVA 1HQGA 1HQHA 4Q3RC 3E9BA 1RLAA 4Q3RA 4HZEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IXU A;  2PHA A;  1P8M A;  1GQ7 A;  4MXR A;  4IU1 A;  4GSV A;  4GWC A;  3E6K A;  1WVB A;  4RLA A;  2EIV A;  4GSZ A;  2PHO A;  4MYN A;  5CEV A;  4IU5 A;  2AEB A;  4Q3P A;  4ITY A;  3MFV A;  3E8Q A;  3LP7 A;  3M1R A;  2EF5 A;  3CEV A;  3DJ8 A;  5RLA A;  4MYF A;  4Q40 A;  4Q3U A;  1R1O A;  1T4R A;  4GSM A;  2A0M A;  3TF3 A;  3SL1 A;  3E8Z A;  1GQ6 A;  1T4P A;  1WOH A;  1TBL A;  1P8P A;  1HQX A;  1T4S A;  2CEV A;  1WOG A;  1WVA A;  3F80 A;  4IE1 A;  4IE3 A;  4Q3V A;  1HQF A;  3KV2 A;  1T5F A;  1WOI A;  1TBH A;  1PQ3 A;  3RLA A;  4DZ4 A;  4G3H A;  4FCK A;  5HJ9 A;  3MMR A;  1ZPG A;  1XFK A;  1ZPE A;  1TBJ A;  4HXQ A;  4HWW A;  3SL0 A;  3NIO A;  4FCI A;  4Q3T A;  3THJ A;  1P8N A;  2RLA A;  3NIP A;  2ZAV A;  1P8O A;  4IE2 A;  1P8R A;  3SJT A;  3THE A;  1TA1 A;  4MYL A;  3MFW A;  4IU4 A;  1HQ5 A;  4IXV A;  4RHL A;  4IU0 A;  3PZL A;  2PLL A;  4RHI A;  4GWD A;  4Q3S A;  4MYK A;  3GN0 A;  3LHL A;  3SKK A;  3THH A;  1P8S A;  3MJL A;  1CEV A;  2EF4 A;  3NIQ A;  4RHJ A;  5HJA A;  4RHM A;  1P8Q A;  4I06 A;  4RHQ A;  4RHK A;  4Q41 A;  1T5G A;  3GMZ A;  3LP4 A;  1D3V A;  4Q42 A;  1T4T A;  3TH7 A;  3E6V A;  4Q3Q A;  4CEV A;  1HQG A;  1HQH A;  4Q3R C;  3E9B A;  1RLA A;  4Q3R A;  4HZE A; 
#chains in the Genus database with same CATH topology
 4IXU A;  3MZ6 A;  4BZ8 A;  2PHA A;  1P8M A;  1GQ7 A;  4QA2 A;  4MXR A;  5EFN A;  5EEN A;  4IU1 A;  5G3W A;  4GSV A;  4GWC A;  3E6K A;  5G17 A;  1WVB A;  4RLA A;  5JI5 A;  1ZZ1 A;  2EIV A;  2VQM A;  5D1C A;  5THV A;  1C3R A;  4GSZ A;  2PHO A;  4MYN A;  5CEV A;  4IU5 A;  5EEI A;  5G0H A;  2AEB A;  3EZT A;  4Q3P A;  4RN2 A;  4ITY A;  3MFV A;  5EFH A;  3E8Q A;  3LP7 A;  3M1R A;  2EF5 A;  3CEV A;  2VQW G;  3DJ8 A;  5RLA A;  4MYF A;  5EFG A;  4Q40 A;  3Q9F A;  4Q3U A;  1R1O A;  1VKG A;  1T4R A;  4GSM A;  2A0M A;  4QA6 A;  3SFH A;  3TF3 A;  4LY1 A;  3SL1 A;  3E8Z A;  1GQ6 A;  1T4P A;  1WOH A;  1TBL A;  5G1A A;  5DC7 A;  1P8P A;  3SFF A;  3MZ4 A;  1C3S A;  5BWZ A;  1HQX A;  1T4S A;  2CEV A;  4BZ9 A;  1WOG A;  1WVA A;  1T64 A;  3F80 A;  5G0G A;  5G0I A;  4IE1 A;  3EWF A;  4IE3 A;  3MZ7 A;  5G0J A;  2VQV A;  4Q3V A;  5D1B A;  5G0X A;  5EF8 A;  2VQJ A;  3EW8 A;  3MAX A;  4ZUN A;  1HQF A;  3KV2 A;  5G11 A;  3C0Y A;  1T5F A;  5D1D A;  1WOI A;  1TBH A;  1PQ3 A;  5G1C A;  3EZP A;  3RLA A;  4DZ4 A;  4G3H A;  4FCK A;  5FCW A;  5HJ9 A;  3F06 A;  5THT A;  3MMR A;  5DC8 A;  4RN0 A;  1ZPG A;  1XFK A;  1ZPE A;  1TBJ A;  4HXQ A;  4HWW A;  4ZUP A;  5FUE A;  3SL0 A;  3NIO A;  3MZ3 A;  3Q9E A;  4FCI A;  4Q3T A;  5EFJ D;  3RQD A;  4ZUQ A;  5EFB D;  1T67 A;  1ZZ3 A;  5A2S A;  3THJ A;  1P8N A;  1ZZ0 A;  2RLA A;  3Q9B A;  3NIP A;  5THU A;  2ZAV A;  4BZ7 A;  1P8O A;  4IE2 A;  1P8R A;  5IX0 A;  5EFK B;  3SJT A;  3THE A;  5DC6 A;  1TA1 A;  3C0Z A;  4MYL A;  5G1B A;  4A69 A;  3MFW A;  4IU4 A;  1HQ5 A;  4IXV A;  4RHL A;  4IU0 A;  5G0Y A;  2VCG A;  3PZL A;  2PLL A;  4RHI A;  5G12 A;  4GWD A;  4Q3S A;  1T69 A;  5EEK A;  4QA7 A;  2VQQ A;  3MEN A;  4QA1 A;  3C10 A;  5LI3 A;  4MYK A;  3GN0 A;  3F07 A;  3LHL A;  3SKK A;  5DC5 A;  3THH A;  4BZ5 A;  4CBY A;  4ZUO A;  4LXZ A;  1P8S A;  3MJL A;  1CEV A;  2EF4 A;  3NIQ A;  4RHJ A;  5HJA A;  4QA0 A;  4RHM A;  1P8Q A;  4I06 A;  4RHQ A;  5G13 A;  4RHK A;  4Q41 A;  2VQO A;  5EEM A;  3ZNS A;  4ZUR A;  1T5G A;  3GMZ A;  2V5X A;  1D3V A;  3LP4 A;  4ZUM A;  5IWG A;  3ZNR A;  4Q42 A;  1T4T A;  4QA5 A;  1C3P A;  3E6V A;  4QA4 A;  3TH7 A;  4BZ6 A;  4RN1 A;  4CQF A;  5ICN B;  2GH6 A;  3Q9C A;  5EEF A;  4Q3Q A;  4CBT A;  5THS A;  5EF7 A;  4CEV A;  5G10 A;  1HQG A;  1HQH A;  4Q3R C;  4BKX B;  3F0R A;  3E9B A;  1RLA A;  4Q3R A;  4HZE A;  2V5W A;  4QA3 A;  1W22 A; 
#chains in the Genus database with same CATH homology
 4IXU A;  2PHA A;  1P8M A;  1GQ7 A;  4MXR A;  4IU1 A;  4GSV A;  4GWC A;  3E6K A;  1WVB A;  4RLA A;  2EIV A;  4GSZ A;  2PHO A;  4MYN A;  5CEV A;  4IU5 A;  2AEB A;  4Q3P A;  4ITY A;  3MFV A;  3E8Q A;  3LP7 A;  3M1R A;  2EF5 A;  3CEV A;  3DJ8 A;  5RLA A;  4MYF A;  4Q40 A;  4Q3U A;  1R1O A;  1T4R A;  4GSM A;  2A0M A;  3TF3 A;  3SL1 A;  3E8Z A;  1GQ6 A;  1T4P A;  1WOH A;  1TBL A;  1P8P A;  1HQX A;  1T4S A;  2CEV A;  1WOG A;  1WVA A;  3F80 A;  4IE1 A;  4IE3 A;  4Q3V A;  1HQF A;  3KV2 A;  1T5F A;  1WOI A;  1TBH A;  1PQ3 A;  3RLA A;  4DZ4 A;  4G3H A;  4FCK A;  5HJ9 A;  3MMR A;  1ZPG A;  1XFK A;  1ZPE A;  1TBJ A;  4HXQ A;  4HWW A;  3SL0 A;  3NIO A;  4FCI A;  4Q3T A;  3THJ A;  1P8N A;  2RLA A;  3NIP A;  2ZAV A;  1P8O A;  4IE2 A;  1P8R A;  3SJT A;  3THE A;  1TA1 A;  4MYL A;  3MFW A;  4IU4 A;  1HQ5 A;  4IXV A;  4RHL A;  4IU0 A;  3PZL A;  2PLL A;  4RHI A;  4GWD A;  4Q3S A;  4MYK A;  3GN0 A;  3LHL A;  3SKK A;  3THH A;  1P8S A;  3MJL A;  1CEV A;  2EF4 A;  3NIQ A;  4RHJ A;  5HJA A;  4RHM A;  1P8Q A;  4I06 A;  4RHQ A;  4RHK A;  4Q41 A;  1T5G A;  3GMZ A;  3LP4 A;  1D3V A;  4Q42 A;  1T4T A;  3TH7 A;  3E6V A;  4Q3Q A;  4CEV A;  1HQG A;  1HQH A;  4Q3R C;  3E9B A;  1RLA A;  4Q3R A;  4HZE A; 
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similar chains in the Genus database (?% sequence similarity)
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