3RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 106
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 106
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3rlaA00
1HQFA 1WVBA 4RHMA 3SL0A 2EF4A 4HXQA 2EF5A 3THEA 2CEVA 3THJA 4Q3QA 3NIPA 3TH7A 1TBJA 4CEVA 4Q3RA 4FCIA 4GSZA 3SKKA 1D3VA 4IXUA 3MMRA 5HJAA 3GMZA 3DJ8A 4G3HA 3NIOA 1T5GA 1P8MA 1HQGA 1P8NA 4MYNA 4IXVA 3MFWA 4Q3TA 3LP7A 4RHLA 5HJ9A 4Q3UA 1T4SA 2ZAVA 1T4TA 4IE1A 2PHAA 4Q40A 3THHA 3RLAA 4IU1A 1ZPEA 3E8QA 4I06A 1P8SA 4GWDA 1CEVA 4IU5A 3GN0A 1XFKA 4RLAA 1PQ3A 4GSMA 4HWWA 1HQHA 1RLAA 4FCKA 3CEVA 2A0MA 3F80A 4RHJA 1P8QA 1WOGA 1P8RA 3SJTA 4Q42A 4GWCA 1HQ5A 4ITYA 3MFVA 3E6VA 3E8ZA 4HZEA 1HQXA 3E9BA 2AEBA 1T5FA 4GSVA 3E6KA 4MYKA 4DZ4A 1WVAA 4IE2A 1TBHA 5RLAA 1WOIA 2PLLA 4IE3A 4RHQA 1TBLA 3LHLA 2RLAA 4RHIA 3TF3A 2EIVA 3KV2A 4MYFA 4Q3SA 4RHKA 4MXRA 1ZPGA 1R1OA 1T4RA 3NIQA 1P8PA 1TA1A 1GQ6A 3PZLA 4Q3RC 2PHOA 5CEVA 1GQ7A 1P8OA 1WOHA 3SL1A 3MJLA 4IU4A 3LP4A 4Q3VA 3M1RA 1T4PA 4MYLA 4Q41A 4Q3PA 4IU0A
chains in the Genus database with same CATH superfamily
1HQFA 3C0YA 4A69A 1WVBA 4ZUNA 4RHMA 3EZPA 2GH6A 2EF4A 5EEKA 3SL0A 4CQFA 1T67A 5DC6A 4HXQA 2EF5A 5G3WA 4LXZA 3THEA 2CEVA 3THJA 2VQOA 4Q3QA 4RN0A 3NIPA 3ZNRA 3EW8A 3TH7A 3ZNSA 1TBJA 4QA5A 4CEVA 4Q3RA 5DC8A 4FCIA 4GSZA 5DC5A 4BZ7A 5EENA 5EEMA 5EFJD 3SKKA 1ZZ3A 1D3VA 4QA3A 4IXUA 3MMRA 5HJAA 5A2SA 4QA0A 3GMZA 5G12A 1T64A 3C0ZA 3DJ8A 2VQMA 1P8MA 3NIOA 1T5GA 1HQGA 1P8NA 4G3HA 4LY1A 4MYNA 5G0JA 4IXVA 5EFGA 5IWGA 5THTA 4BZ9A 3MFWA 4Q3TA 3SFFA 3LP7A 5EFNA 4RHLA 5G13A 5HJ9A 4Q3UA 1T4SA 2ZAVA 5EFBD 4ZURA 5G0XA 5EEIA 1T4TA 4BZ8A 4BZ6A 5G17A 3MAXA 4IE1A 5EEFA 5EFKB 5G11A 2PHAA 4Q40A 5EF7A 4QA7A 3THHA 4BKXB 4RN2A 3RLAA 3Q9FA 5D1DA 4IU1A 4ZUMA 3EZTA 1ZPEA 5THUA 3E8QA 1C3SA 4I06A 1P8SA 4GWDA 2VQWG 5DC7A 1CEVA 4IU5A 3GN0A 4RN1A 5G1AA 4IU0A 2V5XA 5THSA 1XFKA 3Q9BA 4RLAA 1PQ3A 4GSMA 3MZ6A 4HWWA 1HQHA 1RLAA 3CEVA 4FCKA 5FUEA 2A0MA 3MENA 3F80A 1C3PA 4RHJA 1P8QA 1WOGA 3Q9EA 5D1BA 5BWZA 1P8RA 5LI3A 1W22A 3SJTA 4Q42A 4GWCA 3MZ3A 1HQ5A 4ITYA 4ZUQA 3MZ4A 4QA6A 2VQQA 5ICNB 4QA2A 3MFVA 3E6VA 3E8ZA 4HZEA 1ZZ1A 1HQXA 3E9BA 5FCWA 2AEBA 3RQDA 3SFHA 1T5FA 4GSVA 4QA1A 3E6KA 4MYKA 5G0IA 4DZ4A 2VQVA 1WVAA 4IE2A 2V5WA 1TBHA 5EFHA 3MZ7A 1WOIA 5RLAA 4QA4A 2PLLA 4CBTA 3F06A 4IE3A 4RHQA 1TBLA 1C3RA 3LHLA 5G10A 2RLAA 4RHIA 3TF3A 2EIVA 3C10A 3KV2A 1ZZ0A 3F07A 4MYFA 4Q3SA 4RHKA 4MXRA 3Q9CA 1ZPGA 1R1OA 5IX0A 5THVA 5D1CA 1VKGA 5JI5A 1T4RA 3NIQA 1P8PA 1TA1A 3EWFA 1GQ6A 4ZUOA 5G0YA 3PZLA 4Q3RC 4ZUPA 2PHOA 4BZ5A 5EF8A 5CEVA 1T69A 1GQ7A 2VQJA 1P8OA 1WOHA 3SL1A 3MJLA 5G1CA 5G1BA 4CBYA 4IU4A 2VCGA 3LP4A 5G0GA 4Q3VA 3M1RA 1T4PA 4MYLA 4Q41A 4Q3PA 5G0HA 3F0RA
chains in the Genus database with same CATH topology
1HQFA 1WVBA 4RHMA 3SL0A 2EF4A 4HXQA 2EF5A 3THEA 2CEVA 3THJA 4Q3QA 3NIPA 3TH7A 1TBJA 4CEVA 4Q3RA 4FCIA 4GSZA 3SKKA 1D3VA 4IXUA 3MMRA 5HJAA 3GMZA 3DJ8A 4G3HA 3NIOA 1T5GA 1P8MA 1HQGA 1P8NA 4MYNA 4IXVA 3MFWA 4Q3TA 3LP7A 4RHLA 5HJ9A 4Q3UA 1T4SA 2ZAVA 1T4TA 4IE1A 2PHAA 4Q40A 3THHA 3RLAA 4IU1A 1ZPEA 3E8QA 4I06A 1P8SA 4GWDA 1CEVA 4IU5A 3GN0A 1XFKA 4RLAA 1PQ3A 4GSMA 4HWWA 1HQHA 1RLAA 4FCKA 3CEVA 2A0MA 3F80A 4RHJA 1P8QA 1WOGA 1P8RA 3SJTA 4Q42A 4GWCA 1HQ5A 4ITYA 3MFVA 3E6VA 3E8ZA 4HZEA 1HQXA 3E9BA 2AEBA 1T5FA 4GSVA 3E6KA 4MYKA 4DZ4A 1WVAA 4IE2A 1TBHA 5RLAA 1WOIA 2PLLA 4IE3A 4RHQA 1TBLA 3LHLA 2RLAA 4RHIA 3TF3A 2EIVA 3KV2A 4MYFA 4Q3SA 4RHKA 4MXRA 1ZPGA 1R1OA 1T4RA 3NIQA 1P8PA 1TA1A 1GQ6A 3PZLA 4Q3RC 2PHOA 5CEVA 1GQ7A 1P8OA 1WOHA 3SL1A 3MJLA 4IU4A 3LP4A 4Q3VA 3M1RA 1T4PA 4MYLA 4Q41A 4Q3PA 4IU0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQF A;  1WVB A;  4RHM A;  3SL0 A;  2EF4 A;  4HXQ A;  2EF5 A;  3THE A;  2CEV A;  3THJ A;  4Q3Q A;  3NIP A;  3TH7 A;  1TBJ A;  4CEV A;  4Q3R A;  4FCI A;  4GSZ A;  3SKK A;  1D3V A;  4IXU A;  3MMR A;  5HJA A;  3GMZ A;  3DJ8 A;  4G3H A;  3NIO A;  1T5G A;  1P8M A;  1HQG A;  1P8N A;  4MYN A;  4IXV A;  3MFW A;  4Q3T A;  3LP7 A;  4RHL A;  5HJ9 A;  4Q3U A;  1T4S A;  2ZAV A;  1T4T A;  4IE1 A;  2PHA A;  4Q40 A;  3THH A;  3RLA A;  4IU1 A;  1ZPE A;  3E8Q A;  4I06 A;  1P8S A;  4GWD A;  1CEV A;  4IU5 A;  3GN0 A;  1XFK A;  4RLA A;  1PQ3 A;  4GSM A;  4HWW A;  1HQH A;  1RLA A;  4FCK A;  3CEV A;  2A0M A;  3F80 A;  4RHJ A;  1P8Q A;  1WOG A;  1P8R A;  3SJT A;  4Q42 A;  4GWC A;  1HQ5 A;  4ITY A;  3MFV A;  3E6V A;  3E8Z A;  4HZE A;  1HQX A;  3E9B A;  2AEB A;  1T5F A;  4GSV A;  3E6K A;  4MYK A;  4DZ4 A;  1WVA A;  4IE2 A;  1TBH A;  5RLA A;  1WOI A;  2PLL A;  4IE3 A;  4RHQ A;  1TBL A;  3LHL A;  2RLA A;  4RHI A;  3TF3 A;  2EIV A;  3KV2 A;  4MYF A;  4Q3S A;  4RHK A;  4MXR A;  1ZPG A;  1R1O A;  1T4R A;  3NIQ A;  1P8P A;  1TA1 A;  1GQ6 A;  3PZL A;  4Q3R C;  2PHO A;  5CEV A;  1GQ7 A;  1P8O A;  1WOH A;  3SL1 A;  3MJL A;  4IU4 A;  3LP4 A;  4Q3V A;  3M1R A;  1T4P A;  4MYL A;  4Q41 A;  4Q3P A;  4IU0 A; 
#chains in the Genus database with same CATH topology
 1HQF A;  3C0Y A;  4A69 A;  1WVB A;  4ZUN A;  4RHM A;  3EZP A;  2GH6 A;  2EF4 A;  5EEK A;  3SL0 A;  4CQF A;  1T67 A;  5DC6 A;  4HXQ A;  2EF5 A;  5G3W A;  4LXZ A;  3THE A;  2CEV A;  3THJ A;  2VQO A;  4Q3Q A;  4RN0 A;  3NIP A;  3ZNR A;  3EW8 A;  3TH7 A;  3ZNS A;  1TBJ A;  4QA5 A;  4CEV A;  4Q3R A;  5DC8 A;  4FCI A;  4GSZ A;  5DC5 A;  4BZ7 A;  5EEN A;  5EEM A;  5EFJ D;  3SKK A;  1ZZ3 A;  1D3V A;  4QA3 A;  4IXU A;  3MMR A;  5HJA A;  5A2S A;  4QA0 A;  3GMZ A;  5G12 A;  1T64 A;  3C0Z A;  3DJ8 A;  2VQM A;  1P8M A;  3NIO A;  1T5G A;  1HQG A;  1P8N A;  4G3H A;  4LY1 A;  4MYN A;  5G0J A;  4IXV A;  5EFG A;  5IWG A;  5THT A;  4BZ9 A;  3MFW A;  4Q3T A;  3SFF A;  3LP7 A;  5EFN A;  4RHL A;  5G13 A;  5HJ9 A;  4Q3U A;  1T4S A;  2ZAV A;  5EFB D;  4ZUR A;  5G0X A;  5EEI A;  1T4T A;  4BZ8 A;  4BZ6 A;  5G17 A;  3MAX A;  4IE1 A;  5EEF A;  5EFK B;  5G11 A;  2PHA A;  4Q40 A;  5EF7 A;  4QA7 A;  3THH A;  4BKX B;  4RN2 A;  3RLA A;  3Q9F A;  5D1D A;  4IU1 A;  4ZUM A;  3EZT A;  1ZPE A;  5THU A;  3E8Q A;  1C3S A;  4I06 A;  1P8S A;  4GWD A;  2VQW G;  5DC7 A;  1CEV A;  4IU5 A;  3GN0 A;  4RN1 A;  5G1A A;  4IU0 A;  2V5X A;  5THS A;  1XFK A;  3Q9B A;  4RLA A;  1PQ3 A;  4GSM A;  3MZ6 A;  4HWW A;  1HQH A;  1RLA A;  3CEV A;  4FCK A;  5FUE A;  2A0M A;  3MEN A;  3F80 A;  1C3P A;  4RHJ A;  1P8Q A;  1WOG A;  3Q9E A;  5D1B A;  5BWZ A;  1P8R A;  5LI3 A;  1W22 A;  3SJT A;  4Q42 A;  4GWC A;  3MZ3 A;  1HQ5 A;  4ITY A;  4ZUQ A;  3MZ4 A;  4QA6 A;  2VQQ A;  5ICN B;  4QA2 A;  3MFV A;  3E6V A;  3E8Z A;  4HZE A;  1ZZ1 A;  1HQX A;  3E9B A;  5FCW A;  2AEB A;  3RQD A;  3SFH A;  1T5F A;  4GSV A;  4QA1 A;  3E6K A;  4MYK A;  5G0I A;  4DZ4 A;  2VQV A;  1WVA A;  4IE2 A;  2V5W A;  1TBH A;  5EFH A;  3MZ7 A;  1WOI A;  5RLA A;  4QA4 A;  2PLL A;  4CBT A;  3F06 A;  4IE3 A;  4RHQ A;  1TBL A;  1C3R A;  3LHL A;  5G10 A;  2RLA A;  4RHI A;  3TF3 A;  2EIV A;  3C10 A;  3KV2 A;  1ZZ0 A;  3F07 A;  4MYF A;  4Q3S A;  4RHK A;  4MXR A;  3Q9C A;  1ZPG A;  1R1O A;  5IX0 A;  5THV A;  5D1C A;  1VKG A;  5JI5 A;  1T4R A;  3NIQ A;  1P8P A;  1TA1 A;  3EWF A;  1GQ6 A;  4ZUO A;  5G0Y A;  3PZL A;  4Q3R C;  4ZUP A;  2PHO A;  4BZ5 A;  5EF8 A;  5CEV A;  1T69 A;  1GQ7 A;  2VQJ A;  1P8O A;  1WOH A;  3SL1 A;  3MJL A;  5G1C A;  5G1B A;  4CBY A;  4IU4 A;  2VCG A;  3LP4 A;  5G0G A;  4Q3V A;  3M1R A;  1T4P A;  4MYL A;  4Q41 A;  4Q3P A;  5G0H A;  3F0R A; 
#chains in the Genus database with same CATH homology
 1HQF A;  1WVB A;  4RHM A;  3SL0 A;  2EF4 A;  4HXQ A;  2EF5 A;  3THE A;  2CEV A;  3THJ A;  4Q3Q A;  3NIP A;  3TH7 A;  1TBJ A;  4CEV A;  4Q3R A;  4FCI A;  4GSZ A;  3SKK A;  1D3V A;  4IXU A;  3MMR A;  5HJA A;  3GMZ A;  3DJ8 A;  4G3H A;  3NIO A;  1T5G A;  1P8M A;  1HQG A;  1P8N A;  4MYN A;  4IXV A;  3MFW A;  4Q3T A;  3LP7 A;  4RHL A;  5HJ9 A;  4Q3U A;  1T4S A;  2ZAV A;  1T4T A;  4IE1 A;  2PHA A;  4Q40 A;  3THH A;  3RLA A;  4IU1 A;  1ZPE A;  3E8Q A;  4I06 A;  1P8S A;  4GWD A;  1CEV A;  4IU5 A;  3GN0 A;  1XFK A;  4RLA A;  1PQ3 A;  4GSM A;  4HWW A;  1HQH A;  1RLA A;  4FCK A;  3CEV A;  2A0M A;  3F80 A;  4RHJ A;  1P8Q A;  1WOG A;  1P8R A;  3SJT A;  4Q42 A;  4GWC A;  1HQ5 A;  4ITY A;  3MFV A;  3E6V A;  3E8Z A;  4HZE A;  1HQX A;  3E9B A;  2AEB A;  1T5F A;  4GSV A;  3E6K A;  4MYK A;  4DZ4 A;  1WVA A;  4IE2 A;  1TBH A;  5RLA A;  1WOI A;  2PLL A;  4IE3 A;  4RHQ A;  1TBL A;  3LHL A;  2RLA A;  4RHI A;  3TF3 A;  2EIV A;  3KV2 A;  4MYF A;  4Q3S A;  4RHK A;  4MXR A;  1ZPG A;  1R1O A;  1T4R A;  3NIQ A;  1P8P A;  1TA1 A;  1GQ6 A;  3PZL A;  4Q3R C;  2PHO A;  5CEV A;  1GQ7 A;  1P8O A;  1WOH A;  3SL1 A;  3MJL A;  4IU4 A;  3LP4 A;  4Q3V A;  3M1R A;  1T4P A;  4MYL A;  4Q41 A;  4Q3P A;  4IU0 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...