The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
130
|
sequence length |
364
|
structure length |
342
|
Chain Sequence |
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
pubmed doi rcsb |
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
Histone deacetylase 8
|
| total genus |
130
|
| structure length |
342
|
| sequence length |
364
|
| ec nomenclature |
ec
3.5.1.98: Histone deacetylase. |
| pdb deposition date | 2011-06-13 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00850 | Hist_deacetyl | Histone deacetylase domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Arginase; Chain A | Histone deacetylase domain |
#chains in the Genus database with same CATH superfamily 3SFF A; 1C3R A; 4QA4 A; 5D1D A; 5DC8 A; 3EZT A; 5JI5 A; 5THU A; 5G0G A; 5D1C A; 4CQF A; 5EFH A; 3F06 A; 4ZUN A; 5DC7 A; 5EEI A; 1C3S A; 5G1B A; 3MEN A; 1T69 A; 5EEK A; 5THV A; 5G3W A; 2VQW G; 2VQQ A; 5EFK B; 4QA2 A; 5THS A; 5DC5 A; 2VQV A; 5EF8 A; 3Q9B A; 5LI3 A; 3Q9C A; 1T67 A; 1ZZ3 A; 2V5X A; 3EW8 A; 5G0I A; 4ZUP A; 4QA7 A; 5EFG A; 4BZ9 A; 5BWZ A; 2VQO A; 3F0R A; 5THT A; 4RN2 A; 4ZUO A; 3Q9E A; 4RN0 A; 5EEF A; 4QA0 A; 4CBT A; 2V5W A; 3MZ7 A; 5IWG A; 5G0X A; 3MAX A; 5G0H A; 3EWF A; 4LXZ A; 5EFJ D; 3MZ3 A; 4ZUQ A; 3RQD A; 3Q9F A; 4ZUR A; 4BZ8 A; 4BZ5 A; 2GH6 A; 4QA5 A; 5G1C A; 5ICN B; 5FUE A; 4BZ6 A; 3SFH A; 4QA6 A; 5G1A A; 5G17 A; 5G12 A; 3MZ4 A; 3ZNR A; 1VKG A; 1W22 A; 5G11 A; 5EF7 A; 3C0Z A; 5G0Y A; 4CBY A; 1ZZ1 A; 1ZZ0 A; 4RN1 A; 5EFN A; 3EZP A; 4QA3 A; 3C10 A; 4A69 A; 2VQJ A; 3MZ6 A; 5D1B A; 5DC6 A; 3ZNS A; 1C3P A; 3F07 A; 5G10 A; 5FCW A; 4QA1 A; 5A2S A; 5G13 A; 2VQM A; 5EFB D; 3C0Y A; 5EEN A; 5EEM A; 5G0J A; 4LY1 A; 4BZ7 A; 1T64 A; 5IX0 A; 4BKX B; 2VCG A; 4ZUM A; #chains in the Genus database with same CATH topology 1WOI A; 3SFF A; 4IE1 A; 1C3R A; 4QA4 A; 5D1D A; 5DC8 A; 3SKK A; 1GQ7 A; 5CEV A; 3TH7 A; 2ZAV A; 1HQ5 A; 3EZT A; 4HZE A; 4IE2 A; 5G0G A; 5THU A; 3SL1 A; 5JI5 A; 1PQ3 A; 5D1C A; 4CQF A; 1T4P A; 1WVB A; 5EFH A; 3F06 A; 4CEV A; 4ZUN A; 4Q40 A; 5DC7 A; 1C3S A; 3E6V A; 1P8M A; 5EEI A; 3MEN A; 5G1B A; 5HJ9 A; 4Q3P A; 4MYK A; 4G3H A; 1T69 A; 1HQH A; 3MFW A; 5EEK A; 5THV A; 5G3W A; 1TBL A; 2VQQ A; 2VQW G; 1TBJ A; 1T4T A; 5EFK B; 4QA2 A; 5THS A; 5DC5 A; 2VQV A; 4IU4 A; 1HQG A; 3E8Q A; 1P8R A; 5EF8 A; 1P8Q A; 3Q9B A; 4ITY A; 4MXR A; 1P8S A; 3CEV A; 5RLA A; 3F80 A; 5LI3 A; 1WVA A; 1CEV A; 1T67 A; 1TBH A; 3Q9C A; 1ZZ3 A; 3LP4 A; 2V5X A; 1T4S A; 3EW8 A; 4IU5 A; 2CEV A; 2PHA A; 1ZPG A; 4IXU A; 4Q3U A; 4GWC A; 4Q3Q A; 1GQ6 A; 5G0I A; 4IU0 A; 4GSZ A; 2AEB A; 4ZUP A; 4QA7 A; 3MJL A; 1WOG A; 5EFG A; 4GWD A; 4Q3T A; 4BZ9 A; 2EF5 A; 3NIP A; 3LHL A; 5BWZ A; 2PLL A; 1D3V A; 2VQO A; 4DZ4 A; 3F0R A; 4I06 A; 5THT A; 3E6K A; 3E8Z A; 4RN2 A; 4Q3V A; 1P8N A; 4ZUO A; 1P8P A; 4Q3R A; 3Q9E A; 4MYL A; 4RN0 A; 5EEF A; 4QA0 A; 4CBT A; 4IE3 A; 2V5W A; 3THE A; 2RLA A; 1HQF A; 4IXV A; 4RHM A; 3SJT A; 3MZ7 A; 1P8O A; 3TF3 A; 3NIQ A; 5IWG A; 3THJ A; 5G0X A; 4FCI A; 4Q3S A; 3MAX A; 5G0H A; 3EWF A; 4LXZ A; 4Q3R C; 4MYN A; 3MMR A; 1RLA A; 5EFJ D; 3MZ3 A; 4ZUQ A; 3RQD A; 1HQX A; 3Q9F A; 4ZUR A; 4BZ8 A; 2A0M A; 4BZ5 A; 3DJ8 A; 2GH6 A; 4QA5 A; 5G1C A; 1ZPE A; 4GSM A; 1TA1 A; 5ICN B; 1T5F A; 5FUE A; 4GSV A; 4BZ6 A; 3SL0 A; 3SFH A; 4QA6 A; 5G1A A; 4RHK A; 2EIV A; 3GMZ A; 4FCK A; 5G17 A; 3LP7 A; 3M1R A; 5G12 A; 3MZ4 A; 3ZNR A; 3PZL A; 1VKG A; 3E9B A; 1W22 A; 1XFK A; 5G11 A; 5EF7 A; 5HJA A; 3C0Z A; 5G0Y A; 4CBY A; 1WOH A; 1ZZ1 A; 4MYF A; 3KV2 A; 1ZZ0 A; 3MFV A; 4RHI A; 1R1O A; 4RN1 A; 3EZP A; 4QA3 A; 5EFN A; 4Q42 A; 1T4R A; 3GN0 A; 4HXQ A; 3C10 A; 4A69 A; 2VQJ A; 3THH A; 3MZ6 A; 5D1B A; 5DC6 A; 3ZNS A; 1C3P A; 3F07 A; 5G10 A; 4RHQ A; 5FCW A; 2PHO A; 4QA1 A; 4RHL A; 4Q41 A; 5A2S A; 4RHJ A; 5G13 A; 2VQM A; 4IU1 A; 3C0Y A; 5EEN A; 1T5G A; 4RLA A; 5EFB D; 5EEM A; 5G0J A; 4LY1 A; 4BZ7 A; 2EF4 A; 1T64 A; 5IX0 A; 3RLA A; 4BKX B; 3NIO A; 2VCG A; 4ZUM A; 4HWW A; #chains in the Genus database with same CATH homology 3SFF A; 1C3R A; 4QA4 A; 5D1D A; 5DC8 A; 3EZT A; 5JI5 A; 5THU A; 5G0G A; 5D1C A; 4CQF A; 5EFH A; 3F06 A; 4ZUN A; 5DC7 A; 5EEI A; 1C3S A; 5G1B A; 3MEN A; 1T69 A; 5EEK A; 5THV A; 5G3W A; 2VQW G; 2VQQ A; 5EFK B; 4QA2 A; 5THS A; 5DC5 A; 2VQV A; 5EF8 A; 3Q9B A; 5LI3 A; 3Q9C A; 1T67 A; 1ZZ3 A; 2V5X A; 3EW8 A; 5G0I A; 4ZUP A; 4QA7 A; 5EFG A; 4BZ9 A; 5BWZ A; 2VQO A; 3F0R A; 5THT A; 4RN2 A; 4ZUO A; 3Q9E A; 4RN0 A; 5EEF A; 4QA0 A; 4CBT A; 2V5W A; 3MZ7 A; 5IWG A; 5G0X A; 3MAX A; 5G0H A; 3EWF A; 4LXZ A; 5EFJ D; 3MZ3 A; 4ZUQ A; 3RQD A; 3Q9F A; 4ZUR A; 4BZ8 A; 4BZ5 A; 2GH6 A; 4QA5 A; 5G1C A; 5ICN B; 5FUE A; 4BZ6 A; 3SFH A; 4QA6 A; 5G1A A; 5G17 A; 5G12 A; 3MZ4 A; 3ZNR A; 1VKG A; 1W22 A; 5G11 A; 5EF7 A; 3C0Z A; 5G0Y A; 4CBY A; 1ZZ1 A; 1ZZ0 A; 4RN1 A; 5EFN A; 3EZP A; 4QA3 A; 3C10 A; 4A69 A; 2VQJ A; 3MZ6 A; 5D1B A; 5DC6 A; 3ZNS A; 1C3P A; 3F07 A; 5G10 A; 5FCW A; 4QA1 A; 5A2S A; 5G13 A; 2VQM A; 5EFB D; 3C0Y A; 5EEN A; 5EEM A; 5G0J A; 4LY1 A; 4BZ7 A; 1T64 A; 5IX0 A; 4BKX B; 2VCG A; 4ZUM A;
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