3SJTA

Crystal structure of human arginase i in complex with the inhibitor me-abh, resolution 1.60 a, twinned structure
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
313
structure length
313
Chain Sequence
RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of alpha,alpha-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Arginase-1
total genus 114
structure length 313
sequence length 313
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2011-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3sjtA00
4Q40A 2PHOA 1HQHA 4RLAA 2RLAA 1GQ7A 1HQXA 2PLLA 4Q42A 1PQ3A 5RLAA 3RLAA 4MYKA 3E6VA 1WOHA 3F80A 3LP7A 3THHA 4IU5A 3SL0A 1T4TA 4CEVA 1ZPGA 1RLAA 4RHLA 4MXRA 1HQFA 1WOGA 3CEVA 4MYLA 3E8QA 1P8MA 4Q3QA 4RHJA 2EF5A 2ZAVA 3GMZA 4Q3SA 1CEVA 2EF4A 4FCIA 4IE2A 5HJAA 4IE3A 3NIQA 3NIOA 1P8SA 4MYNA 3SKKA 1D3VA 4GSMA 2PHAA 2CEVA 3E8ZA 1R1OA 4Q41A 3MFVA 4RHMA 3THJA 3LHLA 4Q3UA 1TBJA 2A0MA 4I06A 5HJ9A 4FCKA 3DJ8A 1TBLA 1T4RA 4RHQA 4RHKA 4IU0A 1ZPEA 4GWCA 1WVBA 1P8QA 4MYFA 4IE1A 3TF3A 4GSZA 4IU4A 4HXQA 1P8OA 4Q3VA 1T4SA 3E6KA 1WVAA 3SL1A 4Q3RA 5CEVA 4HZEA 4DZ4A 4IXVA 4HWWA 3SJTA 1P8PA 1WOIA 4Q3RC 1HQ5A 4IXUA 3THEA 4Q3PA 1HQGA 1P8RA 3NIPA 4ITYA 3GN0A 2AEBA 4IU1A 3MFWA 3LP4A 3MMRA 1T5FA 1TBHA 3PZLA 4GSVA 1XFKA 3MJLA 4Q3TA 4GWDA 4RHIA 3KV2A 3E9BA 3M1RA 1P8NA 1GQ6A 1T4PA 2EIVA 1TA1A 4G3HA 3TH7A 1T5GA
chains in the Genus database with same CATH superfamily
1T69A 4Q40A 2PHOA 1HQHA 4RLAA 4BZ5A 4QA0A 5THTA 2RLAA 1GQ7A 4QA3A 3MZ7A 1HQXA 5EEIA 5G0HA 2PLLA 4CQFA 4Q42A 4BZ9A 1PQ3A 5RLAA 2VQWG 5THVA 3RLAA 4MYKA 5D1BA 4QA1A 1C3PA 3EWFA 4ZUNA 5G13A 4LY1A 3E6VA 3MZ6A 5JI5A 1WOHA 3F80A 5THUA 5EFHA 3LP7A 5EF7A 3Q9EA 3THHA 4ZUMA 4IU5A 3SL0A 1T4TA 4RN2A 4ZUOA 5G0XA 4CEVA 1ZPGA 5EEKA 4RN1A 4BZ7A 4A69A 1RLAA 4RHLA 4MXRA 4LXZA 1HQFA 1WOGA 3CEVA 5G0JA 4MYLA 2VQMA 3E8QA 1P8MA 4Q3QA 4RHJA 2EF5A 2ZAVA 3GMZA 4Q3SA 1CEVA 5G1AA 4BZ6A 3EZPA 2EF4A 5FUEA 4FCIA 4IE2A 5HJAA 4IE3A 3SFFA 3C0ZA 3NIQA 3NIOA 1P8SA 4MYNA 3SKKA 1D3VA 4GSMA 2PHAA 4BKXB 2CEVA 2VCGA 4CBTA 3F07A 3E8ZA 1ZZ0A 1R1OA 5G0IA 5THSA 3MFVA 4RHMA 4QA6A 3THJA 4Q41A 5G1CA 3LHLA 4Q3UA 1TBJA 2A0MA 4I06A 5HJ9A 4FCKA 3DJ8A 5EEMA 1TBLA 5G17A 1T4RA 4RHQA 3ZNSA 4RHKA 4IU0A 1ZPEA 4GWCA 1WVBA 1P8QA 4MYFA 1T67A 3RQDA 4IE1A 3TF3A 5D1DA 4GSZA 4IU4A 5EFJD 4HXQA 5EEFA 1P8OA 3MZ4A 4Q3VA 5G12A 1T4SA 3SFHA 4QA2A 3E6KA 1WVAA 5G0GA 3SL1A 1T64A 4Q3RA 3EZTA 5EFGA 5EFNA 3ZNRA 5CEVA 4HZEA 3C0YA 5DC5A 1ZZ3A 5EENA 5G10A 4DZ4A 5LI3A 4IXVA 5G11A 4RN0A 4HWWA 2VQQA 3C10A 5EF8A 1C3SA 1P8PA 1WOIA 2VQOA 3MAXA 3F06A 3SJTA 4Q3RC 1C3RA 2GH6A 1HQ5A 5G3WA 4IXUA 3MZ3A 4Q3PA 1HQGA 5G0YA 3THEA 2VQVA 5FCWA 1P8RA 1ZZ1A 3NIPA 5D1CA 4QA7A 4ITYA 3GN0A 5EFKB 2AEBA 4IU1A 1W22A 3MFWA 5DC7A 3Q9CA 3LP4A 4BZ8A 3MMRA 1T5FA 1TBHA 3PZLA 2VQJA 4QA5A 5BWZA 4ZUPA 5G1BA 4GSVA 5IWGA 3MENA 1XFKA 5DC6A 5EFBD 4ZUQA 5DC8A 4ZURA 3MJLA 4Q3TA 4GWDA 4QA4A 4CBYA 3EW8A 5A2SA 4RHIA 2V5XA 3KV2A 3E9BA 2V5WA 3F0RA 3M1RA 1VKGA 1P8NA 1GQ6A 3Q9BA 5ICNB 1T4PA 2EIVA 5IX0A 1TA1A 3Q9FA 4G3HA 3TH7A 1T5GA
chains in the Genus database with same CATH topology
4Q40A 2PHOA 1HQHA 4RLAA 2RLAA 1GQ7A 1HQXA 2PLLA 4Q42A 1PQ3A 5RLAA 3RLAA 4MYKA 3E6VA 1WOHA 3F80A 3LP7A 3THHA 4IU5A 3SL0A 1T4TA 4CEVA 1ZPGA 1RLAA 4RHLA 4MXRA 1HQFA 1WOGA 3CEVA 4MYLA 3E8QA 1P8MA 4Q3QA 4RHJA 2EF5A 2ZAVA 3GMZA 4Q3SA 1CEVA 2EF4A 4FCIA 4IE2A 5HJAA 4IE3A 3NIQA 3NIOA 1P8SA 4MYNA 3SKKA 1D3VA 4GSMA 2PHAA 2CEVA 3E8ZA 1R1OA 4Q41A 3MFVA 4RHMA 3THJA 3LHLA 4Q3UA 1TBJA 2A0MA 4I06A 5HJ9A 4FCKA 3DJ8A 1TBLA 1T4RA 4RHQA 4RHKA 4IU0A 1ZPEA 4GWCA 1WVBA 1P8QA 4MYFA 4IE1A 3TF3A 4GSZA 4IU4A 4HXQA 1P8OA 4Q3VA 1T4SA 3E6KA 1WVAA 3SL1A 4Q3RA 5CEVA 4HZEA 4DZ4A 4IXVA 4HWWA 3SJTA 1P8PA 1WOIA 4Q3RC 1HQ5A 4IXUA 3THEA 4Q3PA 1HQGA 1P8RA 3NIPA 4ITYA 3GN0A 2AEBA 4IU1A 3MFWA 3LP4A 3MMRA 1T5FA 1TBHA 3PZLA 4GSVA 1XFKA 3MJLA 4Q3TA 4GWDA 4RHIA 3KV2A 3E9BA 3M1RA 1P8NA 1GQ6A 1T4PA 2EIVA 1TA1A 4G3HA 3TH7A 1T5GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q40 A;  2PHO A;  1HQH A;  4RLA A;  2RLA A;  1GQ7 A;  1HQX A;  2PLL A;  4Q42 A;  1PQ3 A;  5RLA A;  3RLA A;  4MYK A;  3E6V A;  1WOH A;  3F80 A;  3LP7 A;  3THH A;  4IU5 A;  3SL0 A;  1T4T A;  4CEV A;  1ZPG A;  1RLA A;  4RHL A;  4MXR A;  1HQF A;  1WOG A;  3CEV A;  4MYL A;  3E8Q A;  1P8M A;  4Q3Q A;  4RHJ A;  2EF5 A;  2ZAV A;  3GMZ A;  4Q3S A;  1CEV A;  2EF4 A;  4FCI A;  4IE2 A;  5HJA A;  4IE3 A;  3NIQ A;  3NIO A;  1P8S A;  4MYN A;  3SKK A;  1D3V A;  4GSM A;  2PHA A;  2CEV A;  3E8Z A;  1R1O A;  4Q41 A;  3MFV A;  4RHM A;  3THJ A;  3LHL A;  4Q3U A;  1TBJ A;  2A0M A;  4I06 A;  5HJ9 A;  4FCK A;  3DJ8 A;  1TBL A;  1T4R A;  4RHQ A;  4RHK A;  4IU0 A;  1ZPE A;  4GWC A;  1WVB A;  1P8Q A;  4MYF A;  4IE1 A;  3TF3 A;  4GSZ A;  4IU4 A;  4HXQ A;  1P8O A;  4Q3V A;  1T4S A;  3E6K A;  1WVA A;  3SL1 A;  4Q3R A;  5CEV A;  4HZE A;  4DZ4 A;  4IXV A;  4HWW A;  3SJT A;  1P8P A;  1WOI A;  4Q3R C;  1HQ5 A;  4IXU A;  3THE A;  4Q3P A;  1HQG A;  1P8R A;  3NIP A;  4ITY A;  3GN0 A;  2AEB A;  4IU1 A;  3MFW A;  3LP4 A;  3MMR A;  1T5F A;  1TBH A;  3PZL A;  4GSV A;  1XFK A;  3MJL A;  4Q3T A;  4GWD A;  4RHI A;  3KV2 A;  3E9B A;  3M1R A;  1P8N A;  1GQ6 A;  1T4P A;  2EIV A;  1TA1 A;  4G3H A;  3TH7 A;  1T5G A; 
#chains in the Genus database with same CATH topology
 1T69 A;  4Q40 A;  2PHO A;  1HQH A;  4RLA A;  4BZ5 A;  4QA0 A;  5THT A;  2RLA A;  1GQ7 A;  4QA3 A;  3MZ7 A;  1HQX A;  5EEI A;  5G0H A;  2PLL A;  4CQF A;  4Q42 A;  4BZ9 A;  1PQ3 A;  5RLA A;  2VQW G;  5THV A;  3RLA A;  4MYK A;  5D1B A;  4QA1 A;  1C3P A;  3EWF A;  4ZUN A;  5G13 A;  4LY1 A;  3E6V A;  3MZ6 A;  5JI5 A;  1WOH A;  3F80 A;  5THU A;  5EFH A;  3LP7 A;  5EF7 A;  3Q9E A;  3THH A;  4ZUM A;  4IU5 A;  3SL0 A;  1T4T A;  4RN2 A;  4ZUO A;  5G0X A;  4CEV A;  1ZPG A;  5EEK A;  4RN1 A;  4BZ7 A;  4A69 A;  1RLA A;  4RHL A;  4MXR A;  4LXZ A;  1HQF A;  1WOG A;  3CEV A;  5G0J A;  4MYL A;  2VQM A;  3E8Q A;  1P8M A;  4Q3Q A;  4RHJ A;  2EF5 A;  2ZAV A;  3GMZ A;  4Q3S A;  1CEV A;  5G1A A;  4BZ6 A;  3EZP A;  2EF4 A;  5FUE A;  4FCI A;  4IE2 A;  5HJA A;  4IE3 A;  3SFF A;  3C0Z A;  3NIQ A;  3NIO A;  1P8S A;  4MYN A;  3SKK A;  1D3V A;  4GSM A;  2PHA A;  4BKX B;  2CEV A;  2VCG A;  4CBT A;  3F07 A;  3E8Z A;  1ZZ0 A;  1R1O A;  5G0I A;  5THS A;  3MFV A;  4RHM A;  4QA6 A;  3THJ A;  4Q41 A;  5G1C A;  3LHL A;  4Q3U A;  1TBJ A;  2A0M A;  4I06 A;  5HJ9 A;  4FCK A;  3DJ8 A;  5EEM A;  1TBL A;  5G17 A;  1T4R A;  4RHQ A;  3ZNS A;  4RHK A;  4IU0 A;  1ZPE A;  4GWC A;  1WVB A;  1P8Q A;  4MYF A;  1T67 A;  3RQD A;  4IE1 A;  3TF3 A;  5D1D A;  4GSZ A;  4IU4 A;  5EFJ D;  4HXQ A;  5EEF A;  1P8O A;  3MZ4 A;  4Q3V A;  5G12 A;  1T4S A;  3SFH A;  4QA2 A;  3E6K A;  1WVA A;  5G0G A;  3SL1 A;  1T64 A;  4Q3R A;  3EZT A;  5EFG A;  5EFN A;  3ZNR A;  5CEV A;  4HZE A;  3C0Y A;  5DC5 A;  1ZZ3 A;  5EEN A;  5G10 A;  4DZ4 A;  5LI3 A;  4IXV A;  5G11 A;  4RN0 A;  4HWW A;  2VQQ A;  3C10 A;  5EF8 A;  1C3S A;  1P8P A;  1WOI A;  2VQO A;  3MAX A;  3F06 A;  3SJT A;  4Q3R C;  1C3R A;  2GH6 A;  1HQ5 A;  5G3W A;  4IXU A;  3MZ3 A;  4Q3P A;  1HQG A;  5G0Y A;  3THE A;  2VQV A;  5FCW A;  1P8R A;  1ZZ1 A;  3NIP A;  5D1C A;  4QA7 A;  4ITY A;  3GN0 A;  5EFK B;  2AEB A;  4IU1 A;  1W22 A;  3MFW A;  5DC7 A;  3Q9C A;  3LP4 A;  4BZ8 A;  3MMR A;  1T5F A;  1TBH A;  3PZL A;  2VQJ A;  4QA5 A;  5BWZ A;  4ZUP A;  5G1B A;  4GSV A;  5IWG A;  3MEN A;  1XFK A;  5DC6 A;  5EFB D;  4ZUQ A;  5DC8 A;  4ZUR A;  3MJL A;  4Q3T A;  4GWD A;  4QA4 A;  4CBY A;  3EW8 A;  5A2S A;  4RHI A;  2V5X A;  3KV2 A;  3E9B A;  2V5W A;  3F0R A;  3M1R A;  1VKG A;  1P8N A;  1GQ6 A;  3Q9B A;  5ICN B;  1T4P A;  2EIV A;  5IX0 A;  1TA1 A;  3Q9F A;  4G3H A;  3TH7 A;  1T5G A; 
#chains in the Genus database with same CATH homology
 4Q40 A;  2PHO A;  1HQH A;  4RLA A;  2RLA A;  1GQ7 A;  1HQX A;  2PLL A;  4Q42 A;  1PQ3 A;  5RLA A;  3RLA A;  4MYK A;  3E6V A;  1WOH A;  3F80 A;  3LP7 A;  3THH A;  4IU5 A;  3SL0 A;  1T4T A;  4CEV A;  1ZPG A;  1RLA A;  4RHL A;  4MXR A;  1HQF A;  1WOG A;  3CEV A;  4MYL A;  3E8Q A;  1P8M A;  4Q3Q A;  4RHJ A;  2EF5 A;  2ZAV A;  3GMZ A;  4Q3S A;  1CEV A;  2EF4 A;  4FCI A;  4IE2 A;  5HJA A;  4IE3 A;  3NIQ A;  3NIO A;  1P8S A;  4MYN A;  3SKK A;  1D3V A;  4GSM A;  2PHA A;  2CEV A;  3E8Z A;  1R1O A;  4Q41 A;  3MFV A;  4RHM A;  3THJ A;  3LHL A;  4Q3U A;  1TBJ A;  2A0M A;  4I06 A;  5HJ9 A;  4FCK A;  3DJ8 A;  1TBL A;  1T4R A;  4RHQ A;  4RHK A;  4IU0 A;  1ZPE A;  4GWC A;  1WVB A;  1P8Q A;  4MYF A;  4IE1 A;  3TF3 A;  4GSZ A;  4IU4 A;  4HXQ A;  1P8O A;  4Q3V A;  1T4S A;  3E6K A;  1WVA A;  3SL1 A;  4Q3R A;  5CEV A;  4HZE A;  4DZ4 A;  4IXV A;  4HWW A;  3SJT A;  1P8P A;  1WOI A;  4Q3R C;  1HQ5 A;  4IXU A;  3THE A;  4Q3P A;  1HQG A;  1P8R A;  3NIP A;  4ITY A;  3GN0 A;  2AEB A;  4IU1 A;  3MFW A;  3LP4 A;  3MMR A;  1T5F A;  1TBH A;  3PZL A;  4GSV A;  1XFK A;  3MJL A;  4Q3T A;  4GWD A;  4RHI A;  3KV2 A;  3E9B A;  3M1R A;  1P8N A;  1GQ6 A;  1T4P A;  2EIV A;  1TA1 A;  4G3H A;  3TH7 A;  1T5G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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