3SL0A

Crystal structure of p. falciparum arginase complexed with 2-amino-6-borono-2-(difluoromethyl)hexanoic acid
Total Genus 118

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
390
structure length
308
Chain Sequence
KNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDNCYYDNIRNIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYFEWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVHGDSLPILDNATKTGKLCLELIARVLGYDIV
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (23-28)S5 (265-270)EMPTYO1 (29-31)AH1 (43-59)TI1 (32-35)3H1 (40-42)AH7 (299-310)TI2 (207-210)TIV1 (156-159)TII1 (159-162)AH2 (162-182)TI3 (223-226)3H2 (193-196)S3 (185-189)TI6 (254-257)S4 (211-215)TI4 (224-227)3H3 (232-234)TI5 (227-230)TII2 (248-251)S6 (287-290)AH5 (275-284)AH6 (291-297)AH4 (235-241)AH3 (197-206)3H4 (252-254)S2 (62-68)3H5 (262-264)TVIII1 (216-219)Updating...
connected with : NaN
molecule tags Hydrolase/hydrolase inhibitor
source organism Plasmodium falciparum
publication title Binding of alpha,alpha-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design
pubmed doi rcsb
molecule keywords Arginase
total genus 118
structure length 308
sequence length 390
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2011-06-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3sl0A00
4Q42A 1P8SA 4GSZA 3LP4A 4MYFA 3LHLA 3SKKA 3DJ8A 3NIOA 4HZEA 4RHLA 3E6VA 3E9BA 5CEVA 3SL0A 1P8QA 4RHIA 1P8RA 2EF4A 3TF3A 4MYKA 1WOGA 3THHA 1T4SA 3MMRA 2PHAA 1GQ6A 5RLAA 4GSMA 3LP7A 1XFKA 3THEA 4IU1A 2CEVA 3GMZA 1GQ7A 1WVAA 3THJA 1HQ5A 4MYNA 1T4RA 3SL1A 2RLAA 1TA1A 4MYLA 4FCKA 3NIPA 4I06A 4HWWA 4RLAA 1D3VA 3E8ZA 1HQHA 4Q41A 1P8OA 4GWDA 1TBJA 3GN0A 4ITYA 2A0MA 4IE2A 1T4PA 4GWCA 3MFWA 3F80A 1R1OA 1TBHA 4MXRA 1WOHA 5HJ9A 3TH7A 1T5GA 4CEVA 4GSVA 4RHMA 4Q3PA 3E6KA 4IU5A 4Q3VA 4IXUA 2EIVA 4G3HA 1HQXA 1WOIA 4RHKA 4IXVA 4IE3A 1ZPGA 3E8QA 4FCIA 4DZ4A 4Q3UA 1P8PA 1P8NA 3RLAA 1CEVA 2PLLA 1TBLA 4IU0A 4Q3TA 4Q3RC 5HJAA 2AEBA 1T4TA 2PHOA 3CEVA 4IE1A 4RHJA 1RLAA 4Q40A 3M1RA 4Q3RA 1T5FA 4RHQA 3PZLA 3KV2A 4Q3SA 3NIQA 2EF5A 3MFVA 1ZPEA 1PQ3A 1HQGA 4IU4A 2ZAVA 3MJLA 1P8MA 4Q3QA 1HQFA 3SJTA 1WVBA 4HXQA
chains in the Genus database with same CATH superfamily
3SFHA 5DC8A 4Q42A 1P8SA 3ZNRA 4GSZA 3C0YA 3LP4A 4MYFA 3LHLA 5EFGA 5ICNB 1C3PA 3DJ8A 3NIOA 4HZEA 5D1CA 3Q9EA 3E6VA 3E9BA 4RHLA 3EW8A 3ZNSA 5CEVA 3SL0A 1P8QA 2VCGA 1ZZ1A 4RHIA 4BZ7A 2V5XA 5THVA 1P8RA 2EF4A 5G13A 3RQDA 5EEIA 5EFBD 4CBYA 3TF3A 5D1DA 5FUEA 5EEKA 4MYKA 4ZUOA 5G3WA 5EFKB 5BWZA 1T67A 1WOGA 4QA3A 3THHA 1T4SA 3MMRA 4BZ5A 2PHAA 5EF8A 3MZ7A 5D1BA 5EEMA 1GQ6A 4BZ6A 5RLAA 4GSMA 3LP7A 4ZURA 3F07A 4BKXB 1XFKA 5IWGA 4LXZA 3THEA 2VQMA 4IU1A 5G17A 2CEVA 3F0RA 3GMZA 1GQ7A 3MZ3A 1WVAA 3THJA 4A69A 1HQ5A 5G1BA 4MYNA 1T4RA 3SL1A 2RLAA 5LI3A 3MENA 1TA1A 1T64A 4MYLA 4FCKA 3SFFA 3NIPA 4I06A 4HWWA 5EF7A 4RLAA 1D3VA 3E8ZA 1HQHA 4RN0A 5G1CA 2V5WA 1C3RA 5FCWA 4RN1A 2VQWG 5G10A 4Q41A 1P8OA 4GWDA 1TBJA 3GN0A 5G0GA 4ITYA 3EWFA 2A0MA 3C10A 4ZUNA 3MZ4A 4IE2A 4RN2A 1T4PA 4GWCA 3F80A 3MAXA 3MFWA 1R1OA 3F06A 1ZZ3A 5EFJD 3SKKA 1TBHA 4MXRA 4ZUPA 1WOHA 4LY1A 5HJ9A 5EFHA 3TH7A 4BZ9A 1T5GA 4ZUQA 4CEVA 4QA7A 4GSVA 1VKGA 4Q3PA 4RHMA 3EZTA 5G12A 3C0ZA 3E6KA 2VQVA 4IU5A 4Q3VA 3Q9BA 4IXUA 2EIVA 4G3HA 4BZ8A 5G0IA 1HQXA 4QA5A 5G1AA 5G0HA 4ZUMA 1WOIA 2GH6A 3Q9FA 4RHKA 5JI5A 4IXVA 4IE3A 1ZPGA 3E8QA 4FCIA 4DZ4A 4Q3UA 5G0YA 1P8PA 1P8NA 3RLAA 1CEVA 1ZZ0A 2PLLA 4QA1A 1TBLA 4IU0A 5DC7A 3Q9CA 4Q3TA 4QA6A 4Q3RC 5EEFA 5HJAA 2AEBA 1T4TA 2PHOA 1W22A 2VQOA 3CEVA 1RLAA 4IE1A 4Q40A 4RHJA 3EZPA 3M1RA 5EFNA 4QA4A 4Q3RA 1T5FA 5G11A 5THTA 5G0XA 5EENA 2VQJA 4QA0A 4RHQA 3PZLA 5THSA 3KV2A 4CQFA 4Q3SA 3NIQA 2EF5A 3MFVA 1ZPEA 1PQ3A 1HQGA 1T69A 4QA2A 5DC5A 4IU4A 3MZ6A 5DC6A 5THUA 5IX0A 2ZAVA 5A2SA 1C3SA 5G0JA 3MJLA 1P8MA 2VQQA 4Q3QA 1HQFA 3SJTA 4CBTA 1WVBA 4HXQA
chains in the Genus database with same CATH topology
4Q42A 1P8SA 4GSZA 3LP4A 4MYFA 3LHLA 3SKKA 3DJ8A 3NIOA 4HZEA 4RHLA 3E6VA 3E9BA 5CEVA 3SL0A 1P8QA 4RHIA 1P8RA 2EF4A 3TF3A 4MYKA 1WOGA 3THHA 1T4SA 3MMRA 2PHAA 1GQ6A 5RLAA 4GSMA 3LP7A 1XFKA 3THEA 4IU1A 2CEVA 3GMZA 1GQ7A 1WVAA 3THJA 1HQ5A 4MYNA 1T4RA 3SL1A 2RLAA 1TA1A 4MYLA 4FCKA 3NIPA 4I06A 4HWWA 4RLAA 1D3VA 3E8ZA 1HQHA 4Q41A 1P8OA 4GWDA 1TBJA 3GN0A 4ITYA 2A0MA 4IE2A 1T4PA 4GWCA 3MFWA 3F80A 1R1OA 1TBHA 4MXRA 1WOHA 5HJ9A 3TH7A 1T5GA 4CEVA 4GSVA 4RHMA 4Q3PA 3E6KA 4IU5A 4Q3VA 4IXUA 2EIVA 4G3HA 1HQXA 1WOIA 4RHKA 4IXVA 4IE3A 1ZPGA 3E8QA 4FCIA 4DZ4A 4Q3UA 1P8PA 1P8NA 3RLAA 1CEVA 2PLLA 1TBLA 4IU0A 4Q3TA 4Q3RC 5HJAA 2AEBA 1T4TA 2PHOA 3CEVA 4IE1A 4RHJA 1RLAA 4Q40A 3M1RA 4Q3RA 1T5FA 4RHQA 3PZLA 3KV2A 4Q3SA 3NIQA 2EF5A 3MFVA 1ZPEA 1PQ3A 1HQGA 4IU4A 2ZAVA 3MJLA 1P8MA 4Q3QA 1HQFA 3SJTA 1WVBA 4HXQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q42 A;  1P8S A;  4GSZ A;  3LP4 A;  4MYF A;  3LHL A;  3SKK A;  3DJ8 A;  3NIO A;  4HZE A;  4RHL A;  3E6V A;  3E9B A;  5CEV A;  3SL0 A;  1P8Q A;  4RHI A;  1P8R A;  2EF4 A;  3TF3 A;  4MYK A;  1WOG A;  3THH A;  1T4S A;  3MMR A;  2PHA A;  1GQ6 A;  5RLA A;  4GSM A;  3LP7 A;  1XFK A;  3THE A;  4IU1 A;  2CEV A;  3GMZ A;  1GQ7 A;  1WVA A;  3THJ A;  1HQ5 A;  4MYN A;  1T4R A;  3SL1 A;  2RLA A;  1TA1 A;  4MYL A;  4FCK A;  3NIP A;  4I06 A;  4HWW A;  4RLA A;  1D3V A;  3E8Z A;  1HQH A;  4Q41 A;  1P8O A;  4GWD A;  1TBJ A;  3GN0 A;  4ITY A;  2A0M A;  4IE2 A;  1T4P A;  4GWC A;  3MFW A;  3F80 A;  1R1O A;  1TBH A;  4MXR A;  1WOH A;  5HJ9 A;  3TH7 A;  1T5G A;  4CEV A;  4GSV A;  4RHM A;  4Q3P A;  3E6K A;  4IU5 A;  4Q3V A;  4IXU A;  2EIV A;  4G3H A;  1HQX A;  1WOI A;  4RHK A;  4IXV A;  4IE3 A;  1ZPG A;  3E8Q A;  4FCI A;  4DZ4 A;  4Q3U A;  1P8P A;  1P8N A;  3RLA A;  1CEV A;  2PLL A;  1TBL A;  4IU0 A;  4Q3T A;  4Q3R C;  5HJA A;  2AEB A;  1T4T A;  2PHO A;  3CEV A;  4IE1 A;  4RHJ A;  1RLA A;  4Q40 A;  3M1R A;  4Q3R A;  1T5F A;  4RHQ A;  3PZL A;  3KV2 A;  4Q3S A;  3NIQ A;  2EF5 A;  3MFV A;  1ZPE A;  1PQ3 A;  1HQG A;  4IU4 A;  2ZAV A;  3MJL A;  1P8M A;  4Q3Q A;  1HQF A;  3SJT A;  1WVB A;  4HXQ A; 
#chains in the Genus database with same CATH topology
 3SFH A;  5DC8 A;  4Q42 A;  1P8S A;  3ZNR A;  4GSZ A;  3C0Y A;  3LP4 A;  4MYF A;  3LHL A;  5EFG A;  5ICN B;  1C3P A;  3DJ8 A;  3NIO A;  4HZE A;  5D1C A;  3Q9E A;  3E6V A;  3E9B A;  4RHL A;  3EW8 A;  3ZNS A;  5CEV A;  3SL0 A;  1P8Q A;  2VCG A;  1ZZ1 A;  4RHI A;  4BZ7 A;  2V5X A;  5THV A;  1P8R A;  2EF4 A;  5G13 A;  3RQD A;  5EEI A;  5EFB D;  4CBY A;  3TF3 A;  5D1D A;  5FUE A;  5EEK A;  4MYK A;  4ZUO A;  5G3W A;  5EFK B;  5BWZ A;  1T67 A;  1WOG A;  4QA3 A;  3THH A;  1T4S A;  3MMR A;  4BZ5 A;  2PHA A;  5EF8 A;  3MZ7 A;  5D1B A;  5EEM A;  1GQ6 A;  4BZ6 A;  5RLA A;  4GSM A;  3LP7 A;  4ZUR A;  3F07 A;  4BKX B;  1XFK A;  5IWG A;  4LXZ A;  3THE A;  2VQM A;  4IU1 A;  5G17 A;  2CEV A;  3F0R A;  3GMZ A;  1GQ7 A;  3MZ3 A;  1WVA A;  3THJ A;  4A69 A;  1HQ5 A;  5G1B A;  4MYN A;  1T4R A;  3SL1 A;  2RLA A;  5LI3 A;  3MEN A;  1TA1 A;  1T64 A;  4MYL A;  4FCK A;  3SFF A;  3NIP A;  4I06 A;  4HWW A;  5EF7 A;  4RLA A;  1D3V A;  3E8Z A;  1HQH A;  4RN0 A;  5G1C A;  2V5W A;  1C3R A;  5FCW A;  4RN1 A;  2VQW G;  5G10 A;  4Q41 A;  1P8O A;  4GWD A;  1TBJ A;  3GN0 A;  5G0G A;  4ITY A;  3EWF A;  2A0M A;  3C10 A;  4ZUN A;  3MZ4 A;  4IE2 A;  4RN2 A;  1T4P A;  4GWC A;  3F80 A;  3MAX A;  3MFW A;  1R1O A;  3F06 A;  1ZZ3 A;  5EFJ D;  3SKK A;  1TBH A;  4MXR A;  4ZUP A;  1WOH A;  4LY1 A;  5HJ9 A;  5EFH A;  3TH7 A;  4BZ9 A;  1T5G A;  4ZUQ A;  4CEV A;  4QA7 A;  4GSV A;  1VKG A;  4Q3P A;  4RHM A;  3EZT A;  5G12 A;  3C0Z A;  3E6K A;  2VQV A;  4IU5 A;  4Q3V A;  3Q9B A;  4IXU A;  2EIV A;  4G3H A;  4BZ8 A;  5G0I A;  1HQX A;  4QA5 A;  5G1A A;  5G0H A;  4ZUM A;  1WOI A;  2GH6 A;  3Q9F A;  4RHK A;  5JI5 A;  4IXV A;  4IE3 A;  1ZPG A;  3E8Q A;  4FCI A;  4DZ4 A;  4Q3U A;  5G0Y A;  1P8P A;  1P8N A;  3RLA A;  1CEV A;  1ZZ0 A;  2PLL A;  4QA1 A;  1TBL A;  4IU0 A;  5DC7 A;  3Q9C A;  4Q3T A;  4QA6 A;  4Q3R C;  5EEF A;  5HJA A;  2AEB A;  1T4T A;  2PHO A;  1W22 A;  2VQO A;  3CEV A;  1RLA A;  4IE1 A;  4Q40 A;  4RHJ A;  3EZP A;  3M1R A;  5EFN A;  4QA4 A;  4Q3R A;  1T5F A;  5G11 A;  5THT A;  5G0X A;  5EEN A;  2VQJ A;  4QA0 A;  4RHQ A;  3PZL A;  5THS A;  3KV2 A;  4CQF A;  4Q3S A;  3NIQ A;  2EF5 A;  3MFV A;  1ZPE A;  1PQ3 A;  1HQG A;  1T69 A;  4QA2 A;  5DC5 A;  4IU4 A;  3MZ6 A;  5DC6 A;  5THU A;  5IX0 A;  2ZAV A;  5A2S A;  1C3S A;  5G0J A;  3MJL A;  1P8M A;  2VQQ A;  4Q3Q A;  1HQF A;  3SJT A;  4CBT A;  1WVB A;  4HXQ A; 
#chains in the Genus database with same CATH homology
 4Q42 A;  1P8S A;  4GSZ A;  3LP4 A;  4MYF A;  3LHL A;  3SKK A;  3DJ8 A;  3NIO A;  4HZE A;  4RHL A;  3E6V A;  3E9B A;  5CEV A;  3SL0 A;  1P8Q A;  4RHI A;  1P8R A;  2EF4 A;  3TF3 A;  4MYK A;  1WOG A;  3THH A;  1T4S A;  3MMR A;  2PHA A;  1GQ6 A;  5RLA A;  4GSM A;  3LP7 A;  1XFK A;  3THE A;  4IU1 A;  2CEV A;  3GMZ A;  1GQ7 A;  1WVA A;  3THJ A;  1HQ5 A;  4MYN A;  1T4R A;  3SL1 A;  2RLA A;  1TA1 A;  4MYL A;  4FCK A;  3NIP A;  4I06 A;  4HWW A;  4RLA A;  1D3V A;  3E8Z A;  1HQH A;  4Q41 A;  1P8O A;  4GWD A;  1TBJ A;  3GN0 A;  4ITY A;  2A0M A;  4IE2 A;  1T4P A;  4GWC A;  3MFW A;  3F80 A;  1R1O A;  1TBH A;  4MXR A;  1WOH A;  5HJ9 A;  3TH7 A;  1T5G A;  4CEV A;  4GSV A;  4RHM A;  4Q3P A;  3E6K A;  4IU5 A;  4Q3V A;  4IXU A;  2EIV A;  4G3H A;  1HQX A;  1WOI A;  4RHK A;  4IXV A;  4IE3 A;  1ZPG A;  3E8Q A;  4FCI A;  4DZ4 A;  4Q3U A;  1P8P A;  1P8N A;  3RLA A;  1CEV A;  2PLL A;  1TBL A;  4IU0 A;  4Q3T A;  4Q3R C;  5HJA A;  2AEB A;  1T4T A;  2PHO A;  3CEV A;  4IE1 A;  4RHJ A;  1RLA A;  4Q40 A;  3M1R A;  4Q3R A;  1T5F A;  4RHQ A;  3PZL A;  3KV2 A;  4Q3S A;  3NIQ A;  2EF5 A;  3MFV A;  1ZPE A;  1PQ3 A;  1HQG A;  4IU4 A;  2ZAV A;  3MJL A;  1P8M A;  4Q3Q A;  1HQF A;  3SJT A;  1WVB A;  4HXQ A; 
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