3SL0A

Crystal structure of p. falciparum arginase complexed with 2-amino-6-borono-2-(difluoromethyl)hexanoic acid
Total Genus 118
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
118
sequence length
390
structure length
308
Chain Sequence
KNVSIIGSPLAAGQPLGGVQLACDDLRKLGLHNVIDVLGWKYEDIGNIDNCYYDNIRNIKEIGIFSKNLFDTMSNELRKKNFVLNIGGDHGVAFSSILSSLQMYQNLRVIWIDAHGDINIPETSPSGNYHGMTLAHTLGLFKKKVPYFEWSENLTYLKPENTAIIGIRDIDAYEKIILKKCNINYYTIFDIEKNGIYNTICTALEKIDPNSNCPIHISLDIDSVDNVFAPGTGTVAKGGLNYREINLLMKILAETKRVVSMDLVEYNPSLDEVDKKVHGDSLPILDNATKTGKLCLELIARVLGYDIV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of alpha,alpha-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Plasmodium falciparum
molecule keywords Arginase
total genus 118
structure length 308
sequence length 390
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2011-06-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 3sl0A00
1WVBA 1HQFA 4IE3A 3GN0A 4Q3RC 1T4RA 3DJ8A 2A0MA 4HZEA 4IU4A 4RHIA 4Q3UA 1P8RA 3LP4A 1D3VA 5RLAA 1GQ6A 4RHKA 1P8PA 1T4PA 1P8SA 3MMRA 4IXUA 4RHJA 3SJTA 1T5FA 4GSMA 3M1RA 4MYKA 1ZPEA 1P8MA 4GWCA 3E6VA 2PHAA 3SL0A 3E6KA 3NIOA 4MYLA 3F80A 1P8NA 1P8OA 2ZAVA 4IXVA 4RHQA 1GQ7A 4FCIA 4Q42A 2CEVA 3RLAA 3NIQA 2AEBA 4Q3VA 3THEA 4GSZA 1R1OA 4Q3PA 1WOIA 4IE1A 3GMZA 1TA1A 3CEVA 1WOHA 3THHA 4MYFA 1XFKA 4MXRA 2PHOA 1ZPGA 4RLAA 1PQ3A 1HQXA 2EIVA 4HWWA 1WOGA 3MJLA 4RHMA 1HQ5A 1HQHA 1T5GA 1P8QA 3E8QA 3LHLA 3TH7A 4IU0A 4Q3TA 4CEVA 4RHLA 1WVAA 1TBLA 1RLAA 4Q3RA 1TBHA 4Q40A 3SL1A 4FCKA 5HJAA 1T4TA 3SKKA 4GWDA 4IE2A 2EF4A 2PLLA 3PZLA 4MYNA 3TF3A 4Q41A 4GSVA 2RLAA 4Q3SA 3MFVA 4HXQA 3E9BA 3NIPA 4Q3QA 5CEVA 1CEVA 4G3HA 3KV2A 3LP7A 3E8ZA 2EF5A 1TBJA 4I06A 4ITYA 4IU5A 4IU1A 1T4SA 3THJA 4DZ4A 5HJ9A 3MFWA 1HQGA
chains in the Genus database with same CATH superfamily
1WVBA 1HQFA 4IE3A 3GN0A 2VCGA 1ZZ0A 4Q3RC 5D1DA 4RN2A 1T4RA 3DJ8A 5G17A 2A0MA 4HZEA 4IU4A 4RHIA 4Q3UA 4QA6A 4QA3A 1P8RA 5G10A 3LP4A 4QA4A 1D3VA 5RLAA 1GQ6A 5EFGA 5G0YA 5D1BA 4RHKA 1P8PA 1T4PA 3SFHA 1P8SA 5A2SA 2VQVA 3MMRA 4IXUA 4RHJA 5EENA 3SJTA 5EEMA 1T5FA 4GSMA 5EFJD 3M1RA 4MYKA 5DC5A 5THTA 5FCWA 1ZPEA 1P8MA 2VQOA 4GWCA 4BZ8A 3E6VA 2PHAA 3SL0A 3E6KA 3NIOA 4MYLA 5G0XA 3F80A 1P8NA 5G13A 1P8OA 5G12A 4BKXB 2V5XA 2ZAVA 4ZUPA 5G1BA 4QA2A 5EFBD 4IXVA 5G1AA 4A69A 3MAXA 4RHQA 3EWFA 5HJAA 5G0JA 1GQ7A 1VKGA 4ZUOA 4FCIA 4Q42A 5ICNB 2CEVA 5G0IA 3RLAA 2VQWG 3NIQA 4ZUMA 2AEBA 4Q3VA 3THEA 5LI3A 4GSZA 3RQDA 1R1OA 4Q3PA 1WOIA 4IE1A 3GMZA 3MZ7A 5BWZA 1TA1A 3CEVA 1C3RA 1WOHA 5EFKB 4MYFA 3C0YA 3THHA 1XFKA 3MZ6A 1ZZ3A 3EZTA 3F07A 3Q9FA 4MXRA 4QA0A 4QA1A 5EEFA 5JI5A 5G3WA 2PHOA 1ZPGA 4RLAA 4BZ9A 1PQ3A 1HQXA 4RN0A 5IX0A 2EIVA 4HWWA 4LY1A 1WOGA 3MJLA 4RHMA 1HQ5A 1HQHA 1T5GA 1P8QA 1ZZ1A 3F0RA 3E8QA 1C3PA 3LHLA 3SFFA 3TH7A 5EEKA 4IU0A 4Q3TA 5EF8A 3ZNRA 5EFNA 4RHLA 4CEVA 4BZ6A 5D1CA 5G0HA 1WVAA 1TBLA 5EFHA 1RLAA 5EEIA 4Q3RA 2GH6A 2VQMA 4CQFA 1TBHA 5DC7A 5DC6A 4QA7A 4QA5A 4ZUNA 4Q40A 3Q9BA 1T67A 5THUA 5THVA 5THSA 3SL1A 4FCKA 3C0ZA 4CBYA 1T4TA 3SKKA 4GWDA 4IE2A 2EF4A 2PLLA 3PZLA 3F06A 4MYNA 3TF3A 3MZ4A 3Q9CA 3ZNSA 4Q41A 4GSVA 1W22A 2RLAA 4Q3SA 3MFVA 4HXQA 3E9BA 3EW8A 1T69A 3EZPA 4ZURA 3Q9EA 5FUEA 3NIPA 5G1CA 4BZ7A 4Q3QA 5CEVA 1C3SA 1CEVA 4G3HA 4ZUQA 3KV2A 5EF7A 3LP7A 4RN1A 5IWGA 3E8ZA 2EF5A 1TBJA 4LXZA 3C10A 4I06A 2V5WA 3MENA 2VQJA 4ITYA 5G0GA 4IU5A 4IU1A 5G11A 1T4SA 4BZ5A 4CBTA 3THJA 4DZ4A 3MZ3A 5HJ9A 5DC8A 1T64A 3MFWA 1HQGA 2VQQA
chains in the Genus database with same CATH topology
1WVBA 1HQFA 4IE3A 3GN0A 4Q3RC 1T4RA 3DJ8A 2A0MA 4HZEA 4IU4A 4RHIA 4Q3UA 1P8RA 3LP4A 1D3VA 5RLAA 1GQ6A 4RHKA 1P8PA 1T4PA 1P8SA 3MMRA 4IXUA 4RHJA 3SJTA 1T5FA 4GSMA 3M1RA 4MYKA 1ZPEA 1P8MA 4GWCA 3E6VA 2PHAA 3SL0A 3E6KA 3NIOA 4MYLA 3F80A 1P8NA 1P8OA 2ZAVA 4IXVA 4RHQA 1GQ7A 4FCIA 4Q42A 2CEVA 3RLAA 3NIQA 2AEBA 4Q3VA 3THEA 4GSZA 1R1OA 4Q3PA 1WOIA 4IE1A 3GMZA 1TA1A 3CEVA 1WOHA 3THHA 4MYFA 1XFKA 4MXRA 2PHOA 1ZPGA 4RLAA 1PQ3A 1HQXA 2EIVA 4HWWA 1WOGA 3MJLA 4RHMA 1HQ5A 1HQHA 1T5GA 1P8QA 3E8QA 3LHLA 3TH7A 4IU0A 4Q3TA 4CEVA 4RHLA 1WVAA 1TBLA 1RLAA 4Q3RA 1TBHA 4Q40A 3SL1A 4FCKA 5HJAA 1T4TA 3SKKA 4GWDA 4IE2A 2EF4A 2PLLA 3PZLA 4MYNA 3TF3A 4Q41A 4GSVA 2RLAA 4Q3SA 3MFVA 4HXQA 3E9BA 3NIPA 4Q3QA 5CEVA 1CEVA 4G3HA 3KV2A 3LP7A 3E8ZA 2EF5A 1TBJA 4I06A 4ITYA 4IU5A 4IU1A 1T4SA 3THJA 4DZ4A 5HJ9A 3MFWA 1HQGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WVB A;  1HQF A;  4IE3 A;  3GN0 A;  4Q3R C;  1T4R A;  3DJ8 A;  2A0M A;  4HZE A;  4IU4 A;  4RHI A;  4Q3U A;  1P8R A;  3LP4 A;  1D3V A;  5RLA A;  1GQ6 A;  4RHK A;  1P8P A;  1T4P A;  1P8S A;  3MMR A;  4IXU A;  4RHJ A;  3SJT A;  1T5F A;  4GSM A;  3M1R A;  4MYK A;  1ZPE A;  1P8M A;  4GWC A;  3E6V A;  2PHA A;  3SL0 A;  3E6K A;  3NIO A;  4MYL A;  3F80 A;  1P8N A;  1P8O A;  2ZAV A;  4IXV A;  4RHQ A;  1GQ7 A;  4FCI A;  4Q42 A;  2CEV A;  3RLA A;  3NIQ A;  2AEB A;  4Q3V A;  3THE A;  4GSZ A;  1R1O A;  4Q3P A;  1WOI A;  4IE1 A;  3GMZ A;  1TA1 A;  3CEV A;  1WOH A;  3THH A;  4MYF A;  1XFK A;  4MXR A;  2PHO A;  1ZPG A;  4RLA A;  1PQ3 A;  1HQX A;  2EIV A;  4HWW A;  1WOG A;  3MJL A;  4RHM A;  1HQ5 A;  1HQH A;  1T5G A;  1P8Q A;  3E8Q A;  3LHL A;  3TH7 A;  4IU0 A;  4Q3T A;  4CEV A;  4RHL A;  1WVA A;  1TBL A;  1RLA A;  4Q3R A;  1TBH A;  4Q40 A;  3SL1 A;  4FCK A;  5HJA A;  1T4T A;  3SKK A;  4GWD A;  4IE2 A;  2EF4 A;  2PLL A;  3PZL A;  4MYN A;  3TF3 A;  4Q41 A;  4GSV A;  2RLA A;  4Q3S A;  3MFV A;  4HXQ A;  3E9B A;  3NIP A;  4Q3Q A;  5CEV A;  1CEV A;  4G3H A;  3KV2 A;  3LP7 A;  3E8Z A;  2EF5 A;  1TBJ A;  4I06 A;  4ITY A;  4IU5 A;  4IU1 A;  1T4S A;  3THJ A;  4DZ4 A;  5HJ9 A;  3MFW A;  1HQG A; 
#chains in the Genus database with same CATH topology
 1WVB A;  1HQF A;  4IE3 A;  3GN0 A;  2VCG A;  1ZZ0 A;  4Q3R C;  5D1D A;  4RN2 A;  1T4R A;  3DJ8 A;  5G17 A;  2A0M A;  4HZE A;  4IU4 A;  4RHI A;  4Q3U A;  4QA6 A;  4QA3 A;  1P8R A;  5G10 A;  3LP4 A;  4QA4 A;  1D3V A;  5RLA A;  1GQ6 A;  5EFG A;  5G0Y A;  5D1B A;  4RHK A;  1P8P A;  1T4P A;  3SFH A;  1P8S A;  5A2S A;  2VQV A;  3MMR A;  4IXU A;  4RHJ A;  5EEN A;  3SJT A;  5EEM A;  1T5F A;  4GSM A;  5EFJ D;  3M1R A;  4MYK A;  5DC5 A;  5THT A;  5FCW A;  1ZPE A;  1P8M A;  2VQO A;  4GWC A;  4BZ8 A;  3E6V A;  2PHA A;  3SL0 A;  3E6K A;  3NIO A;  4MYL A;  5G0X A;  3F80 A;  1P8N A;  5G13 A;  1P8O A;  5G12 A;  4BKX B;  2V5X A;  2ZAV A;  4ZUP A;  5G1B A;  4QA2 A;  5EFB D;  4IXV A;  5G1A A;  4A69 A;  3MAX A;  4RHQ A;  3EWF A;  5HJA A;  5G0J A;  1GQ7 A;  1VKG A;  4ZUO A;  4FCI A;  4Q42 A;  5ICN B;  2CEV A;  5G0I A;  3RLA A;  2VQW G;  3NIQ A;  4ZUM A;  2AEB A;  4Q3V A;  3THE A;  5LI3 A;  4GSZ A;  3RQD A;  1R1O A;  4Q3P A;  1WOI A;  4IE1 A;  3GMZ A;  3MZ7 A;  5BWZ A;  1TA1 A;  3CEV A;  1C3R A;  1WOH A;  5EFK B;  4MYF A;  3C0Y A;  3THH A;  1XFK A;  3MZ6 A;  1ZZ3 A;  3EZT A;  3F07 A;  3Q9F A;  4MXR A;  4QA0 A;  4QA1 A;  5EEF A;  5JI5 A;  5G3W A;  2PHO A;  1ZPG A;  4RLA A;  4BZ9 A;  1PQ3 A;  1HQX A;  4RN0 A;  5IX0 A;  2EIV A;  4HWW A;  4LY1 A;  1WOG A;  3MJL A;  4RHM A;  1HQ5 A;  1HQH A;  1T5G A;  1P8Q A;  1ZZ1 A;  3F0R A;  3E8Q A;  1C3P A;  3LHL A;  3SFF A;  3TH7 A;  5EEK A;  4IU0 A;  4Q3T A;  5EF8 A;  3ZNR A;  5EFN A;  4RHL A;  4CEV A;  4BZ6 A;  5D1C A;  5G0H A;  1WVA A;  1TBL A;  5EFH A;  1RLA A;  5EEI A;  4Q3R A;  2GH6 A;  2VQM A;  4CQF A;  1TBH A;  5DC7 A;  5DC6 A;  4QA7 A;  4QA5 A;  4ZUN A;  4Q40 A;  3Q9B A;  1T67 A;  5THU A;  5THV A;  5THS A;  3SL1 A;  4FCK A;  3C0Z A;  4CBY A;  1T4T A;  3SKK A;  4GWD A;  4IE2 A;  2EF4 A;  2PLL A;  3PZL A;  3F06 A;  4MYN A;  3TF3 A;  3MZ4 A;  3Q9C A;  3ZNS A;  4Q41 A;  4GSV A;  1W22 A;  2RLA A;  4Q3S A;  3MFV A;  4HXQ A;  3E9B A;  3EW8 A;  1T69 A;  3EZP A;  4ZUR A;  3Q9E A;  5FUE A;  3NIP A;  5G1C A;  4BZ7 A;  4Q3Q A;  5CEV A;  1C3S A;  1CEV A;  4G3H A;  4ZUQ A;  3KV2 A;  5EF7 A;  3LP7 A;  4RN1 A;  5IWG A;  3E8Z A;  2EF5 A;  1TBJ A;  4LXZ A;  3C10 A;  4I06 A;  2V5W A;  3MEN A;  2VQJ A;  4ITY A;  5G0G A;  4IU5 A;  4IU1 A;  5G11 A;  1T4S A;  4BZ5 A;  4CBT A;  3THJ A;  4DZ4 A;  3MZ3 A;  5HJ9 A;  5DC8 A;  1T64 A;  3MFW A;  1HQG A;  2VQQ A; 
#chains in the Genus database with same CATH homology
 1WVB A;  1HQF A;  4IE3 A;  3GN0 A;  4Q3R C;  1T4R A;  3DJ8 A;  2A0M A;  4HZE A;  4IU4 A;  4RHI A;  4Q3U A;  1P8R A;  3LP4 A;  1D3V A;  5RLA A;  1GQ6 A;  4RHK A;  1P8P A;  1T4P A;  1P8S A;  3MMR A;  4IXU A;  4RHJ A;  3SJT A;  1T5F A;  4GSM A;  3M1R A;  4MYK A;  1ZPE A;  1P8M A;  4GWC A;  3E6V A;  2PHA A;  3SL0 A;  3E6K A;  3NIO A;  4MYL A;  3F80 A;  1P8N A;  1P8O A;  2ZAV A;  4IXV A;  4RHQ A;  1GQ7 A;  4FCI A;  4Q42 A;  2CEV A;  3RLA A;  3NIQ A;  2AEB A;  4Q3V A;  3THE A;  4GSZ A;  1R1O A;  4Q3P A;  1WOI A;  4IE1 A;  3GMZ A;  1TA1 A;  3CEV A;  1WOH A;  3THH A;  4MYF A;  1XFK A;  4MXR A;  2PHO A;  1ZPG A;  4RLA A;  1PQ3 A;  1HQX A;  2EIV A;  4HWW A;  1WOG A;  3MJL A;  4RHM A;  1HQ5 A;  1HQH A;  1T5G A;  1P8Q A;  3E8Q A;  3LHL A;  3TH7 A;  4IU0 A;  4Q3T A;  4CEV A;  4RHL A;  1WVA A;  1TBL A;  1RLA A;  4Q3R A;  1TBH A;  4Q40 A;  3SL1 A;  4FCK A;  5HJA A;  1T4T A;  3SKK A;  4GWD A;  4IE2 A;  2EF4 A;  2PLL A;  3PZL A;  4MYN A;  3TF3 A;  4Q41 A;  4GSV A;  2RLA A;  4Q3S A;  3MFV A;  4HXQ A;  3E9B A;  3NIP A;  4Q3Q A;  5CEV A;  1CEV A;  4G3H A;  3KV2 A;  3LP7 A;  3E8Z A;  2EF5 A;  1TBJ A;  4I06 A;  4ITY A;  4IU5 A;  4IU1 A;  1T4S A;  3THJ A;  4DZ4 A;  5HJ9 A;  3MFW A;  1HQG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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