4BZ7 | Genus

Total Genus 152

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	152
sequence length	434
structure length	399
Chain Sequence	SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLY

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Schistosoma mansoni
publication title	Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni. pubmed doi rcsb
molecule keywords	HISTONE DEACETYLASE 8
total genus	152
structure length	399
sequence length	434
chains with identical sequence	B, C, D
ec nomenclature
pdb deposition date	2013-07-24

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00850	Hist_deacetyl	Histone deacetylase domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase; Chain A	Histone deacetylase domain	4bz7A00

2GH6A 5G0JA 2VQJA 3MENA 5THTA 5LI3A 4BZ6A 3C0YA 5DC7A 5G0XA 3MZ3A 5THSA 1ZZ3A 5EFBD 1ZZ0A 3F0RA 4QA4A 5A2SA 3MZ7A 2VQOA 3RQDA 5EFGA 1C3RA 5THVA 5G3WA 2V5WA 4ZUPA 3ZNRA 5EFNA 4A69A 5G10A 5EFKB 2VCGA 5G1BA 5G17A 5DC8A 5G12A 4RN0A 5EENA 5G0IA 4QA2A 3EW8A 5EEMA 5G1CA 5G11A 5EEKA 4BZ9A 4ZUMA 3Q9BA 3MZ4A 1T69A 4BZ8A 1VKGA 4ZUNA 5THUA 4QA0A 4QA6A 3F06A 4BZ7A 3Q9EA 3ZNSA 5D1BA 2V5XA 3SFFA 5EFHA 5G0YA 5IX0A 4RN2A 3MZ6A 3Q9CA 5DC6A 3EZTA 4ZUOA 4ZURA 4CBTA 5FUEA 3EWFA 4BKXB 4QA3A 2VQVA 4CBYA 5EEFA 1C3SA 5EF8A 4QA5A 5IWGA 1T67A 4ZUQA 3Q9FA 5EF7A 4LXZA 5JI5A 3C0ZA 1T64A 4RN1A 3EZPA 4CQFA 3C10A 5G13A 5D1CA 4BZ5A 5BWZA 3SFHA 2VQWG 1W22A 5G1AA 5ICNB 4QA1A 5D1DA 5DC5A 1ZZ1A 2VQQA 2VQMA 5EFJD 4QA7A 5G0GA 5EEIA 3F07A 5FCWA 1C3PA 5G0HA 4LY1A 3MAXA
chains in the Genus database with same CATH superfamily

2GH6A 4GWCA 2VQJA 5G0JA 3F80A 3MENA 5THTA 5LI3A 2ZAVA 4IU4A 4BZ6A 3C0YA 5DC7A 5CEVA 5G0XA 3MZ3A 3E6KA 3NIQA 5THSA 4HZEA 1ZZ3A 2RLAA 1ZZ0A 1HQFA 4Q3UA 4RHIA 5EFBD 4I06A 3F0RA 4QA4A 3RLAA 3MZ7A 3GMZA 5A2SA 3NIOA 1T4TA 1ZPGA 2VQOA 5EFGA 3RQDA 1TA1A 3NIPA 1C3RA 4FCIA 5THVA 5G3WA 4GSMA 4RHMA 2V5WA 4ZUPA 3ZNRA 4MYNA 5EFNA 4A69A 1TBHA 5G10A 2VCGA 1XFKA 1ZPEA 1RLAA 5EFKB 3MMRA 5G1BA 4Q40A 5G17A 5DC8A 4IE3A 5G12A 2EIVA 4RN0A 4Q41A 1R1OA 4ITYA 4Q3SA 4MYLA 4Q3TA 2A0MA 3MFVA 4HXQA 4IU1A 3LP4A 3THEA 3SJTA 5EENA 5G0IA 4QA2A 3EW8A 5EEMA 4MXRA 2CEVA 2PHAA 4MYFA 4RHLA 5EEKA 5G1CA 4ZUMA 5G11A 4BZ9A 4IU0A 3Q9BA 3PZLA 1T5GA 4GSZA 4IU5A 1PQ3A 1T69A 1P8QA 1VKGA 3KV2A 2AEBA 3MZ4A 4ZUNA 4BZ8A 5THUA 4QA0A 4Q3RA 1WOIA 4QA6A 3F06A 3TF3A 3SL1A 4BZ7A 3THHA 4Q3RC 1P8OA 3Q9EA 4Q3QA 1D3VA 1T4PA 3ZNSA 5D1BA 3SL0A 2V5XA 4Q42A 1WOHA 3SFFA 5EFHA 5G0YA 4MYKA 1P8MA 5IX0A 1HQHA 1P8NA 1T4SA 5HJ9A 4RN2A 3MZ6A 4IXVA 3E8QA 4RLAA 3Q9CA 4FCKA 2EF5A 5DC6A 3EZTA 4ZUOA 4Q3VA 4ZURA 4CBTA 5FUEA 3GN0A 3EWFA 4BKXB 4QA3A 2VQVA 4CBYA 1WVBA 5EEFA 1C3SA 1T4RA 1TBLA 5EF8A 4IE2A 1CEVA 4QA5A 5IWGA 3E8ZA 1T67A 1WOGA 4CEVA 3CEVA 3Q9FA 4GSVA 4ZUQA 3E6VA 5EF7A 1HQGA 1T5FA 4LXZA 5JI5A 3C0ZA 1T64A 4RHJA 3MAXA 3M1RA 3SKKA 4RN1A 2PHOA 4IE1A 2PLLA 3EZPA 4CQFA 2EF4A 1P8PA 3C10A 5G13A 5D1CA 4BZ5A 3THJA 5BWZA 3MFWA 3SFHA 3DJ8A 2VQWG 1HQ5A 1W22A 5G1AA 5ICNB 4DZ4A 5RLAA 5HJAA 4QA1A 4RHKA 4G3HA 5D1DA 4GWDA 1P8SA 5DC5A 1GQ7A 3LHLA 3LP7A 1GQ6A 1ZZ1A 4Q3PA 2VQQA 2VQMA 4IXUA 1HQXA 1TBJA 3MJLA 1P8RA 5EFJD 4QA7A 4RHQA 5G0GA 5EEIA 3F07A 5FCWA 1C3PA 5G0HA 3TH7A 3E9BA 4LY1A 1WVAA 4HWWA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2GH6 A;  5G0J A;  2VQJ A;  3MEN A;  5THT A;  5LI3 A;  4BZ6 A;  3C0Y A;  5DC7 A;  5G0X A;  3MZ3 A;  5THS A;  1ZZ3 A;  5EFB D;  1ZZ0 A;  3F0R A;  4QA4 A;  5A2S A;  3MZ7 A;  2VQO A;  3RQD A;  5EFG A;  1C3R A;  5THV A;  5G3W A;  2V5W A;  4ZUP A;  3ZNR A;  5EFN A;  4A69 A;  5G10 A;  5EFK B;  2VCG A;  5G1B A;  5G17 A;  5DC8 A;  5G12 A;  4RN0 A;  5EEN A;  5G0I A;  4QA2 A;  3EW8 A;  5EEM A;  5G1C A;  5G11 A;  5EEK A;  4BZ9 A;  4ZUM A;  3Q9B A;  3MZ4 A;  1T69 A;  4BZ8 A;  1VKG A;  4ZUN A;  5THU A;  4QA0 A;  4QA6 A;  3F06 A;  4BZ7 A;  3Q9E A;  3ZNS A;  5D1B A;  2V5X A;  3SFF A;  5EFH A;  5G0Y A;  5IX0 A;  4RN2 A;  3MZ6 A;  3Q9C A;  5DC6 A;  3EZT A;  4ZUO A;  4ZUR A;  4CBT A;  5FUE A;  3EWF A;  4BKX B;  4QA3 A;  2VQV A;  4CBY A;  5EEF A;  1C3S A;  5EF8 A;  4QA5 A;  5IWG A;  1T67 A;  4ZUQ A;  3Q9F A;  5EF7 A;  4LXZ A;  5JI5 A;  3C0Z A;  1T64 A;  4RN1 A;  3EZP A;  4CQF A;  3C10 A;  5G13 A;  5D1C A;  4BZ5 A;  5BWZ A;  3SFH A;  2VQW G;  1W22 A;  5G1A A;  5ICN B;  4QA1 A;  5D1D A;  5DC5 A;  1ZZ1 A;  2VQQ A;  2VQM A;  5EFJ D;  4QA7 A;  5G0G A;  5EEI A;  3F07 A;  5FCW A;  1C3P A;  5G0H A;  4LY1 A;  3MAX A; 
#chains in the Genus database with same CATH topology
 2GH6 A;  4GWC A;  2VQJ A;  5G0J A;  3F80 A;  3MEN A;  5THT A;  5LI3 A;  2ZAV A;  4IU4 A;  4BZ6 A;  3C0Y A;  5DC7 A;  5CEV A;  5G0X A;  3MZ3 A;  3E6K A;  3NIQ A;  5THS A;  4HZE A;  1ZZ3 A;  2RLA A;  1ZZ0 A;  1HQF A;  4Q3U A;  4RHI A;  5EFB D;  4I06 A;  3F0R A;  4QA4 A;  3RLA A;  3MZ7 A;  3GMZ A;  5A2S A;  3NIO A;  1T4T A;  1ZPG A;  2VQO A;  5EFG A;  3RQD A;  1TA1 A;  3NIP A;  1C3R A;  4FCI A;  5THV A;  5G3W A;  4GSM A;  4RHM A;  2V5W A;  4ZUP A;  3ZNR A;  4MYN A;  5EFN A;  4A69 A;  1TBH A;  5G10 A;  2VCG A;  1XFK A;  1ZPE A;  1RLA A;  5EFK B;  3MMR A;  5G1B A;  4Q40 A;  5G17 A;  5DC8 A;  4IE3 A;  5G12 A;  2EIV A;  4RN0 A;  4Q41 A;  1R1O A;  4ITY A;  4Q3S A;  4MYL A;  4Q3T A;  2A0M A;  3MFV A;  4HXQ A;  4IU1 A;  3LP4 A;  3THE A;  3SJT A;  5EEN A;  5G0I A;  4QA2 A;  3EW8 A;  5EEM A;  4MXR A;  2CEV A;  2PHA A;  4MYF A;  4RHL A;  5EEK A;  5G1C A;  4ZUM A;  5G11 A;  4BZ9 A;  4IU0 A;  3Q9B A;  3PZL A;  1T5G A;  4GSZ A;  4IU5 A;  1PQ3 A;  1T69 A;  1P8Q A;  1VKG A;  3KV2 A;  2AEB A;  3MZ4 A;  4ZUN A;  4BZ8 A;  5THU A;  4QA0 A;  4Q3R A;  1WOI A;  4QA6 A;  3F06 A;  3TF3 A;  3SL1 A;  4BZ7 A;  3THH A;  4Q3R C;  1P8O A;  3Q9E A;  4Q3Q A;  1D3V A;  1T4P A;  3ZNS A;  5D1B A;  3SL0 A;  2V5X A;  4Q42 A;  1WOH A;  3SFF A;  5EFH A;  5G0Y A;  4MYK A;  1P8M A;  5IX0 A;  1HQH A;  1P8N A;  1T4S A;  5HJ9 A;  4RN2 A;  3MZ6 A;  4IXV A;  3E8Q A;  4RLA A;  3Q9C A;  4FCK A;  2EF5 A;  5DC6 A;  3EZT A;  4ZUO A;  4Q3V A;  4ZUR A;  4CBT A;  5FUE A;  3GN0 A;  3EWF A;  4BKX B;  4QA3 A;  2VQV A;  4CBY A;  1WVB A;  5EEF A;  1C3S A;  1T4R A;  1TBL A;  5EF8 A;  4IE2 A;  1CEV A;  4QA5 A;  5IWG A;  3E8Z A;  1T67 A;  1WOG A;  4CEV A;  3CEV A;  3Q9F A;  4GSV A;  4ZUQ A;  3E6V A;  5EF7 A;  1HQG A;  1T5F A;  4LXZ A;  5JI5 A;  3C0Z A;  1T64 A;  4RHJ A;  3MAX A;  3M1R A;  3SKK A;  4RN1 A;  2PHO A;  4IE1 A;  2PLL A;  3EZP A;  4CQF A;  2EF4 A;  1P8P A;  3C10 A;  5G13 A;  5D1C A;  4BZ5 A;  3THJ A;  5BWZ A;  3MFW A;  3SFH A;  3DJ8 A;  2VQW G;  1HQ5 A;  1W22 A;  5G1A A;  5ICN B;  4DZ4 A;  5RLA A;  5HJA A;  4QA1 A;  4RHK A;  4G3H A;  5D1D A;  4GWD A;  1P8S A;  5DC5 A;  1GQ7 A;  3LHL A;  3LP7 A;  1GQ6 A;  1ZZ1 A;  4Q3P A;  2VQQ A;  2VQM A;  4IXU A;  1HQX A;  1TBJ A;  3MJL A;  1P8R A;  5EFJ D;  4QA7 A;  4RHQ A;  5G0G A;  5EEI A;  3F07 A;  5FCW A;  1C3P A;  5G0H A;  3TH7 A;  3E9B A;  4LY1 A;  1WVA A;  4HWW A; 
#chains in the Genus database with same CATH homology
 2GH6 A;  5G0J A;  2VQJ A;  3MEN A;  5THT A;  5LI3 A;  4BZ6 A;  3C0Y A;  5DC7 A;  5G0X A;  3MZ3 A;  5THS A;  1ZZ3 A;  5EFB D;  1ZZ0 A;  3F0R A;  4QA4 A;  5A2S A;  3MZ7 A;  2VQO A;  3RQD A;  5EFG A;  1C3R A;  5THV A;  5G3W A;  2V5W A;  4ZUP A;  3ZNR A;  5EFN A;  4A69 A;  5G10 A;  5EFK B;  2VCG A;  5G1B A;  5G17 A;  5DC8 A;  5G12 A;  4RN0 A;  5EEN A;  5G0I A;  4QA2 A;  3EW8 A;  5EEM A;  5G1C A;  5G11 A;  5EEK A;  4BZ9 A;  4ZUM A;  3Q9B A;  3MZ4 A;  1T69 A;  4BZ8 A;  1VKG A;  4ZUN A;  5THU A;  4QA0 A;  4QA6 A;  3F06 A;  4BZ7 A;  3Q9E A;  3ZNS A;  5D1B A;  2V5X A;  3SFF A;  5EFH A;  5G0Y A;  5IX0 A;  4RN2 A;  3MZ6 A;  3Q9C A;  5DC6 A;  3EZT A;  4ZUO A;  4ZUR A;  4CBT A;  5FUE A;  3EWF A;  4BKX B;  4QA3 A;  2VQV A;  4CBY A;  5EEF A;  1C3S A;  5EF8 A;  4QA5 A;  5IWG A;  1T67 A;  4ZUQ A;  3Q9F A;  5EF7 A;  4LXZ A;  5JI5 A;  3C0Z A;  1T64 A;  4RN1 A;  3EZP A;  4CQF A;  3C10 A;  5G13 A;  5D1C A;  4BZ5 A;  5BWZ A;  3SFH A;  2VQW G;  1W22 A;  5G1A A;  5ICN B;  4QA1 A;  5D1D A;  5DC5 A;  1ZZ1 A;  2VQQ A;  2VQM A;  5EFJ D;  4QA7 A;  5G0G A;  5EEI A;  3F07 A;  5FCW A;  1C3P A;  5G0H A;  4LY1 A;  3MAX A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4BZ7A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations