4BZ8A

Crystal structure of schistosoma mansoni hdac8 complexed with j1038
Total Genus 144
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
426
structure length
393
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSTPTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPNSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYD
50100150200250300350300200100
020406080100120140Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTVIII1 (128-131)S1 (3-6)AH2 (23-35)AH1 (9-16)S3 (132-135)TI2 (104-107)TIV1 (18-21)TI1 (19-22)AH11 (343-362)3H1 (38-40)S8 (333-336)AH6 (107-127)AH3 (52-60)AH4 (65-78)TIV2 (60-63)TVIII3 (152-155)TI'1 (149-152)AH5 (86-94)TIV4 (144-147)TII'1 (98-101)AH7 (156-166)TIV7 (302-316)AH10 (318-328)TI3 (135-138)TI4 (140-143)AH9 (255-273)S4 (180-184)S5 (203-210)AH8 (191-197)TI11 (382-385)TI5 (197-200)TIV5 (222-231)TI6 (200-203)TII1 (212-215)TVIa1 (215-218)TI10 (375-378)S7 (277-281)3H2 (238-240)S6 (244-249)TI9 (290-293)TII3 (250-253)TVIII5 (275-278)TI7 (284-287)3H3 (378-380)TIV6 (223-232)TII2 (240-243)S2 (42-44)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Schistosoma mansoni
publication title Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
pubmed doi rcsb
molecule keywords HISTONE DEACETYLASE 8
total genus 144
structure length 393
sequence length 426
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4bz8A00
4A69A 4QA3A 4CQFA 3MENA 5FUEA 4QA4A 1C3PA 5EFNA 5G0HA 5DC7A 5G13A 5G10A 3F06A 5EEKA 4BZ7A 2VQMA 3RQDA 4CBTA 3C0YA 3Q9BA 2VCGA 3EZPA 5G3WA 5IX0A 5FCWA 3F07A 4ZUMA 4RN0A 5EENA 5EFKB 4QA7A 4QA2A 5EF7A 2VQVA 3MZ6A 4RN1A 1W22A 5DC5A 5EFBD 3EZTA 2V5XA 5G0YA 4RN2A 3ZNRA 5G1CA 3F0RA 5EFHA 5G0JA 3MZ7A 5ICNB 5EFGA 5THVA 1ZZ3A 4BKXB 5JI5A 5EF8A 5A2SA 5IWGA 1ZZ1A 2VQWG 5D1CA 1T69A 3ZNSA 5BWZA 3Q9EA 1T64A 4ZUOA 4QA6A 5EEMA 3C0ZA 1ZZ0A 3SFFA 5THSA 4CBYA 1VKGA 3MZ4A 2V5WA 3Q9FA 4ZUQA 5G1AA 2GH6A 5THTA 4LY1A 4BZ8A 5D1DA 4QA0A 5G1BA 4ZUPA 3SFHA 5G0GA 3EWFA 5DC8A 5EEIA 5DC6A 4BZ6A 1C3RA 1C3SA 4LXZA 3EW8A 4QA5A 1T67A 2VQJA 2VQOA 5EFJD 5D1BA 3Q9CA 5G11A 5LI3A 3MZ3A 2VQQA 5THUA 5G0XA 4QA1A 4BZ9A 3MAXA 4BZ5A 5G17A 5EEFA 3C10A 5G0IA 4ZURA 5G12A 4ZUNA
chains in the Genus database with same CATH superfamily
1D3VA 3DJ8A 4RLAA 4Q3TA 1P8RA 4A69A 2PHAA 4QA3A 4CQFA 1TBHA 2AEBA 3MENA 5FUEA 1WVAA 4QA4A 1P8NA 3F80A 1C3PA 4I06A 2PHOA 5EFNA 1ZPEA 5G0HA 4MYKA 5DC7A 3SJTA 5G13A 5G10A 4GSZA 4RHMA 3F06A 4IE1A 3E8ZA 2VQMA 5EEKA 1HQFA 3RQDA 4BZ7A 4CBTA 4HXQA 3C0YA 4HZEA 3Q9BA 2VCGA 3EZPA 4IU4A 5G3WA 5IX0A 5FCWA 3THEA 3F07A 4Q3UA 4ZUMA 2EIVA 1HQHA 2EF4A 4G3HA 4QA7A 2VQVA 3NIQA 4QA2A 4RN0A 5EF7A 5EFKB 3MZ6A 4RN1A 1W22A 5DC5A 5EFBD 3EZTA 4IE3A 2V5XA 5G0YA 4MYLA 1CEVA 1P8QA 4RN2A 3ZNRA 4GSVA 5G1CA 3LHLA 3F0RA 5EFHA 5G0JA 3MZ7A 3GMZA 5ICNB 1WOHA 4Q3RA 5EFGA 4Q3QA 3E6KA 1T4PA 2EF5A 5THVA 3MFVA 1ZZ3A 4IU0A 4BKXB 4RHJA 5JI5A 5EF8A 5HJAA 4Q3RC 3SL0A 5A2SA 1GQ6A 3E9BA 5IWGA 1ZZ1A 2VQWG 5RLAA 3M1RA 4IU1A 4Q40A 3SKKA 3E6VA 5D1CA 1T69A 1P8MA 3ZNSA 5BWZA 3Q9EA 1T64A 3LP4A 4ZUOA 3PZLA 4QA6A 4ZUNA 1WOGA 5EEMA 1T5FA 4RHIA 3C0ZA 1HQGA 1ZZ0A 3SFFA 3SL1A 4DZ4A 4IXUA 5THSA 3MMRA 4CBYA 3THHA 1VKGA 4IU5A 3MZ4A 1R1OA 1GQ7A 1ZPGA 4MYNA 1TA1A 2V5WA 3Q9FA 4Q42A 4RHKA 2CEVA 4MXRA 4ZUQA 5G1AA 2PLLA 5HJ9A 2GH6A 4GWDA 5THTA 3TH7A 4LY1A 4BZ8A 3THJA 1T4TA 5D1DA 4GSMA 3RLAA 1P8OA 4QA0A 5G1BA 3MJLA 1P8PA 4IE2A 3TF3A 4RHQA 4CEVA 4ZUPA 1PQ3A 1XFKA 2A0MA 1T4RA 3SFHA 5G0GA 1WVBA 2ZAVA 3EWFA 1WOIA 3NIOA 3E8QA 4GWCA 5DC8A 2RLAA 4RHLA 5EEIA 5DC6A 4BZ6A 3GN0A 1C3RA 3MFWA 1C3SA 1HQXA 3EW8A 3LP7A 3NIPA 4LXZA 4QA5A 1T67A 2VQJA 5G0IA 1P8SA 2VQOA 4Q41A 4ITYA 4Q3PA 5EFJD 5D1BA 3Q9CA 4FCKA 5G11A 1T5GA 5EENA 3MZ3A 5LI3A 1TBLA 4MYFA 2VQQA 5THUA 5G0XA 5CEVA 4QA1A 1RLAA 4BZ9A 3MAXA 4Q3SA 4Q3VA 4BZ5A 4FCIA 4IXVA 1HQ5A 4HWWA 3CEVA 1T4SA 3C10A 1TBJA 5EEFA 5G17A 4ZURA 5G12A 3KV2A
chains in the Genus database with same CATH topology
4A69A 4QA3A 4CQFA 3MENA 5FUEA 4QA4A 1C3PA 5EFNA 5G0HA 5DC7A 5G13A 5G10A 3F06A 5EEKA 4BZ7A 2VQMA 3RQDA 4CBTA 3C0YA 3Q9BA 2VCGA 3EZPA 5G3WA 5IX0A 5FCWA 3F07A 4ZUMA 4RN0A 5EENA 5EFKB 4QA7A 4QA2A 5EF7A 2VQVA 3MZ6A 4RN1A 1W22A 5DC5A 5EFBD 3EZTA 2V5XA 5G0YA 4RN2A 3ZNRA 5G1CA 3F0RA 5EFHA 5G0JA 3MZ7A 5ICNB 5EFGA 5THVA 1ZZ3A 4BKXB 5JI5A 5EF8A 5A2SA 5IWGA 1ZZ1A 2VQWG 5D1CA 1T69A 3ZNSA 5BWZA 3Q9EA 1T64A 4ZUOA 4QA6A 5EEMA 3C0ZA 1ZZ0A 3SFFA 5THSA 4CBYA 1VKGA 3MZ4A 2V5WA 3Q9FA 4ZUQA 5G1AA 2GH6A 5THTA 4LY1A 4BZ8A 5D1DA 4QA0A 5G1BA 4ZUPA 3SFHA 5G0GA 3EWFA 5DC8A 5EEIA 5DC6A 4BZ6A 1C3RA 1C3SA 4LXZA 3EW8A 4QA5A 1T67A 2VQJA 2VQOA 5EFJD 5D1BA 3Q9CA 5G11A 5LI3A 3MZ3A 2VQQA 5THUA 5G0XA 4QA1A 4BZ9A 3MAXA 4BZ5A 5G17A 5EEFA 3C10A 5G0IA 4ZURA 5G12A 4ZUNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A69 A;  4QA3 A;  4CQF A;  3MEN A;  5FUE A;  4QA4 A;  1C3P A;  5EFN A;  5G0H A;  5DC7 A;  5G13 A;  5G10 A;  3F06 A;  5EEK A;  4BZ7 A;  2VQM A;  3RQD A;  4CBT A;  3C0Y A;  3Q9B A;  2VCG A;  3EZP A;  5G3W A;  5IX0 A;  5FCW A;  3F07 A;  4ZUM A;  4RN0 A;  5EEN A;  5EFK B;  4QA7 A;  4QA2 A;  5EF7 A;  2VQV A;  3MZ6 A;  4RN1 A;  1W22 A;  5DC5 A;  5EFB D;  3EZT A;  2V5X A;  5G0Y A;  4RN2 A;  3ZNR A;  5G1C A;  3F0R A;  5EFH A;  5G0J A;  3MZ7 A;  5ICN B;  5EFG A;  5THV A;  1ZZ3 A;  4BKX B;  5JI5 A;  5EF8 A;  5A2S A;  5IWG A;  1ZZ1 A;  2VQW G;  5D1C A;  1T69 A;  3ZNS A;  5BWZ A;  3Q9E A;  1T64 A;  4ZUO A;  4QA6 A;  5EEM A;  3C0Z A;  1ZZ0 A;  3SFF A;  5THS A;  4CBY A;  1VKG A;  3MZ4 A;  2V5W A;  3Q9F A;  4ZUQ A;  5G1A A;  2GH6 A;  5THT A;  4LY1 A;  4BZ8 A;  5D1D A;  4QA0 A;  5G1B A;  4ZUP A;  3SFH A;  5G0G A;  3EWF A;  5DC8 A;  5EEI A;  5DC6 A;  4BZ6 A;  1C3R A;  1C3S A;  4LXZ A;  3EW8 A;  4QA5 A;  1T67 A;  2VQJ A;  2VQO A;  5EFJ D;  5D1B A;  3Q9C A;  5G11 A;  5LI3 A;  3MZ3 A;  2VQQ A;  5THU A;  5G0X A;  4QA1 A;  4BZ9 A;  3MAX A;  4BZ5 A;  5G17 A;  5EEF A;  3C10 A;  5G0I A;  4ZUR A;  5G12 A;  4ZUN A; 
#chains in the Genus database with same CATH topology
 1D3V A;  3DJ8 A;  4RLA A;  4Q3T A;  1P8R A;  4A69 A;  2PHA A;  4QA3 A;  4CQF A;  1TBH A;  2AEB A;  3MEN A;  5FUE A;  1WVA A;  4QA4 A;  1P8N A;  3F80 A;  1C3P A;  4I06 A;  2PHO A;  5EFN A;  1ZPE A;  5G0H A;  4MYK A;  5DC7 A;  3SJT A;  5G13 A;  5G10 A;  4GSZ A;  4RHM A;  3F06 A;  4IE1 A;  3E8Z A;  2VQM A;  5EEK A;  1HQF A;  3RQD A;  4BZ7 A;  4CBT A;  4HXQ A;  3C0Y A;  4HZE A;  3Q9B A;  2VCG A;  3EZP A;  4IU4 A;  5G3W A;  5IX0 A;  5FCW A;  3THE A;  3F07 A;  4Q3U A;  4ZUM A;  2EIV A;  1HQH A;  2EF4 A;  4G3H A;  4QA7 A;  2VQV A;  3NIQ A;  4QA2 A;  4RN0 A;  5EF7 A;  5EFK B;  3MZ6 A;  4RN1 A;  1W22 A;  5DC5 A;  5EFB D;  3EZT A;  4IE3 A;  2V5X A;  5G0Y A;  4MYL A;  1CEV A;  1P8Q A;  4RN2 A;  3ZNR A;  4GSV A;  5G1C A;  3LHL A;  3F0R A;  5EFH A;  5G0J A;  3MZ7 A;  3GMZ A;  5ICN B;  1WOH A;  4Q3R A;  5EFG A;  4Q3Q A;  3E6K A;  1T4P A;  2EF5 A;  5THV A;  3MFV A;  1ZZ3 A;  4IU0 A;  4BKX B;  4RHJ A;  5JI5 A;  5EF8 A;  5HJA A;  4Q3R C;  3SL0 A;  5A2S A;  1GQ6 A;  3E9B A;  5IWG A;  1ZZ1 A;  2VQW G;  5RLA A;  3M1R A;  4IU1 A;  4Q40 A;  3SKK A;  3E6V A;  5D1C A;  1T69 A;  1P8M A;  3ZNS A;  5BWZ A;  3Q9E A;  1T64 A;  3LP4 A;  4ZUO A;  3PZL A;  4QA6 A;  4ZUN A;  1WOG A;  5EEM A;  1T5F A;  4RHI A;  3C0Z A;  1HQG A;  1ZZ0 A;  3SFF A;  3SL1 A;  4DZ4 A;  4IXU A;  5THS A;  3MMR A;  4CBY A;  3THH A;  1VKG A;  4IU5 A;  3MZ4 A;  1R1O A;  1GQ7 A;  1ZPG A;  4MYN A;  1TA1 A;  2V5W A;  3Q9F A;  4Q42 A;  4RHK A;  2CEV A;  4MXR A;  4ZUQ A;  5G1A A;  2PLL A;  5HJ9 A;  2GH6 A;  4GWD A;  5THT A;  3TH7 A;  4LY1 A;  4BZ8 A;  3THJ A;  1T4T A;  5D1D A;  4GSM A;  3RLA A;  1P8O A;  4QA0 A;  5G1B A;  3MJL A;  1P8P A;  4IE2 A;  3TF3 A;  4RHQ A;  4CEV A;  4ZUP A;  1PQ3 A;  1XFK A;  2A0M A;  1T4R A;  3SFH A;  5G0G A;  1WVB A;  2ZAV A;  3EWF A;  1WOI A;  3NIO A;  3E8Q A;  4GWC A;  5DC8 A;  2RLA A;  4RHL A;  5EEI A;  5DC6 A;  4BZ6 A;  3GN0 A;  1C3R A;  3MFW A;  1C3S A;  1HQX A;  3EW8 A;  3LP7 A;  3NIP A;  4LXZ A;  4QA5 A;  1T67 A;  2VQJ A;  5G0I A;  1P8S A;  2VQO A;  4Q41 A;  4ITY A;  4Q3P A;  5EFJ D;  5D1B A;  3Q9C A;  4FCK A;  5G11 A;  1T5G A;  5EEN A;  3MZ3 A;  5LI3 A;  1TBL A;  4MYF A;  2VQQ A;  5THU A;  5G0X A;  5CEV A;  4QA1 A;  1RLA A;  4BZ9 A;  3MAX A;  4Q3S A;  4Q3V A;  4BZ5 A;  4FCI A;  4IXV A;  1HQ5 A;  4HWW A;  3CEV A;  1T4S A;  3C10 A;  1TBJ A;  5EEF A;  5G17 A;  4ZUR A;  5G12 A;  3KV2 A; 
#chains in the Genus database with same CATH homology
 4A69 A;  4QA3 A;  4CQF A;  3MEN A;  5FUE A;  4QA4 A;  1C3P A;  5EFN A;  5G0H A;  5DC7 A;  5G13 A;  5G10 A;  3F06 A;  5EEK A;  4BZ7 A;  2VQM A;  3RQD A;  4CBT A;  3C0Y A;  3Q9B A;  2VCG A;  3EZP A;  5G3W A;  5IX0 A;  5FCW A;  3F07 A;  4ZUM A;  4RN0 A;  5EEN A;  5EFK B;  4QA7 A;  4QA2 A;  5EF7 A;  2VQV A;  3MZ6 A;  4RN1 A;  1W22 A;  5DC5 A;  5EFB D;  3EZT A;  2V5X A;  5G0Y A;  4RN2 A;  3ZNR A;  5G1C A;  3F0R A;  5EFH A;  5G0J A;  3MZ7 A;  5ICN B;  5EFG A;  5THV A;  1ZZ3 A;  4BKX B;  5JI5 A;  5EF8 A;  5A2S A;  5IWG A;  1ZZ1 A;  2VQW G;  5D1C A;  1T69 A;  3ZNS A;  5BWZ A;  3Q9E A;  1T64 A;  4ZUO A;  4QA6 A;  5EEM A;  3C0Z A;  1ZZ0 A;  3SFF A;  5THS A;  4CBY A;  1VKG A;  3MZ4 A;  2V5W A;  3Q9F A;  4ZUQ A;  5G1A A;  2GH6 A;  5THT A;  4LY1 A;  4BZ8 A;  5D1D A;  4QA0 A;  5G1B A;  4ZUP A;  3SFH A;  5G0G A;  3EWF A;  5DC8 A;  5EEI A;  5DC6 A;  4BZ6 A;  1C3R A;  1C3S A;  4LXZ A;  3EW8 A;  4QA5 A;  1T67 A;  2VQJ A;  2VQO A;  5EFJ D;  5D1B A;  3Q9C A;  5G11 A;  5LI3 A;  3MZ3 A;  2VQQ A;  5THU A;  5G0X A;  4QA1 A;  4BZ9 A;  3MAX A;  4BZ5 A;  5G17 A;  5EEF A;  3C10 A;  5G0I A;  4ZUR A;  5G12 A;  4ZUN A; 
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