4FCIA

Crystal structure of the mn2+2-human arginase i-agpa complex
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
313
structure length
313
Chain Sequence
SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Arginase-1
total genus 109
structure length 313
sequence length 313
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-05-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4fciA00
3GN0A 3E6KA 3NIPA 4MYLA 1HQHA 1HQGA 4GSMA 1TBJA 3TH7A 3LHLA 2EF4A 4MXRA 4RHQA 3SL0A 3E8QA 3NIOA 4RHJA 1P8OA 1HQFA 1ZPEA 3CEVA 1GQ6A 1TA1A 4CEVA 5CEVA 1T4SA 1WOIA 4GWCA 1WVAA 1WOGA 1P8QA 3E9BA 4MYNA 1TBHA 4GWDA 1T5FA 3KV2A 4I06A 4DZ4A 3TF3A 2EF5A 1P8NA 4G3HA 3E6VA 1GQ7A 3THEA 4Q3TA 4IU5A 1D3VA 1WOHA 1P8MA 4IE1A 3RLAA 4Q3PA 4IU1A 3SL1A 2CEVA 1P8PA 3SJTA 1ZPGA 4GSVA 4GSZA 1T5GA 3SKKA 2RLAA 3E8ZA 3THJA 3GMZA 1T4RA 4Q42A 5HJ9A 2AEBA 4IXUA 1CEVA 2ZAVA 1HQ5A 4HXQA 1WVBA 4FCIA 2PHOA 4IU0A 3MJLA 3M1RA 3THHA 1T4TA 1XFKA 4IU4A 4MYKA 4RHLA 2A0MA 3LP4A 4Q3VA 4RHMA 4Q3SA 4MYFA 4RHKA 1T4PA 2PLLA 4Q3QA 1PQ3A 4IXVA 1TBLA 3MFVA 4Q40A 5HJAA 3LP7A 4HWWA 4IE2A 1RLAA 4Q3RC 1R1OA 3F80A 3MMRA 4RHIA 4Q3RA 4RLAA 4Q3UA 3PZLA 3DJ8A 1HQXA 2PHAA 1P8RA 4IE3A 5RLAA 2EIVA 3NIQA 4ITYA 4FCKA 1P8SA 4HZEA 3MFWA 4Q41A
chains in the Genus database with same CATH superfamily
3GN0A 5A2SA 4CBYA 3E6KA 3NIPA 4MYLA 1HQHA 1HQGA 5G0GA 4GSMA 1TBJA 3TH7A 3LHLA 2EF4A 5DC7A 5G0JA 4CBTA 4MXRA 4QA0A 4RHQA 3MZ6A 5DC8A 3SL0A 4CQFA 5G11A 3E8QA 3NIOA 3C0YA 4RHJA 1P8OA 1HQFA 1ZPEA 3CEVA 1GQ6A 1TA1A 4QA2A 4CEVA 5CEVA 4RN0A 5D1CA 5EF8A 1T4SA 1WOIA 3EWFA 1WVAA 4GWCA 1WOGA 1W22A 3C0ZA 3SFHA 2VQQA 1P8QA 2V5WA 3E9BA 4MYNA 1TBHA 4GWDA 1T5FA 3KV2A 4I06A 5EFHA 4DZ4A 3TF3A 5G1AA 5G10A 5BWZA 2EF5A 1P8NA 4ZUOA 5FCWA 5EEFA 1T64A 4G3HA 3E6VA 4QA7A 5D1DA 1GQ7A 5IX0A 3THEA 5G3WA 4ZUQA 4Q3TA 5EF7A 2VQJA 4BZ5A 3EZPA 4IU5A 3Q9FA 1D3VA 5FUEA 1T67A 1WOHA 3MAXA 1P8MA 4IE1A 5DC6A 5EFNA 4RN2A 3RLAA 2VQOA 4Q3PA 3EZTA 3MZ7A 4IU1A 5G1BA 3SL1A 2CEVA 2VQVA 5THTA 2VQWG 1P8PA 3C10A 1ZPGA 4GSVA 3SJTA 4QA1A 4GSZA 1T5GA 4BZ7A 3Q9CA 5EEMA 2RLAA 5G0YA 3RQDA 3SKKA 3E8ZA 3THJA 1C3PA 3GMZA 1T4RA 4LY1A 5G0XA 4A69A 4Q42A 5HJ9A 3MZ4A 2AEBA 1ZZ0A 4IXUA 3SFFA 1CEVA 3EW8A 1C3SA 2ZAVA 5DC5A 1HQ5A 4HXQA 5THSA 5G13A 2PHOA 1VKGA 1WVBA 4FCIA 1ZZ3A 5G0IA 4IU0A 3MJLA 3M1RA 5EFJD 5G0HA 5G17A 3THHA 5G12A 1T4TA 1XFKA 4IU4A 4MYKA 4RHLA 2A0MA 5EEKA 5G1CA 3LP4A 4Q3VA 4RHMA 4QA5A 4RN1A 4Q3SA 4MYFA 1T69A 4RHKA 1T4PA 3MZ3A 2PLLA 5EEIA 5EFGA 5IWGA 4Q3QA 2GH6A 2V5XA 4ZUMA 3F07A 1PQ3A 3ZNRA 4BZ6A 4IXVA 1TBLA 3MENA 3MFVA 4Q40A 5HJAA 3LP7A 4HWWA 4IE2A 5THUA 1RLAA 1ZZ1A 4Q3RC 5D1BA 4ZUNA 1R1OA 3F80A 3MMRA 4QA6A 5JI5A 4RHIA 4ZUPA 4Q3RA 3Q9BA 4Q3UA 3PZLA 4RLAA 2VCGA 1HQXA 2VQMA 2PHAA 1P8RA 3DJ8A 5EFKB 4IE3A 5EFBD 5RLAA 4QA3A 2EIVA 3NIQA 5EENA 4ITYA 5ICNB 4FCKA 1P8SA 4BZ8A 4HZEA 3ZNSA 4QA4A 3F06A 4LXZA 4BKXB 1C3RA 3MFWA 3F0RA 4ZURA 5THVA 4Q41A 5LI3A 3Q9EA 4BZ9A
chains in the Genus database with same CATH topology
3GN0A 3E6KA 3NIPA 4MYLA 1HQHA 1HQGA 4GSMA 1TBJA 3TH7A 3LHLA 2EF4A 4MXRA 4RHQA 3SL0A 3E8QA 3NIOA 4RHJA 1P8OA 1HQFA 1ZPEA 3CEVA 1GQ6A 1TA1A 4CEVA 5CEVA 1T4SA 1WOIA 4GWCA 1WVAA 1WOGA 1P8QA 3E9BA 4MYNA 1TBHA 4GWDA 1T5FA 3KV2A 4I06A 4DZ4A 3TF3A 2EF5A 1P8NA 4G3HA 3E6VA 1GQ7A 3THEA 4Q3TA 4IU5A 1D3VA 1WOHA 1P8MA 4IE1A 3RLAA 4Q3PA 4IU1A 3SL1A 2CEVA 1P8PA 3SJTA 1ZPGA 4GSVA 4GSZA 1T5GA 3SKKA 2RLAA 3E8ZA 3THJA 3GMZA 1T4RA 4Q42A 5HJ9A 2AEBA 4IXUA 1CEVA 2ZAVA 1HQ5A 4HXQA 1WVBA 4FCIA 2PHOA 4IU0A 3MJLA 3M1RA 3THHA 1T4TA 1XFKA 4IU4A 4MYKA 4RHLA 2A0MA 3LP4A 4Q3VA 4RHMA 4Q3SA 4MYFA 4RHKA 1T4PA 2PLLA 4Q3QA 1PQ3A 4IXVA 1TBLA 3MFVA 4Q40A 5HJAA 3LP7A 4HWWA 4IE2A 1RLAA 4Q3RC 1R1OA 3F80A 3MMRA 4RHIA 4Q3RA 4RLAA 4Q3UA 3PZLA 3DJ8A 1HQXA 2PHAA 1P8RA 4IE3A 5RLAA 2EIVA 3NIQA 4ITYA 4FCKA 1P8SA 4HZEA 3MFWA 4Q41A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GN0 A;  3E6K A;  3NIP A;  4MYL A;  1HQH A;  1HQG A;  4GSM A;  1TBJ A;  3TH7 A;  3LHL A;  2EF4 A;  4MXR A;  4RHQ A;  3SL0 A;  3E8Q A;  3NIO A;  4RHJ A;  1P8O A;  1HQF A;  1ZPE A;  3CEV A;  1GQ6 A;  1TA1 A;  4CEV A;  5CEV A;  1T4S A;  1WOI A;  4GWC A;  1WVA A;  1WOG A;  1P8Q A;  3E9B A;  4MYN A;  1TBH A;  4GWD A;  1T5F A;  3KV2 A;  4I06 A;  4DZ4 A;  3TF3 A;  2EF5 A;  1P8N A;  4G3H A;  3E6V A;  1GQ7 A;  3THE A;  4Q3T A;  4IU5 A;  1D3V A;  1WOH A;  1P8M A;  4IE1 A;  3RLA A;  4Q3P A;  4IU1 A;  3SL1 A;  2CEV A;  1P8P A;  3SJT A;  1ZPG A;  4GSV A;  4GSZ A;  1T5G A;  3SKK A;  2RLA A;  3E8Z A;  3THJ A;  3GMZ A;  1T4R A;  4Q42 A;  5HJ9 A;  2AEB A;  4IXU A;  1CEV A;  2ZAV A;  1HQ5 A;  4HXQ A;  1WVB A;  4FCI A;  2PHO A;  4IU0 A;  3MJL A;  3M1R A;  3THH A;  1T4T A;  1XFK A;  4IU4 A;  4MYK A;  4RHL A;  2A0M A;  3LP4 A;  4Q3V A;  4RHM A;  4Q3S A;  4MYF A;  4RHK A;  1T4P A;  2PLL A;  4Q3Q A;  1PQ3 A;  4IXV A;  1TBL A;  3MFV A;  4Q40 A;  5HJA A;  3LP7 A;  4HWW A;  4IE2 A;  1RLA A;  4Q3R C;  1R1O A;  3F80 A;  3MMR A;  4RHI A;  4Q3R A;  4RLA A;  4Q3U A;  3PZL A;  3DJ8 A;  1HQX A;  2PHA A;  1P8R A;  4IE3 A;  5RLA A;  2EIV A;  3NIQ A;  4ITY A;  4FCK A;  1P8S A;  4HZE A;  3MFW A;  4Q41 A; 
#chains in the Genus database with same CATH topology
 3GN0 A;  5A2S A;  4CBY A;  3E6K A;  3NIP A;  4MYL A;  1HQH A;  1HQG A;  5G0G A;  4GSM A;  1TBJ A;  3TH7 A;  3LHL A;  2EF4 A;  5DC7 A;  5G0J A;  4CBT A;  4MXR A;  4QA0 A;  4RHQ A;  3MZ6 A;  5DC8 A;  3SL0 A;  4CQF A;  5G11 A;  3E8Q A;  3NIO A;  3C0Y A;  4RHJ A;  1P8O A;  1HQF A;  1ZPE A;  3CEV A;  1GQ6 A;  1TA1 A;  4QA2 A;  4CEV A;  5CEV A;  4RN0 A;  5D1C A;  5EF8 A;  1T4S A;  1WOI A;  3EWF A;  1WVA A;  4GWC A;  1WOG A;  1W22 A;  3C0Z A;  3SFH A;  2VQQ A;  1P8Q A;  2V5W A;  3E9B A;  4MYN A;  1TBH A;  4GWD A;  1T5F A;  3KV2 A;  4I06 A;  5EFH A;  4DZ4 A;  3TF3 A;  5G1A A;  5G10 A;  5BWZ A;  2EF5 A;  1P8N A;  4ZUO A;  5FCW A;  5EEF A;  1T64 A;  4G3H A;  3E6V A;  4QA7 A;  5D1D A;  1GQ7 A;  5IX0 A;  3THE A;  5G3W A;  4ZUQ A;  4Q3T A;  5EF7 A;  2VQJ A;  4BZ5 A;  3EZP A;  4IU5 A;  3Q9F A;  1D3V A;  5FUE A;  1T67 A;  1WOH A;  3MAX A;  1P8M A;  4IE1 A;  5DC6 A;  5EFN A;  4RN2 A;  3RLA A;  2VQO A;  4Q3P A;  3EZT A;  3MZ7 A;  4IU1 A;  5G1B A;  3SL1 A;  2CEV A;  2VQV A;  5THT A;  2VQW G;  1P8P A;  3C10 A;  1ZPG A;  4GSV A;  3SJT A;  4QA1 A;  4GSZ A;  1T5G A;  4BZ7 A;  3Q9C A;  5EEM A;  2RLA A;  5G0Y A;  3RQD A;  3SKK A;  3E8Z A;  3THJ A;  1C3P A;  3GMZ A;  1T4R A;  4LY1 A;  5G0X A;  4A69 A;  4Q42 A;  5HJ9 A;  3MZ4 A;  2AEB A;  1ZZ0 A;  4IXU A;  3SFF A;  1CEV A;  3EW8 A;  1C3S A;  2ZAV A;  5DC5 A;  1HQ5 A;  4HXQ A;  5THS A;  5G13 A;  2PHO A;  1VKG A;  1WVB A;  4FCI A;  1ZZ3 A;  5G0I A;  4IU0 A;  3MJL A;  3M1R A;  5EFJ D;  5G0H A;  5G17 A;  3THH A;  5G12 A;  1T4T A;  1XFK A;  4IU4 A;  4MYK A;  4RHL A;  2A0M A;  5EEK A;  5G1C A;  3LP4 A;  4Q3V A;  4RHM A;  4QA5 A;  4RN1 A;  4Q3S A;  4MYF A;  1T69 A;  4RHK A;  1T4P A;  3MZ3 A;  2PLL A;  5EEI A;  5EFG A;  5IWG A;  4Q3Q A;  2GH6 A;  2V5X A;  4ZUM A;  3F07 A;  1PQ3 A;  3ZNR A;  4BZ6 A;  4IXV A;  1TBL A;  3MEN A;  3MFV A;  4Q40 A;  5HJA A;  3LP7 A;  4HWW A;  4IE2 A;  5THU A;  1RLA A;  1ZZ1 A;  4Q3R C;  5D1B A;  4ZUN A;  1R1O A;  3F80 A;  3MMR A;  4QA6 A;  5JI5 A;  4RHI A;  4ZUP A;  4Q3R A;  3Q9B A;  4Q3U A;  3PZL A;  4RLA A;  2VCG A;  1HQX A;  2VQM A;  2PHA A;  1P8R A;  3DJ8 A;  5EFK B;  4IE3 A;  5EFB D;  5RLA A;  4QA3 A;  2EIV A;  3NIQ A;  5EEN A;  4ITY A;  5ICN B;  4FCK A;  1P8S A;  4BZ8 A;  4HZE A;  3ZNS A;  4QA4 A;  3F06 A;  4LXZ A;  4BKX B;  1C3R A;  3MFW A;  3F0R A;  4ZUR A;  5THV A;  4Q41 A;  5LI3 A;  3Q9E A;  4BZ9 A; 
#chains in the Genus database with same CATH homology
 3GN0 A;  3E6K A;  3NIP A;  4MYL A;  1HQH A;  1HQG A;  4GSM A;  1TBJ A;  3TH7 A;  3LHL A;  2EF4 A;  4MXR A;  4RHQ A;  3SL0 A;  3E8Q A;  3NIO A;  4RHJ A;  1P8O A;  1HQF A;  1ZPE A;  3CEV A;  1GQ6 A;  1TA1 A;  4CEV A;  5CEV A;  1T4S A;  1WOI A;  4GWC A;  1WVA A;  1WOG A;  1P8Q A;  3E9B A;  4MYN A;  1TBH A;  4GWD A;  1T5F A;  3KV2 A;  4I06 A;  4DZ4 A;  3TF3 A;  2EF5 A;  1P8N A;  4G3H A;  3E6V A;  1GQ7 A;  3THE A;  4Q3T A;  4IU5 A;  1D3V A;  1WOH A;  1P8M A;  4IE1 A;  3RLA A;  4Q3P A;  4IU1 A;  3SL1 A;  2CEV A;  1P8P A;  3SJT A;  1ZPG A;  4GSV A;  4GSZ A;  1T5G A;  3SKK A;  2RLA A;  3E8Z A;  3THJ A;  3GMZ A;  1T4R A;  4Q42 A;  5HJ9 A;  2AEB A;  4IXU A;  1CEV A;  2ZAV A;  1HQ5 A;  4HXQ A;  1WVB A;  4FCI A;  2PHO A;  4IU0 A;  3MJL A;  3M1R A;  3THH A;  1T4T A;  1XFK A;  4IU4 A;  4MYK A;  4RHL A;  2A0M A;  3LP4 A;  4Q3V A;  4RHM A;  4Q3S A;  4MYF A;  4RHK A;  1T4P A;  2PLL A;  4Q3Q A;  1PQ3 A;  4IXV A;  1TBL A;  3MFV A;  4Q40 A;  5HJA A;  3LP7 A;  4HWW A;  4IE2 A;  1RLA A;  4Q3R C;  1R1O A;  3F80 A;  3MMR A;  4RHI A;  4Q3R A;  4RLA A;  4Q3U A;  3PZL A;  3DJ8 A;  1HQX A;  2PHA A;  1P8R A;  4IE3 A;  5RLA A;  2EIV A;  3NIQ A;  4ITY A;  4FCK A;  1P8S A;  4HZE A;  3MFW A;  4Q41 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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