4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
3H1 (42-44)S1 (25-30)AH1 (45-52)TIV1 (33-36)S8 (289-295)TVIII2 (302-305)TIV2 (35-38)AH2 (54-61)S2 (64-70)TI2 (134-137)3H2 (159-161)EMPTYTIV4 (81-84)TIV5 (83-86)AH3 (89-109)TIV11 (263-266)AH6 (219-225)S3 (112-116)AH4 (121-133)AH7 (227-240)3H4 (169-174)TIV7 (179-182)TII1 (178-181)AH8 (273-286)S4 (138-142)TI3 (150-153)TI5 (154-157)3H3 (163-166)TI7 (189-192)S5 (193-198)S6 (215-218)TIV12 (267-270)S7 (246-251)3H5 (252-254)TI9 (256-259)TI10 (257-260)TIV9 (258-261)TIV10 (260-263)3H6 (299-301)O1 (31-33)TI1 (34-37)TI'1 (82-85)TIV6 (86-89)TI6 (181-184)AH5 (203-212)AH9 (305-323)TIV3 (76-79)TVIII1 (143-146)Updating...
connected with : NaN
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
molecule keywords Arginase-2, mitochondrial
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
3SKKA 1HQHA 3E6VA 4FCIA 4Q3RA 4MXRA 3THJA 2A0MA 3F80A 4Q3UA 3GMZA 4ITYA 1CEVA 2PHAA 3SJTA 4IXVA 3DJ8A 1P8OA 4RHQA 3SL0A 1T4TA 4Q3VA 4HWWA 1WVBA 4G3HA 4Q3QA 4GSZA 2PHOA 3RLAA 3SL1A 4RHKA 3E8ZA 2EF4A 4GSMA 4IU4A 1TA1A 1TBJA 4CEVA 4RLAA 3CEVA 4HZEA 1P8RA 5RLAA 1T4RA 3MMRA 4RHLA 1P8PA 4Q3SA 1ZPGA 2ZAVA 1P8QA 3E8QA 5CEVA 4FCKA 1RLAA 3TH7A 4RHMA 4Q42A 4IU0A 1T5FA 3MFWA 1PQ3A 3KV2A 4RHJA 1WOGA 4IE3A 4MYFA 2RLAA 3THEA 3TF3A 1HQGA 3LP7A 1T4PA 1XFKA 3NIOA 1P8NA 4DZ4A 1P8SA 2CEVA 1WOIA 3MJLA 4GWDA 3M1RA 3NIPA 4MYNA 1T5GA 4MYLA 4Q40A 1HQ5A 3PZLA 1WOHA 1ZPEA 2EIVA 1WVAA 1R1OA 1P8MA 4IU1A 4Q3PA 5HJAA 4IU5A 1HQFA 3THHA 4RHIA 1GQ7A 3NIQA 4Q3TA 3LHLA 2EF5A 3E9BA 4IXUA 5HJ9A 1TBLA 1GQ6A 1HQXA 2PLLA 4GWCA 4IE2A 3GN0A 2AEBA 3E6KA 4IE1A 4Q3RC 4Q41A 4GSVA 4HXQA 1T4SA 3LP4A 1TBHA 4I06A 4MYKA 1D3VA 3MFVA
chains in the Genus database with same CATH superfamily
4QA1A 5G12A 3SKKA 1HQHA 3E6VA 4FCIA 5EF8A 4Q3RA 4MXRA 1C3PA 3THJA 3MZ7A 2A0MA 3F80A 4Q3UA 3GMZA 3MZ4A 3F0RA 1CEVA 4ITYA 2PHAA 4QA7A 5LI3A 5EENA 3SJTA 4IXVA 3DJ8A 5EFBD 1P8OA 3Q9CA 5JI5A 5G1CA 5G10A 4RHQA 3SL0A 1T4TA 4Q3VA 5D1DA 5A2SA 4HWWA 3C0ZA 4CBTA 1WVBA 4G3HA 4QA2A 4Q3QA 4GSZA 2PHOA 2VQJA 4ZUOA 3RLAA 4QA3A 3SL1A 4RHKA 5THVA 3E8ZA 5DC7A 3EZPA 2EF4A 4GSMA 4IU4A 1TA1A 1T67A 5G0GA 1TBJA 4BZ5A 5EFHA 3ZNSA 4CEVA 2GH6A 4RLAA 3CEVA 4HZEA 1C3RA 1P8RA 5RLAA 2VQOA 1T4RA 3MMRA 4CQFA 4RHLA 4QA6A 1P8PA 4Q3SA 4CBYA 1ZPGA 3F06A 2ZAVA 1P8QA 3E8QA 4ZURA 5G3WA 5CEVA 5EEKA 5G0JA 5FUEA 4FCKA 1RLAA 3TH7A 4RHMA 5DC8A 4Q42A 4IU0A 5G1AA 1T5FA 3MFWA 1PQ3A 3KV2A 4RHJA 1T69A 3EZTA 1WOGA 4IE3A 3EW8A 4MYFA 2RLAA 3THEA 1W22A 5EEFA 3TF3A 4BZ9A 1HQGA 5THSA 3LP7A 3MZ3A 3Q9BA 5BWZA 5DC5A 5EFKB 4QA0A 1T4PA 4RN2A 5FCWA 3MAXA 5ICNB 1XFKA 3SFHA 3NIOA 1P8NA 4RN1A 5EFJD 5IWGA 1P8SA 1VKGA 4DZ4A 2CEVA 1WOIA 3MJLA 3MENA 5G11A 4BZ7A 4GWDA 4ZUPA 1ZZ3A 3M1RA 3NIPA 5DC6A 4MYNA 5G0XA 5D1BA 3F07A 1T5GA 4MYLA 4Q40A 3ZNRA 1HQ5A 2V5WA 3PZLA 1WOHA 4LXZA 5THUA 1ZPEA 2EIVA 1WVAA 5EEMA 5G13A 1R1OA 1P8MA 5G0HA 4IU1A 4Q3PA 3C10A 5HJAA 4QA4A 5G0YA 4IU5A 1HQFA 3THHA 1C3SA 2VQQA 4RHIA 4ZUQA 2VCGA 1GQ7A 2VQVA 3NIQA 4Q3TA 4BKXB 5EEIA 4LY1A 1ZZ0A 4QA5A 3EWFA 3LHLA 4ZUMA 4A69A 4BZ6A 4RN0A 2EF5A 2VQMA 3C0YA 3E9BA 4IXUA 5HJ9A 5IX0A 3RQDA 1TBLA 1GQ6A 1HQXA 2PLLA 4GWCA 4IE2A 3GN0A 5D1CA 2AEBA 3MZ6A 3E6KA 4IE1A 4BZ8A 1ZZ1A 4Q3RC 4ZUNA 5EFGA 5EFNA 4GSVA 4HXQA 5G17A 1T4SA 4Q41A 3SFFA 3LP4A 1TBHA 2V5XA 5EF7A 5G1BA 4I06A 4MYKA 5G0IA 1T64A 3Q9EA 3Q9FA 2VQWG 1D3VA 3MFVA 5THTA
chains in the Genus database with same CATH topology
3SKKA 1HQHA 3E6VA 4FCIA 4Q3RA 4MXRA 3THJA 2A0MA 3F80A 4Q3UA 3GMZA 4ITYA 1CEVA 2PHAA 3SJTA 4IXVA 3DJ8A 1P8OA 4RHQA 3SL0A 1T4TA 4Q3VA 4HWWA 1WVBA 4G3HA 4Q3QA 4GSZA 2PHOA 3RLAA 3SL1A 4RHKA 3E8ZA 2EF4A 4GSMA 4IU4A 1TA1A 1TBJA 4CEVA 4RLAA 3CEVA 4HZEA 1P8RA 5RLAA 1T4RA 3MMRA 4RHLA 1P8PA 4Q3SA 1ZPGA 2ZAVA 1P8QA 3E8QA 5CEVA 4FCKA 1RLAA 3TH7A 4RHMA 4Q42A 4IU0A 1T5FA 3MFWA 1PQ3A 3KV2A 4RHJA 1WOGA 4IE3A 4MYFA 2RLAA 3THEA 3TF3A 1HQGA 3LP7A 1T4PA 1XFKA 3NIOA 1P8NA 4DZ4A 1P8SA 2CEVA 1WOIA 3MJLA 4GWDA 3M1RA 3NIPA 4MYNA 1T5GA 4MYLA 4Q40A 1HQ5A 3PZLA 1WOHA 1ZPEA 2EIVA 1WVAA 1R1OA 1P8MA 4IU1A 4Q3PA 5HJAA 4IU5A 1HQFA 3THHA 4RHIA 1GQ7A 3NIQA 4Q3TA 3LHLA 2EF5A 3E9BA 4IXUA 5HJ9A 1TBLA 1GQ6A 1HQXA 2PLLA 4GWCA 4IE2A 3GN0A 2AEBA 3E6KA 4IE1A 4Q3RC 4Q41A 4GSVA 4HXQA 1T4SA 3LP4A 1TBHA 4I06A 4MYKA 1D3VA 3MFVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SKK A;  1HQH A;  3E6V A;  4FCI A;  4Q3R A;  4MXR A;  3THJ A;  2A0M A;  3F80 A;  4Q3U A;  3GMZ A;  4ITY A;  1CEV A;  2PHA A;  3SJT A;  4IXV A;  3DJ8 A;  1P8O A;  4RHQ A;  3SL0 A;  1T4T A;  4Q3V A;  4HWW A;  1WVB A;  4G3H A;  4Q3Q A;  4GSZ A;  2PHO A;  3RLA A;  3SL1 A;  4RHK A;  3E8Z A;  2EF4 A;  4GSM A;  4IU4 A;  1TA1 A;  1TBJ A;  4CEV A;  4RLA A;  3CEV A;  4HZE A;  1P8R A;  5RLA A;  1T4R A;  3MMR A;  4RHL A;  1P8P A;  4Q3S A;  1ZPG A;  2ZAV A;  1P8Q A;  3E8Q A;  5CEV A;  4FCK A;  1RLA A;  3TH7 A;  4RHM A;  4Q42 A;  4IU0 A;  1T5F A;  3MFW A;  1PQ3 A;  3KV2 A;  4RHJ A;  1WOG A;  4IE3 A;  4MYF A;  2RLA A;  3THE A;  3TF3 A;  1HQG A;  3LP7 A;  1T4P A;  1XFK A;  3NIO A;  1P8N A;  4DZ4 A;  1P8S A;  2CEV A;  1WOI A;  3MJL A;  4GWD A;  3M1R A;  3NIP A;  4MYN A;  1T5G A;  4MYL A;  4Q40 A;  1HQ5 A;  3PZL A;  1WOH A;  1ZPE A;  2EIV A;  1WVA A;  1R1O A;  1P8M A;  4IU1 A;  4Q3P A;  5HJA A;  4IU5 A;  1HQF A;  3THH A;  4RHI A;  1GQ7 A;  3NIQ A;  4Q3T A;  3LHL A;  2EF5 A;  3E9B A;  4IXU A;  5HJ9 A;  1TBL A;  1GQ6 A;  1HQX A;  2PLL A;  4GWC A;  4IE2 A;  3GN0 A;  2AEB A;  3E6K A;  4IE1 A;  4Q3R C;  4Q41 A;  4GSV A;  4HXQ A;  1T4S A;  3LP4 A;  1TBH A;  4I06 A;  4MYK A;  1D3V A;  3MFV A; 
#chains in the Genus database with same CATH topology
 4QA1 A;  5G12 A;  3SKK A;  1HQH A;  3E6V A;  4FCI A;  5EF8 A;  4Q3R A;  4MXR A;  1C3P A;  3THJ A;  3MZ7 A;  2A0M A;  3F80 A;  4Q3U A;  3GMZ A;  3MZ4 A;  3F0R A;  1CEV A;  4ITY A;  2PHA A;  4QA7 A;  5LI3 A;  5EEN A;  3SJT A;  4IXV A;  3DJ8 A;  5EFB D;  1P8O A;  3Q9C A;  5JI5 A;  5G1C A;  5G10 A;  4RHQ A;  3SL0 A;  1T4T A;  4Q3V A;  5D1D A;  5A2S A;  4HWW A;  3C0Z A;  4CBT A;  1WVB A;  4G3H A;  4QA2 A;  4Q3Q A;  4GSZ A;  2PHO A;  2VQJ A;  4ZUO A;  3RLA A;  4QA3 A;  3SL1 A;  4RHK A;  5THV A;  3E8Z A;  5DC7 A;  3EZP A;  2EF4 A;  4GSM A;  4IU4 A;  1TA1 A;  1T67 A;  5G0G A;  1TBJ A;  4BZ5 A;  5EFH A;  3ZNS A;  4CEV A;  2GH6 A;  4RLA A;  3CEV A;  4HZE A;  1C3R A;  1P8R A;  5RLA A;  2VQO A;  1T4R A;  3MMR A;  4CQF A;  4RHL A;  4QA6 A;  1P8P A;  4Q3S A;  4CBY A;  1ZPG A;  3F06 A;  2ZAV A;  1P8Q A;  3E8Q A;  4ZUR A;  5G3W A;  5CEV A;  5EEK A;  5G0J A;  5FUE A;  4FCK A;  1RLA A;  3TH7 A;  4RHM A;  5DC8 A;  4Q42 A;  4IU0 A;  5G1A A;  1T5F A;  3MFW A;  1PQ3 A;  3KV2 A;  4RHJ A;  1T69 A;  3EZT A;  1WOG A;  4IE3 A;  3EW8 A;  4MYF A;  2RLA A;  3THE A;  1W22 A;  5EEF A;  3TF3 A;  4BZ9 A;  1HQG A;  5THS A;  3LP7 A;  3MZ3 A;  3Q9B A;  5BWZ A;  5DC5 A;  5EFK B;  4QA0 A;  1T4P A;  4RN2 A;  5FCW A;  3MAX A;  5ICN B;  1XFK A;  3SFH A;  3NIO A;  1P8N A;  4RN1 A;  5EFJ D;  5IWG A;  1P8S A;  1VKG A;  4DZ4 A;  2CEV A;  1WOI A;  3MJL A;  3MEN A;  5G11 A;  4BZ7 A;  4GWD A;  4ZUP A;  1ZZ3 A;  3M1R A;  3NIP A;  5DC6 A;  4MYN A;  5G0X A;  5D1B A;  3F07 A;  1T5G A;  4MYL A;  4Q40 A;  3ZNR A;  1HQ5 A;  2V5W A;  3PZL A;  1WOH A;  4LXZ A;  5THU A;  1ZPE A;  2EIV A;  1WVA A;  5EEM A;  5G13 A;  1R1O A;  1P8M A;  5G0H A;  4IU1 A;  4Q3P A;  3C10 A;  5HJA A;  4QA4 A;  5G0Y A;  4IU5 A;  1HQF A;  3THH A;  1C3S A;  2VQQ A;  4RHI A;  4ZUQ A;  2VCG A;  1GQ7 A;  2VQV A;  3NIQ A;  4Q3T A;  4BKX B;  5EEI A;  4LY1 A;  1ZZ0 A;  4QA5 A;  3EWF A;  3LHL A;  4ZUM A;  4A69 A;  4BZ6 A;  4RN0 A;  2EF5 A;  2VQM A;  3C0Y A;  3E9B A;  4IXU A;  5HJ9 A;  5IX0 A;  3RQD A;  1TBL A;  1GQ6 A;  1HQX A;  2PLL A;  4GWC A;  4IE2 A;  3GN0 A;  5D1C A;  2AEB A;  3MZ6 A;  3E6K A;  4IE1 A;  4BZ8 A;  1ZZ1 A;  4Q3R C;  4ZUN A;  5EFG A;  5EFN A;  4GSV A;  4HXQ A;  5G17 A;  1T4S A;  4Q41 A;  3SFF A;  3LP4 A;  1TBH A;  2V5X A;  5EF7 A;  5G1B A;  4I06 A;  4MYK A;  5G0I A;  1T64 A;  3Q9E A;  3Q9F A;  2VQW G;  1D3V A;  3MFV A;  5THT A; 
#chains in the Genus database with same CATH homology
 3SKK A;  1HQH A;  3E6V A;  4FCI A;  4Q3R A;  4MXR A;  3THJ A;  2A0M A;  3F80 A;  4Q3U A;  3GMZ A;  4ITY A;  1CEV A;  2PHA A;  3SJT A;  4IXV A;  3DJ8 A;  1P8O A;  4RHQ A;  3SL0 A;  1T4T A;  4Q3V A;  4HWW A;  1WVB A;  4G3H A;  4Q3Q A;  4GSZ A;  2PHO A;  3RLA A;  3SL1 A;  4RHK A;  3E8Z A;  2EF4 A;  4GSM A;  4IU4 A;  1TA1 A;  1TBJ A;  4CEV A;  4RLA A;  3CEV A;  4HZE A;  1P8R A;  5RLA A;  1T4R A;  3MMR A;  4RHL A;  1P8P A;  4Q3S A;  1ZPG A;  2ZAV A;  1P8Q A;  3E8Q A;  5CEV A;  4FCK A;  1RLA A;  3TH7 A;  4RHM A;  4Q42 A;  4IU0 A;  1T5F A;  3MFW A;  1PQ3 A;  3KV2 A;  4RHJ A;  1WOG A;  4IE3 A;  4MYF A;  2RLA A;  3THE A;  3TF3 A;  1HQG A;  3LP7 A;  1T4P A;  1XFK A;  3NIO A;  1P8N A;  4DZ4 A;  1P8S A;  2CEV A;  1WOI A;  3MJL A;  4GWD A;  3M1R A;  3NIP A;  4MYN A;  1T5G A;  4MYL A;  4Q40 A;  1HQ5 A;  3PZL A;  1WOH A;  1ZPE A;  2EIV A;  1WVA A;  1R1O A;  1P8M A;  4IU1 A;  4Q3P A;  5HJA A;  4IU5 A;  1HQF A;  3THH A;  4RHI A;  1GQ7 A;  3NIQ A;  4Q3T A;  3LHL A;  2EF5 A;  3E9B A;  4IXU A;  5HJ9 A;  1TBL A;  1GQ6 A;  1HQX A;  2PLL A;  4GWC A;  4IE2 A;  3GN0 A;  2AEB A;  3E6K A;  4IE1 A;  4Q3R C;  4Q41 A;  4GSV A;  4HXQ A;  1T4S A;  3LP4 A;  1TBH A;  4I06 A;  4MYK A;  1D3V A;  3MFV A; 
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