4LXZA

Structure of human hdac2 in complex with saha (vorinostat)
Total Genus 148
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
368
structure length
368
Chain Sequence
GKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLP
5010015020025030035035030025020015010050
050100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS1 (16-19)TI5 (144-147)TI1 (21-24)S7 (261-265)AH4 (92-99)TII1 (30-33)TIV6 (307-310)AH1 (37-50)AH10 (310-325)3H2 (52-54)TIV2 (102-105)AH2 (66-70)AH3 (75-83)TIV1 (70-73)TI2 (85-88)TI4 (139-142)3H3 (89-91)TIV3 (103-106)TII2 (108-111)AH5 (111-131)TIV4 (148-151)TI'1 (153-156)TVIII1 (134-137)AH6 (160-170)S3 (136-139)S4 (175-179)TVIII2 (172-175)AH9 (283-295)S5 (198-205)AH7 (186-192)TI6 (192-195)TI8 (215-218)3H4 (222-224)TI9 (267-270)TI13 (343-346)TII3 (224-227)S6 (228-233)TI10 (268-271)TII4 (234-237)AH8 (239-257)TI11 (274-277)3H5 (339-342)TII5 (271-274)S8 (300-303)TIV7 (342-345)3H1 (24-26)S2 (57-59)TIV5 (206-209)TI12 (336-339)TVIa1 (209-212)AH11 (361-377)Updating...
connected with : NaN
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
pubmed doi rcsb
molecule keywords Histone deacetylase 2
total genus 148
structure length 368
sequence length 368
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2013-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4lxzA00
3Q9FA 4QA7A 3Q9BA 1C3SA 5EEIA 4BZ6A 2GH6A 4ZUOA 4QA5A 5DC7A 4BZ8A 2VQWG 5A2SA 4CQFA 3EZPA 5EF8A 3F06A 4ZUPA 5ICNB 3Q9EA 5G11A 4QA1A 4ZUQA 5G3WA 3EW8A 3ZNSA 3F07A 5G0JA 2V5XA 4LY1A 5EFBD 5D1DA 3ZNRA 5THSA 5DC6A 4CBTA 4ZUMA 1W22A 4QA4A 2V5WA 5EFHA 5G13A 4QA0A 5G0IA 2VQMA 4LXZA 5G0XA 5DC8A 4BZ7A 2VQJA 5G0YA 5LI3A 5EFKB 5EFNA 5D1BA 4CBYA 3SFHA 5D1CA 5G0GA 3MENA 1T69A 5BWZA 5FCWA 3MZ6A 5EEMA 4BKXB 5G12A 3Q9CA 2VQVA 1ZZ1A 5FUEA 4ZUNA 5G1AA 2VCGA 5G1BA 4QA2A 3RQDA 5THTA 3MZ7A 4ZURA 4QA6A 5EF7A 5EEFA 1T67A 5G1CA 5IX0A 2VQQA 4BZ5A 4RN2A 3SFFA 3EZTA 3MZ3A 1ZZ0A 5IWGA 1VKGA 1C3PA 3MZ4A 5EENA 5G10A 5EEKA 1C3RA 2VQOA 5JI5A 4A69A 3C0YA 4RN1A 4QA3A 4BZ9A 5THVA 5G17A 4RN0A 3EWFA 3C0ZA 1ZZ3A 5THUA 3C10A 3MAXA 5EFGA 3F0RA 5EFJD 5DC5A 1T64A 5G0HA
chains in the Genus database with same CATH superfamily
1HQGA 3Q9FA 4QA7A 1HQFA 4HZEA 3RLAA 5HJAA 3Q9BA 3E9BA 1C3SA 1GQ7A 2EIVA 1ZPGA 5EEIA 4BZ6A 2GH6A 4ZUOA 4QA5A 3F80A 5DC7A 2VQWG 4BZ8A 5A2SA 5CEVA 4CQFA 3E6VA 3EZPA 4Q3TA 3GMZA 5EF8A 4RHQA 3F06A 4FCIA 4MXRA 4ZUPA 4Q3QA 5ICNB 3Q9EA 5G11A 4QA1A 4ZUQA 5G3WA 3EW8A 2A0MA 1P8QA 3ZNSA 3F07A 5G0JA 1P8PA 2V5XA 3SL0A 1HQ5A 4Q3UA 1T4TA 1ZPEA 4IE2A 3MMRA 1TA1A 4LY1A 4GWCA 5D1DA 5EFBD 3ZNRA 4GSMA 5THSA 5DC6A 4CBTA 4ZUMA 5HJ9A 4MYLA 1W22A 3TF3A 4QA4A 2V5WA 1WOHA 3LP4A 4I06A 4MYKA 3TH7A 3THEA 5EFHA 5G13A 4QA0A 5G0IA 4G3HA 4MYFA 1T5GA 1T4RA 2VQMA 3GN0A 3KV2A 4Q3SA 4LXZA 5G0XA 1TBHA 5DC8A 4Q41A 1WOGA 4BZ7A 2VQJA 4FCKA 3LHLA 5G0YA 3SKKA 1WOIA 5EFKB 1WVAA 5LI3A 1P8RA 5EFNA 5D1BA 1P8SA 4CBYA 4IU5A 3SFHA 5D1CA 4GWDA 3NIOA 4Q3PA 3NIQA 5G0GA 3THJA 1T5FA 1T69A 3MENA 3MJLA 5EFJD 4IE3A 5BWZA 5FCWA 3MZ6A 3M1RA 4Q3RA 4RLAA 5EEMA 4BKXB 4IE1A 5G12A 3Q9CA 4CEVA 2VQVA 1P8MA 1ZZ1A 5FUEA 4ZUNA 2PHAA 5G1AA 3SL1A 2VCGA 5G1BA 1XFKA 1HQXA 4QA2A 3RQDA 5THTA 3MZ7A 4ZURA 4QA6A 5EF7A 3DJ8A 5EEFA 3CEVA 1T67A 1PQ3A 2PHOA 4RHMA 4GSVA 4IXUA 4RHJA 4MYNA 5G1CA 4RHKA 3MFWA 4RHIA 4ITYA 5IX0A 2VQQA 4BZ5A 2EF4A 3E6KA 4RN2A 3LP7A 3SFFA 1R1OA 1WVBA 3EZTA 4GSZA 2RLAA 3MZ3A 4HXQA 1P8OA 1ZZ0A 4RHLA 1VKGA 3NIPA 4Q3RC 5IWGA 4IU4A 1C3PA 3MZ4A 4Q40A 5EENA 1P8NA 1T4PA 4Q42A 5EEKA 5G10A 1C3RA 4HWWA 2VQOA 5JI5A 4A69A 1D3VA 3E8ZA 2AEBA 1RLAA 3C0YA 1TBJA 4RN1A 5RLAA 5THVA 3SJTA 4BZ9A 2EF5A 4IXVA 5G17A 2ZAVA 4RN0A 2PLLA 1CEVA 3EWFA 1HQHA 3THHA 3C0ZA 4DZ4A 1T4SA 1ZZ3A 5THUA 1TBLA 3C10A 3MAXA 3E8QA 4IU0A 4IU1A 5EFGA 3F0RA 3MFVA 4QA3A 2CEVA 4Q3VA 3PZLA 5DC5A 1T64A 5G0HA 1GQ6A
chains in the Genus database with same CATH topology
3Q9FA 4QA7A 3Q9BA 1C3SA 5EEIA 4BZ6A 2GH6A 4ZUOA 4QA5A 5DC7A 4BZ8A 2VQWG 5A2SA 4CQFA 3EZPA 5EF8A 3F06A 4ZUPA 5ICNB 3Q9EA 5G11A 4QA1A 4ZUQA 5G3WA 3EW8A 3ZNSA 3F07A 5G0JA 2V5XA 4LY1A 5EFBD 5D1DA 3ZNRA 5THSA 5DC6A 4CBTA 4ZUMA 1W22A 4QA4A 2V5WA 5EFHA 5G13A 4QA0A 5G0IA 2VQMA 4LXZA 5G0XA 5DC8A 4BZ7A 2VQJA 5G0YA 5LI3A 5EFKB 5EFNA 5D1BA 4CBYA 3SFHA 5D1CA 5G0GA 3MENA 1T69A 5BWZA 5FCWA 3MZ6A 5EEMA 4BKXB 5G12A 3Q9CA 2VQVA 1ZZ1A 5FUEA 4ZUNA 5G1AA 2VCGA 5G1BA 4QA2A 3RQDA 5THTA 3MZ7A 4ZURA 4QA6A 5EF7A 5EEFA 1T67A 5G1CA 5IX0A 2VQQA 4BZ5A 4RN2A 3SFFA 3EZTA 3MZ3A 1ZZ0A 5IWGA 1VKGA 1C3PA 3MZ4A 5EENA 5G10A 5EEKA 1C3RA 2VQOA 5JI5A 4A69A 3C0YA 4RN1A 4QA3A 4BZ9A 5THVA 5G17A 4RN0A 3EWFA 3C0ZA 1ZZ3A 5THUA 3C10A 3MAXA 5EFGA 3F0RA 5EFJD 5DC5A 1T64A 5G0HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q9F A;  4QA7 A;  3Q9B A;  1C3S A;  5EEI A;  4BZ6 A;  2GH6 A;  4ZUO A;  4QA5 A;  5DC7 A;  4BZ8 A;  2VQW G;  5A2S A;  4CQF A;  3EZP A;  5EF8 A;  3F06 A;  4ZUP A;  5ICN B;  3Q9E A;  5G11 A;  4QA1 A;  4ZUQ A;  5G3W A;  3EW8 A;  3ZNS A;  3F07 A;  5G0J A;  2V5X A;  4LY1 A;  5EFB D;  5D1D A;  3ZNR A;  5THS A;  5DC6 A;  4CBT A;  4ZUM A;  1W22 A;  4QA4 A;  2V5W A;  5EFH A;  5G13 A;  4QA0 A;  5G0I A;  2VQM A;  4LXZ A;  5G0X A;  5DC8 A;  4BZ7 A;  2VQJ A;  5G0Y A;  5LI3 A;  5EFK B;  5EFN A;  5D1B A;  4CBY A;  3SFH A;  5D1C A;  5G0G A;  3MEN A;  1T69 A;  5BWZ A;  5FCW A;  3MZ6 A;  5EEM A;  4BKX B;  5G12 A;  3Q9C A;  2VQV A;  1ZZ1 A;  5FUE A;  4ZUN A;  5G1A A;  2VCG A;  5G1B A;  4QA2 A;  3RQD A;  5THT A;  3MZ7 A;  4ZUR A;  4QA6 A;  5EF7 A;  5EEF A;  1T67 A;  5G1C A;  5IX0 A;  2VQQ A;  4BZ5 A;  4RN2 A;  3SFF A;  3EZT A;  3MZ3 A;  1ZZ0 A;  5IWG A;  1VKG A;  1C3P A;  3MZ4 A;  5EEN A;  5G10 A;  5EEK A;  1C3R A;  2VQO A;  5JI5 A;  4A69 A;  3C0Y A;  4RN1 A;  4QA3 A;  4BZ9 A;  5THV A;  5G17 A;  4RN0 A;  3EWF A;  3C0Z A;  1ZZ3 A;  5THU A;  3C10 A;  3MAX A;  5EFG A;  3F0R A;  5EFJ D;  5DC5 A;  1T64 A;  5G0H A; 
#chains in the Genus database with same CATH topology
 1HQG A;  3Q9F A;  4QA7 A;  1HQF A;  4HZE A;  3RLA A;  5HJA A;  3Q9B A;  3E9B A;  1C3S A;  1GQ7 A;  2EIV A;  1ZPG A;  5EEI A;  4BZ6 A;  2GH6 A;  4ZUO A;  4QA5 A;  3F80 A;  5DC7 A;  2VQW G;  4BZ8 A;  5A2S A;  5CEV A;  4CQF A;  3E6V A;  3EZP A;  4Q3T A;  3GMZ A;  5EF8 A;  4RHQ A;  3F06 A;  4FCI A;  4MXR A;  4ZUP A;  4Q3Q A;  5ICN B;  3Q9E A;  5G11 A;  4QA1 A;  4ZUQ A;  5G3W A;  3EW8 A;  2A0M A;  1P8Q A;  3ZNS A;  3F07 A;  5G0J A;  1P8P A;  2V5X A;  3SL0 A;  1HQ5 A;  4Q3U A;  1T4T A;  1ZPE A;  4IE2 A;  3MMR A;  1TA1 A;  4LY1 A;  4GWC A;  5D1D A;  5EFB D;  3ZNR A;  4GSM A;  5THS A;  5DC6 A;  4CBT A;  4ZUM A;  5HJ9 A;  4MYL A;  1W22 A;  3TF3 A;  4QA4 A;  2V5W A;  1WOH A;  3LP4 A;  4I06 A;  4MYK A;  3TH7 A;  3THE A;  5EFH A;  5G13 A;  4QA0 A;  5G0I A;  4G3H A;  4MYF A;  1T5G A;  1T4R A;  2VQM A;  3GN0 A;  3KV2 A;  4Q3S A;  4LXZ A;  5G0X A;  1TBH A;  5DC8 A;  4Q41 A;  1WOG A;  4BZ7 A;  2VQJ A;  4FCK A;  3LHL A;  5G0Y A;  3SKK A;  1WOI A;  5EFK B;  1WVA A;  5LI3 A;  1P8R A;  5EFN A;  5D1B A;  1P8S A;  4CBY A;  4IU5 A;  3SFH A;  5D1C A;  4GWD A;  3NIO A;  4Q3P A;  3NIQ A;  5G0G A;  3THJ A;  1T5F A;  1T69 A;  3MEN A;  3MJL A;  5EFJ D;  4IE3 A;  5BWZ A;  5FCW A;  3MZ6 A;  3M1R A;  4Q3R A;  4RLA A;  5EEM A;  4BKX B;  4IE1 A;  5G12 A;  3Q9C A;  4CEV A;  2VQV A;  1P8M A;  1ZZ1 A;  5FUE A;  4ZUN A;  2PHA A;  5G1A A;  3SL1 A;  2VCG A;  5G1B A;  1XFK A;  1HQX A;  4QA2 A;  3RQD A;  5THT A;  3MZ7 A;  4ZUR A;  4QA6 A;  5EF7 A;  3DJ8 A;  5EEF A;  3CEV A;  1T67 A;  1PQ3 A;  2PHO A;  4RHM A;  4GSV A;  4IXU A;  4RHJ A;  4MYN A;  5G1C A;  4RHK A;  3MFW A;  4RHI A;  4ITY A;  5IX0 A;  2VQQ A;  4BZ5 A;  2EF4 A;  3E6K A;  4RN2 A;  3LP7 A;  3SFF A;  1R1O A;  1WVB A;  3EZT A;  4GSZ A;  2RLA A;  3MZ3 A;  4HXQ A;  1P8O A;  1ZZ0 A;  4RHL A;  1VKG A;  3NIP A;  4Q3R C;  5IWG A;  4IU4 A;  1C3P A;  3MZ4 A;  4Q40 A;  5EEN A;  1P8N A;  1T4P A;  4Q42 A;  5EEK A;  5G10 A;  1C3R A;  4HWW A;  2VQO A;  5JI5 A;  4A69 A;  1D3V A;  3E8Z A;  2AEB A;  1RLA A;  3C0Y A;  1TBJ A;  4RN1 A;  5RLA A;  5THV A;  3SJT A;  4BZ9 A;  2EF5 A;  4IXV A;  5G17 A;  2ZAV A;  4RN0 A;  2PLL A;  1CEV A;  3EWF A;  1HQH A;  3THH A;  3C0Z A;  4DZ4 A;  1T4S A;  1ZZ3 A;  5THU A;  1TBL A;  3C10 A;  3MAX A;  3E8Q A;  4IU0 A;  4IU1 A;  5EFG A;  3F0R A;  3MFV A;  4QA3 A;  2CEV A;  4Q3V A;  3PZL A;  5DC5 A;  1T64 A;  5G0H A;  1GQ6 A; 
#chains in the Genus database with same CATH homology
 3Q9F A;  4QA7 A;  3Q9B A;  1C3S A;  5EEI A;  4BZ6 A;  2GH6 A;  4ZUO A;  4QA5 A;  5DC7 A;  4BZ8 A;  2VQW G;  5A2S A;  4CQF A;  3EZP A;  5EF8 A;  3F06 A;  4ZUP A;  5ICN B;  3Q9E A;  5G11 A;  4QA1 A;  4ZUQ A;  5G3W A;  3EW8 A;  3ZNS A;  3F07 A;  5G0J A;  2V5X A;  4LY1 A;  5EFB D;  5D1D A;  3ZNR A;  5THS A;  5DC6 A;  4CBT A;  4ZUM A;  1W22 A;  4QA4 A;  2V5W A;  5EFH A;  5G13 A;  4QA0 A;  5G0I A;  2VQM A;  4LXZ A;  5G0X A;  5DC8 A;  4BZ7 A;  2VQJ A;  5G0Y A;  5LI3 A;  5EFK B;  5EFN A;  5D1B A;  4CBY A;  3SFH A;  5D1C A;  5G0G A;  3MEN A;  1T69 A;  5BWZ A;  5FCW A;  3MZ6 A;  5EEM A;  4BKX B;  5G12 A;  3Q9C A;  2VQV A;  1ZZ1 A;  5FUE A;  4ZUN A;  5G1A A;  2VCG A;  5G1B A;  4QA2 A;  3RQD A;  5THT A;  3MZ7 A;  4ZUR A;  4QA6 A;  5EF7 A;  5EEF A;  1T67 A;  5G1C A;  5IX0 A;  2VQQ A;  4BZ5 A;  4RN2 A;  3SFF A;  3EZT A;  3MZ3 A;  1ZZ0 A;  5IWG A;  1VKG A;  1C3P A;  3MZ4 A;  5EEN A;  5G10 A;  5EEK A;  1C3R A;  2VQO A;  5JI5 A;  4A69 A;  3C0Y A;  4RN1 A;  4QA3 A;  4BZ9 A;  5THV A;  5G17 A;  4RN0 A;  3EWF A;  3C0Z A;  1ZZ3 A;  5THU A;  3C10 A;  3MAX A;  5EFG A;  3F0R A;  5EFJ D;  5DC5 A;  1T64 A;  5G0H A; 
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