4Q3RA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
345
structure length
335
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHRSGHLPFKVRNLTDQGIMSRAAHMQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 125
structure length 335
sequence length 345
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3rA00
1R1OA 2PHAA 4MYFA 4Q3RC 3KV2A 2CEVA 1T4PA 1P8QA 1P8NA 4RHQA 4IU5A 3PZLA 3F80A 3SJTA 3MFVA 3MJLA 3NIOA 1HQFA 1ZPGA 3MMRA 1T5GA 1P8MA 4IU1A 3THEA 1RLAA 3MFWA 4FCKA 1T5FA 1TBJA 1P8SA 2PLLA 4MYLA 3GN0A 1T4SA 4IE3A 1T4TA 4GSZA 3LP7A 2A0MA 2EIVA 3SL0A 4MYKA 1GQ7A 3CEVA 1HQGA 1WVBA 1WVAA 1XFKA 4GSMA 3DJ8A 1P8PA 4Q42A 1T4RA 4IXVA 4Q3PA 5HJAA 1TA1A 2EF5A 4Q3UA 4CEVA 1PQ3A 1P8RA 1WOIA 1CEVA 3E6KA 3THHA 3SKKA 1TBHA 3THJA 4IE2A 1TBLA 3LP4A 4GWDA 3NIPA 4Q41A 1HQ5A 1ZPEA 4Q3SA 4GWCA 1HQXA 4I06A 3TH7A 3E6VA 3LHLA 2EF4A 4RHIA 3E8ZA 5RLAA 4MYNA 2AEBA 3RLAA 2RLAA 4RLAA 4ITYA 3M1RA 4Q3TA 4HWWA 4RHJA 4HZEA 5HJ9A 2ZAVA 4Q3RA 4IU4A 4G3HA 3E8QA 3NIQA 3E9BA 1GQ6A 4RHMA 4FCIA 4IXUA 2PHOA 1HQHA 4IE1A 4GSVA 1WOGA 3GMZA 4RHLA 4Q3VA 4DZ4A 4IU0A 1WOHA 3SL1A 4HXQA 4MXRA 4RHKA 1P8OA 1D3VA 5CEVA 4Q40A 4Q3QA 3TF3A
chains in the Genus database with same CATH superfamily
1R1OA 3F06A 2PHAA 3MENA 4MYFA 3ZNRA 3C0YA 4Q3RC 3KV2A 2CEVA 1VKGA 1T4PA 1P8QA 1P8NA 2VQMA 4RHQA 4RN0A 4IU5A 3PZLA 5EF7A 5EFBD 5IX0A 3F80A 3SJTA 2GH6A 4BKXB 3MFVA 5EFKB 3MJLA 3NIOA 2VQQA 1HQFA 4QA1A 1ZPGA 1W22A 3MMRA 1T5GA 5JI5A 1P8MA 2VQOA 4IU1A 3THEA 1RLAA 2VCGA 3MFWA 4FCKA 1T5FA 1TBJA 5ICNB 2V5XA 4ZUNA 4QA3A 1P8SA 1T64A 2PLLA 4MYLA 3EZTA 5G13A 3GN0A 1T4SA 4BZ7A 4IE3A 1T4TA 4GSZA 4QA0A 3LP7A 5THUA 2A0MA 5D1CA 2EIVA 3SL0A 4MYKA 3Q9BA 4LXZA 5EEIA 5A2SA 1GQ7A 4CBYA 4BZ9A 3CEVA 4QA4A 1C3PA 3MZ3A 1HQGA 1WVBA 1WVAA 1XFKA 4GSMA 3DJ8A 1P8PA 4Q42A 5EENA 4A69A 1T4RA 4IXVA 4Q3PA 3SFHA 2VQWG 4ZUQA 5HJAA 1TA1A 3TF3A 2EF5A 4Q3UA 4CEVA 5G1AA 1PQ3A 1P8RA 1WOIA 1CEVA 3E6KA 4QA7A 3THHA 5EEMA 3SKKA 4CQFA 1ZZ1A 2V5WA 1TBHA 5THSA 3THJA 5EFNA 3MZ6A 4IE2A 4CBTA 4QA6A 1ZZ3A 4LY1A 1TBLA 1C3RA 5EFJD 3LP4A 5EEFA 2VQJA 4ZUOA 4GWDA 3NIPA 5LI3A 4QA2A 1HQ5A 4Q41A 4RN1A 4ZURA 1ZPEA 4RN2A 5FCWA 4BZ5A 5EFGA 4Q3SA 5EF8A 4GWCA 3EZPA 1HQXA 4I06A 5THTA 5G12A 3TH7A 5DC7A 3SFFA 4ZUPA 3E6VA 3ZNSA 4BZ6A 5G1BA 4ZUMA 4QA5A 5G0HA 3LHLA 2EF4A 4RHIA 3E8ZA 5RLAA 5G0XA 4MYNA 3EW8A 2AEBA 5D1DA 3RLAA 2RLAA 3MZ7A 5G17A 4RLAA 4ITYA 3M1RA 1T67A 4Q3TA 4HWWA 4RHJA 4HZEA 4BZ8A 5HJ9A 2ZAVA 1ZZ0A 4Q3RA 3C0ZA 4IU4A 4G3HA 3E8QA 3NIQA 5EEKA 5G0YA 3C10A 5DC5A 5EFHA 3E9BA 5D1BA 1GQ6A 3Q9FA 4RHMA 3Q9EA 4FCIA 5G0GA 5G0IA 4IXUA 5DC8A 2PHOA 3MAXA 5THVA 1HQHA 4IE1A 4GSVA 1C3SA 1WOGA 3GMZA 4RHLA 3Q9CA 3EWFA 5IWGA 3MZ4A 3F0RA 4Q3VA 4DZ4A 5DC6A 4IU0A 1T69A 1WOHA 2VQVA 3SL1A 4HXQA 5G10A 5G1CA 4MXRA 4RHKA 1P8OA 3F07A 5G11A 5G0JA 5FUEA 1D3VA 3RQDA 5BWZA 5CEVA 4Q40A 4Q3QA 5G3WA
chains in the Genus database with same CATH topology
1R1OA 2PHAA 4MYFA 4Q3RC 3KV2A 2CEVA 1T4PA 1P8QA 1P8NA 4RHQA 4IU5A 3PZLA 3F80A 3SJTA 3MFVA 3MJLA 3NIOA 1HQFA 1ZPGA 3MMRA 1T5GA 1P8MA 4IU1A 3THEA 1RLAA 3MFWA 4FCKA 1T5FA 1TBJA 1P8SA 2PLLA 4MYLA 3GN0A 1T4SA 4IE3A 1T4TA 4GSZA 3LP7A 2A0MA 2EIVA 3SL0A 4MYKA 1GQ7A 3CEVA 1HQGA 1WVBA 1WVAA 1XFKA 4GSMA 3DJ8A 1P8PA 4Q42A 1T4RA 4IXVA 4Q3PA 5HJAA 1TA1A 2EF5A 4Q3UA 4CEVA 1PQ3A 1P8RA 1WOIA 1CEVA 3E6KA 3THHA 3SKKA 1TBHA 3THJA 4IE2A 1TBLA 3LP4A 4GWDA 3NIPA 4Q41A 1HQ5A 1ZPEA 4Q3SA 4GWCA 1HQXA 4I06A 3TH7A 3E6VA 3LHLA 2EF4A 4RHIA 3E8ZA 5RLAA 4MYNA 2AEBA 3RLAA 2RLAA 4RLAA 4ITYA 3M1RA 4Q3TA 4HWWA 4RHJA 4HZEA 5HJ9A 2ZAVA 4Q3RA 4IU4A 4G3HA 3E8QA 3NIQA 3E9BA 1GQ6A 4RHMA 4FCIA 4IXUA 2PHOA 1HQHA 4IE1A 4GSVA 1WOGA 3GMZA 4RHLA 4Q3VA 4DZ4A 4IU0A 1WOHA 3SL1A 4HXQA 4MXRA 4RHKA 1P8OA 1D3VA 5CEVA 4Q40A 4Q3QA 3TF3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R1O A;  2PHA A;  4MYF A;  4Q3R C;  3KV2 A;  2CEV A;  1T4P A;  1P8Q A;  1P8N A;  4RHQ A;  4IU5 A;  3PZL A;  3F80 A;  3SJT A;  3MFV A;  3MJL A;  3NIO A;  1HQF A;  1ZPG A;  3MMR A;  1T5G A;  1P8M A;  4IU1 A;  3THE A;  1RLA A;  3MFW A;  4FCK A;  1T5F A;  1TBJ A;  1P8S A;  2PLL A;  4MYL A;  3GN0 A;  1T4S A;  4IE3 A;  1T4T A;  4GSZ A;  3LP7 A;  2A0M A;  2EIV A;  3SL0 A;  4MYK A;  1GQ7 A;  3CEV A;  1HQG A;  1WVB A;  1WVA A;  1XFK A;  4GSM A;  3DJ8 A;  1P8P A;  4Q42 A;  1T4R A;  4IXV A;  4Q3P A;  5HJA A;  1TA1 A;  2EF5 A;  4Q3U A;  4CEV A;  1PQ3 A;  1P8R A;  1WOI A;  1CEV A;  3E6K A;  3THH A;  3SKK A;  1TBH A;  3THJ A;  4IE2 A;  1TBL A;  3LP4 A;  4GWD A;  3NIP A;  4Q41 A;  1HQ5 A;  1ZPE A;  4Q3S A;  4GWC A;  1HQX A;  4I06 A;  3TH7 A;  3E6V A;  3LHL A;  2EF4 A;  4RHI A;  3E8Z A;  5RLA A;  4MYN A;  2AEB A;  3RLA A;  2RLA A;  4RLA A;  4ITY A;  3M1R A;  4Q3T A;  4HWW A;  4RHJ A;  4HZE A;  5HJ9 A;  2ZAV A;  4Q3R A;  4IU4 A;  4G3H A;  3E8Q A;  3NIQ A;  3E9B A;  1GQ6 A;  4RHM A;  4FCI A;  4IXU A;  2PHO A;  1HQH A;  4IE1 A;  4GSV A;  1WOG A;  3GMZ A;  4RHL A;  4Q3V A;  4DZ4 A;  4IU0 A;  1WOH A;  3SL1 A;  4HXQ A;  4MXR A;  4RHK A;  1P8O A;  1D3V A;  5CEV A;  4Q40 A;  4Q3Q A;  3TF3 A; 
#chains in the Genus database with same CATH topology
 1R1O A;  3F06 A;  2PHA A;  3MEN A;  4MYF A;  3ZNR A;  3C0Y A;  4Q3R C;  3KV2 A;  2CEV A;  1VKG A;  1T4P A;  1P8Q A;  1P8N A;  2VQM A;  4RHQ A;  4RN0 A;  4IU5 A;  3PZL A;  5EF7 A;  5EFB D;  5IX0 A;  3F80 A;  3SJT A;  2GH6 A;  4BKX B;  3MFV A;  5EFK B;  3MJL A;  3NIO A;  2VQQ A;  1HQF A;  4QA1 A;  1ZPG A;  1W22 A;  3MMR A;  1T5G A;  5JI5 A;  1P8M A;  2VQO A;  4IU1 A;  3THE A;  1RLA A;  2VCG A;  3MFW A;  4FCK A;  1T5F A;  1TBJ A;  5ICN B;  2V5X A;  4ZUN A;  4QA3 A;  1P8S A;  1T64 A;  2PLL A;  4MYL A;  3EZT A;  5G13 A;  3GN0 A;  1T4S A;  4BZ7 A;  4IE3 A;  1T4T A;  4GSZ A;  4QA0 A;  3LP7 A;  5THU A;  2A0M A;  5D1C A;  2EIV A;  3SL0 A;  4MYK A;  3Q9B A;  4LXZ A;  5EEI A;  5A2S A;  1GQ7 A;  4CBY A;  4BZ9 A;  3CEV A;  4QA4 A;  1C3P A;  3MZ3 A;  1HQG A;  1WVB A;  1WVA A;  1XFK A;  4GSM A;  3DJ8 A;  1P8P A;  4Q42 A;  5EEN A;  4A69 A;  1T4R A;  4IXV A;  4Q3P A;  3SFH A;  2VQW G;  4ZUQ A;  5HJA A;  1TA1 A;  3TF3 A;  2EF5 A;  4Q3U A;  4CEV A;  5G1A A;  1PQ3 A;  1P8R A;  1WOI A;  1CEV A;  3E6K A;  4QA7 A;  3THH A;  5EEM A;  3SKK A;  4CQF A;  1ZZ1 A;  2V5W A;  1TBH A;  5THS A;  3THJ A;  5EFN A;  3MZ6 A;  4IE2 A;  4CBT A;  4QA6 A;  1ZZ3 A;  4LY1 A;  1TBL A;  1C3R A;  5EFJ D;  3LP4 A;  5EEF A;  2VQJ A;  4ZUO A;  4GWD A;  3NIP A;  5LI3 A;  4QA2 A;  1HQ5 A;  4Q41 A;  4RN1 A;  4ZUR A;  1ZPE A;  4RN2 A;  5FCW A;  4BZ5 A;  5EFG A;  4Q3S A;  5EF8 A;  4GWC A;  3EZP A;  1HQX A;  4I06 A;  5THT A;  5G12 A;  3TH7 A;  5DC7 A;  3SFF A;  4ZUP A;  3E6V A;  3ZNS A;  4BZ6 A;  5G1B A;  4ZUM A;  4QA5 A;  5G0H A;  3LHL A;  2EF4 A;  4RHI A;  3E8Z A;  5RLA A;  5G0X A;  4MYN A;  3EW8 A;  2AEB A;  5D1D A;  3RLA A;  2RLA A;  3MZ7 A;  5G17 A;  4RLA A;  4ITY A;  3M1R A;  1T67 A;  4Q3T A;  4HWW A;  4RHJ A;  4HZE A;  4BZ8 A;  5HJ9 A;  2ZAV A;  1ZZ0 A;  4Q3R A;  3C0Z A;  4IU4 A;  4G3H A;  3E8Q A;  3NIQ A;  5EEK A;  5G0Y A;  3C10 A;  5DC5 A;  5EFH A;  3E9B A;  5D1B A;  1GQ6 A;  3Q9F A;  4RHM A;  3Q9E A;  4FCI A;  5G0G A;  5G0I A;  4IXU A;  5DC8 A;  2PHO A;  3MAX A;  5THV A;  1HQH A;  4IE1 A;  4GSV A;  1C3S A;  1WOG A;  3GMZ A;  4RHL A;  3Q9C A;  3EWF A;  5IWG A;  3MZ4 A;  3F0R A;  4Q3V A;  4DZ4 A;  5DC6 A;  4IU0 A;  1T69 A;  1WOH A;  2VQV A;  3SL1 A;  4HXQ A;  5G10 A;  5G1C A;  4MXR A;  4RHK A;  1P8O A;  3F07 A;  5G11 A;  5G0J A;  5FUE A;  1D3V A;  3RQD A;  5BWZ A;  5CEV A;  4Q40 A;  4Q3Q A;  5G3W A; 
#chains in the Genus database with same CATH homology
 1R1O A;  2PHA A;  4MYF A;  4Q3R C;  3KV2 A;  2CEV A;  1T4P A;  1P8Q A;  1P8N A;  4RHQ A;  4IU5 A;  3PZL A;  3F80 A;  3SJT A;  3MFV A;  3MJL A;  3NIO A;  1HQF A;  1ZPG A;  3MMR A;  1T5G A;  1P8M A;  4IU1 A;  3THE A;  1RLA A;  3MFW A;  4FCK A;  1T5F A;  1TBJ A;  1P8S A;  2PLL A;  4MYL A;  3GN0 A;  1T4S A;  4IE3 A;  1T4T A;  4GSZ A;  3LP7 A;  2A0M A;  2EIV A;  3SL0 A;  4MYK A;  1GQ7 A;  3CEV A;  1HQG A;  1WVB A;  1WVA A;  1XFK A;  4GSM A;  3DJ8 A;  1P8P A;  4Q42 A;  1T4R A;  4IXV A;  4Q3P A;  5HJA A;  1TA1 A;  2EF5 A;  4Q3U A;  4CEV A;  1PQ3 A;  1P8R A;  1WOI A;  1CEV A;  3E6K A;  3THH A;  3SKK A;  1TBH A;  3THJ A;  4IE2 A;  1TBL A;  3LP4 A;  4GWD A;  3NIP A;  4Q41 A;  1HQ5 A;  1ZPE A;  4Q3S A;  4GWC A;  1HQX A;  4I06 A;  3TH7 A;  3E6V A;  3LHL A;  2EF4 A;  4RHI A;  3E8Z A;  5RLA A;  4MYN A;  2AEB A;  3RLA A;  2RLA A;  4RLA A;  4ITY A;  3M1R A;  4Q3T A;  4HWW A;  4RHJ A;  4HZE A;  5HJ9 A;  2ZAV A;  4Q3R A;  4IU4 A;  4G3H A;  3E8Q A;  3NIQ A;  3E9B A;  1GQ6 A;  4RHM A;  4FCI A;  4IXU A;  2PHO A;  1HQH A;  4IE1 A;  4GSV A;  1WOG A;  3GMZ A;  4RHL A;  4Q3V A;  4DZ4 A;  4IU0 A;  1WOH A;  3SL1 A;  4HXQ A;  4MXR A;  4RHK A;  1P8O A;  1D3V A;  5CEV A;  4Q40 A;  4Q3Q A;  3TF3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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