4Q3RC

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
345
structure length
333
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 126
structure length 333
sequence length 345
chains with identical sequence D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3rC00
4MXRA 3THHA 4MYFA 1HQGA 3MFVA 4MYNA 4RHQA 4IU4A 4FCKA 4GSMA 3MMRA 1ZPGA 1WOGA 1PQ3A 1T4PA 4GWCA 5HJ9A 1P8MA 4Q3UA 4HZEA 4RHKA 5CEVA 1WVAA 3TH7A 1GQ7A 1T5FA 1T4SA 1P8OA 5HJAA 3CEVA 3E8QA 4HXQA 3SJTA 4RLAA 4IU0A 3E6KA 2ZAVA 3KV2A 1T4TA 4RHJA 3SL0A 2CEVA 4IXVA 3LP7A 1GQ6A 1P8RA 1P8NA 1TBHA 4I06A 4FCIA 1WOIA 3GMZA 3NIQA 2AEBA 4RHIA 1T4RA 4G3HA 2PLLA 2RLAA 3E6VA 4IE3A 4Q3RA 4Q3QA 1RLAA 1TBLA 3LHLA 1HQHA 1WVBA 3GN0A 1P8SA 4IU1A 2EIVA 4RHMA 1ZPEA 4CEVA 4IE1A 3E8ZA 4GWDA 1P8PA 4IXUA 2PHAA 4MYLA 4Q3RC 3SL1A 4Q3TA 3MJLA 4Q3PA 3PZLA 4ITYA 4Q40A 1TA1A 1T5GA 3TF3A 2A0MA 1TBJA 3SKKA 1HQ5A 3MFWA 4RHLA 1P8QA 1R1OA 5RLAA 4Q41A 4HWWA 4IU5A 1HQXA 4GSZA 4Q3VA 2PHOA 1XFKA 2EF5A 1WOHA 4Q42A 1D3VA 3THJA 4DZ4A 3THEA 4GSVA 3M1RA 3NIPA 2EF4A 4Q3SA 3NIOA 3DJ8A 1CEVA 4IE2A 1HQFA 3E9BA 3F80A 4MYKA 3RLAA 3LP4A
chains in the Genus database with same CATH superfamily
3C0YA 4MXRA 5G3WA 2V5XA 5IX0A 4ZURA 3THHA 4MYFA 3C0ZA 4ZUOA 3EW8A 5D1CA 1HQGA 3MFVA 4MYNA 5EENA 4RHQA 4IU4A 4FCKA 4GSMA 4RN1A 5G12A 3MMRA 1ZPGA 1WOGA 1PQ3A 4BKXB 5JI5A 1T4PA 4GWCA 5EFNA 5G0YA 3MZ4A 5HJ9A 4QA6A 4BZ6A 1P8MA 4Q3UA 4HZEA 4RHKA 4ZUNA 4LY1A 1C3PA 3ZNRA 4ZUQA 5CEVA 1WVAA 4ZUPA 3TH7A 3F0RA 2VQMA 1GQ7A 1T5FA 3F07A 1T4SA 5DC5A 1P8OA 5G0IA 5G0HA 5EF8A 5HJAA 1VKGA 2VQJA 3CEVA 3E8QA 5EF7A 4HXQA 4ZUMA 3SJTA 4QA5A 5FCWA 4RLAA 4IU0A 3E6KA 5DC7A 5DC6A 2ZAVA 5THUA 3KV2A 1T4TA 5G10A 4RHJA 4LXZA 4BZ8A 3SL0A 4QA4A 1ZZ0A 2CEVA 3LP7A 4IXVA 1GQ6A 1P8RA 4QA2A 1P8NA 5THVA 5EEFA 1TBHA 1C3SA 2V5WA 4I06A 5FUEA 2VQOA 4QA7A 1W22A 4QA1A 4BZ9A 3EWFA 2GH6A 4FCIA 5A2SA 1WOIA 2VQVA 3GMZA 3NIQA 4BZ5A 2AEBA 4RHIA 5G1CA 4A69A 4CQFA 1T4RA 5LI3A 4G3HA 2PLLA 2VQQA 5DC8A 2RLAA 3E6VA 4IE3A 4Q3RA 3MAXA 4Q3QA 1RLAA 1TBLA 3LHLA 3Q9CA 1HQHA 5EEIA 5G0GA 1WVBA 1ZZ1A 1P8SA 3GN0A 4IU1A 4QA3A 4RN0A 2EIVA 4RHMA 1ZPEA 4CEVA 4IE1A 5EEKA 3E8ZA 4GWDA 1P8PA 4IXUA 2PHAA 5G1AA 5G13A 4MYLA 5G0JA 4Q3RC 4CBTA 3SL1A 4Q3TA 3F06A 3MJLA 4Q3PA 5ICNB 3MZ3A 3PZLA 4ITYA 3Q9FA 4Q40A 3RQDA 1TA1A 4BZ7A 2VCGA 3Q9BA 1T5GA 3TF3A 1T64A 2A0MA 1TBJA 3SFFA 5EEMA 3SKKA 1HQ5A 4QA0A 3MFWA 5D1BA 5G1BA 3SFHA 4RHLA 1P8QA 5BWZA 1R1OA 3MZ7A 5RLAA 3MENA 5G11A 3EZTA 4Q41A 4HWWA 4IU5A 3EZPA 1T69A 1HQXA 4GSZA 5EFBD 5THSA 1T67A 4Q3VA 5EFJD 2PHOA 1C3RA 1XFKA 5G17A 2EF5A 1WOHA 4Q42A 1D3VA 5EFGA 5G0XA 3THJA 4DZ4A 3THEA 4CBYA 3Q9EA 2VQWG 4GSVA 5D1DA 4RN2A 3ZNSA 3M1RA 3NIPA 3MZ6A 2EF4A 4Q3SA 1ZZ3A 5THTA 3NIOA 3DJ8A 1CEVA 4IE2A 1HQFA 3E9BA 3F80A 4MYKA 5IWGA 3RLAA 5EFHA 3C10A 5EFKB 3LP4A
chains in the Genus database with same CATH topology
4MXRA 3THHA 4MYFA 1HQGA 3MFVA 4MYNA 4RHQA 4IU4A 4FCKA 4GSMA 3MMRA 1ZPGA 1WOGA 1PQ3A 1T4PA 4GWCA 5HJ9A 1P8MA 4Q3UA 4HZEA 4RHKA 5CEVA 1WVAA 3TH7A 1GQ7A 1T5FA 1T4SA 1P8OA 5HJAA 3CEVA 3E8QA 4HXQA 3SJTA 4RLAA 4IU0A 3E6KA 2ZAVA 3KV2A 1T4TA 4RHJA 3SL0A 2CEVA 4IXVA 3LP7A 1GQ6A 1P8RA 1P8NA 1TBHA 4I06A 4FCIA 1WOIA 3GMZA 3NIQA 2AEBA 4RHIA 1T4RA 4G3HA 2PLLA 2RLAA 3E6VA 4IE3A 4Q3RA 4Q3QA 1RLAA 1TBLA 3LHLA 1HQHA 1WVBA 3GN0A 1P8SA 4IU1A 2EIVA 4RHMA 1ZPEA 4CEVA 4IE1A 3E8ZA 4GWDA 1P8PA 4IXUA 2PHAA 4MYLA 4Q3RC 3SL1A 4Q3TA 3MJLA 4Q3PA 3PZLA 4ITYA 4Q40A 1TA1A 1T5GA 3TF3A 2A0MA 1TBJA 3SKKA 1HQ5A 3MFWA 4RHLA 1P8QA 1R1OA 5RLAA 4Q41A 4HWWA 4IU5A 1HQXA 4GSZA 4Q3VA 2PHOA 1XFKA 2EF5A 1WOHA 4Q42A 1D3VA 3THJA 4DZ4A 3THEA 4GSVA 3M1RA 3NIPA 2EF4A 4Q3SA 3NIOA 3DJ8A 1CEVA 4IE2A 1HQFA 3E9BA 3F80A 4MYKA 3RLAA 3LP4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MXR A;  3THH A;  4MYF A;  1HQG A;  3MFV A;  4MYN A;  4RHQ A;  4IU4 A;  4FCK A;  4GSM A;  3MMR A;  1ZPG A;  1WOG A;  1PQ3 A;  1T4P A;  4GWC A;  5HJ9 A;  1P8M A;  4Q3U A;  4HZE A;  4RHK A;  5CEV A;  1WVA A;  3TH7 A;  1GQ7 A;  1T5F A;  1T4S A;  1P8O A;  5HJA A;  3CEV A;  3E8Q A;  4HXQ A;  3SJT A;  4RLA A;  4IU0 A;  3E6K A;  2ZAV A;  3KV2 A;  1T4T A;  4RHJ A;  3SL0 A;  2CEV A;  4IXV A;  3LP7 A;  1GQ6 A;  1P8R A;  1P8N A;  1TBH A;  4I06 A;  4FCI A;  1WOI A;  3GMZ A;  3NIQ A;  2AEB A;  4RHI A;  1T4R A;  4G3H A;  2PLL A;  2RLA A;  3E6V A;  4IE3 A;  4Q3R A;  4Q3Q A;  1RLA A;  1TBL A;  3LHL A;  1HQH A;  1WVB A;  3GN0 A;  1P8S A;  4IU1 A;  2EIV A;  4RHM A;  1ZPE A;  4CEV A;  4IE1 A;  3E8Z A;  4GWD A;  1P8P A;  4IXU A;  2PHA A;  4MYL A;  4Q3R C;  3SL1 A;  4Q3T A;  3MJL A;  4Q3P A;  3PZL A;  4ITY A;  4Q40 A;  1TA1 A;  1T5G A;  3TF3 A;  2A0M A;  1TBJ A;  3SKK A;  1HQ5 A;  3MFW A;  4RHL A;  1P8Q A;  1R1O A;  5RLA A;  4Q41 A;  4HWW A;  4IU5 A;  1HQX A;  4GSZ A;  4Q3V A;  2PHO A;  1XFK A;  2EF5 A;  1WOH A;  4Q42 A;  1D3V A;  3THJ A;  4DZ4 A;  3THE A;  4GSV A;  3M1R A;  3NIP A;  2EF4 A;  4Q3S A;  3NIO A;  3DJ8 A;  1CEV A;  4IE2 A;  1HQF A;  3E9B A;  3F80 A;  4MYK A;  3RLA A;  3LP4 A; 
#chains in the Genus database with same CATH topology
 3C0Y A;  4MXR A;  5G3W A;  2V5X A;  5IX0 A;  4ZUR A;  3THH A;  4MYF A;  3C0Z A;  4ZUO A;  3EW8 A;  5D1C A;  1HQG A;  3MFV A;  4MYN A;  5EEN A;  4RHQ A;  4IU4 A;  4FCK A;  4GSM A;  4RN1 A;  5G12 A;  3MMR A;  1ZPG A;  1WOG A;  1PQ3 A;  4BKX B;  5JI5 A;  1T4P A;  4GWC A;  5EFN A;  5G0Y A;  3MZ4 A;  5HJ9 A;  4QA6 A;  4BZ6 A;  1P8M A;  4Q3U A;  4HZE A;  4RHK A;  4ZUN A;  4LY1 A;  1C3P A;  3ZNR A;  4ZUQ A;  5CEV A;  1WVA A;  4ZUP A;  3TH7 A;  3F0R A;  2VQM A;  1GQ7 A;  1T5F A;  3F07 A;  1T4S A;  5DC5 A;  1P8O A;  5G0I A;  5G0H A;  5EF8 A;  5HJA A;  1VKG A;  2VQJ A;  3CEV A;  3E8Q A;  5EF7 A;  4HXQ A;  4ZUM A;  3SJT A;  4QA5 A;  5FCW A;  4RLA A;  4IU0 A;  3E6K A;  5DC7 A;  5DC6 A;  2ZAV A;  5THU A;  3KV2 A;  1T4T A;  5G10 A;  4RHJ A;  4LXZ A;  4BZ8 A;  3SL0 A;  4QA4 A;  1ZZ0 A;  2CEV A;  3LP7 A;  4IXV A;  1GQ6 A;  1P8R A;  4QA2 A;  1P8N A;  5THV A;  5EEF A;  1TBH A;  1C3S A;  2V5W A;  4I06 A;  5FUE A;  2VQO A;  4QA7 A;  1W22 A;  4QA1 A;  4BZ9 A;  3EWF A;  2GH6 A;  4FCI A;  5A2S A;  1WOI A;  2VQV A;  3GMZ A;  3NIQ A;  4BZ5 A;  2AEB A;  4RHI A;  5G1C A;  4A69 A;  4CQF A;  1T4R A;  5LI3 A;  4G3H A;  2PLL A;  2VQQ A;  5DC8 A;  2RLA A;  3E6V A;  4IE3 A;  4Q3R A;  3MAX A;  4Q3Q A;  1RLA A;  1TBL A;  3LHL A;  3Q9C A;  1HQH A;  5EEI A;  5G0G A;  1WVB A;  1ZZ1 A;  1P8S A;  3GN0 A;  4IU1 A;  4QA3 A;  4RN0 A;  2EIV A;  4RHM A;  1ZPE A;  4CEV A;  4IE1 A;  5EEK A;  3E8Z A;  4GWD A;  1P8P A;  4IXU A;  2PHA A;  5G1A A;  5G13 A;  4MYL A;  5G0J A;  4Q3R C;  4CBT A;  3SL1 A;  4Q3T A;  3F06 A;  3MJL A;  4Q3P A;  5ICN B;  3MZ3 A;  3PZL A;  4ITY A;  3Q9F A;  4Q40 A;  3RQD A;  1TA1 A;  4BZ7 A;  2VCG A;  3Q9B A;  1T5G A;  3TF3 A;  1T64 A;  2A0M A;  1TBJ A;  3SFF A;  5EEM A;  3SKK A;  1HQ5 A;  4QA0 A;  3MFW A;  5D1B A;  5G1B A;  3SFH A;  4RHL A;  1P8Q A;  5BWZ A;  1R1O A;  3MZ7 A;  5RLA A;  3MEN A;  5G11 A;  3EZT A;  4Q41 A;  4HWW A;  4IU5 A;  3EZP A;  1T69 A;  1HQX A;  4GSZ A;  5EFB D;  5THS A;  1T67 A;  4Q3V A;  5EFJ D;  2PHO A;  1C3R A;  1XFK A;  5G17 A;  2EF5 A;  1WOH A;  4Q42 A;  1D3V A;  5EFG A;  5G0X A;  3THJ A;  4DZ4 A;  3THE A;  4CBY A;  3Q9E A;  2VQW G;  4GSV A;  5D1D A;  4RN2 A;  3ZNS A;  3M1R A;  3NIP A;  3MZ6 A;  2EF4 A;  4Q3S A;  1ZZ3 A;  5THT A;  3NIO A;  3DJ8 A;  1CEV A;  4IE2 A;  1HQF A;  3E9B A;  3F80 A;  4MYK A;  5IWG A;  3RLA A;  5EFH A;  3C10 A;  5EFK B;  3LP4 A; 
#chains in the Genus database with same CATH homology
 4MXR A;  3THH A;  4MYF A;  1HQG A;  3MFV A;  4MYN A;  4RHQ A;  4IU4 A;  4FCK A;  4GSM A;  3MMR A;  1ZPG A;  1WOG A;  1PQ3 A;  1T4P A;  4GWC A;  5HJ9 A;  1P8M A;  4Q3U A;  4HZE A;  4RHK A;  5CEV A;  1WVA A;  3TH7 A;  1GQ7 A;  1T5F A;  1T4S A;  1P8O A;  5HJA A;  3CEV A;  3E8Q A;  4HXQ A;  3SJT A;  4RLA A;  4IU0 A;  3E6K A;  2ZAV A;  3KV2 A;  1T4T A;  4RHJ A;  3SL0 A;  2CEV A;  4IXV A;  3LP7 A;  1GQ6 A;  1P8R A;  1P8N A;  1TBH A;  4I06 A;  4FCI A;  1WOI A;  3GMZ A;  3NIQ A;  2AEB A;  4RHI A;  1T4R A;  4G3H A;  2PLL A;  2RLA A;  3E6V A;  4IE3 A;  4Q3R A;  4Q3Q A;  1RLA A;  1TBL A;  3LHL A;  1HQH A;  1WVB A;  3GN0 A;  1P8S A;  4IU1 A;  2EIV A;  4RHM A;  1ZPE A;  4CEV A;  4IE1 A;  3E8Z A;  4GWD A;  1P8P A;  4IXU A;  2PHA A;  4MYL A;  4Q3R C;  3SL1 A;  4Q3T A;  3MJL A;  4Q3P A;  3PZL A;  4ITY A;  4Q40 A;  1TA1 A;  1T5G A;  3TF3 A;  2A0M A;  1TBJ A;  3SKK A;  1HQ5 A;  3MFW A;  4RHL A;  1P8Q A;  1R1O A;  5RLA A;  4Q41 A;  4HWW A;  4IU5 A;  1HQX A;  4GSZ A;  4Q3V A;  2PHO A;  1XFK A;  2EF5 A;  1WOH A;  4Q42 A;  1D3V A;  3THJ A;  4DZ4 A;  3THE A;  4GSV A;  3M1R A;  3NIP A;  2EF4 A;  4Q3S A;  3NIO A;  3DJ8 A;  1CEV A;  4IE2 A;  1HQF A;  3E9B A;  3F80 A;  4MYK A;  3RLA A;  3LP4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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