4Q3SA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
344
structure length
335
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 127
structure length 335
sequence length 344
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3sA00
3LP7A 1P8QA 4Q3VA 1T4TA 3KV2A 3NIPA 1RLAA 4FCKA 2A0MA 4GSZA 4GSVA 4Q3QA 3SJTA 3TH7A 2EIVA 4Q3TA 4IXVA 1HQ5A 4RHMA 4IXUA 1ZPEA 5CEVA 4Q3PA 1HQFA 5HJ9A 4I06A 4MYFA 2PHOA 2AEBA 4RHLA 4GWCA 3SL0A 1TBJA 4Q42A 4GSMA 2PHAA 4G3HA 2EF4A 4MYKA 4GWDA 3MJLA 3E8QA 3SKKA 4MYLA 3SL1A 1TBLA 1WVBA 3M1RA 3E9BA 3E6KA 4CEVA 4Q3SA 4Q40A 5HJAA 3GN0A 4RHIA 1PQ3A 1ZPGA 1TBHA 4RHQA 1P8OA 1HQGA 1D3VA 1XFKA 2PLLA 4Q3RA 3THHA 2RLAA 4IU1A 4MYNA 4IE3A 4RHKA 4RLAA 5RLAA 3F80A 2ZAVA 1CEVA 1WVAA 1P8PA 3LHLA 3LP4A 1T5FA 1WOHA 3NIQA 2CEVA 4IE1A 1HQHA 4IU4A 3E6VA 3GMZA 1GQ6A 4HXQA 4IU5A 1P8NA 1T4RA 1T5GA 3THJA 4DZ4A 4Q3UA 1P8MA 3DJ8A 3MMRA 1WOIA 1P8RA 1GQ7A 3MFVA 3TF3A 3E8ZA 4FCIA 1T4PA 4Q3RC 1R1OA 1T4SA 2EF5A 4IE2A 1P8SA 4RHJA 4IU0A 3RLAA 4Q41A 4HWWA 3PZLA 4HZEA 3THEA 3NIOA 1HQXA 1TA1A 3MFWA 1WOGA 3CEVA 4ITYA 4MXRA
chains in the Genus database with same CATH superfamily
3SFFA 3F0RA 5EF8A 1T64A 2VQQA 2VQMA 3C10A 3LP7A 1P8QA 4Q3VA 4QA3A 1T4TA 3KV2A 5EFGA 3RQDA 1T67A 3NIPA 1RLAA 3Q9FA 4FCKA 2A0MA 4GSZA 4GSVA 4Q3QA 5G13A 3SJTA 3TH7A 2EIVA 4Q3TA 4IXVA 1HQ5A 3F06A 5THVA 4RHMA 5DC7A 5EENA 4LXZA 4RN0A 4IXUA 1ZPEA 4CBYA 5CEVA 4Q3PA 1HQFA 5HJ9A 4I06A 4MYFA 2PHOA 5JI5A 2AEBA 5EFKB 4QA6A 4RHLA 4GWCA 1T69A 4LY1A 5FCWA 4ZUOA 1TBJA 3SL0A 4Q42A 3MZ3A 2GH6A 4CQFA 4GSMA 1C3RA 2PHAA 5G1AA 5G3WA 4G3HA 2EF4A 3ZNRA 4MYKA 4GWDA 3MJLA 5IX0A 3E8QA 3MZ7A 4RN2A 3SKKA 4MYLA 1ZZ0A 3SL1A 1TBLA 1WVBA 3M1RA 3E9BA 3E6KA 5G0HA 3ZNSA 4CEVA 4ZUQA 5BWZA 4QA7A 4Q3SA 4Q40A 5EEMA 5HJAA 3GN0A 4RHIA 1PQ3A 4QA2A 1ZPGA 1TBHA 1ZZ3A 4QA4A 4RHQA 1P8OA 5THSA 5EFJD 1HQGA 2VCGA 5D1DA 5G0GA 1D3VA 1XFKA 2PLLA 4Q3RA 3THHA 2RLAA 4IU1A 4MYNA 5G11A 4ZUNA 4IE3A 4BZ7A 4RHKA 4RLAA 5RLAA 3F80A 3SFHA 5LI3A 2ZAVA 1VKGA 3Q9EA 1CEVA 1WVAA 4BZ8A 3EW8A 1P8PA 3LHLA 4QA5A 5G17A 5G0JA 5EFNA 5DC5A 3LP4A 5EFBD 5EEIA 3C0YA 1T5FA 1WOHA 3NIQA 2CEVA 4IE1A 1HQHA 4IU4A 4RN1A 1W22A 2VQOA 3MZ6A 5DC8A 4ZUPA 3E6VA 3GMZA 3EWFA 1GQ6A 3MAXA 4HXQA 4IU5A 1P8NA 4ZURA 1T4RA 4BZ6A 1T5GA 3THJA 5G0IA 5FUEA 4QA1A 3F07A 5THTA 3MZ4A 4BZ5A 5EFHA 1C3PA 4DZ4A 5DC6A 4Q3UA 1P8MA 3DJ8A 3MMRA 1ZZ1A 5EF7A 3EZPA 5G0YA 1WOIA 1P8RA 1GQ7A 3MFVA 5G0XA 5G1BA 3Q9BA 5G1CA 4BZ9A 3E8ZA 4FCIA 1T4PA 4Q3RC 3TF3A 1R1OA 2VQJA 5A2SA 1T4SA 2V5XA 2VQWG 3Q9CA 2EF5A 1C3SA 4CBTA 5ICNB 4IE2A 3MENA 1P8SA 4RHJA 4IU0A 3RLAA 4Q41A 3C0ZA 4HWWA 5D1BA 5EEFA 4ZUMA 2V5WA 3PZLA 4BKXB 5G12A 5D1CA 4HZEA 5G10A 3THEA 3NIOA 1HQXA 1TA1A 3MFWA 3EZTA 4QA0A 5IWGA 5THUA 5EEKA 1WOGA 3CEVA 4ITYA 4A69A 4MXRA 2VQVA
chains in the Genus database with same CATH topology
3LP7A 1P8QA 4Q3VA 1T4TA 3KV2A 3NIPA 1RLAA 4FCKA 2A0MA 4GSZA 4GSVA 4Q3QA 3SJTA 3TH7A 2EIVA 4Q3TA 4IXVA 1HQ5A 4RHMA 4IXUA 1ZPEA 5CEVA 4Q3PA 1HQFA 5HJ9A 4I06A 4MYFA 2PHOA 2AEBA 4RHLA 4GWCA 3SL0A 1TBJA 4Q42A 4GSMA 2PHAA 4G3HA 2EF4A 4MYKA 4GWDA 3MJLA 3E8QA 3SKKA 4MYLA 3SL1A 1TBLA 1WVBA 3M1RA 3E9BA 3E6KA 4CEVA 4Q3SA 4Q40A 5HJAA 3GN0A 4RHIA 1PQ3A 1ZPGA 1TBHA 4RHQA 1P8OA 1HQGA 1D3VA 1XFKA 2PLLA 4Q3RA 3THHA 2RLAA 4IU1A 4MYNA 4IE3A 4RHKA 4RLAA 5RLAA 3F80A 2ZAVA 1CEVA 1WVAA 1P8PA 3LHLA 3LP4A 1T5FA 1WOHA 3NIQA 2CEVA 4IE1A 1HQHA 4IU4A 3E6VA 3GMZA 1GQ6A 4HXQA 4IU5A 1P8NA 1T4RA 1T5GA 3THJA 4DZ4A 4Q3UA 1P8MA 3DJ8A 3MMRA 1WOIA 1P8RA 1GQ7A 3MFVA 3TF3A 3E8ZA 4FCIA 1T4PA 4Q3RC 1R1OA 1T4SA 2EF5A 4IE2A 1P8SA 4RHJA 4IU0A 3RLAA 4Q41A 4HWWA 3PZLA 4HZEA 3THEA 3NIOA 1HQXA 1TA1A 3MFWA 1WOGA 3CEVA 4ITYA 4MXRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LP7 A;  1P8Q A;  4Q3V A;  1T4T A;  3KV2 A;  3NIP A;  1RLA A;  4FCK A;  2A0M A;  4GSZ A;  4GSV A;  4Q3Q A;  3SJT A;  3TH7 A;  2EIV A;  4Q3T A;  4IXV A;  1HQ5 A;  4RHM A;  4IXU A;  1ZPE A;  5CEV A;  4Q3P A;  1HQF A;  5HJ9 A;  4I06 A;  4MYF A;  2PHO A;  2AEB A;  4RHL A;  4GWC A;  3SL0 A;  1TBJ A;  4Q42 A;  4GSM A;  2PHA A;  4G3H A;  2EF4 A;  4MYK A;  4GWD A;  3MJL A;  3E8Q A;  3SKK A;  4MYL A;  3SL1 A;  1TBL A;  1WVB A;  3M1R A;  3E9B A;  3E6K A;  4CEV A;  4Q3S A;  4Q40 A;  5HJA A;  3GN0 A;  4RHI A;  1PQ3 A;  1ZPG A;  1TBH A;  4RHQ A;  1P8O A;  1HQG A;  1D3V A;  1XFK A;  2PLL A;  4Q3R A;  3THH A;  2RLA A;  4IU1 A;  4MYN A;  4IE3 A;  4RHK A;  4RLA A;  5RLA A;  3F80 A;  2ZAV A;  1CEV A;  1WVA A;  1P8P A;  3LHL A;  3LP4 A;  1T5F A;  1WOH A;  3NIQ A;  2CEV A;  4IE1 A;  1HQH A;  4IU4 A;  3E6V A;  3GMZ A;  1GQ6 A;  4HXQ A;  4IU5 A;  1P8N A;  1T4R A;  1T5G A;  3THJ A;  4DZ4 A;  4Q3U A;  1P8M A;  3DJ8 A;  3MMR A;  1WOI A;  1P8R A;  1GQ7 A;  3MFV A;  3TF3 A;  3E8Z A;  4FCI A;  1T4P A;  4Q3R C;  1R1O A;  1T4S A;  2EF5 A;  4IE2 A;  1P8S A;  4RHJ A;  4IU0 A;  3RLA A;  4Q41 A;  4HWW A;  3PZL A;  4HZE A;  3THE A;  3NIO A;  1HQX A;  1TA1 A;  3MFW A;  1WOG A;  3CEV A;  4ITY A;  4MXR A; 
#chains in the Genus database with same CATH topology
 3SFF A;  3F0R A;  5EF8 A;  1T64 A;  2VQQ A;  2VQM A;  3C10 A;  3LP7 A;  1P8Q A;  4Q3V A;  4QA3 A;  1T4T A;  3KV2 A;  5EFG A;  3RQD A;  1T67 A;  3NIP A;  1RLA A;  3Q9F A;  4FCK A;  2A0M A;  4GSZ A;  4GSV A;  4Q3Q A;  5G13 A;  3SJT A;  3TH7 A;  2EIV A;  4Q3T A;  4IXV A;  1HQ5 A;  3F06 A;  5THV A;  4RHM A;  5DC7 A;  5EEN A;  4LXZ A;  4RN0 A;  4IXU A;  1ZPE A;  4CBY A;  5CEV A;  4Q3P A;  1HQF A;  5HJ9 A;  4I06 A;  4MYF A;  2PHO A;  5JI5 A;  2AEB A;  5EFK B;  4QA6 A;  4RHL A;  4GWC A;  1T69 A;  4LY1 A;  5FCW A;  4ZUO A;  1TBJ A;  3SL0 A;  4Q42 A;  3MZ3 A;  2GH6 A;  4CQF A;  4GSM A;  1C3R A;  2PHA A;  5G1A A;  5G3W A;  4G3H A;  2EF4 A;  3ZNR A;  4MYK A;  4GWD A;  3MJL A;  5IX0 A;  3E8Q A;  3MZ7 A;  4RN2 A;  3SKK A;  4MYL A;  1ZZ0 A;  3SL1 A;  1TBL A;  1WVB A;  3M1R A;  3E9B A;  3E6K A;  5G0H A;  3ZNS A;  4CEV A;  4ZUQ A;  5BWZ A;  4QA7 A;  4Q3S A;  4Q40 A;  5EEM A;  5HJA A;  3GN0 A;  4RHI A;  1PQ3 A;  4QA2 A;  1ZPG A;  1TBH A;  1ZZ3 A;  4QA4 A;  4RHQ A;  1P8O A;  5THS A;  5EFJ D;  1HQG A;  2VCG A;  5D1D A;  5G0G A;  1D3V A;  1XFK A;  2PLL A;  4Q3R A;  3THH A;  2RLA A;  4IU1 A;  4MYN A;  5G11 A;  4ZUN A;  4IE3 A;  4BZ7 A;  4RHK A;  4RLA A;  5RLA A;  3F80 A;  3SFH A;  5LI3 A;  2ZAV A;  1VKG A;  3Q9E A;  1CEV A;  1WVA A;  4BZ8 A;  3EW8 A;  1P8P A;  3LHL A;  4QA5 A;  5G17 A;  5G0J A;  5EFN A;  5DC5 A;  3LP4 A;  5EFB D;  5EEI A;  3C0Y A;  1T5F A;  1WOH A;  3NIQ A;  2CEV A;  4IE1 A;  1HQH A;  4IU4 A;  4RN1 A;  1W22 A;  2VQO A;  3MZ6 A;  5DC8 A;  4ZUP A;  3E6V A;  3GMZ A;  3EWF A;  1GQ6 A;  3MAX A;  4HXQ A;  4IU5 A;  1P8N A;  4ZUR A;  1T4R A;  4BZ6 A;  1T5G A;  3THJ A;  5G0I A;  5FUE A;  4QA1 A;  3F07 A;  5THT A;  3MZ4 A;  4BZ5 A;  5EFH A;  1C3P A;  4DZ4 A;  5DC6 A;  4Q3U A;  1P8M A;  3DJ8 A;  3MMR A;  1ZZ1 A;  5EF7 A;  3EZP A;  5G0Y A;  1WOI A;  1P8R A;  1GQ7 A;  3MFV A;  5G0X A;  5G1B A;  3Q9B A;  5G1C A;  4BZ9 A;  3E8Z A;  4FCI A;  1T4P A;  4Q3R C;  3TF3 A;  1R1O A;  2VQJ A;  5A2S A;  1T4S A;  2V5X A;  2VQW G;  3Q9C A;  2EF5 A;  1C3S A;  4CBT A;  5ICN B;  4IE2 A;  3MEN A;  1P8S A;  4RHJ A;  4IU0 A;  3RLA A;  4Q41 A;  3C0Z A;  4HWW A;  5D1B A;  5EEF A;  4ZUM A;  2V5W A;  3PZL A;  4BKX B;  5G12 A;  5D1C A;  4HZE A;  5G10 A;  3THE A;  3NIO A;  1HQX A;  1TA1 A;  3MFW A;  3EZT A;  4QA0 A;  5IWG A;  5THU A;  5EEK A;  1WOG A;  3CEV A;  4ITY A;  4A69 A;  4MXR A;  2VQV A; 
#chains in the Genus database with same CATH homology
 3LP7 A;  1P8Q A;  4Q3V A;  1T4T A;  3KV2 A;  3NIP A;  1RLA A;  4FCK A;  2A0M A;  4GSZ A;  4GSV A;  4Q3Q A;  3SJT A;  3TH7 A;  2EIV A;  4Q3T A;  4IXV A;  1HQ5 A;  4RHM A;  4IXU A;  1ZPE A;  5CEV A;  4Q3P A;  1HQF A;  5HJ9 A;  4I06 A;  4MYF A;  2PHO A;  2AEB A;  4RHL A;  4GWC A;  3SL0 A;  1TBJ A;  4Q42 A;  4GSM A;  2PHA A;  4G3H A;  2EF4 A;  4MYK A;  4GWD A;  3MJL A;  3E8Q A;  3SKK A;  4MYL A;  3SL1 A;  1TBL A;  1WVB A;  3M1R A;  3E9B A;  3E6K A;  4CEV A;  4Q3S A;  4Q40 A;  5HJA A;  3GN0 A;  4RHI A;  1PQ3 A;  1ZPG A;  1TBH A;  4RHQ A;  1P8O A;  1HQG A;  1D3V A;  1XFK A;  2PLL A;  4Q3R A;  3THH A;  2RLA A;  4IU1 A;  4MYN A;  4IE3 A;  4RHK A;  4RLA A;  5RLA A;  3F80 A;  2ZAV A;  1CEV A;  1WVA A;  1P8P A;  3LHL A;  3LP4 A;  1T5F A;  1WOH A;  3NIQ A;  2CEV A;  4IE1 A;  1HQH A;  4IU4 A;  3E6V A;  3GMZ A;  1GQ6 A;  4HXQ A;  4IU5 A;  1P8N A;  1T4R A;  1T5G A;  3THJ A;  4DZ4 A;  4Q3U A;  1P8M A;  3DJ8 A;  3MMR A;  1WOI A;  1P8R A;  1GQ7 A;  3MFV A;  3TF3 A;  3E8Z A;  4FCI A;  1T4P A;  4Q3R C;  1R1O A;  1T4S A;  2EF5 A;  4IE2 A;  1P8S A;  4RHJ A;  4IU0 A;  3RLA A;  4Q41 A;  4HWW A;  3PZL A;  4HZE A;  3THE A;  3NIO A;  1HQX A;  1TA1 A;  3MFW A;  1WOG A;  3CEV A;  4ITY A;  4MXR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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