4Q3SA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
344
structure length
335
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 127
structure length 335
sequence length 344
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3sA00
4Q3RA 3THJA 4HWWA 3M1RA 4CEVA 4IE3A 1TA1A 1P8PA 2RLAA 4Q3UA 3MFWA 4RHJA 1P8NA 1HQXA 1R1OA 3E8QA 2PHAA 4IU1A 4IXVA 4IXUA 1T4PA 4MXRA 4GWCA 4Q3PA 4MYKA 1WVBA 3DJ8A 1GQ6A 3MMRA 1GQ7A 4Q3RC 3RLAA 4Q3VA 4IU0A 3SL1A 4DZ4A 2EF4A 3NIOA 1WOGA 4IU5A 3MJLA 1HQHA 4RLAA 4RHLA 3TH7A 1PQ3A 4GSZA 1RLAA 4MYLA 2ZAVA 3GMZA 1HQGA 1ZPEA 3NIPA 3SL0A 4I06A 1P8OA 1P8RA 4RHMA 3E8ZA 1T4SA 3LP4A 4MYFA 4G3HA 3PZLA 4IU4A 4IE1A 5RLAA 5HJAA 2PHOA 1WOIA 3NIQA 1TBHA 1ZPGA 1WOHA 3GN0A 1D3VA 3TF3A 1WVAA 1TBJA 1T5FA 4HXQA 1HQ5A 5CEVA 2CEVA 4ITYA 4FCKA 1XFKA 4GSMA 2EIVA 4Q3QA 3KV2A 3E6VA 4MYNA 4Q40A 4Q3TA 3SKKA 4RHQA 3THHA 4GWDA 2EF5A 4FCIA 5HJ9A 3CEVA 1P8QA 1CEVA 1TBLA 4GSVA 4RHKA 2A0MA 3F80A 3LHLA 1P8SA 3E9BA 1P8MA 4Q3SA 4Q42A 3MFVA 3SJTA 4IE2A 1HQFA 2AEBA 4HZEA 3LP7A 1T5GA 3E6KA 2PLLA 1T4TA 4RHIA 4Q41A 1T4RA 3THEA
chains in the Genus database with same CATH superfamily
5DC7A 4Q3RA 5EEFA 3THJA 4HWWA 3Q9BA 4QA6A 5EF8A 3M1RA 4ZURA 2VQVA 4BZ5A 4CEVA 4LY1A 5DC8A 4IE3A 1TA1A 1P8PA 5G1AA 5EFBD 2RLAA 3MENA 5IWGA 4Q3UA 3MFWA 4RHJA 5EFNA 5THTA 1P8NA 1HQXA 1R1OA 3E8QA 2PHAA 3F06A 4IU1A 4IXVA 5LI3A 3C0ZA 4IXUA 1T4PA 4MXRA 5DC6A 4QA5A 2V5WA 4GWCA 4Q3PA 4ZUMA 4MYKA 1WVBA 3DJ8A 4RN2A 3F0RA 5G0HA 1W22A 1GQ6A 2VQWG 3MMRA 3Q9EA 1GQ7A 4Q3RC 4BZ7A 5A2SA 1ZZ3A 3RLAA 4Q3VA 4IU0A 3SL1A 5IX0A 3MZ3A 4QA7A 4QA1A 5DC5A 5G17A 3EWFA 2EF4A 3EZPA 3MZ6A 3NIOA 4DZ4A 1WOGA 5JI5A 4IU5A 1VKGA 3EZTA 1HQHA 2GH6A 3MJLA 4RLAA 4RHLA 2V5XA 5EEKA 1C3SA 5G12A 1PQ3A 4GSZA 3TH7A 1RLAA 2VQMA 2ZAVA 4MYLA 5G0XA 3GMZA 4A69A 4BKXB 5ICNB 1HQGA 4BZ8A 1ZPEA 3NIPA 4CBYA 3SL0A 5G1BA 5EF7A 1T64A 1P8OA 1P8RA 4I06A 4RHMA 3E8ZA 1T4SA 2VQJA 3LP4A 4MYFA 3SFHA 3MAXA 4G3HA 3PZLA 4IU4A 5EEMA 5D1BA 4IE1A 5RLAA 1T69A 5HJAA 2PHOA 5EENA 5G10A 1WOIA 3NIQA 1TBHA 1ZPGA 5G13A 4BZ6A 4ZUPA 1C3RA 5FCWA 5BWZA 1WOHA 5EFJD 1ZZ1A 3GN0A 1D3VA 5G11A 5EFGA 4BZ9A 5G3WA 3TF3A 5G0IA 1WVAA 5THSA 4CBTA 1TBJA 4QA2A 1T5FA 4HXQA 5THVA 3ZNSA 1HQ5A 5CEVA 2VCGA 2CEVA 4ITYA 4QA3A 5G1CA 4FCKA 1XFKA 1C3PA 5EFHA 5EFKB 3RQDA 3EW8A 4CQFA 4ZUOA 4GSMA 3C10A 2EIVA 4Q3QA 3MZ7A 5THUA 3KV2A 3E6VA 4MYNA 4Q40A 4Q3TA 5D1DA 4RHQA 3SKKA 4GWDA 2EF5A 3THHA 4QA0A 4FCIA 5HJ9A 4LXZA 4RN1A 2VQQA 3F07A 3Q9CA 3CEVA 1P8QA 3C0YA 5FUEA 1CEVA 1TBLA 4GSVA 4RHKA 5D1CA 5G0GA 2A0MA 3F80A 3LHLA 5G0YA 3MZ4A 1P8SA 3E9BA 5G0JA 1P8MA 4Q3SA 1ZZ0A 4Q42A 3MFVA 4RN0A 4IE2A 3SJTA 1HQFA 2AEBA 3ZNRA 1T67A 5EEIA 4HZEA 3LP7A 1T5GA 4QA4A 3E6KA 3SFFA 2PLLA 1T4TA 3Q9FA 4ZUNA 4ZUQA 4RHIA 4Q41A 1T4RA 3THEA 2VQOA
chains in the Genus database with same CATH topology
4Q3RA 3THJA 4HWWA 3M1RA 4CEVA 4IE3A 1TA1A 1P8PA 2RLAA 4Q3UA 3MFWA 4RHJA 1P8NA 1HQXA 1R1OA 3E8QA 2PHAA 4IU1A 4IXVA 4IXUA 1T4PA 4MXRA 4GWCA 4Q3PA 4MYKA 1WVBA 3DJ8A 1GQ6A 3MMRA 1GQ7A 4Q3RC 3RLAA 4Q3VA 4IU0A 3SL1A 4DZ4A 2EF4A 3NIOA 1WOGA 4IU5A 3MJLA 1HQHA 4RLAA 4RHLA 3TH7A 1PQ3A 4GSZA 1RLAA 4MYLA 2ZAVA 3GMZA 1HQGA 1ZPEA 3NIPA 3SL0A 4I06A 1P8OA 1P8RA 4RHMA 3E8ZA 1T4SA 3LP4A 4MYFA 4G3HA 3PZLA 4IU4A 4IE1A 5RLAA 5HJAA 2PHOA 1WOIA 3NIQA 1TBHA 1ZPGA 1WOHA 3GN0A 1D3VA 3TF3A 1WVAA 1TBJA 1T5FA 4HXQA 1HQ5A 5CEVA 2CEVA 4ITYA 4FCKA 1XFKA 4GSMA 2EIVA 4Q3QA 3KV2A 3E6VA 4MYNA 4Q40A 4Q3TA 3SKKA 4RHQA 3THHA 4GWDA 2EF5A 4FCIA 5HJ9A 3CEVA 1P8QA 1CEVA 1TBLA 4GSVA 4RHKA 2A0MA 3F80A 3LHLA 1P8SA 3E9BA 1P8MA 4Q3SA 4Q42A 3MFVA 3SJTA 4IE2A 1HQFA 2AEBA 4HZEA 3LP7A 1T5GA 3E6KA 2PLLA 1T4TA 4RHIA 4Q41A 1T4RA 3THEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q3R A;  3THJ A;  4HWW A;  3M1R A;  4CEV A;  4IE3 A;  1TA1 A;  1P8P A;  2RLA A;  4Q3U A;  3MFW A;  4RHJ A;  1P8N A;  1HQX A;  1R1O A;  3E8Q A;  2PHA A;  4IU1 A;  4IXV A;  4IXU A;  1T4P A;  4MXR A;  4GWC A;  4Q3P A;  4MYK A;  1WVB A;  3DJ8 A;  1GQ6 A;  3MMR A;  1GQ7 A;  4Q3R C;  3RLA A;  4Q3V A;  4IU0 A;  3SL1 A;  4DZ4 A;  2EF4 A;  3NIO A;  1WOG A;  4IU5 A;  3MJL A;  1HQH A;  4RLA A;  4RHL A;  3TH7 A;  1PQ3 A;  4GSZ A;  1RLA A;  4MYL A;  2ZAV A;  3GMZ A;  1HQG A;  1ZPE A;  3NIP A;  3SL0 A;  4I06 A;  1P8O A;  1P8R A;  4RHM A;  3E8Z A;  1T4S A;  3LP4 A;  4MYF A;  4G3H A;  3PZL A;  4IU4 A;  4IE1 A;  5RLA A;  5HJA A;  2PHO A;  1WOI A;  3NIQ A;  1TBH A;  1ZPG A;  1WOH A;  3GN0 A;  1D3V A;  3TF3 A;  1WVA A;  1TBJ A;  1T5F A;  4HXQ A;  1HQ5 A;  5CEV A;  2CEV A;  4ITY A;  4FCK A;  1XFK A;  4GSM A;  2EIV A;  4Q3Q A;  3KV2 A;  3E6V A;  4MYN A;  4Q40 A;  4Q3T A;  3SKK A;  4RHQ A;  3THH A;  4GWD A;  2EF5 A;  4FCI A;  5HJ9 A;  3CEV A;  1P8Q A;  1CEV A;  1TBL A;  4GSV A;  4RHK A;  2A0M A;  3F80 A;  3LHL A;  1P8S A;  3E9B A;  1P8M A;  4Q3S A;  4Q42 A;  3MFV A;  3SJT A;  4IE2 A;  1HQF A;  2AEB A;  4HZE A;  3LP7 A;  1T5G A;  3E6K A;  2PLL A;  1T4T A;  4RHI A;  4Q41 A;  1T4R A;  3THE A; 
#chains in the Genus database with same CATH topology
 5DC7 A;  4Q3R A;  5EEF A;  3THJ A;  4HWW A;  3Q9B A;  4QA6 A;  5EF8 A;  3M1R A;  4ZUR A;  2VQV A;  4BZ5 A;  4CEV A;  4LY1 A;  5DC8 A;  4IE3 A;  1TA1 A;  1P8P A;  5G1A A;  5EFB D;  2RLA A;  3MEN A;  5IWG A;  4Q3U A;  3MFW A;  4RHJ A;  5EFN A;  5THT A;  1P8N A;  1HQX A;  1R1O A;  3E8Q A;  2PHA A;  3F06 A;  4IU1 A;  4IXV A;  5LI3 A;  3C0Z A;  4IXU A;  1T4P A;  4MXR A;  5DC6 A;  4QA5 A;  2V5W A;  4GWC A;  4Q3P A;  4ZUM A;  4MYK A;  1WVB A;  3DJ8 A;  4RN2 A;  3F0R A;  5G0H A;  1W22 A;  1GQ6 A;  2VQW G;  3MMR A;  3Q9E A;  1GQ7 A;  4Q3R C;  4BZ7 A;  5A2S A;  1ZZ3 A;  3RLA A;  4Q3V A;  4IU0 A;  3SL1 A;  5IX0 A;  3MZ3 A;  4QA7 A;  4QA1 A;  5DC5 A;  5G17 A;  3EWF A;  2EF4 A;  3EZP A;  3MZ6 A;  3NIO A;  4DZ4 A;  1WOG A;  5JI5 A;  4IU5 A;  1VKG A;  3EZT A;  1HQH A;  2GH6 A;  3MJL A;  4RLA A;  4RHL A;  2V5X A;  5EEK A;  1C3S A;  5G12 A;  1PQ3 A;  4GSZ A;  3TH7 A;  1RLA A;  2VQM A;  2ZAV A;  4MYL A;  5G0X A;  3GMZ A;  4A69 A;  4BKX B;  5ICN B;  1HQG A;  4BZ8 A;  1ZPE A;  3NIP A;  4CBY A;  3SL0 A;  5G1B A;  5EF7 A;  1T64 A;  1P8O A;  1P8R A;  4I06 A;  4RHM A;  3E8Z A;  1T4S A;  2VQJ A;  3LP4 A;  4MYF A;  3SFH A;  3MAX A;  4G3H A;  3PZL A;  4IU4 A;  5EEM A;  5D1B A;  4IE1 A;  5RLA A;  1T69 A;  5HJA A;  2PHO A;  5EEN A;  5G10 A;  1WOI A;  3NIQ A;  1TBH A;  1ZPG A;  5G13 A;  4BZ6 A;  4ZUP A;  1C3R A;  5FCW A;  5BWZ A;  1WOH A;  5EFJ D;  1ZZ1 A;  3GN0 A;  1D3V A;  5G11 A;  5EFG A;  4BZ9 A;  5G3W A;  3TF3 A;  5G0I A;  1WVA A;  5THS A;  4CBT A;  1TBJ A;  4QA2 A;  1T5F A;  4HXQ A;  5THV A;  3ZNS A;  1HQ5 A;  5CEV A;  2VCG A;  2CEV A;  4ITY A;  4QA3 A;  5G1C A;  4FCK A;  1XFK A;  1C3P A;  5EFH A;  5EFK B;  3RQD A;  3EW8 A;  4CQF A;  4ZUO A;  4GSM A;  3C10 A;  2EIV A;  4Q3Q A;  3MZ7 A;  5THU A;  3KV2 A;  3E6V A;  4MYN A;  4Q40 A;  4Q3T A;  5D1D A;  4RHQ A;  3SKK A;  4GWD A;  2EF5 A;  3THH A;  4QA0 A;  4FCI A;  5HJ9 A;  4LXZ A;  4RN1 A;  2VQQ A;  3F07 A;  3Q9C A;  3CEV A;  1P8Q A;  3C0Y A;  5FUE A;  1CEV A;  1TBL A;  4GSV A;  4RHK A;  5D1C A;  5G0G A;  2A0M A;  3F80 A;  3LHL A;  5G0Y A;  3MZ4 A;  1P8S A;  3E9B A;  5G0J A;  1P8M A;  4Q3S A;  1ZZ0 A;  4Q42 A;  3MFV A;  4RN0 A;  4IE2 A;  3SJT A;  1HQF A;  2AEB A;  3ZNR A;  1T67 A;  5EEI A;  4HZE A;  3LP7 A;  1T5G A;  4QA4 A;  3E6K A;  3SFF A;  2PLL A;  1T4T A;  3Q9F A;  4ZUN A;  4ZUQ A;  4RHI A;  4Q41 A;  1T4R A;  3THE A;  2VQO A; 
#chains in the Genus database with same CATH homology
 4Q3R A;  3THJ A;  4HWW A;  3M1R A;  4CEV A;  4IE3 A;  1TA1 A;  1P8P A;  2RLA A;  4Q3U A;  3MFW A;  4RHJ A;  1P8N A;  1HQX A;  1R1O A;  3E8Q A;  2PHA A;  4IU1 A;  4IXV A;  4IXU A;  1T4P A;  4MXR A;  4GWC A;  4Q3P A;  4MYK A;  1WVB A;  3DJ8 A;  1GQ6 A;  3MMR A;  1GQ7 A;  4Q3R C;  3RLA A;  4Q3V A;  4IU0 A;  3SL1 A;  4DZ4 A;  2EF4 A;  3NIO A;  1WOG A;  4IU5 A;  3MJL A;  1HQH A;  4RLA A;  4RHL A;  3TH7 A;  1PQ3 A;  4GSZ A;  1RLA A;  4MYL A;  2ZAV A;  3GMZ A;  1HQG A;  1ZPE A;  3NIP A;  3SL0 A;  4I06 A;  1P8O A;  1P8R A;  4RHM A;  3E8Z A;  1T4S A;  3LP4 A;  4MYF A;  4G3H A;  3PZL A;  4IU4 A;  4IE1 A;  5RLA A;  5HJA A;  2PHO A;  1WOI A;  3NIQ A;  1TBH A;  1ZPG A;  1WOH A;  3GN0 A;  1D3V A;  3TF3 A;  1WVA A;  1TBJ A;  1T5F A;  4HXQ A;  1HQ5 A;  5CEV A;  2CEV A;  4ITY A;  4FCK A;  1XFK A;  4GSM A;  2EIV A;  4Q3Q A;  3KV2 A;  3E6V A;  4MYN A;  4Q40 A;  4Q3T A;  3SKK A;  4RHQ A;  3THH A;  4GWD A;  2EF5 A;  4FCI A;  5HJ9 A;  3CEV A;  1P8Q A;  1CEV A;  1TBL A;  4GSV A;  4RHK A;  2A0M A;  3F80 A;  3LHL A;  1P8S A;  3E9B A;  1P8M A;  4Q3S A;  4Q42 A;  3MFV A;  3SJT A;  4IE2 A;  1HQF A;  2AEB A;  4HZE A;  3LP7 A;  1T5G A;  3E6K A;  2PLL A;  1T4T A;  4RHI A;  4Q41 A;  1T4R A;  3THE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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