4Q3UA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
345
structure length
336
Chain Sequence
PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 122
structure length 336
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3uA00
5HJAA 1T4RA 4ITYA 1P8NA 3MJLA 1ZPEA 1HQHA 2PHOA 4Q40A 2EF5A 4RHIA 1R1OA 1WOIA 1P8QA 1PQ3A 4I06A 1HQFA 4Q3RC 3GMZA 3SKKA 3THJA 2A0MA 4Q3UA 4IU4A 4Q3TA 4Q3QA 4CEVA 1P8OA 4MYFA 3E8QA 4Q3SA 4IU1A 4IXUA 4FCIA 1P8MA 4GSVA 3MMRA 3SJTA 4IU0A 2RLAA 4MYNA 3SL1A 2CEVA 1T4PA 4IE2A 3THHA 1HQ5A 5RLAA 4GWDA 4RHKA 4Q3RA 1T5GA 3E6VA 4RHLA 4Q3VA 3E9BA 3E6KA 1RLAA 3MFVA 3KV2A 3CEVA 1GQ7A 3NIQA 4IXVA 4DZ4A 3GN0A 4Q42A 4G3HA 4MYLA 1WVAA 4HXQA 1WOHA 5CEVA 3PZLA 1WVBA 1TBLA 3MFWA 1WOGA 1TBJA 4MXRA 2EIVA 2PLLA 1TBHA 4RHJA 4RLAA 2PHAA 1ZPGA 4HWWA 1P8RA 4RHQA 3DJ8A 3E8ZA 2EF4A 1CEVA 4IE1A 3NIPA 3LP4A 5HJ9A 2ZAVA 2AEBA 3LHLA 1HQGA 1T4SA 4IE3A 1HQXA 3M1RA 4IU5A 3RLAA 4Q41A 4MYKA 4Q3PA 4HZEA 3F80A 3SL0A 3THEA 1P8PA 4FCKA 1XFKA 3NIOA 3TF3A 4GWCA 1P8SA 1GQ6A 1D3VA 3LP7A 1T4TA 1TA1A 1T5FA 3TH7A 4GSMA 4RHMA 4GSZA
chains in the Genus database with same CATH superfamily
5HJAA 1T4RA 5IX0A 1C3RA 5EFHA 2V5XA 4ITYA 1P8NA 5G13A 3MJLA 5EEMA 1ZPEA 3ZNRA 1HQHA 2PHOA 4Q40A 2EF5A 4RHIA 5EFKB 1R1OA 4BZ8A 1WOIA 4LY1A 1P8QA 3Q9BA 1PQ3A 4I06A 4QA2A 1HQFA 4Q3RC 3GMZA 3SKKA 4QA4A 4A69A 4CBTA 4QA5A 3THJA 4BZ5A 4RN0A 2A0MA 5G0GA 4Q3UA 4IU4A 4Q3TA 4CQFA 4Q3QA 3EZPA 5D1CA 5G12A 5DC5A 3Q9FA 4BZ6A 4CEVA 1P8OA 4MYFA 5FCWA 3E8QA 4QA7A 1W22A 5JI5A 4Q3SA 5EFNA 4IU1A 4IXUA 4FCIA 1P8MA 4GSVA 4ZUOA 3C10A 5EFBD 3MMRA 3SJTA 5THVA 4IU0A 1ZZ1A 2RLAA 5DC7A 5EF7A 1T67A 4MYNA 3SL1A 2CEVA 1T4PA 2V5WA 5G0YA 3EW8A 4IE2A 5THTA 3THHA 5THUA 1HQ5A 4RN1A 5EEIA 5G0XA 5RLAA 5ICNB 3MENA 1T69A 4LXZA 3F0RA 5G17A 3C0YA 4GWDA 4RHKA 4Q3RA 1T5GA 3F06A 4QA3A 3E6VA 4RHLA 5G1AA 4Q3VA 3E9BA 5EENA 2VQMA 3E6KA 4ZUMA 1RLAA 3MZ4A 3MFVA 3KV2A 4BZ9A 5FUEA 5THSA 3CEVA 5G1CA 4ZUPA 1GQ7A 3NIQA 4IXVA 4ZUNA 3GN0A 3MZ6A 4Q42A 5DC8A 4ZURA 3SFFA 4DZ4A 5LI3A 4G3HA 4MYLA 1WVAA 4HXQA 1WOHA 3Q9EA 3PZLA 5G11A 1WVBA 5CEVA 1T64A 1TBLA 3C0ZA 3MFWA 5G10A 1WOGA 3EZTA 1ZZ3A 1TBJA 4MXRA 2EIVA 2PLLA 1TBHA 4RHJA 4RLAA 5D1BA 3EWFA 2PHAA 4BZ7A 5IWGA 1ZPGA 4HWWA 4CBYA 5EFJD 1P8RA 4RHQA 3F07A 3DJ8A 3E8ZA 4BKXB 1C3SA 2VQJA 4ZUQA 2EF4A 3MAXA 1CEVA 2VQVA 5EF8A 2VCGA 4IE1A 2VQQA 5DC6A 4QA1A 3LP4A 3NIPA 5G1BA 5G0IA 5HJ9A 4RN2A 4QA6A 2ZAVA 2AEBA 3LHLA 1HQGA 1T4SA 4QA0A 4IE3A 1C3PA 1HQXA 3M1RA 2VQOA 5EEKA 4IU5A 3RLAA 4Q41A 5BWZA 3SFHA 4MYKA 4Q3PA 3MZ3A 5EEFA 5A2SA 4HZEA 3F80A 3RQDA 3SL0A 3THEA 1VKGA 1P8PA 4FCKA 5EFGA 5G0HA 1XFKA 1ZZ0A 3NIOA 3TF3A 5D1DA 4GWCA 5G0JA 1P8SA 1D3VA 1GQ6A 2GH6A 3LP7A 1T4TA 1TA1A 1T5FA 3ZNSA 2VQWG 3TH7A 4GSMA 5G3WA 4RHMA 3MZ7A 3Q9CA 4GSZA
chains in the Genus database with same CATH topology
5HJAA 1T4RA 4ITYA 1P8NA 3MJLA 1ZPEA 1HQHA 2PHOA 4Q40A 2EF5A 4RHIA 1R1OA 1WOIA 1P8QA 1PQ3A 4I06A 1HQFA 4Q3RC 3GMZA 3SKKA 3THJA 2A0MA 4Q3UA 4IU4A 4Q3TA 4Q3QA 4CEVA 1P8OA 4MYFA 3E8QA 4Q3SA 4IU1A 4IXUA 4FCIA 1P8MA 4GSVA 3MMRA 3SJTA 4IU0A 2RLAA 4MYNA 3SL1A 2CEVA 1T4PA 4IE2A 3THHA 1HQ5A 5RLAA 4GWDA 4RHKA 4Q3RA 1T5GA 3E6VA 4RHLA 4Q3VA 3E9BA 3E6KA 1RLAA 3MFVA 3KV2A 3CEVA 1GQ7A 3NIQA 4IXVA 4DZ4A 3GN0A 4Q42A 4G3HA 4MYLA 1WVAA 4HXQA 1WOHA 5CEVA 3PZLA 1WVBA 1TBLA 3MFWA 1WOGA 1TBJA 4MXRA 2EIVA 2PLLA 1TBHA 4RHJA 4RLAA 2PHAA 1ZPGA 4HWWA 1P8RA 4RHQA 3DJ8A 3E8ZA 2EF4A 1CEVA 4IE1A 3NIPA 3LP4A 5HJ9A 2ZAVA 2AEBA 3LHLA 1HQGA 1T4SA 4IE3A 1HQXA 3M1RA 4IU5A 3RLAA 4Q41A 4MYKA 4Q3PA 4HZEA 3F80A 3SL0A 3THEA 1P8PA 4FCKA 1XFKA 3NIOA 3TF3A 4GWCA 1P8SA 1GQ6A 1D3VA 3LP7A 1T4TA 1TA1A 1T5FA 3TH7A 4GSMA 4RHMA 4GSZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HJA A;  1T4R A;  4ITY A;  1P8N A;  3MJL A;  1ZPE A;  1HQH A;  2PHO A;  4Q40 A;  2EF5 A;  4RHI A;  1R1O A;  1WOI A;  1P8Q A;  1PQ3 A;  4I06 A;  1HQF A;  4Q3R C;  3GMZ A;  3SKK A;  3THJ A;  2A0M A;  4Q3U A;  4IU4 A;  4Q3T A;  4Q3Q A;  4CEV A;  1P8O A;  4MYF A;  3E8Q A;  4Q3S A;  4IU1 A;  4IXU A;  4FCI A;  1P8M A;  4GSV A;  3MMR A;  3SJT A;  4IU0 A;  2RLA A;  4MYN A;  3SL1 A;  2CEV A;  1T4P A;  4IE2 A;  3THH A;  1HQ5 A;  5RLA A;  4GWD A;  4RHK A;  4Q3R A;  1T5G A;  3E6V A;  4RHL A;  4Q3V A;  3E9B A;  3E6K A;  1RLA A;  3MFV A;  3KV2 A;  3CEV A;  1GQ7 A;  3NIQ A;  4IXV A;  4DZ4 A;  3GN0 A;  4Q42 A;  4G3H A;  4MYL A;  1WVA A;  4HXQ A;  1WOH A;  5CEV A;  3PZL A;  1WVB A;  1TBL A;  3MFW A;  1WOG A;  1TBJ A;  4MXR A;  2EIV A;  2PLL A;  1TBH A;  4RHJ A;  4RLA A;  2PHA A;  1ZPG A;  4HWW A;  1P8R A;  4RHQ A;  3DJ8 A;  3E8Z A;  2EF4 A;  1CEV A;  4IE1 A;  3NIP A;  3LP4 A;  5HJ9 A;  2ZAV A;  2AEB A;  3LHL A;  1HQG A;  1T4S A;  4IE3 A;  1HQX A;  3M1R A;  4IU5 A;  3RLA A;  4Q41 A;  4MYK A;  4Q3P A;  4HZE A;  3F80 A;  3SL0 A;  3THE A;  1P8P A;  4FCK A;  1XFK A;  3NIO A;  3TF3 A;  4GWC A;  1P8S A;  1GQ6 A;  1D3V A;  3LP7 A;  1T4T A;  1TA1 A;  1T5F A;  3TH7 A;  4GSM A;  4RHM A;  4GSZ A; 
#chains in the Genus database with same CATH topology
 5HJA A;  1T4R A;  5IX0 A;  1C3R A;  5EFH A;  2V5X A;  4ITY A;  1P8N A;  5G13 A;  3MJL A;  5EEM A;  1ZPE A;  3ZNR A;  1HQH A;  2PHO A;  4Q40 A;  2EF5 A;  4RHI A;  5EFK B;  1R1O A;  4BZ8 A;  1WOI A;  4LY1 A;  1P8Q A;  3Q9B A;  1PQ3 A;  4I06 A;  4QA2 A;  1HQF A;  4Q3R C;  3GMZ A;  3SKK A;  4QA4 A;  4A69 A;  4CBT A;  4QA5 A;  3THJ A;  4BZ5 A;  4RN0 A;  2A0M A;  5G0G A;  4Q3U A;  4IU4 A;  4Q3T A;  4CQF A;  4Q3Q A;  3EZP A;  5D1C A;  5G12 A;  5DC5 A;  3Q9F A;  4BZ6 A;  4CEV A;  1P8O A;  4MYF A;  5FCW A;  3E8Q A;  4QA7 A;  1W22 A;  5JI5 A;  4Q3S A;  5EFN A;  4IU1 A;  4IXU A;  4FCI A;  1P8M A;  4GSV A;  4ZUO A;  3C10 A;  5EFB D;  3MMR A;  3SJT A;  5THV A;  4IU0 A;  1ZZ1 A;  2RLA A;  5DC7 A;  5EF7 A;  1T67 A;  4MYN A;  3SL1 A;  2CEV A;  1T4P A;  2V5W A;  5G0Y A;  3EW8 A;  4IE2 A;  5THT A;  3THH A;  5THU A;  1HQ5 A;  4RN1 A;  5EEI A;  5G0X A;  5RLA A;  5ICN B;  3MEN A;  1T69 A;  4LXZ A;  3F0R A;  5G17 A;  3C0Y A;  4GWD A;  4RHK A;  4Q3R A;  1T5G A;  3F06 A;  4QA3 A;  3E6V A;  4RHL A;  5G1A A;  4Q3V A;  3E9B A;  5EEN A;  2VQM A;  3E6K A;  4ZUM A;  1RLA A;  3MZ4 A;  3MFV A;  3KV2 A;  4BZ9 A;  5FUE A;  5THS A;  3CEV A;  5G1C A;  4ZUP A;  1GQ7 A;  3NIQ A;  4IXV A;  4ZUN A;  3GN0 A;  3MZ6 A;  4Q42 A;  5DC8 A;  4ZUR A;  3SFF A;  4DZ4 A;  5LI3 A;  4G3H A;  4MYL A;  1WVA A;  4HXQ A;  1WOH A;  3Q9E A;  3PZL A;  5G11 A;  1WVB A;  5CEV A;  1T64 A;  1TBL A;  3C0Z A;  3MFW A;  5G10 A;  1WOG A;  3EZT A;  1ZZ3 A;  1TBJ A;  4MXR A;  2EIV A;  2PLL A;  1TBH A;  4RHJ A;  4RLA A;  5D1B A;  3EWF A;  2PHA A;  4BZ7 A;  5IWG A;  1ZPG A;  4HWW A;  4CBY A;  5EFJ D;  1P8R A;  4RHQ A;  3F07 A;  3DJ8 A;  3E8Z A;  4BKX B;  1C3S A;  2VQJ A;  4ZUQ A;  2EF4 A;  3MAX A;  1CEV A;  2VQV A;  5EF8 A;  2VCG A;  4IE1 A;  2VQQ A;  5DC6 A;  4QA1 A;  3LP4 A;  3NIP A;  5G1B A;  5G0I A;  5HJ9 A;  4RN2 A;  4QA6 A;  2ZAV A;  2AEB A;  3LHL A;  1HQG A;  1T4S A;  4QA0 A;  4IE3 A;  1C3P A;  1HQX A;  3M1R A;  2VQO A;  5EEK A;  4IU5 A;  3RLA A;  4Q41 A;  5BWZ A;  3SFH A;  4MYK A;  4Q3P A;  3MZ3 A;  5EEF A;  5A2S A;  4HZE A;  3F80 A;  3RQD A;  3SL0 A;  3THE A;  1VKG A;  1P8P A;  4FCK A;  5EFG A;  5G0H A;  1XFK A;  1ZZ0 A;  3NIO A;  3TF3 A;  5D1D A;  4GWC A;  5G0J A;  1P8S A;  1D3V A;  1GQ6 A;  2GH6 A;  3LP7 A;  1T4T A;  1TA1 A;  1T5F A;  3ZNS A;  2VQW G;  3TH7 A;  4GSM A;  5G3W A;  4RHM A;  3MZ7 A;  3Q9C A;  4GSZ A; 
#chains in the Genus database with same CATH homology
 5HJA A;  1T4R A;  4ITY A;  1P8N A;  3MJL A;  1ZPE A;  1HQH A;  2PHO A;  4Q40 A;  2EF5 A;  4RHI A;  1R1O A;  1WOI A;  1P8Q A;  1PQ3 A;  4I06 A;  1HQF A;  4Q3R C;  3GMZ A;  3SKK A;  3THJ A;  2A0M A;  4Q3U A;  4IU4 A;  4Q3T A;  4Q3Q A;  4CEV A;  1P8O A;  4MYF A;  3E8Q A;  4Q3S A;  4IU1 A;  4IXU A;  4FCI A;  1P8M A;  4GSV A;  3MMR A;  3SJT A;  4IU0 A;  2RLA A;  4MYN A;  3SL1 A;  2CEV A;  1T4P A;  4IE2 A;  3THH A;  1HQ5 A;  5RLA A;  4GWD A;  4RHK A;  4Q3R A;  1T5G A;  3E6V A;  4RHL A;  4Q3V A;  3E9B A;  3E6K A;  1RLA A;  3MFV A;  3KV2 A;  3CEV A;  1GQ7 A;  3NIQ A;  4IXV A;  4DZ4 A;  3GN0 A;  4Q42 A;  4G3H A;  4MYL A;  1WVA A;  4HXQ A;  1WOH A;  5CEV A;  3PZL A;  1WVB A;  1TBL A;  3MFW A;  1WOG A;  1TBJ A;  4MXR A;  2EIV A;  2PLL A;  1TBH A;  4RHJ A;  4RLA A;  2PHA A;  1ZPG A;  4HWW A;  1P8R A;  4RHQ A;  3DJ8 A;  3E8Z A;  2EF4 A;  1CEV A;  4IE1 A;  3NIP A;  3LP4 A;  5HJ9 A;  2ZAV A;  2AEB A;  3LHL A;  1HQG A;  1T4S A;  4IE3 A;  1HQX A;  3M1R A;  4IU5 A;  3RLA A;  4Q41 A;  4MYK A;  4Q3P A;  4HZE A;  3F80 A;  3SL0 A;  3THE A;  1P8P A;  4FCK A;  1XFK A;  3NIO A;  3TF3 A;  4GWC A;  1P8S A;  1GQ6 A;  1D3V A;  3LP7 A;  1T4T A;  1TA1 A;  1T5F A;  3TH7 A;  4GSM A;  4RHM A;  4GSZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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