4Q3UA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
345
structure length
336
Chain Sequence
PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 122
structure length 336
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3uA00
1P8OA 1HQHA 4IU0A 4DZ4A 4IU5A 1HQFA 3PZLA 4Q3VA 1HQXA 4IE2A 3TF3A 3E6VA 4Q3TA 3DJ8A 4GWDA 2RLAA 4G3HA 3MFWA 3NIPA 4HXQA 1P8MA 4MXRA 1PQ3A 3E9BA 2AEBA 4IU4A 1GQ6A 4IU1A 1T4SA 2CEVA 4RHKA 1WOGA 3NIQA 1D3VA 1T4RA 4MYNA 1ZPGA 3SL0A 1TBHA 1WVAA 1TBLA 4IXUA 4RHIA 3THEA 3GN0A 4RHQA 3LP4A 1P8NA 2A0MA 4Q3SA 1T5FA 3NIOA 2PHAA 5CEVA 4MYKA 1R1OA 4GSMA 4Q41A 3M1RA 3SL1A 3THJA 3F80A 4Q3RA 4HZEA 4IE3A 3RLAA 1HQGA 3TH7A 4Q3PA 1T4PA 4Q3QA 3E8QA 3CEVA 1CEVA 4I06A 5HJ9A 1TBJA 3E8ZA 4RHLA 4GWCA 3KV2A 4FCKA 1P8QA 5RLAA 4Q3RC 4RHMA 1T4TA 4IXVA 3MJLA 4MYFA 3MFVA 4GSZA 2EIVA 4RLAA 3LHLA 3LP7A 1RLAA 1WVBA 3THHA 1GQ7A 4GSVA 3SJTA 1P8SA 3GMZA 2EF5A 1P8PA 2PLLA 1WOIA 4Q42A 2EF4A 1TA1A 4RHJA 4Q3UA 3E6KA 4HWWA 4Q40A 2PHOA 1HQ5A 4ITYA 3MMRA 1P8RA 4MYLA 1XFKA 4CEVA 1ZPEA 1WOHA 4IE1A 4FCIA 2ZAVA 5HJAA 1T5GA 3SKKA
chains in the Genus database with same CATH superfamily
1P8OA 1HQHA 4IU0A 4DZ4A 4IU5A 1HQFA 2VQJA 3PZLA 4Q3VA 1HQXA 4IE2A 5G3WA 5EEKA 5LI3A 3E6VA 3TF3A 4Q3TA 5EFBD 5EEFA 3DJ8A 4GWDA 2RLAA 4G3HA 4BZ9A 3MZ3A 2V5WA 3MENA 3MFWA 5IWGA 3EZPA 3NIPA 4ZUQA 4BZ6A 4HXQA 1P8MA 4MXRA 5DC8A 1PQ3A 2GH6A 2AEBA 3E9BA 4IU4A 1GQ6A 3ZNSA 3ZNRA 4BZ7A 4IU1A 1T69A 1T4SA 5EEIA 2CEVA 4RN0A 1ZZ0A 4RHKA 1T67A 1WOGA 3NIQA 5G0GA 1D3VA 1T4RA 2VQMA 4MYNA 1ZPGA 4RN1A 3SL0A 4ZUPA 1ZZ1A 1TBHA 4BZ8A 1WVAA 4QA0A 1TBLA 4ZUNA 4IXUA 5EF8A 5THVA 4RN2A 2V5XA 4RHIA 4BKXB 2VCGA 3THEA 3GN0A 4RHQA 5G1AA 2VQWG 5G12A 3LP4A 1C3SA 1P8NA 5G1CA 2A0MA 4Q3SA 5EFGA 5D1CA 1T5FA 3NIOA 5G11A 2PHAA 5CEVA 5G0YA 3MZ4A 4CBTA 4MYKA 5EENA 1R1OA 4GSMA 4QA3A 2VQVA 4Q41A 5G0XA 1W22A 4ZUMA 5EFNA 3Q9EA 3M1RA 5BWZA 3F06A 3C10A 3SL1A 3THJA 3F80A 4Q3RA 4HZEA 4IE3A 5EFHA 3RLAA 1HQGA 1VKGA 5G17A 2VQQA 5G0JA 4Q3PA 5EFJD 1T4PA 4LY1A 4Q3QA 5G0IA 3E8QA 5THTA 3TH7A 5JI5A 4QA2A 4ZUOA 3F07A 3CEVA 1CEVA 4I06A 4LXZA 1TBJA 5HJ9A 3E8ZA 4ZURA 3C0YA 2VQOA 4RHLA 3SFFA 4GWCA 5D1BA 4CQFA 4A69A 5A2SA 5IX0A 5THSA 3KV2A 1ZZ3A 4FCKA 5ICNB 1P8QA 3Q9FA 1C3RA 4Q3RC 5RLAA 5DC7A 5G13A 4RHMA 5FUEA 5THUA 1T4TA 4IXVA 3MJLA 4MYFA 1T64A 4QA5A 3EWFA 3MFVA 4GSZA 2EIVA 4RLAA 3RQDA 3LHLA 3LP7A 1RLAA 1WVBA 4BZ5A 3F0RA 5EF7A 1GQ7A 3THHA 4GSVA 3SJTA 3MAXA 1P8SA 3GMZA 5EEMA 5FCWA 2EF5A 1P8PA 2PLLA 4CBYA 1WOIA 4Q42A 2EF4A 1TA1A 4RHJA 5DC6A 4Q3UA 3E6KA 4HWWA 5EFKB 4Q40A 2PHOA 1HQ5A 4ITYA 3C0ZA 4QA4A 3MMRA 1P8RA 4MYLA 4QA7A 1XFKA 3EW8A 3Q9BA 5G10A 4CEVA 3MZ7A 1ZPEA 1WOHA 3Q9CA 4QA6A 3MZ6A 4IE1A 4QA1A 5DC5A 4FCIA 5G0HA 3SFHA 1C3PA 2ZAVA 5HJAA 5G1BA 1T5GA 3EZTA 3SKKA 5D1DA
chains in the Genus database with same CATH topology
1P8OA 1HQHA 4IU0A 4DZ4A 4IU5A 1HQFA 3PZLA 4Q3VA 1HQXA 4IE2A 3TF3A 3E6VA 4Q3TA 3DJ8A 4GWDA 2RLAA 4G3HA 3MFWA 3NIPA 4HXQA 1P8MA 4MXRA 1PQ3A 3E9BA 2AEBA 4IU4A 1GQ6A 4IU1A 1T4SA 2CEVA 4RHKA 1WOGA 3NIQA 1D3VA 1T4RA 4MYNA 1ZPGA 3SL0A 1TBHA 1WVAA 1TBLA 4IXUA 4RHIA 3THEA 3GN0A 4RHQA 3LP4A 1P8NA 2A0MA 4Q3SA 1T5FA 3NIOA 2PHAA 5CEVA 4MYKA 1R1OA 4GSMA 4Q41A 3M1RA 3SL1A 3THJA 3F80A 4Q3RA 4HZEA 4IE3A 3RLAA 1HQGA 3TH7A 4Q3PA 1T4PA 4Q3QA 3E8QA 3CEVA 1CEVA 4I06A 5HJ9A 1TBJA 3E8ZA 4RHLA 4GWCA 3KV2A 4FCKA 1P8QA 5RLAA 4Q3RC 4RHMA 1T4TA 4IXVA 3MJLA 4MYFA 3MFVA 4GSZA 2EIVA 4RLAA 3LHLA 3LP7A 1RLAA 1WVBA 3THHA 1GQ7A 4GSVA 3SJTA 1P8SA 3GMZA 2EF5A 1P8PA 2PLLA 1WOIA 4Q42A 2EF4A 1TA1A 4RHJA 4Q3UA 3E6KA 4HWWA 4Q40A 2PHOA 1HQ5A 4ITYA 3MMRA 1P8RA 4MYLA 1XFKA 4CEVA 1ZPEA 1WOHA 4IE1A 4FCIA 2ZAVA 5HJAA 1T5GA 3SKKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8O A;  1HQH A;  4IU0 A;  4DZ4 A;  4IU5 A;  1HQF A;  3PZL A;  4Q3V A;  1HQX A;  4IE2 A;  3TF3 A;  3E6V A;  4Q3T A;  3DJ8 A;  4GWD A;  2RLA A;  4G3H A;  3MFW A;  3NIP A;  4HXQ A;  1P8M A;  4MXR A;  1PQ3 A;  3E9B A;  2AEB A;  4IU4 A;  1GQ6 A;  4IU1 A;  1T4S A;  2CEV A;  4RHK A;  1WOG A;  3NIQ A;  1D3V A;  1T4R A;  4MYN A;  1ZPG A;  3SL0 A;  1TBH A;  1WVA A;  1TBL A;  4IXU A;  4RHI A;  3THE A;  3GN0 A;  4RHQ A;  3LP4 A;  1P8N A;  2A0M A;  4Q3S A;  1T5F A;  3NIO A;  2PHA A;  5CEV A;  4MYK A;  1R1O A;  4GSM A;  4Q41 A;  3M1R A;  3SL1 A;  3THJ A;  3F80 A;  4Q3R A;  4HZE A;  4IE3 A;  3RLA A;  1HQG A;  3TH7 A;  4Q3P A;  1T4P A;  4Q3Q A;  3E8Q A;  3CEV A;  1CEV A;  4I06 A;  5HJ9 A;  1TBJ A;  3E8Z A;  4RHL A;  4GWC A;  3KV2 A;  4FCK A;  1P8Q A;  5RLA A;  4Q3R C;  4RHM A;  1T4T A;  4IXV A;  3MJL A;  4MYF A;  3MFV A;  4GSZ A;  2EIV A;  4RLA A;  3LHL A;  3LP7 A;  1RLA A;  1WVB A;  3THH A;  1GQ7 A;  4GSV A;  3SJT A;  1P8S A;  3GMZ A;  2EF5 A;  1P8P A;  2PLL A;  1WOI A;  4Q42 A;  2EF4 A;  1TA1 A;  4RHJ A;  4Q3U A;  3E6K A;  4HWW A;  4Q40 A;  2PHO A;  1HQ5 A;  4ITY A;  3MMR A;  1P8R A;  4MYL A;  1XFK A;  4CEV A;  1ZPE A;  1WOH A;  4IE1 A;  4FCI A;  2ZAV A;  5HJA A;  1T5G A;  3SKK A; 
#chains in the Genus database with same CATH topology
 1P8O A;  1HQH A;  4IU0 A;  4DZ4 A;  4IU5 A;  1HQF A;  2VQJ A;  3PZL A;  4Q3V A;  1HQX A;  4IE2 A;  5G3W A;  5EEK A;  5LI3 A;  3E6V A;  3TF3 A;  4Q3T A;  5EFB D;  5EEF A;  3DJ8 A;  4GWD A;  2RLA A;  4G3H A;  4BZ9 A;  3MZ3 A;  2V5W A;  3MEN A;  3MFW A;  5IWG A;  3EZP A;  3NIP A;  4ZUQ A;  4BZ6 A;  4HXQ A;  1P8M A;  4MXR A;  5DC8 A;  1PQ3 A;  2GH6 A;  2AEB A;  3E9B A;  4IU4 A;  1GQ6 A;  3ZNS A;  3ZNR A;  4BZ7 A;  4IU1 A;  1T69 A;  1T4S A;  5EEI A;  2CEV A;  4RN0 A;  1ZZ0 A;  4RHK A;  1T67 A;  1WOG A;  3NIQ A;  5G0G A;  1D3V A;  1T4R A;  2VQM A;  4MYN A;  1ZPG A;  4RN1 A;  3SL0 A;  4ZUP A;  1ZZ1 A;  1TBH A;  4BZ8 A;  1WVA A;  4QA0 A;  1TBL A;  4ZUN A;  4IXU A;  5EF8 A;  5THV A;  4RN2 A;  2V5X A;  4RHI A;  4BKX B;  2VCG A;  3THE A;  3GN0 A;  4RHQ A;  5G1A A;  2VQW G;  5G12 A;  3LP4 A;  1C3S A;  1P8N A;  5G1C A;  2A0M A;  4Q3S A;  5EFG A;  5D1C A;  1T5F A;  3NIO A;  5G11 A;  2PHA A;  5CEV A;  5G0Y A;  3MZ4 A;  4CBT A;  4MYK A;  5EEN A;  1R1O A;  4GSM A;  4QA3 A;  2VQV A;  4Q41 A;  5G0X A;  1W22 A;  4ZUM A;  5EFN A;  3Q9E A;  3M1R A;  5BWZ A;  3F06 A;  3C10 A;  3SL1 A;  3THJ A;  3F80 A;  4Q3R A;  4HZE A;  4IE3 A;  5EFH A;  3RLA A;  1HQG A;  1VKG A;  5G17 A;  2VQQ A;  5G0J A;  4Q3P A;  5EFJ D;  1T4P A;  4LY1 A;  4Q3Q A;  5G0I A;  3E8Q A;  5THT A;  3TH7 A;  5JI5 A;  4QA2 A;  4ZUO A;  3F07 A;  3CEV A;  1CEV A;  4I06 A;  4LXZ A;  1TBJ A;  5HJ9 A;  3E8Z A;  4ZUR A;  3C0Y A;  2VQO A;  4RHL A;  3SFF A;  4GWC A;  5D1B A;  4CQF A;  4A69 A;  5A2S A;  5IX0 A;  5THS A;  3KV2 A;  1ZZ3 A;  4FCK A;  5ICN B;  1P8Q A;  3Q9F A;  1C3R A;  4Q3R C;  5RLA A;  5DC7 A;  5G13 A;  4RHM A;  5FUE A;  5THU A;  1T4T A;  4IXV A;  3MJL A;  4MYF A;  1T64 A;  4QA5 A;  3EWF A;  3MFV A;  4GSZ A;  2EIV A;  4RLA A;  3RQD A;  3LHL A;  3LP7 A;  1RLA A;  1WVB A;  4BZ5 A;  3F0R A;  5EF7 A;  1GQ7 A;  3THH A;  4GSV A;  3SJT A;  3MAX A;  1P8S A;  3GMZ A;  5EEM A;  5FCW A;  2EF5 A;  1P8P A;  2PLL A;  4CBY A;  1WOI A;  4Q42 A;  2EF4 A;  1TA1 A;  4RHJ A;  5DC6 A;  4Q3U A;  3E6K A;  4HWW A;  5EFK B;  4Q40 A;  2PHO A;  1HQ5 A;  4ITY A;  3C0Z A;  4QA4 A;  3MMR A;  1P8R A;  4MYL A;  4QA7 A;  1XFK A;  3EW8 A;  3Q9B A;  5G10 A;  4CEV A;  3MZ7 A;  1ZPE A;  1WOH A;  3Q9C A;  4QA6 A;  3MZ6 A;  4IE1 A;  4QA1 A;  5DC5 A;  4FCI A;  5G0H A;  3SFH A;  1C3P A;  2ZAV A;  5HJA A;  5G1B A;  1T5G A;  3EZT A;  3SKK A;  5D1D A; 
#chains in the Genus database with same CATH homology
 1P8O A;  1HQH A;  4IU0 A;  4DZ4 A;  4IU5 A;  1HQF A;  3PZL A;  4Q3V A;  1HQX A;  4IE2 A;  3TF3 A;  3E6V A;  4Q3T A;  3DJ8 A;  4GWD A;  2RLA A;  4G3H A;  3MFW A;  3NIP A;  4HXQ A;  1P8M A;  4MXR A;  1PQ3 A;  3E9B A;  2AEB A;  4IU4 A;  1GQ6 A;  4IU1 A;  1T4S A;  2CEV A;  4RHK A;  1WOG A;  3NIQ A;  1D3V A;  1T4R A;  4MYN A;  1ZPG A;  3SL0 A;  1TBH A;  1WVA A;  1TBL A;  4IXU A;  4RHI A;  3THE A;  3GN0 A;  4RHQ A;  3LP4 A;  1P8N A;  2A0M A;  4Q3S A;  1T5F A;  3NIO A;  2PHA A;  5CEV A;  4MYK A;  1R1O A;  4GSM A;  4Q41 A;  3M1R A;  3SL1 A;  3THJ A;  3F80 A;  4Q3R A;  4HZE A;  4IE3 A;  3RLA A;  1HQG A;  3TH7 A;  4Q3P A;  1T4P A;  4Q3Q A;  3E8Q A;  3CEV A;  1CEV A;  4I06 A;  5HJ9 A;  1TBJ A;  3E8Z A;  4RHL A;  4GWC A;  3KV2 A;  4FCK A;  1P8Q A;  5RLA A;  4Q3R C;  4RHM A;  1T4T A;  4IXV A;  3MJL A;  4MYF A;  3MFV A;  4GSZ A;  2EIV A;  4RLA A;  3LHL A;  3LP7 A;  1RLA A;  1WVB A;  3THH A;  1GQ7 A;  4GSV A;  3SJT A;  1P8S A;  3GMZ A;  2EF5 A;  1P8P A;  2PLL A;  1WOI A;  4Q42 A;  2EF4 A;  1TA1 A;  4RHJ A;  4Q3U A;  3E6K A;  4HWW A;  4Q40 A;  2PHO A;  1HQ5 A;  4ITY A;  3MMR A;  1P8R A;  4MYL A;  1XFK A;  4CEV A;  1ZPE A;  1WOH A;  4IE1 A;  4FCI A;  2ZAV A;  5HJA A;  1T5G A;  3SKK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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