4Q40A

Crystal structure of schistosoma mansoni arginase in complex with l-valine
Total Genus 132
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
344
structure length
335
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 132
structure length 335
sequence length 344
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q40A00
4Q40A 4RHLA 3LHLA 1P8SA 1T4SA 3KV2A 3THEA 1WOIA 4Q3QA 4HXQA 4MXRA 1RLAA 4IU5A 4HZEA 4GSZA 2PHAA 2CEVA 4DZ4A 4MYNA 2RLAA 4Q3PA 3LP4A 4IU1A 4Q3VA 4HWWA 3TH7A 3E8ZA 1P8OA 3MFVA 1WVAA 4GWDA 1GQ7A 3LP7A 4IU0A 3SL0A 5CEVA 3PZLA 1CEVA 4RHKA 1T4PA 1T4TA 1HQXA 1T5GA 1P8RA 3THHA 2ZAVA 1P8QA 4Q3UA 1D3VA 3SL1A 2EF5A 4IXVA 3E8QA 1P8NA 2AEBA 4RHJA 4MYFA 1T4RA 4IXUA 4GSMA 4RHQA 3RLAA 3F80A 1TBLA 3SKKA 3MJLA 4FCKA 1HQHA 4IE2A 1TA1A 3NIQA 3TF3A 4MYKA 4ITYA 4Q3SA 3MFWA 3NIPA 1HQ5A 5HJ9A 5HJAA 4I06A 2EIVA 3E6KA 4IU4A 3SJTA 4Q41A 1WOGA 4GWCA 4Q42A 1WVBA 1T5FA 3E9BA 1HQFA 3E6VA 1R1OA 2PLLA 3MMRA 5RLAA 4MYLA 1XFKA 1HQGA 1TBHA 3M1RA 4IE3A 4RHMA 4Q3TA 4Q3RA 2PHOA 1P8PA 4RHIA 2EF4A 1TBJA 3DJ8A 1GQ6A 1ZPEA 3GN0A 3GMZA 3CEVA 3NIOA 1ZPGA 4Q3RC 1WOHA 4RLAA 4G3HA 1P8MA 1PQ3A 4GSVA 2A0MA 4FCIA 4CEVA 3THJA 4IE1A
chains in the Genus database with same CATH superfamily
4Q40A 4RHLA 4RN1A 3LHLA 1P8SA 1T4SA 3KV2A 5FUEA 5IX0A 3THEA 1WOIA 4Q3QA 4HXQA 4CBTA 2VQOA 1C3PA 4MXRA 4RN0A 1RLAA 5G0YA 4IU5A 4BZ8A 5G0XA 5G1CA 4HZEA 3MZ7A 4BZ6A 1ZZ1A 4GSZA 5G13A 2PHAA 4A69A 2CEVA 5IWGA 3MAXA 4DZ4A 4CBYA 2VCGA 4MYNA 2RLAA 4CQFA 5G0JA 4Q3PA 3C0YA 3LP4A 4IU1A 5EFBD 4Q3VA 5EF7A 4HWWA 5EEIA 4ZUOA 3E8ZA 1P8OA 3TH7A 5EF8A 3F07A 2V5XA 3EZTA 3MFVA 1WVAA 4GWDA 1GQ7A 3LP7A 4IU0A 5D1BA 3SL0A 4ZUNA 5CEVA 3PZLA 5G17A 1CEVA 5D1CA 1T69A 2VQWG 3F06A 1VKGA 4RHKA 5THSA 4BKXB 2VQJA 1T4PA 1T4TA 1HQXA 1T5GA 1P8RA 3EZPA 5EFNA 3Q9BA 3THHA 3MZ3A 2ZAVA 1P8QA 4Q3UA 1D3VA 5THVA 3SFHA 3SL1A 2EF5A 4IXVA 3E8QA 1P8NA 4LY1A 4ZURA 2AEBA 4RHJA 3MZ6A 3Q9CA 4MYFA 5DC6A 2GH6A 5EFHA 1T4RA 4IXUA 4GSMA 4RHQA 5G12A 3RLAA 3EWFA 4BZ7A 3F80A 5G3WA 1TBLA 3SKKA 3MJLA 4QA0A 4FCKA 5DC8A 1HQHA 5EFKB 4QA5A 4IE2A 1TA1A 3NIQA 3TF3A 3MZ4A 4MYKA 2VQMA 2VQQA 2VQVA 4ITYA 5EENA 1C3RA 1T67A 4Q3SA 3MFWA 5EEKA 5G1BA 5G10A 3NIPA 1HQ5A 5HJ9A 5HJAA 5A2SA 4I06A 4QA4A 5G0IA 3RQDA 2EIVA 4QA2A 3C10A 3E6KA 4IU4A 3SJTA 4Q41A 1WOGA 4GWCA 4QA1A 5DC5A 4Q42A 1WVBA 1T5FA 3E9BA 1HQFA 1ZZ0A 3E6VA 5DC7A 5EEMA 1R1OA 5FCWA 4QA3A 5G0GA 5G1AA 2PLLA 5LI3A 3EW8A 3MMRA 1W22A 4RN2A 5RLAA 1ZZ3A 4MYLA 4QA6A 1XFKA 4BZ9A 4ZUQA 1HQGA 1TBHA 5EEFA 3SFFA 3M1RA 5EFGA 4IE3A 4RHMA 4Q3TA 4Q3RA 5D1DA 3F0RA 2PHOA 1P8PA 2V5WA 4RHIA 2EF4A 3Q9FA 4ZUMA 5THTA 4LXZA 1TBJA 5ICNB 3DJ8A 3C0ZA 3MENA 3ZNSA 1GQ6A 3ZNRA 5EFJD 1ZPEA 3GN0A 3GMZA 5G0HA 3CEVA 3NIOA 1T64A 1ZPGA 3Q9EA 4Q3RC 1WOHA 4RLAA 5THUA 5G11A 5JI5A 4G3HA 1P8MA 1PQ3A 4BZ5A 5BWZA 4GSVA 4ZUPA 2A0MA 4FCIA 1C3SA 4QA7A 4CEVA 3THJA 4IE1A
chains in the Genus database with same CATH topology
4Q40A 4RHLA 3LHLA 1P8SA 1T4SA 3KV2A 3THEA 1WOIA 4Q3QA 4HXQA 4MXRA 1RLAA 4IU5A 4HZEA 4GSZA 2PHAA 2CEVA 4DZ4A 4MYNA 2RLAA 4Q3PA 3LP4A 4IU1A 4Q3VA 4HWWA 3TH7A 3E8ZA 1P8OA 3MFVA 1WVAA 4GWDA 1GQ7A 3LP7A 4IU0A 3SL0A 5CEVA 3PZLA 1CEVA 4RHKA 1T4PA 1T4TA 1HQXA 1T5GA 1P8RA 3THHA 2ZAVA 1P8QA 4Q3UA 1D3VA 3SL1A 2EF5A 4IXVA 3E8QA 1P8NA 2AEBA 4RHJA 4MYFA 1T4RA 4IXUA 4GSMA 4RHQA 3RLAA 3F80A 1TBLA 3SKKA 3MJLA 4FCKA 1HQHA 4IE2A 1TA1A 3NIQA 3TF3A 4MYKA 4ITYA 4Q3SA 3MFWA 3NIPA 1HQ5A 5HJ9A 5HJAA 4I06A 2EIVA 3E6KA 4IU4A 3SJTA 4Q41A 1WOGA 4GWCA 4Q42A 1WVBA 1T5FA 3E9BA 1HQFA 3E6VA 1R1OA 2PLLA 3MMRA 5RLAA 4MYLA 1XFKA 1HQGA 1TBHA 3M1RA 4IE3A 4RHMA 4Q3TA 4Q3RA 2PHOA 1P8PA 4RHIA 2EF4A 1TBJA 3DJ8A 1GQ6A 1ZPEA 3GN0A 3GMZA 3CEVA 3NIOA 1ZPGA 4Q3RC 1WOHA 4RLAA 4G3HA 1P8MA 1PQ3A 4GSVA 2A0MA 4FCIA 4CEVA 3THJA 4IE1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q40 A;  4RHL A;  3LHL A;  1P8S A;  1T4S A;  3KV2 A;  3THE A;  1WOI A;  4Q3Q A;  4HXQ A;  4MXR A;  1RLA A;  4IU5 A;  4HZE A;  4GSZ A;  2PHA A;  2CEV A;  4DZ4 A;  4MYN A;  2RLA A;  4Q3P A;  3LP4 A;  4IU1 A;  4Q3V A;  4HWW A;  3TH7 A;  3E8Z A;  1P8O A;  3MFV A;  1WVA A;  4GWD A;  1GQ7 A;  3LP7 A;  4IU0 A;  3SL0 A;  5CEV A;  3PZL A;  1CEV A;  4RHK A;  1T4P A;  1T4T A;  1HQX A;  1T5G A;  1P8R A;  3THH A;  2ZAV A;  1P8Q A;  4Q3U A;  1D3V A;  3SL1 A;  2EF5 A;  4IXV A;  3E8Q A;  1P8N A;  2AEB A;  4RHJ A;  4MYF A;  1T4R A;  4IXU A;  4GSM A;  4RHQ A;  3RLA A;  3F80 A;  1TBL A;  3SKK A;  3MJL A;  4FCK A;  1HQH A;  4IE2 A;  1TA1 A;  3NIQ A;  3TF3 A;  4MYK A;  4ITY A;  4Q3S A;  3MFW A;  3NIP A;  1HQ5 A;  5HJ9 A;  5HJA A;  4I06 A;  2EIV A;  3E6K A;  4IU4 A;  3SJT A;  4Q41 A;  1WOG A;  4GWC A;  4Q42 A;  1WVB A;  1T5F A;  3E9B A;  1HQF A;  3E6V A;  1R1O A;  2PLL A;  3MMR A;  5RLA A;  4MYL A;  1XFK A;  1HQG A;  1TBH A;  3M1R A;  4IE3 A;  4RHM A;  4Q3T A;  4Q3R A;  2PHO A;  1P8P A;  4RHI A;  2EF4 A;  1TBJ A;  3DJ8 A;  1GQ6 A;  1ZPE A;  3GN0 A;  3GMZ A;  3CEV A;  3NIO A;  1ZPG A;  4Q3R C;  1WOH A;  4RLA A;  4G3H A;  1P8M A;  1PQ3 A;  4GSV A;  2A0M A;  4FCI A;  4CEV A;  3THJ A;  4IE1 A; 
#chains in the Genus database with same CATH topology
 4Q40 A;  4RHL A;  4RN1 A;  3LHL A;  1P8S A;  1T4S A;  3KV2 A;  5FUE A;  5IX0 A;  3THE A;  1WOI A;  4Q3Q A;  4HXQ A;  4CBT A;  2VQO A;  1C3P A;  4MXR A;  4RN0 A;  1RLA A;  5G0Y A;  4IU5 A;  4BZ8 A;  5G0X A;  5G1C A;  4HZE A;  3MZ7 A;  4BZ6 A;  1ZZ1 A;  4GSZ A;  5G13 A;  2PHA A;  4A69 A;  2CEV A;  5IWG A;  3MAX A;  4DZ4 A;  4CBY A;  2VCG A;  4MYN A;  2RLA A;  4CQF A;  5G0J A;  4Q3P A;  3C0Y A;  3LP4 A;  4IU1 A;  5EFB D;  4Q3V A;  5EF7 A;  4HWW A;  5EEI A;  4ZUO A;  3E8Z A;  1P8O A;  3TH7 A;  5EF8 A;  3F07 A;  2V5X A;  3EZT A;  3MFV A;  1WVA A;  4GWD A;  1GQ7 A;  3LP7 A;  4IU0 A;  5D1B A;  3SL0 A;  4ZUN A;  5CEV A;  3PZL A;  5G17 A;  1CEV A;  5D1C A;  1T69 A;  2VQW G;  3F06 A;  1VKG A;  4RHK A;  5THS A;  4BKX B;  2VQJ A;  1T4P A;  1T4T A;  1HQX A;  1T5G A;  1P8R A;  3EZP A;  5EFN A;  3Q9B A;  3THH A;  3MZ3 A;  2ZAV A;  1P8Q A;  4Q3U A;  1D3V A;  5THV A;  3SFH A;  3SL1 A;  2EF5 A;  4IXV A;  3E8Q A;  1P8N A;  4LY1 A;  4ZUR A;  2AEB A;  4RHJ A;  3MZ6 A;  3Q9C A;  4MYF A;  5DC6 A;  2GH6 A;  5EFH A;  1T4R A;  4IXU A;  4GSM A;  4RHQ A;  5G12 A;  3RLA A;  3EWF A;  4BZ7 A;  3F80 A;  5G3W A;  1TBL A;  3SKK A;  3MJL A;  4QA0 A;  4FCK A;  5DC8 A;  1HQH A;  5EFK B;  4QA5 A;  4IE2 A;  1TA1 A;  3NIQ A;  3TF3 A;  3MZ4 A;  4MYK A;  2VQM A;  2VQQ A;  2VQV A;  4ITY A;  5EEN A;  1C3R A;  1T67 A;  4Q3S A;  3MFW A;  5EEK A;  5G1B A;  5G10 A;  3NIP A;  1HQ5 A;  5HJ9 A;  5HJA A;  5A2S A;  4I06 A;  4QA4 A;  5G0I A;  3RQD A;  2EIV A;  4QA2 A;  3C10 A;  3E6K A;  4IU4 A;  3SJT A;  4Q41 A;  1WOG A;  4GWC A;  4QA1 A;  5DC5 A;  4Q42 A;  1WVB A;  1T5F A;  3E9B A;  1HQF A;  1ZZ0 A;  3E6V A;  5DC7 A;  5EEM A;  1R1O A;  5FCW A;  4QA3 A;  5G0G A;  5G1A A;  2PLL A;  5LI3 A;  3EW8 A;  3MMR A;  1W22 A;  4RN2 A;  5RLA A;  1ZZ3 A;  4MYL A;  4QA6 A;  1XFK A;  4BZ9 A;  4ZUQ A;  1HQG A;  1TBH A;  5EEF A;  3SFF A;  3M1R A;  5EFG A;  4IE3 A;  4RHM A;  4Q3T A;  4Q3R A;  5D1D A;  3F0R A;  2PHO A;  1P8P A;  2V5W A;  4RHI A;  2EF4 A;  3Q9F A;  4ZUM A;  5THT A;  4LXZ A;  1TBJ A;  5ICN B;  3DJ8 A;  3C0Z A;  3MEN A;  3ZNS A;  1GQ6 A;  3ZNR A;  5EFJ D;  1ZPE A;  3GN0 A;  3GMZ A;  5G0H A;  3CEV A;  3NIO A;  1T64 A;  1ZPG A;  3Q9E A;  4Q3R C;  1WOH A;  4RLA A;  5THU A;  5G11 A;  5JI5 A;  4G3H A;  1P8M A;  1PQ3 A;  4BZ5 A;  5BWZ A;  4GSV A;  4ZUP A;  2A0M A;  4FCI A;  1C3S A;  4QA7 A;  4CEV A;  3THJ A;  4IE1 A; 
#chains in the Genus database with same CATH homology
 4Q40 A;  4RHL A;  3LHL A;  1P8S A;  1T4S A;  3KV2 A;  3THE A;  1WOI A;  4Q3Q A;  4HXQ A;  4MXR A;  1RLA A;  4IU5 A;  4HZE A;  4GSZ A;  2PHA A;  2CEV A;  4DZ4 A;  4MYN A;  2RLA A;  4Q3P A;  3LP4 A;  4IU1 A;  4Q3V A;  4HWW A;  3TH7 A;  3E8Z A;  1P8O A;  3MFV A;  1WVA A;  4GWD A;  1GQ7 A;  3LP7 A;  4IU0 A;  3SL0 A;  5CEV A;  3PZL A;  1CEV A;  4RHK A;  1T4P A;  1T4T A;  1HQX A;  1T5G A;  1P8R A;  3THH A;  2ZAV A;  1P8Q A;  4Q3U A;  1D3V A;  3SL1 A;  2EF5 A;  4IXV A;  3E8Q A;  1P8N A;  2AEB A;  4RHJ A;  4MYF A;  1T4R A;  4IXU A;  4GSM A;  4RHQ A;  3RLA A;  3F80 A;  1TBL A;  3SKK A;  3MJL A;  4FCK A;  1HQH A;  4IE2 A;  1TA1 A;  3NIQ A;  3TF3 A;  4MYK A;  4ITY A;  4Q3S A;  3MFW A;  3NIP A;  1HQ5 A;  5HJ9 A;  5HJA A;  4I06 A;  2EIV A;  3E6K A;  4IU4 A;  3SJT A;  4Q41 A;  1WOG A;  4GWC A;  4Q42 A;  1WVB A;  1T5F A;  3E9B A;  1HQF A;  3E6V A;  1R1O A;  2PLL A;  3MMR A;  5RLA A;  4MYL A;  1XFK A;  1HQG A;  1TBH A;  3M1R A;  4IE3 A;  4RHM A;  4Q3T A;  4Q3R A;  2PHO A;  1P8P A;  4RHI A;  2EF4 A;  1TBJ A;  3DJ8 A;  1GQ6 A;  1ZPE A;  3GN0 A;  3GMZ A;  3CEV A;  3NIO A;  1ZPG A;  4Q3R C;  1WOH A;  4RLA A;  4G3H A;  1P8M A;  1PQ3 A;  4GSV A;  2A0M A;  4FCI A;  4CEV A;  3THJ A;  4IE1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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