4QA4A

Crystal structure of h334r hdac8 in complex with m344
Total Genus 135
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
366
structure length
366
Chain Sequence
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDREFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTIV3 (87-90)AH1 (22-29)TI1 (31-34)TIV1 (32-35)AH10 (308-323)TII1 (34-37)AH2 (37-48)AH5 (108-128)3H1 (50-53)TI3 (99-102)AH3 (64-68)AH4 (73-84)3H2 (93-96)TIV2 (68-71)TI4 (136-139)TI2 (90-93)TI5 (141-144)TVIII1 (100-103)TII2 (105-108)TIV6 (145-148)TI'1 (150-153)TIV10 (305-308)AH8 (237-255)TIV4 (129-132)AH6 (157-166)S3 (133-136)TVIII2 (169-172)TIV7 (153-156)O1 (181-183)TIV8 (166-169)AH9 (281-293)TI6 (189-192)S4 (172-176)S5 (195-202)AH7 (183-189)TI7 (213-216)TII3 (204-207)TVIa1 (207-210)3H3 (220-222)TI11 (341-344)S6 (226-231)TVIa2 (340-343)TII5 (232-235)3H4 (337-340)TI8 (266-269)TI9 (272-275)TII6 (269-272)S8 (297-301)TIV11 (333-336)S2 (55-57)TII4 (222-225)S7 (259-263)AH11 (359-375)S1 (17-19)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 135
structure length 366
sequence length 366
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2014-05-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4qa4A00
5EFKB 5G1AA 5G10A 4ZUMA 5ICNB 4QA6A 3F06A 3MZ3A 5G12A 5JI5A 5THUA 1VKGA 4LXZA 5DC6A 5EEKA 5EFJD 1ZZ3A 3ZNSA 3MENA 5EEMA 4ZUPA 2GH6A 5D1BA 1C3PA 4BKXB 5G11A 3SFFA 5THVA 1T64A 4QA2A 5A2SA 2VQVA 2V5XA 5EFGA 4ZUQA 4QA4A 5EF7A 1T69A 5FUEA 5THTA 4BZ8A 4BZ9A 3ZNRA 1ZZ0A 5G13A 5G1BA 5G0IA 3C10A 4CBYA 5EFHA 3RQDA 4QA0A 4RN2A 3F07A 3Q9FA 2VQJA 4RN1A 3EZPA 2VQMA 5DC7A 4ZUNA 4BZ5A 5DC8A 1ZZ1A 3MAXA 4QA3A 5EFNA 4QA5A 5EF8A 5G0GA 5FCWA 5IWGA 5G0XA 5BWZA 5G0HA 5LI3A 4ZURA 4QA1A 3C0YA 4QA7A 5G1CA 4CQFA 4BZ6A 5G17A 3MZ7A 5G0JA 3MZ4A 2VQOA 4BZ7A 3EWFA 3F0RA 1C3SA 1W22A 4RN0A 3Q9CA 5G3WA 3SFHA 5D1DA 4CBTA 5EFBD 4LY1A 3EZTA 4ZUOA 1T67A 5THSA 3MZ6A 2VQWG 4A69A 5EEFA 5EEIA 2VCGA 2V5WA 5D1CA 3Q9BA 5DC5A 2VQQA 5EENA 5G0YA 3EW8A 1C3RA 3Q9EA 3C0ZA 5IX0A
chains in the Genus database with same CATH superfamily
4RHQA 4Q3QA 5EFKB 5G1AA 2EF5A 4Q3PA 3CEVA 3SL0A 3THJA 5G10A 4ZUMA 5ICNB 1ZPEA 4RLAA 4QA6A 3LHLA 3F06A 3GMZA 3MZ3A 4MYLA 3NIOA 5G12A 3LP4A 5THUA 2CEVA 4FCKA 5JI5A 2PHAA 1VKGA 4LXZA 4IE2A 4MYKA 4RHKA 5DC6A 1T5GA 4Q3TA 5EEKA 5EFJD 1ZZ3A 3ZNSA 3E8ZA 1P8SA 3MENA 4MXRA 5EEMA 4ZUPA 2GH6A 5D1BA 1C3PA 1GQ6A 3KV2A 5G11A 3SFFA 5THVA 1T64A 4BKXB 1HQHA 1T4TA 3LP7A 4GSMA 4QA2A 1XFKA 2VQVA 3RLAA 5A2SA 3DJ8A 2EF4A 1D3VA 2V5XA 1HQGA 5EFGA 1HQ5A 4ZUQA 4QA4A 5EF7A 1T69A 4GSZA 5FUEA 3MJLA 5THTA 2A0MA 3PZLA 4BZ8A 4BZ9A 1ZPGA 2ZAVA 4HXQA 1TBHA 4RHLA 3ZNRA 3TH7A 1P8PA 1ZZ0A 5G13A 3SKKA 5G1BA 1GQ7A 3C10A 3F80A 5G0IA 2EIVA 4CBYA 4Q3RC 5EFHA 3MFVA 4IE3A 3MMRA 3RQDA 4Q42A 4QA0A 4RN2A 3F07A 1T4RA 1T5FA 3Q9FA 2VQJA 4RHIA 4RN1A 3EZPA 4MYNA 1WOGA 2VQMA 5DC7A 4ZUNA 1T4PA 1RLAA 3SL1A 4DZ4A 4BZ5A 4Q3SA 5DC8A 3SJTA 1ZZ1A 1R1OA 3MAXA 4QA3A 5EFNA 4IXUA 4FCIA 3THEA 4QA5A 5EF8A 1WVBA 5FCWA 5G0GA 1TA1A 4MYFA 5G0XA 5IWGA 5BWZA 3TF3A 1P8QA 4Q3RA 5G0HA 3THHA 4GSVA 4HZEA 5LI3A 4RHMA 4ZURA 4QA1A 3C0YA 4IU5A 4QA7A 5G1CA 4CQFA 3M1RA 4BZ6A 1P8MA 3NIQA 5G17A 3MZ7A 2PLLA 5G0JA 4CEVA 3MZ4A 4GWCA 2VQOA 1HQXA 1WVAA 4BZ7A 4HWWA 3EWFA 4Q3VA 3F0RA 1C3SA 4G3HA 3E9BA 1P8NA 1W22A 4Q40A 4RN0A 1P8RA 3E6KA 5CEVA 1TBLA 2AEBA 3Q9CA 4IU1A 4GWDA 4IU0A 1WOIA 4IU4A 5G3WA 1P8OA 3SFHA 5D1DA 3E6VA 3GN0A 3MFWA 5EFBD 4LY1A 4CBTA 4Q41A 3EZTA 2PHOA 1T67A 4ZUOA 3MZ6A 5THSA 2VQWG 4I06A 4A69A 5EEFA 5EEIA 2VCGA 4IXVA 1PQ3A 2V5WA 5D1CA 3Q9BA 5DC5A 1WOHA 1HQFA 5HJ9A 3NIPA 4Q3UA 2VQQA 2RLAA 3E8QA 4RHJA 5EENA 5G0YA 1CEVA 1T4SA 1TBJA 3EW8A 5HJAA 4IE1A 1C3RA 3Q9EA 3C0ZA 5IX0A 5RLAA 4ITYA
chains in the Genus database with same CATH topology
5EFKB 5G1AA 5G10A 4ZUMA 5ICNB 4QA6A 3F06A 3MZ3A 5G12A 5JI5A 5THUA 1VKGA 4LXZA 5DC6A 5EEKA 5EFJD 1ZZ3A 3ZNSA 3MENA 5EEMA 4ZUPA 2GH6A 5D1BA 1C3PA 4BKXB 5G11A 3SFFA 5THVA 1T64A 4QA2A 5A2SA 2VQVA 2V5XA 5EFGA 4ZUQA 4QA4A 5EF7A 1T69A 5FUEA 5THTA 4BZ8A 4BZ9A 3ZNRA 1ZZ0A 5G13A 5G1BA 5G0IA 3C10A 4CBYA 5EFHA 3RQDA 4QA0A 4RN2A 3F07A 3Q9FA 2VQJA 4RN1A 3EZPA 2VQMA 5DC7A 4ZUNA 4BZ5A 5DC8A 1ZZ1A 3MAXA 4QA3A 5EFNA 4QA5A 5EF8A 5G0GA 5FCWA 5IWGA 5G0XA 5BWZA 5G0HA 5LI3A 4ZURA 4QA1A 3C0YA 4QA7A 5G1CA 4CQFA 4BZ6A 5G17A 3MZ7A 5G0JA 3MZ4A 2VQOA 4BZ7A 3EWFA 3F0RA 1C3SA 1W22A 4RN0A 3Q9CA 5G3WA 3SFHA 5D1DA 4CBTA 5EFBD 4LY1A 3EZTA 4ZUOA 1T67A 5THSA 3MZ6A 2VQWG 4A69A 5EEFA 5EEIA 2VCGA 2V5WA 5D1CA 3Q9BA 5DC5A 2VQQA 5EENA 5G0YA 3EW8A 1C3RA 3Q9EA 3C0ZA 5IX0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EFK B;  5G1A A;  5G10 A;  4ZUM A;  5ICN B;  4QA6 A;  3F06 A;  3MZ3 A;  5G12 A;  5JI5 A;  5THU A;  1VKG A;  4LXZ A;  5DC6 A;  5EEK A;  5EFJ D;  1ZZ3 A;  3ZNS A;  3MEN A;  5EEM A;  4ZUP A;  2GH6 A;  5D1B A;  1C3P A;  4BKX B;  5G11 A;  3SFF A;  5THV A;  1T64 A;  4QA2 A;  5A2S A;  2VQV A;  2V5X A;  5EFG A;  4ZUQ A;  4QA4 A;  5EF7 A;  1T69 A;  5FUE A;  5THT A;  4BZ8 A;  4BZ9 A;  3ZNR A;  1ZZ0 A;  5G13 A;  5G1B A;  5G0I A;  3C10 A;  4CBY A;  5EFH A;  3RQD A;  4QA0 A;  4RN2 A;  3F07 A;  3Q9F A;  2VQJ A;  4RN1 A;  3EZP A;  2VQM A;  5DC7 A;  4ZUN A;  4BZ5 A;  5DC8 A;  1ZZ1 A;  3MAX A;  4QA3 A;  5EFN A;  4QA5 A;  5EF8 A;  5G0G A;  5FCW A;  5IWG A;  5G0X A;  5BWZ A;  5G0H A;  5LI3 A;  4ZUR A;  4QA1 A;  3C0Y A;  4QA7 A;  5G1C A;  4CQF A;  4BZ6 A;  5G17 A;  3MZ7 A;  5G0J A;  3MZ4 A;  2VQO A;  4BZ7 A;  3EWF A;  3F0R A;  1C3S A;  1W22 A;  4RN0 A;  3Q9C A;  5G3W A;  3SFH A;  5D1D A;  4CBT A;  5EFB D;  4LY1 A;  3EZT A;  4ZUO A;  1T67 A;  5THS A;  3MZ6 A;  2VQW G;  4A69 A;  5EEF A;  5EEI A;  2VCG A;  2V5W A;  5D1C A;  3Q9B A;  5DC5 A;  2VQQ A;  5EEN A;  5G0Y A;  3EW8 A;  1C3R A;  3Q9E A;  3C0Z A;  5IX0 A; 
#chains in the Genus database with same CATH topology
 4RHQ A;  4Q3Q A;  5EFK B;  5G1A A;  2EF5 A;  4Q3P A;  3CEV A;  3SL0 A;  3THJ A;  5G10 A;  4ZUM A;  5ICN B;  1ZPE A;  4RLA A;  4QA6 A;  3LHL A;  3F06 A;  3GMZ A;  3MZ3 A;  4MYL A;  3NIO A;  5G12 A;  3LP4 A;  5THU A;  2CEV A;  4FCK A;  5JI5 A;  2PHA A;  1VKG A;  4LXZ A;  4IE2 A;  4MYK A;  4RHK A;  5DC6 A;  1T5G A;  4Q3T A;  5EEK A;  5EFJ D;  1ZZ3 A;  3ZNS A;  3E8Z A;  1P8S A;  3MEN A;  4MXR A;  5EEM A;  4ZUP A;  2GH6 A;  5D1B A;  1C3P A;  1GQ6 A;  3KV2 A;  5G11 A;  3SFF A;  5THV A;  1T64 A;  4BKX B;  1HQH A;  1T4T A;  3LP7 A;  4GSM A;  4QA2 A;  1XFK A;  2VQV A;  3RLA A;  5A2S A;  3DJ8 A;  2EF4 A;  1D3V A;  2V5X A;  1HQG A;  5EFG A;  1HQ5 A;  4ZUQ A;  4QA4 A;  5EF7 A;  1T69 A;  4GSZ A;  5FUE A;  3MJL A;  5THT A;  2A0M A;  3PZL A;  4BZ8 A;  4BZ9 A;  1ZPG A;  2ZAV A;  4HXQ A;  1TBH A;  4RHL A;  3ZNR A;  3TH7 A;  1P8P A;  1ZZ0 A;  5G13 A;  3SKK A;  5G1B A;  1GQ7 A;  3C10 A;  3F80 A;  5G0I A;  2EIV A;  4CBY A;  4Q3R C;  5EFH A;  3MFV A;  4IE3 A;  3MMR A;  3RQD A;  4Q42 A;  4QA0 A;  4RN2 A;  3F07 A;  1T4R A;  1T5F A;  3Q9F A;  2VQJ A;  4RHI A;  4RN1 A;  3EZP A;  4MYN A;  1WOG A;  2VQM A;  5DC7 A;  4ZUN A;  1T4P A;  1RLA A;  3SL1 A;  4DZ4 A;  4BZ5 A;  4Q3S A;  5DC8 A;  3SJT A;  1ZZ1 A;  1R1O A;  3MAX A;  4QA3 A;  5EFN A;  4IXU A;  4FCI A;  3THE A;  4QA5 A;  5EF8 A;  1WVB A;  5FCW A;  5G0G A;  1TA1 A;  4MYF A;  5G0X A;  5IWG A;  5BWZ A;  3TF3 A;  1P8Q A;  4Q3R A;  5G0H A;  3THH A;  4GSV A;  4HZE A;  5LI3 A;  4RHM A;  4ZUR A;  4QA1 A;  3C0Y A;  4IU5 A;  4QA7 A;  5G1C A;  4CQF A;  3M1R A;  4BZ6 A;  1P8M A;  3NIQ A;  5G17 A;  3MZ7 A;  2PLL A;  5G0J A;  4CEV A;  3MZ4 A;  4GWC A;  2VQO A;  1HQX A;  1WVA A;  4BZ7 A;  4HWW A;  3EWF A;  4Q3V A;  3F0R A;  1C3S A;  4G3H A;  3E9B A;  1P8N A;  1W22 A;  4Q40 A;  4RN0 A;  1P8R A;  3E6K A;  5CEV A;  1TBL A;  2AEB A;  3Q9C A;  4IU1 A;  4GWD A;  4IU0 A;  1WOI A;  4IU4 A;  5G3W A;  1P8O A;  3SFH A;  5D1D A;  3E6V A;  3GN0 A;  3MFW A;  5EFB D;  4LY1 A;  4CBT A;  4Q41 A;  3EZT A;  2PHO A;  1T67 A;  4ZUO A;  3MZ6 A;  5THS A;  2VQW G;  4I06 A;  4A69 A;  5EEF A;  5EEI A;  2VCG A;  4IXV A;  1PQ3 A;  2V5W A;  5D1C A;  3Q9B A;  5DC5 A;  1WOH A;  1HQF A;  5HJ9 A;  3NIP A;  4Q3U A;  2VQQ A;  2RLA A;  3E8Q A;  4RHJ A;  5EEN A;  5G0Y A;  1CEV A;  1T4S A;  1TBJ A;  3EW8 A;  5HJA A;  4IE1 A;  1C3R A;  3Q9E A;  3C0Z A;  5IX0 A;  5RLA A;  4ITY A; 
#chains in the Genus database with same CATH homology
 5EFK B;  5G1A A;  5G10 A;  4ZUM A;  5ICN B;  4QA6 A;  3F06 A;  3MZ3 A;  5G12 A;  5JI5 A;  5THU A;  1VKG A;  4LXZ A;  5DC6 A;  5EEK A;  5EFJ D;  1ZZ3 A;  3ZNS A;  3MEN A;  5EEM A;  4ZUP A;  2GH6 A;  5D1B A;  1C3P A;  4BKX B;  5G11 A;  3SFF A;  5THV A;  1T64 A;  4QA2 A;  5A2S A;  2VQV A;  2V5X A;  5EFG A;  4ZUQ A;  4QA4 A;  5EF7 A;  1T69 A;  5FUE A;  5THT A;  4BZ8 A;  4BZ9 A;  3ZNR A;  1ZZ0 A;  5G13 A;  5G1B A;  5G0I A;  3C10 A;  4CBY A;  5EFH A;  3RQD A;  4QA0 A;  4RN2 A;  3F07 A;  3Q9F A;  2VQJ A;  4RN1 A;  3EZP A;  2VQM A;  5DC7 A;  4ZUN A;  4BZ5 A;  5DC8 A;  1ZZ1 A;  3MAX A;  4QA3 A;  5EFN A;  4QA5 A;  5EF8 A;  5G0G A;  5FCW A;  5IWG A;  5G0X A;  5BWZ A;  5G0H A;  5LI3 A;  4ZUR A;  4QA1 A;  3C0Y A;  4QA7 A;  5G1C A;  4CQF A;  4BZ6 A;  5G17 A;  3MZ7 A;  5G0J A;  3MZ4 A;  2VQO A;  4BZ7 A;  3EWF A;  3F0R A;  1C3S A;  1W22 A;  4RN0 A;  3Q9C A;  5G3W A;  3SFH A;  5D1D A;  4CBT A;  5EFB D;  4LY1 A;  3EZT A;  4ZUO A;  1T67 A;  5THS A;  3MZ6 A;  2VQW G;  4A69 A;  5EEF A;  5EEI A;  2VCG A;  2V5W A;  5D1C A;  3Q9B A;  5DC5 A;  2VQQ A;  5EEN A;  5G0Y A;  3EW8 A;  1C3R A;  3Q9E A;  3C0Z A;  5IX0 A; 
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