4RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 108
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 108
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4rlaA00
3KV2A 5CEVA 4Q42A 1T4RA 3RLAA 4MYLA 4IXUA 3NIQA 3TH7A 3E6KA 1P8SA 5HJAA 2EIVA 4Q3TA 1P8RA 1GQ7A 2PHAA 3MMRA 1CEVA 4FCKA 4FCIA 3F80A 1ZPEA 1TA1A 3E8QA 2PHOA 2CEVA 3DJ8A 4Q41A 1T5GA 5RLAA 1T4PA 4GSZA 3LP4A 2ZAVA 1D3VA 4HXQA 4Q3QA 4IU1A 4GSVA 1T4TA 1TBHA 3THJA 4IU0A 4IE3A 1WVBA 3GMZA 3SKKA 4Q3PA 3GN0A 4RHQA 4Q3UA 4RHIA 3LP7A 4I06A 4Q3SA 3MJLA 4IXVA 2EF4A 4HWWA 4CEVA 4RHJA 4RHLA 1TBLA 3LHLA 3NIPA 3SL0A 3THHA 3NIOA 4MXRA 3MFWA 5HJ9A 3SL1A 1WOHA 4GWCA 4MYFA 4DZ4A 4RLAA 1P8PA 3TF3A 1R1OA 1ZPGA 3THEA 1GQ6A 3CEVA 3PZLA 3SJTA 4MYKA 4RHMA 1HQHA 4Q40A 2AEBA 3M1RA 1P8NA 1HQ5A 3E8ZA 4Q3RA 4Q3RC 2PLLA 4IE2A 1HQXA 4ITYA 4IU5A 1TBJA 4Q3VA 1T5FA 1P8MA 4HZEA 4MYNA 1PQ3A 4G3HA 2RLAA 1P8QA 3E6VA 1T4SA 2A0MA 4IU4A 1WVAA 1HQGA 1XFKA 3MFVA 1RLAA 2EF5A 3E9BA 4RHKA 4GSMA 1WOIA 1WOGA 4GWDA 1HQFA 4IE1A 1P8OA
chains in the Genus database with same CATH superfamily
1T69A 3Q9FA 1VKGA 3KV2A 5CEVA 5BWZA 4Q42A 5LI3A 5EEMA 5G1AA 1T4RA 4QA6A 3RLAA 4MYLA 4IXUA 4QA2A 3NIQA 3TH7A 3MZ6A 3E6KA 2VQMA 1P8SA 3EW8A 5HJAA 5G0HA 2EIVA 5G1CA 5G0GA 4QA0A 4Q3TA 5DC6A 1P8RA 4ZUMA 1GQ7A 2PHAA 2VQWG 3C10A 3MENA 5G13A 5EFNA 3MMRA 1CEVA 4ZURA 4FCKA 4FCIA 3RQDA 3F80A 1ZPEA 1TA1A 3E8QA 2PHOA 5D1DA 2CEVA 3DJ8A 5EEKA 2V5WA 4BZ5A 4CQFA 4Q41A 1T5GA 4QA5A 4QA4A 5RLAA 4BZ6A 1T4PA 4GSZA 5D1CA 3LP4A 2ZAVA 5THVA 3SFFA 1D3VA 5THSA 4ZUPA 4HXQA 4Q3QA 5EFBD 3SFHA 5EFGA 4IU1A 4GSVA 4BZ8A 4ZUNA 1T67A 1T4TA 1TBHA 5G3WA 5G11A 3THJA 4IU0A 4IE3A 3F07A 1WVBA 3GMZA 3MZ4A 1ZZ0A 4QA1A 5D1BA 3SKKA 3Q9CA 3F06A 4Q3PA 3GN0A 4RHQA 1T64A 4Q3UA 3EWFA 5DC7A 4RHIA 3LP7A 4I06A 4Q3SA 2V5XA 3MJLA 2EF4A 4HWWA 4IXVA 4CBTA 4CEVA 4RHJA 5DC8A 5DC5A 4RHLA 1TBLA 1W22A 3LHLA 1C3SA 3NIPA 3SL0A 3THHA 4RN2A 5G0XA 5G0JA 3C0YA 3NIOA 4MXRA 3MFWA 4RN0A 5EEIA 5HJ9A 3SL1A 1WOHA 5EF7A 4GWCA 4MYFA 4DZ4A 4RLAA 1P8PA 5G1BA 3TF3A 1R1OA 5EFKB 2VQJA 5EENA 1ZPGA 4LY1A 3THEA 5G0IA 1GQ6A 4BZ9A 3CEVA 3PZLA 4CBYA 1C3RA 3MAXA 3EZPA 2VQVA 4MYKA 1HQHA 2VCGA 4RHMA 5G17A 3SJTA 4A69A 5EFJD 4Q40A 2AEBA 4ZUQA 3M1RA 3MZ3A 1P8NA 4LXZA 1HQ5A 3Q9EA 5EFHA 4RN1A 5THTA 3E8ZA 4QA3A 5A2SA 4Q3RA 2GH6A 4Q3RC 2PLLA 3MZ7A 1HQXA 4IE2A 4ITYA 4IU5A 3F0RA 4QA7A 4ZUOA 1TBJA 4Q3VA 1T5FA 1P8MA 4HZEA 4MYNA 1PQ3A 4G3HA 2RLAA 5FUEA 3ZNRA 4BZ7A 1P8QA 5G10A 3E6VA 1T4SA 2A0MA 4IU4A 2VQQA 5IX0A 5G0YA 1ZZ1A 1WVAA 3EZTA 1HQGA 1XFKA 3MFVA 1RLAA 2EF5A 3E9BA 4RHKA 5IWGA 3ZNSA 5G12A 5JI5A 4GSMA 1WOIA 1WOGA 5THUA 5FCWA 3Q9BA 4BKXB 4GWDA 1HQFA 1ZZ3A 4IE1A 5EEFA 2VQOA 5EF8A 5ICNB 3C0ZA 1C3PA 1P8OA
chains in the Genus database with same CATH topology
3KV2A 5CEVA 4Q42A 1T4RA 3RLAA 4MYLA 4IXUA 3NIQA 3TH7A 3E6KA 1P8SA 5HJAA 2EIVA 4Q3TA 1P8RA 1GQ7A 2PHAA 3MMRA 1CEVA 4FCKA 4FCIA 3F80A 1ZPEA 1TA1A 3E8QA 2PHOA 2CEVA 3DJ8A 4Q41A 1T5GA 5RLAA 1T4PA 4GSZA 3LP4A 2ZAVA 1D3VA 4HXQA 4Q3QA 4IU1A 4GSVA 1T4TA 1TBHA 3THJA 4IU0A 4IE3A 1WVBA 3GMZA 3SKKA 4Q3PA 3GN0A 4RHQA 4Q3UA 4RHIA 3LP7A 4I06A 4Q3SA 3MJLA 4IXVA 2EF4A 4HWWA 4CEVA 4RHJA 4RHLA 1TBLA 3LHLA 3NIPA 3SL0A 3THHA 3NIOA 4MXRA 3MFWA 5HJ9A 3SL1A 1WOHA 4GWCA 4MYFA 4DZ4A 4RLAA 1P8PA 3TF3A 1R1OA 1ZPGA 3THEA 1GQ6A 3CEVA 3PZLA 3SJTA 4MYKA 4RHMA 1HQHA 4Q40A 2AEBA 3M1RA 1P8NA 1HQ5A 3E8ZA 4Q3RA 4Q3RC 2PLLA 4IE2A 1HQXA 4ITYA 4IU5A 1TBJA 4Q3VA 1T5FA 1P8MA 4HZEA 4MYNA 1PQ3A 4G3HA 2RLAA 1P8QA 3E6VA 1T4SA 2A0MA 4IU4A 1WVAA 1HQGA 1XFKA 3MFVA 1RLAA 2EF5A 3E9BA 4RHKA 4GSMA 1WOIA 1WOGA 4GWDA 1HQFA 4IE1A 1P8OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KV2 A;  5CEV A;  4Q42 A;  1T4R A;  3RLA A;  4MYL A;  4IXU A;  3NIQ A;  3TH7 A;  3E6K A;  1P8S A;  5HJA A;  2EIV A;  4Q3T A;  1P8R A;  1GQ7 A;  2PHA A;  3MMR A;  1CEV A;  4FCK A;  4FCI A;  3F80 A;  1ZPE A;  1TA1 A;  3E8Q A;  2PHO A;  2CEV A;  3DJ8 A;  4Q41 A;  1T5G A;  5RLA A;  1T4P A;  4GSZ A;  3LP4 A;  2ZAV A;  1D3V A;  4HXQ A;  4Q3Q A;  4IU1 A;  4GSV A;  1T4T A;  1TBH A;  3THJ A;  4IU0 A;  4IE3 A;  1WVB A;  3GMZ A;  3SKK A;  4Q3P A;  3GN0 A;  4RHQ A;  4Q3U A;  4RHI A;  3LP7 A;  4I06 A;  4Q3S A;  3MJL A;  4IXV A;  2EF4 A;  4HWW A;  4CEV A;  4RHJ A;  4RHL A;  1TBL A;  3LHL A;  3NIP A;  3SL0 A;  3THH A;  3NIO A;  4MXR A;  3MFW A;  5HJ9 A;  3SL1 A;  1WOH A;  4GWC A;  4MYF A;  4DZ4 A;  4RLA A;  1P8P A;  3TF3 A;  1R1O A;  1ZPG A;  3THE A;  1GQ6 A;  3CEV A;  3PZL A;  3SJT A;  4MYK A;  4RHM A;  1HQH A;  4Q40 A;  2AEB A;  3M1R A;  1P8N A;  1HQ5 A;  3E8Z A;  4Q3R A;  4Q3R C;  2PLL A;  4IE2 A;  1HQX A;  4ITY A;  4IU5 A;  1TBJ A;  4Q3V A;  1T5F A;  1P8M A;  4HZE A;  4MYN A;  1PQ3 A;  4G3H A;  2RLA A;  1P8Q A;  3E6V A;  1T4S A;  2A0M A;  4IU4 A;  1WVA A;  1HQG A;  1XFK A;  3MFV A;  1RLA A;  2EF5 A;  3E9B A;  4RHK A;  4GSM A;  1WOI A;  1WOG A;  4GWD A;  1HQF A;  4IE1 A;  1P8O A; 
#chains in the Genus database with same CATH topology
 1T69 A;  3Q9F A;  1VKG A;  3KV2 A;  5CEV A;  5BWZ A;  4Q42 A;  5LI3 A;  5EEM A;  5G1A A;  1T4R A;  4QA6 A;  3RLA A;  4MYL A;  4IXU A;  4QA2 A;  3NIQ A;  3TH7 A;  3MZ6 A;  3E6K A;  2VQM A;  1P8S A;  3EW8 A;  5HJA A;  5G0H A;  2EIV A;  5G1C A;  5G0G A;  4QA0 A;  4Q3T A;  5DC6 A;  1P8R A;  4ZUM A;  1GQ7 A;  2PHA A;  2VQW G;  3C10 A;  3MEN A;  5G13 A;  5EFN A;  3MMR A;  1CEV A;  4ZUR A;  4FCK A;  4FCI A;  3RQD A;  3F80 A;  1ZPE A;  1TA1 A;  3E8Q A;  2PHO A;  5D1D A;  2CEV A;  3DJ8 A;  5EEK A;  2V5W A;  4BZ5 A;  4CQF A;  4Q41 A;  1T5G A;  4QA5 A;  4QA4 A;  5RLA A;  4BZ6 A;  1T4P A;  4GSZ A;  5D1C A;  3LP4 A;  2ZAV A;  5THV A;  3SFF A;  1D3V A;  5THS A;  4ZUP A;  4HXQ A;  4Q3Q A;  5EFB D;  3SFH A;  5EFG A;  4IU1 A;  4GSV A;  4BZ8 A;  4ZUN A;  1T67 A;  1T4T A;  1TBH A;  5G3W A;  5G11 A;  3THJ A;  4IU0 A;  4IE3 A;  3F07 A;  1WVB A;  3GMZ A;  3MZ4 A;  1ZZ0 A;  4QA1 A;  5D1B A;  3SKK A;  3Q9C A;  3F06 A;  4Q3P A;  3GN0 A;  4RHQ A;  1T64 A;  4Q3U A;  3EWF A;  5DC7 A;  4RHI A;  3LP7 A;  4I06 A;  4Q3S A;  2V5X A;  3MJL A;  2EF4 A;  4HWW A;  4IXV A;  4CBT A;  4CEV A;  4RHJ A;  5DC8 A;  5DC5 A;  4RHL A;  1TBL A;  1W22 A;  3LHL A;  1C3S A;  3NIP A;  3SL0 A;  3THH A;  4RN2 A;  5G0X A;  5G0J A;  3C0Y A;  3NIO A;  4MXR A;  3MFW A;  4RN0 A;  5EEI A;  5HJ9 A;  3SL1 A;  1WOH A;  5EF7 A;  4GWC A;  4MYF A;  4DZ4 A;  4RLA A;  1P8P A;  5G1B A;  3TF3 A;  1R1O A;  5EFK B;  2VQJ A;  5EEN A;  1ZPG A;  4LY1 A;  3THE A;  5G0I A;  1GQ6 A;  4BZ9 A;  3CEV A;  3PZL A;  4CBY A;  1C3R A;  3MAX A;  3EZP A;  2VQV A;  4MYK A;  1HQH A;  2VCG A;  4RHM A;  5G17 A;  3SJT A;  4A69 A;  5EFJ D;  4Q40 A;  2AEB A;  4ZUQ A;  3M1R A;  3MZ3 A;  1P8N A;  4LXZ A;  1HQ5 A;  3Q9E A;  5EFH A;  4RN1 A;  5THT A;  3E8Z A;  4QA3 A;  5A2S A;  4Q3R A;  2GH6 A;  4Q3R C;  2PLL A;  3MZ7 A;  1HQX A;  4IE2 A;  4ITY A;  4IU5 A;  3F0R A;  4QA7 A;  4ZUO A;  1TBJ A;  4Q3V A;  1T5F A;  1P8M A;  4HZE A;  4MYN A;  1PQ3 A;  4G3H A;  2RLA A;  5FUE A;  3ZNR A;  4BZ7 A;  1P8Q A;  5G10 A;  3E6V A;  1T4S A;  2A0M A;  4IU4 A;  2VQQ A;  5IX0 A;  5G0Y A;  1ZZ1 A;  1WVA A;  3EZT A;  1HQG A;  1XFK A;  3MFV A;  1RLA A;  2EF5 A;  3E9B A;  4RHK A;  5IWG A;  3ZNS A;  5G12 A;  5JI5 A;  4GSM A;  1WOI A;  1WOG A;  5THU A;  5FCW A;  3Q9B A;  4BKX B;  4GWD A;  1HQF A;  1ZZ3 A;  4IE1 A;  5EEF A;  2VQO A;  5EF8 A;  5ICN B;  3C0Z A;  1C3P A;  1P8O A; 
#chains in the Genus database with same CATH homology
 3KV2 A;  5CEV A;  4Q42 A;  1T4R A;  3RLA A;  4MYL A;  4IXU A;  3NIQ A;  3TH7 A;  3E6K A;  1P8S A;  5HJA A;  2EIV A;  4Q3T A;  1P8R A;  1GQ7 A;  2PHA A;  3MMR A;  1CEV A;  4FCK A;  4FCI A;  3F80 A;  1ZPE A;  1TA1 A;  3E8Q A;  2PHO A;  2CEV A;  3DJ8 A;  4Q41 A;  1T5G A;  5RLA A;  1T4P A;  4GSZ A;  3LP4 A;  2ZAV A;  1D3V A;  4HXQ A;  4Q3Q A;  4IU1 A;  4GSV A;  1T4T A;  1TBH A;  3THJ A;  4IU0 A;  4IE3 A;  1WVB A;  3GMZ A;  3SKK A;  4Q3P A;  3GN0 A;  4RHQ A;  4Q3U A;  4RHI A;  3LP7 A;  4I06 A;  4Q3S A;  3MJL A;  4IXV A;  2EF4 A;  4HWW A;  4CEV A;  4RHJ A;  4RHL A;  1TBL A;  3LHL A;  3NIP A;  3SL0 A;  3THH A;  3NIO A;  4MXR A;  3MFW A;  5HJ9 A;  3SL1 A;  1WOH A;  4GWC A;  4MYF A;  4DZ4 A;  4RLA A;  1P8P A;  3TF3 A;  1R1O A;  1ZPG A;  3THE A;  1GQ6 A;  3CEV A;  3PZL A;  3SJT A;  4MYK A;  4RHM A;  1HQH A;  4Q40 A;  2AEB A;  3M1R A;  1P8N A;  1HQ5 A;  3E8Z A;  4Q3R A;  4Q3R C;  2PLL A;  4IE2 A;  1HQX A;  4ITY A;  4IU5 A;  1TBJ A;  4Q3V A;  1T5F A;  1P8M A;  4HZE A;  4MYN A;  1PQ3 A;  4G3H A;  2RLA A;  1P8Q A;  3E6V A;  1T4S A;  2A0M A;  4IU4 A;  1WVA A;  1HQG A;  1XFK A;  3MFV A;  1RLA A;  2EF5 A;  3E9B A;  4RHK A;  4GSM A;  1WOI A;  1WOG A;  4GWD A;  1HQF A;  4IE1 A;  1P8O A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...