4BZ5A

Crystal structure of schistosoma mansoni hdac8
Total Genus 148
50100150200250300350400020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
434
structure length
404
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNMVDNDKLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLY

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (3-6)TVIII1 (128-131)EMPTYAH2 (23-35)AH1 (9-16)S3 (132-135)TI1 (18-21)TI2 (19-22)AH11 (343-362)TIV5 (300-316)TIV6 (301-317)3H1 (38-40)TVIII5 (340-343)AH3 (52-60)AH4 (65-78)TIV1 (60-63)TIV4 (152-155)TI'1 (149-152)AH5 (86-94)AH6 (106-127)TIV3 (144-147)TII'1 (98-101)AH7 (156-166)AH9 (255-273)TI3 (135-138)S4 (180-184)TI4 (140-143)S5 (203-210)AH8 (191-197)O1 (189-191)TI5 (197-200)TI6 (200-203)TII1 (212-215)TVIa1 (215-218)S6 (244-249)TI8 (287-290)TI10 (375-378)TII3 (250-253)AH12 (402-422)AH10 (318-328)TI7 (284-287)TVIII4 (275-278)S7 (277-281)TI11 (382-385)O3 (389-391)S2 (42-44)3H2 (238-240)3H3 (378-380)TII2 (240-243)O2 (225-227)S8 (333-336)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Schistosoma mansoni
publication title Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.
pubmed doi rcsb
molecule keywords HISTONE DEACETYLASE 8
total genus 148
structure length 404
sequence length 434
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-07-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 4bz5A00
4QA7A 5IX0A 4RN1A 1ZZ3A 3C0YA 3F07A 5EEFA 1ZZ1A 1C3PA 5D1BA 4BZ5A 2VQMA 5G13A 4CQFA 5G0XA 4RN2A 5EFJD 3ZNRA 2VQJA 1T64A 3SFFA 5G0IA 3MZ4A 5G1CA 4ZUQA 3ZNSA 4BZ8A 5G3WA 5A2SA 3EZTA 5G10A 3C10A 5G12A 4LY1A 5THSA 3MZ3A 4ZUOA 2VQVA 3F0RA 3MZ7A 5ICNB 1T69A 4BZ9A 5G0HA 5JI5A 5THTA 5EEMA 4BZ7A 2VQOA 3EWFA 4QA3A 3Q9EA 4QA0A 5DC6A 4ZUMA 4QA5A 5G11A 4QA4A 1ZZ0A 5G1AA 5EENA 5FCWA 3RQDA 5EF7A 1C3RA 5G0YA 3MAXA 5D1CA 1W22A 4RN0A 5EFHA 2VCGA 2V5XA 4QA6A 1C3SA 5EFBD 4A69A 5EEKA 4CBYA 2GH6A 5DC7A 5G0JA 5BWZA 4ZURA 3EZPA 3SFHA 5DC8A 3F06A 4LXZA 5EF8A 4BKXB 4BZ6A 1VKGA 3Q9BA 3MZ6A 5G0GA 3EW8A 3C0ZA 5G17A 5EFGA 4CBTA 4ZUPA 5EEIA 3Q9FA 5THUA 3Q9CA 5EFKB 4QA2A 4QA1A 5DC5A 5IWGA 5FUEA 2V5WA 2VQQA 5THVA 4ZUNA 5D1DA 5EFNA 5G1BA 5LI3A 3MENA 2VQWG 1T67A
chains in the Genus database with same CATH superfamily
4ITYA 2EF5A 4Q3QA 3MFVA 4GSZA 4QA7A 4Q3TA 3SKKA 5IX0A 4RN1A 1ZZ3A 1WOIA 3C0YA 3F07A 5EEFA 1ZZ1A 2PHOA 1C3PA 4RLAA 5D1BA 1P8RA 3CEVA 4BZ5A 4G3HA 2VQMA 5G13A 4CQFA 1T4PA 2EIVA 5G0XA 3LP4A 4RN2A 5EFJD 1D3VA 1XFKA 3THEA 3M1RA 3ZNRA 2VQJA 4RHMA 1WOHA 1T64A 5HJ9A 3SFFA 5G0IA 3MZ4A 4IU4A 5G1CA 4ZUQA 3ZNSA 4BZ8A 1HQGA 5G3WA 5A2SA 3EZTA 4Q3RC 3C10A 4Q3SA 5G10A 5G12A 4LY1A 5THSA 3MZ3A 1GQ6A 1RLAA 1CEVA 4FCIA 4ZUOA 2A0MA 5G11A 4MYNA 1P8MA 2VQVA 4I06A 3F0RA 4FCKA 4MYKA 3TH7A 1P8SA 1P8PA 2CEVA 3MZ7A 3NIQA 5ICNB 1T69A 4BZ9A 4GWCA 5G0HA 5JI5A 5THTA 5EEMA 4BZ7A 3RLAA 2VQOA 3EWFA 2RLAA 4QA3A 3Q9EA 4QA0A 5DC6A 4CEVA 3E8QA 3MMRA 4Q3PA 4ZUMA 3E6KA 4IE3A 4IU0A 4Q40A 2PHAA 1WOGA 1ZZ0A 3MFWA 4QA5A 4QA4A 4HXQA 5G1AA 4IE1A 4DZ4A 1TBHA 4MYFA 5EENA 2EF4A 5RLAA 5FCWA 1T4RA 3RQDA 1T4TA 3SL1A 4IE2A 2ZAVA 4IXUA 4Q3UA 3KV2A 5EF7A 1C3RA 5G0YA 3PZLA 3MAXA 5D1CA 3SJTA 1T4SA 1W22A 4RN0A 3E6VA 4Q42A 1HQFA 5EFHA 2VCGA 2V5XA 1T5GA 4GSVA 4QA6A 1C3SA 5EFBD 1P8NA 1P8QA 4RHQA 5EEKA 3MJLA 4HZEA 4A69A 4CBYA 2GH6A 1TA1A 4Q41A 1GQ7A 4Q3RA 5DC7A 3E8ZA 4RHIA 2AEBA 1P8OA 5G0JA 5BWZA 4ZURA 3EZPA 3SFHA 3LHLA 5DC8A 1TBLA 3F06A 4RHKA 3THHA 1R1OA 5HJAA 4LXZA 1PQ3A 5EF8A 4BKXB 3THJA 3SL0A 1WVAA 4BZ6A 1HQXA 1VKGA 3GN0A 3Q9BA 3MZ6A 1ZPEA 5G0GA 1T5FA 3C0ZA 3EW8A 4RHLA 1ZPGA 1HQ5A 3GMZA 5G17A 3NIOA 4IXVA 5EFGA 4CBTA 4Q3VA 4GWDA 3NIPA 4ZUPA 3LP7A 5EEIA 3Q9FA 5THUA 2PLLA 4IU5A 3F80A 3Q9CA 1HQHA 5EFKB 3TF3A 4QA2A 1WVBA 4IU1A 4QA1A 5DC5A 5IWGA 3E9BA 2V5WA 2VQQA 5FUEA 4MXRA 5THVA 4ZUNA 1TBJA 4MYLA 4HWWA 5D1DA 4GSMA 5CEVA 3DJ8A 5EFNA 5G1BA 5LI3A 3MENA 2VQWG 1T67A 4RHJA
chains in the Genus database with same CATH topology
4QA7A 5IX0A 4RN1A 1ZZ3A 3C0YA 3F07A 5EEFA 1ZZ1A 1C3PA 5D1BA 4BZ5A 2VQMA 5G13A 4CQFA 5G0XA 4RN2A 5EFJD 3ZNRA 2VQJA 1T64A 3SFFA 5G0IA 3MZ4A 5G1CA 4ZUQA 3ZNSA 4BZ8A 5G3WA 5A2SA 3EZTA 5G10A 3C10A 5G12A 4LY1A 5THSA 3MZ3A 4ZUOA 2VQVA 3F0RA 3MZ7A 5ICNB 1T69A 4BZ9A 5G0HA 5JI5A 5THTA 5EEMA 4BZ7A 2VQOA 3EWFA 4QA3A 3Q9EA 4QA0A 5DC6A 4ZUMA 4QA5A 5G11A 4QA4A 1ZZ0A 5G1AA 5EENA 5FCWA 3RQDA 5EF7A 1C3RA 5G0YA 3MAXA 5D1CA 1W22A 4RN0A 5EFHA 2VCGA 2V5XA 4QA6A 1C3SA 5EFBD 4A69A 5EEKA 4CBYA 2GH6A 5DC7A 5G0JA 5BWZA 4ZURA 3EZPA 3SFHA 5DC8A 3F06A 4LXZA 5EF8A 4BKXB 4BZ6A 1VKGA 3Q9BA 3MZ6A 5G0GA 3EW8A 3C0ZA 5G17A 5EFGA 4CBTA 4ZUPA 5EEIA 3Q9FA 5THUA 3Q9CA 5EFKB 4QA2A 4QA1A 5DC5A 5IWGA 5FUEA 2V5WA 2VQQA 5THVA 4ZUNA 5D1DA 5EFNA 5G1BA 5LI3A 3MENA 2VQWG 1T67A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QA7 A;  5IX0 A;  4RN1 A;  1ZZ3 A;  3C0Y A;  3F07 A;  5EEF A;  1ZZ1 A;  1C3P A;  5D1B A;  4BZ5 A;  2VQM A;  5G13 A;  4CQF A;  5G0X A;  4RN2 A;  5EFJ D;  3ZNR A;  2VQJ A;  1T64 A;  3SFF A;  5G0I A;  3MZ4 A;  5G1C A;  4ZUQ A;  3ZNS A;  4BZ8 A;  5G3W A;  5A2S A;  3EZT A;  5G10 A;  3C10 A;  5G12 A;  4LY1 A;  5THS A;  3MZ3 A;  4ZUO A;  2VQV A;  3F0R A;  3MZ7 A;  5ICN B;  1T69 A;  4BZ9 A;  5G0H A;  5JI5 A;  5THT A;  5EEM A;  4BZ7 A;  2VQO A;  3EWF A;  4QA3 A;  3Q9E A;  4QA0 A;  5DC6 A;  4ZUM A;  4QA5 A;  5G11 A;  4QA4 A;  1ZZ0 A;  5G1A A;  5EEN A;  5FCW A;  3RQD A;  5EF7 A;  1C3R A;  5G0Y A;  3MAX A;  5D1C A;  1W22 A;  4RN0 A;  5EFH A;  2VCG A;  2V5X A;  4QA6 A;  1C3S A;  5EFB D;  4A69 A;  5EEK A;  4CBY A;  2GH6 A;  5DC7 A;  5G0J A;  5BWZ A;  4ZUR A;  3EZP A;  3SFH A;  5DC8 A;  3F06 A;  4LXZ A;  5EF8 A;  4BKX B;  4BZ6 A;  1VKG A;  3Q9B A;  3MZ6 A;  5G0G A;  3EW8 A;  3C0Z A;  5G17 A;  5EFG A;  4CBT A;  4ZUP A;  5EEI A;  3Q9F A;  5THU A;  3Q9C A;  5EFK B;  4QA2 A;  4QA1 A;  5DC5 A;  5IWG A;  5FUE A;  2V5W A;  2VQQ A;  5THV A;  4ZUN A;  5D1D A;  5EFN A;  5G1B A;  5LI3 A;  3MEN A;  2VQW G;  1T67 A; 
#chains in the Genus database with same CATH topology
 4ITY A;  2EF5 A;  4Q3Q A;  3MFV A;  4GSZ A;  4QA7 A;  4Q3T A;  3SKK A;  5IX0 A;  4RN1 A;  1ZZ3 A;  1WOI A;  3C0Y A;  3F07 A;  5EEF A;  1ZZ1 A;  2PHO A;  1C3P A;  4RLA A;  5D1B A;  1P8R A;  3CEV A;  4BZ5 A;  4G3H A;  2VQM A;  5G13 A;  4CQF A;  1T4P A;  2EIV A;  5G0X A;  3LP4 A;  4RN2 A;  5EFJ D;  1D3V A;  1XFK A;  3THE A;  3M1R A;  3ZNR A;  2VQJ A;  4RHM A;  1WOH A;  1T64 A;  5HJ9 A;  3SFF A;  5G0I A;  3MZ4 A;  4IU4 A;  5G1C A;  4ZUQ A;  3ZNS A;  4BZ8 A;  1HQG A;  5G3W A;  5A2S A;  3EZT A;  4Q3R C;  3C10 A;  4Q3S A;  5G10 A;  5G12 A;  4LY1 A;  5THS A;  3MZ3 A;  1GQ6 A;  1RLA A;  1CEV A;  4FCI A;  4ZUO A;  2A0M A;  5G11 A;  4MYN A;  1P8M A;  2VQV A;  4I06 A;  3F0R A;  4FCK A;  4MYK A;  3TH7 A;  1P8S A;  1P8P A;  2CEV A;  3MZ7 A;  3NIQ A;  5ICN B;  1T69 A;  4BZ9 A;  4GWC A;  5G0H A;  5JI5 A;  5THT A;  5EEM A;  4BZ7 A;  3RLA A;  2VQO A;  3EWF A;  2RLA A;  4QA3 A;  3Q9E A;  4QA0 A;  5DC6 A;  4CEV A;  3E8Q A;  3MMR A;  4Q3P A;  4ZUM A;  3E6K A;  4IE3 A;  4IU0 A;  4Q40 A;  2PHA A;  1WOG A;  1ZZ0 A;  3MFW A;  4QA5 A;  4QA4 A;  4HXQ A;  5G1A A;  4IE1 A;  4DZ4 A;  1TBH A;  4MYF A;  5EEN A;  2EF4 A;  5RLA A;  5FCW A;  1T4R A;  3RQD A;  1T4T A;  3SL1 A;  4IE2 A;  2ZAV A;  4IXU A;  4Q3U A;  3KV2 A;  5EF7 A;  1C3R A;  5G0Y A;  3PZL A;  3MAX A;  5D1C A;  3SJT A;  1T4S A;  1W22 A;  4RN0 A;  3E6V A;  4Q42 A;  1HQF A;  5EFH A;  2VCG A;  2V5X A;  1T5G A;  4GSV A;  4QA6 A;  1C3S A;  5EFB D;  1P8N A;  1P8Q A;  4RHQ A;  5EEK A;  3MJL A;  4HZE A;  4A69 A;  4CBY A;  2GH6 A;  1TA1 A;  4Q41 A;  1GQ7 A;  4Q3R A;  5DC7 A;  3E8Z A;  4RHI A;  2AEB A;  1P8O A;  5G0J A;  5BWZ A;  4ZUR A;  3EZP A;  3SFH A;  3LHL A;  5DC8 A;  1TBL A;  3F06 A;  4RHK A;  3THH A;  1R1O A;  5HJA A;  4LXZ A;  1PQ3 A;  5EF8 A;  4BKX B;  3THJ A;  3SL0 A;  1WVA A;  4BZ6 A;  1HQX A;  1VKG A;  3GN0 A;  3Q9B A;  3MZ6 A;  1ZPE A;  5G0G A;  1T5F A;  3C0Z A;  3EW8 A;  4RHL A;  1ZPG A;  1HQ5 A;  3GMZ A;  5G17 A;  3NIO A;  4IXV A;  5EFG A;  4CBT A;  4Q3V A;  4GWD A;  3NIP A;  4ZUP A;  3LP7 A;  5EEI A;  3Q9F A;  5THU A;  2PLL A;  4IU5 A;  3F80 A;  3Q9C A;  1HQH A;  5EFK B;  3TF3 A;  4QA2 A;  1WVB A;  4IU1 A;  4QA1 A;  5DC5 A;  5IWG A;  3E9B A;  2V5W A;  2VQQ A;  5FUE A;  4MXR A;  5THV A;  4ZUN A;  1TBJ A;  4MYL A;  4HWW A;  5D1D A;  4GSM A;  5CEV A;  3DJ8 A;  5EFN A;  5G1B A;  5LI3 A;  3MEN A;  2VQW G;  1T67 A;  4RHJ A; 
#chains in the Genus database with same CATH homology
 4QA7 A;  5IX0 A;  4RN1 A;  1ZZ3 A;  3C0Y A;  3F07 A;  5EEF A;  1ZZ1 A;  1C3P A;  5D1B A;  4BZ5 A;  2VQM A;  5G13 A;  4CQF A;  5G0X A;  4RN2 A;  5EFJ D;  3ZNR A;  2VQJ A;  1T64 A;  3SFF A;  5G0I A;  3MZ4 A;  5G1C A;  4ZUQ A;  3ZNS A;  4BZ8 A;  5G3W A;  5A2S A;  3EZT A;  5G10 A;  3C10 A;  5G12 A;  4LY1 A;  5THS A;  3MZ3 A;  4ZUO A;  2VQV A;  3F0R A;  3MZ7 A;  5ICN B;  1T69 A;  4BZ9 A;  5G0H A;  5JI5 A;  5THT A;  5EEM A;  4BZ7 A;  2VQO A;  3EWF A;  4QA3 A;  3Q9E A;  4QA0 A;  5DC6 A;  4ZUM A;  4QA5 A;  5G11 A;  4QA4 A;  1ZZ0 A;  5G1A A;  5EEN A;  5FCW A;  3RQD A;  5EF7 A;  1C3R A;  5G0Y A;  3MAX A;  5D1C A;  1W22 A;  4RN0 A;  5EFH A;  2VCG A;  2V5X A;  4QA6 A;  1C3S A;  5EFB D;  4A69 A;  5EEK A;  4CBY A;  2GH6 A;  5DC7 A;  5G0J A;  5BWZ A;  4ZUR A;  3EZP A;  3SFH A;  5DC8 A;  3F06 A;  4LXZ A;  5EF8 A;  4BKX B;  4BZ6 A;  1VKG A;  3Q9B A;  3MZ6 A;  5G0G A;  3EW8 A;  3C0Z A;  5G17 A;  5EFG A;  4CBT A;  4ZUP A;  5EEI A;  3Q9F A;  5THU A;  3Q9C A;  5EFK B;  4QA2 A;  4QA1 A;  5DC5 A;  5IWG A;  5FUE A;  2V5W A;  2VQQ A;  5THV A;  4ZUN A;  5D1D A;  5EFN A;  5G1B A;  5LI3 A;  3MEN A;  2VQW G;  1T67 A; 
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