4FCKA

Crystal structure of the co2+2-human arginase i-agpa complex
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
314
structure length
314
Chain Sequence
RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Arginase-1
total genus 115
structure length 314
sequence length 314
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2012-05-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4fckA00
4IE3A 4Q3UA 1ZPEA 4FCKA 1HQHA 2PLLA 3E8ZA 1P8RA 3MFWA 3GMZA 1TA1A 3E8QA 1HQXA 1T5GA 1WOHA 1GQ6A 3PZLA 4GSZA 1TBHA 3KV2A 4G3HA 3E9BA 3SL0A 1P8NA 1WOIA 2CEVA 2A0MA 2EF4A 3GN0A 2EIVA 1T5FA 1HQ5A 3MFVA 2AEBA 4RHJA 1HQFA 4ITYA 1P8SA 4GSMA 4GWCA 4IU0A 3RLAA 4CEVA 4IXVA 4MYNA 2PHOA 3NIQA 1TBJA 4Q42A 3SL1A 3NIOA 1P8MA 3NIPA 3DJ8A 3CEVA 4Q3VA 4Q3SA 4IU1A 4DZ4A 4IE1A 1WVAA 1P8OA 5RLAA 2PHAA 3SKKA 4IU4A 4Q41A 3THHA 3LP7A 3M1RA 4IU5A 3F80A 1ZPGA 1RLAA 2EF5A 3E6KA 3LHLA 1T4RA 1GQ7A 4Q3QA 4Q40A 3E6VA 1CEVA 1T4TA 4HZEA 3MMRA 4RHIA 1HQGA 4MXRA 1TBLA 5HJ9A 1PQ3A 4MYKA 5CEVA 3LP4A 1D3VA 1P8QA 3SJTA 4GSVA 4IE2A 4GWDA 4Q3RA 4MYFA 4RHLA 3MJLA 1WVBA 4MYLA 1T4PA 3THEA 4I06A 4RHQA 4RLAA 2ZAVA 4Q3RC 2RLAA 5HJAA 4FCIA 4RHMA 1XFKA 4HXQA 1P8PA 4Q3TA 1R1OA 1WOGA 4IXUA 3TH7A 1T4SA 3TF3A 4RHKA 4HWWA 4Q3PA 3THJA
chains in the Genus database with same CATH superfamily
4IE3A 4Q3UA 3Q9BA 1T64A 5FCWA 1ZPEA 4FCKA 5BWZA 1HQHA 2PLLA 5EFHA 3E8ZA 4LY1A 1P8RA 3MFWA 5EENA 3GMZA 5ICNB 5DC5A 1TA1A 3E8QA 1HQXA 5G0GA 4CBYA 1T5GA 3MZ3A 1WOHA 4QA1A 4QA7A 1GQ6A 3PZLA 5EFBD 4GSZA 5EEIA 4ZURA 4CQFA 1TBHA 3KV2A 4QA5A 2VQOA 4G3HA 3E9BA 4RN0A 3SL0A 5D1BA 5G0YA 4ZUQA 2VQVA 1P8NA 1WOIA 4QA4A 4BZ6A 5G0XA 4RN2A 2CEVA 2A0MA 1VKGA 2EF4A 2VQJA 3MZ4A 3SFHA 3GN0A 2EIVA 1T5FA 3RQDA 4ZUPA 1HQ5A 3MFVA 2AEBA 5G12A 5IX0A 4RHJA 5D1CA 4BZ8A 3MAXA 4BZ5A 1HQFA 4ITYA 1C3SA 1ZZ1A 1P8SA 4GSMA 4GWCA 4IU0A 5DC6A 3RLAA 4CEVA 3C10A 3Q9FA 4IXVA 4MYNA 5G0HA 2PHOA 3NIQA 1TBJA 4Q42A 3SL1A 1C3PA 5FUEA 3NIOA 5G1AA 1P8MA 3NIPA 5EEMA 3DJ8A 3CEVA 4Q3VA 4ZUMA 4Q3SA 4IU1A 4DZ4A 4IE1A 1WVAA 1P8OA 5G1CA 3EZPA 5RLAA 2PHAA 5EEKA 3Q9CA 4ZUOA 3MZ7A 3SKKA 3C0ZA 4CBTA 4IU4A 4QA0A 4Q41A 3MENA 3THHA 4LXZA 5G17A 3LP7A 3EW8A 3M1RA 5EEFA 4IU5A 4BZ9A 3F80A 1ZPGA 1RLAA 2EF5A 3E6KA 3LHLA 1T4RA 1W22A 1GQ7A 5THSA 2VQMA 4Q3QA 3F06A 3Q9EA 3SFFA 4Q40A 3E6VA 1CEVA 5D1DA 1T4TA 4HZEA 3MMRA 4RHIA 2V5WA 1HQGA 4MXRA 4QA6A 1TBLA 5EFJD 5G3WA 5G13A 1PQ3A 4MYKA 4QA3A 5HJ9A 4BKXB 5CEVA 3LP4A 5G11A 1D3VA 5EF7A 5THUA 1P8QA 2VQWG 5G0IA 5LI3A 3SJTA 4QA2A 1C3RA 4GSVA 4IE2A 4GWDA 3EWFA 5DC8A 4Q3RA 4MYFA 4RHLA 5THTA 4A69A 3F0RA 3MJLA 2V5XA 5EF8A 1WVBA 3C0YA 5EFNA 4BZ7A 3ZNSA 4MYLA 5A2SA 1T4PA 5THVA 4I06A 3THEA 2VQQA 3MZ6A 4RHQA 4RLAA 2ZAVA 5G1BA 2GH6A 1T67A 2VCGA 4Q3RC 2RLAA 3ZNRA 5HJAA 4FCIA 4RHMA 3EZTA 5DC7A 1XFKA 1ZZ0A 1ZZ3A 4RN1A 5EFKB 4ZUNA 5IWGA 5JI5A 4HXQA 1P8PA 4Q3TA 1R1OA 1WOGA 4IXUA 3TH7A 1T4SA 5G0JA 3TF3A 5EFGA 4RHKA 4HWWA 4Q3PA 5G10A 3THJA 1T69A 3F07A
chains in the Genus database with same CATH topology
4IE3A 4Q3UA 1ZPEA 4FCKA 1HQHA 2PLLA 3E8ZA 1P8RA 3MFWA 3GMZA 1TA1A 3E8QA 1HQXA 1T5GA 1WOHA 1GQ6A 3PZLA 4GSZA 1TBHA 3KV2A 4G3HA 3E9BA 3SL0A 1P8NA 1WOIA 2CEVA 2A0MA 2EF4A 3GN0A 2EIVA 1T5FA 1HQ5A 3MFVA 2AEBA 4RHJA 1HQFA 4ITYA 1P8SA 4GSMA 4GWCA 4IU0A 3RLAA 4CEVA 4IXVA 4MYNA 2PHOA 3NIQA 1TBJA 4Q42A 3SL1A 3NIOA 1P8MA 3NIPA 3DJ8A 3CEVA 4Q3VA 4Q3SA 4IU1A 4DZ4A 4IE1A 1WVAA 1P8OA 5RLAA 2PHAA 3SKKA 4IU4A 4Q41A 3THHA 3LP7A 3M1RA 4IU5A 3F80A 1ZPGA 1RLAA 2EF5A 3E6KA 3LHLA 1T4RA 1GQ7A 4Q3QA 4Q40A 3E6VA 1CEVA 1T4TA 4HZEA 3MMRA 4RHIA 1HQGA 4MXRA 1TBLA 5HJ9A 1PQ3A 4MYKA 5CEVA 3LP4A 1D3VA 1P8QA 3SJTA 4GSVA 4IE2A 4GWDA 4Q3RA 4MYFA 4RHLA 3MJLA 1WVBA 4MYLA 1T4PA 3THEA 4I06A 4RHQA 4RLAA 2ZAVA 4Q3RC 2RLAA 5HJAA 4FCIA 4RHMA 1XFKA 4HXQA 1P8PA 4Q3TA 1R1OA 1WOGA 4IXUA 3TH7A 1T4SA 3TF3A 4RHKA 4HWWA 4Q3PA 3THJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IE3 A;  4Q3U A;  1ZPE A;  4FCK A;  1HQH A;  2PLL A;  3E8Z A;  1P8R A;  3MFW A;  3GMZ A;  1TA1 A;  3E8Q A;  1HQX A;  1T5G A;  1WOH A;  1GQ6 A;  3PZL A;  4GSZ A;  1TBH A;  3KV2 A;  4G3H A;  3E9B A;  3SL0 A;  1P8N A;  1WOI A;  2CEV A;  2A0M A;  2EF4 A;  3GN0 A;  2EIV A;  1T5F A;  1HQ5 A;  3MFV A;  2AEB A;  4RHJ A;  1HQF A;  4ITY A;  1P8S A;  4GSM A;  4GWC A;  4IU0 A;  3RLA A;  4CEV A;  4IXV A;  4MYN A;  2PHO A;  3NIQ A;  1TBJ A;  4Q42 A;  3SL1 A;  3NIO A;  1P8M A;  3NIP A;  3DJ8 A;  3CEV A;  4Q3V A;  4Q3S A;  4IU1 A;  4DZ4 A;  4IE1 A;  1WVA A;  1P8O A;  5RLA A;  2PHA A;  3SKK A;  4IU4 A;  4Q41 A;  3THH A;  3LP7 A;  3M1R A;  4IU5 A;  3F80 A;  1ZPG A;  1RLA A;  2EF5 A;  3E6K A;  3LHL A;  1T4R A;  1GQ7 A;  4Q3Q A;  4Q40 A;  3E6V A;  1CEV A;  1T4T A;  4HZE A;  3MMR A;  4RHI A;  1HQG A;  4MXR A;  1TBL A;  5HJ9 A;  1PQ3 A;  4MYK A;  5CEV A;  3LP4 A;  1D3V A;  1P8Q A;  3SJT A;  4GSV A;  4IE2 A;  4GWD A;  4Q3R A;  4MYF A;  4RHL A;  3MJL A;  1WVB A;  4MYL A;  1T4P A;  3THE A;  4I06 A;  4RHQ A;  4RLA A;  2ZAV A;  4Q3R C;  2RLA A;  5HJA A;  4FCI A;  4RHM A;  1XFK A;  4HXQ A;  1P8P A;  4Q3T A;  1R1O A;  1WOG A;  4IXU A;  3TH7 A;  1T4S A;  3TF3 A;  4RHK A;  4HWW A;  4Q3P A;  3THJ A; 
#chains in the Genus database with same CATH topology
 4IE3 A;  4Q3U A;  3Q9B A;  1T64 A;  5FCW A;  1ZPE A;  4FCK A;  5BWZ A;  1HQH A;  2PLL A;  5EFH A;  3E8Z A;  4LY1 A;  1P8R A;  3MFW A;  5EEN A;  3GMZ A;  5ICN B;  5DC5 A;  1TA1 A;  3E8Q A;  1HQX A;  5G0G A;  4CBY A;  1T5G A;  3MZ3 A;  1WOH A;  4QA1 A;  4QA7 A;  1GQ6 A;  3PZL A;  5EFB D;  4GSZ A;  5EEI A;  4ZUR A;  4CQF A;  1TBH A;  3KV2 A;  4QA5 A;  2VQO A;  4G3H A;  3E9B A;  4RN0 A;  3SL0 A;  5D1B A;  5G0Y A;  4ZUQ A;  2VQV A;  1P8N A;  1WOI A;  4QA4 A;  4BZ6 A;  5G0X A;  4RN2 A;  2CEV A;  2A0M A;  1VKG A;  2EF4 A;  2VQJ A;  3MZ4 A;  3SFH A;  3GN0 A;  2EIV A;  1T5F A;  3RQD A;  4ZUP A;  1HQ5 A;  3MFV A;  2AEB A;  5G12 A;  5IX0 A;  4RHJ A;  5D1C A;  4BZ8 A;  3MAX A;  4BZ5 A;  1HQF A;  4ITY A;  1C3S A;  1ZZ1 A;  1P8S A;  4GSM A;  4GWC A;  4IU0 A;  5DC6 A;  3RLA A;  4CEV A;  3C10 A;  3Q9F A;  4IXV A;  4MYN A;  5G0H A;  2PHO A;  3NIQ A;  1TBJ A;  4Q42 A;  3SL1 A;  1C3P A;  5FUE A;  3NIO A;  5G1A A;  1P8M A;  3NIP A;  5EEM A;  3DJ8 A;  3CEV A;  4Q3V A;  4ZUM A;  4Q3S A;  4IU1 A;  4DZ4 A;  4IE1 A;  1WVA A;  1P8O A;  5G1C A;  3EZP A;  5RLA A;  2PHA A;  5EEK A;  3Q9C A;  4ZUO A;  3MZ7 A;  3SKK A;  3C0Z A;  4CBT A;  4IU4 A;  4QA0 A;  4Q41 A;  3MEN A;  3THH A;  4LXZ A;  5G17 A;  3LP7 A;  3EW8 A;  3M1R A;  5EEF A;  4IU5 A;  4BZ9 A;  3F80 A;  1ZPG A;  1RLA A;  2EF5 A;  3E6K A;  3LHL A;  1T4R A;  1W22 A;  1GQ7 A;  5THS A;  2VQM A;  4Q3Q A;  3F06 A;  3Q9E A;  3SFF A;  4Q40 A;  3E6V A;  1CEV A;  5D1D A;  1T4T A;  4HZE A;  3MMR A;  4RHI A;  2V5W A;  1HQG A;  4MXR A;  4QA6 A;  1TBL A;  5EFJ D;  5G3W A;  5G13 A;  1PQ3 A;  4MYK A;  4QA3 A;  5HJ9 A;  4BKX B;  5CEV A;  3LP4 A;  5G11 A;  1D3V A;  5EF7 A;  5THU A;  1P8Q A;  2VQW G;  5G0I A;  5LI3 A;  3SJT A;  4QA2 A;  1C3R A;  4GSV A;  4IE2 A;  4GWD A;  3EWF A;  5DC8 A;  4Q3R A;  4MYF A;  4RHL A;  5THT A;  4A69 A;  3F0R A;  3MJL A;  2V5X A;  5EF8 A;  1WVB A;  3C0Y A;  5EFN A;  4BZ7 A;  3ZNS A;  4MYL A;  5A2S A;  1T4P A;  5THV A;  4I06 A;  3THE A;  2VQQ A;  3MZ6 A;  4RHQ A;  4RLA A;  2ZAV A;  5G1B A;  2GH6 A;  1T67 A;  2VCG A;  4Q3R C;  2RLA A;  3ZNR A;  5HJA A;  4FCI A;  4RHM A;  3EZT A;  5DC7 A;  1XFK A;  1ZZ0 A;  1ZZ3 A;  4RN1 A;  5EFK B;  4ZUN A;  5IWG A;  5JI5 A;  4HXQ A;  1P8P A;  4Q3T A;  1R1O A;  1WOG A;  4IXU A;  3TH7 A;  1T4S A;  5G0J A;  3TF3 A;  5EFG A;  4RHK A;  4HWW A;  4Q3P A;  5G10 A;  3THJ A;  1T69 A;  3F07 A; 
#chains in the Genus database with same CATH homology
 4IE3 A;  4Q3U A;  1ZPE A;  4FCK A;  1HQH A;  2PLL A;  3E8Z A;  1P8R A;  3MFW A;  3GMZ A;  1TA1 A;  3E8Q A;  1HQX A;  1T5G A;  1WOH A;  1GQ6 A;  3PZL A;  4GSZ A;  1TBH A;  3KV2 A;  4G3H A;  3E9B A;  3SL0 A;  1P8N A;  1WOI A;  2CEV A;  2A0M A;  2EF4 A;  3GN0 A;  2EIV A;  1T5F A;  1HQ5 A;  3MFV A;  2AEB A;  4RHJ A;  1HQF A;  4ITY A;  1P8S A;  4GSM A;  4GWC A;  4IU0 A;  3RLA A;  4CEV A;  4IXV A;  4MYN A;  2PHO A;  3NIQ A;  1TBJ A;  4Q42 A;  3SL1 A;  3NIO A;  1P8M A;  3NIP A;  3DJ8 A;  3CEV A;  4Q3V A;  4Q3S A;  4IU1 A;  4DZ4 A;  4IE1 A;  1WVA A;  1P8O A;  5RLA A;  2PHA A;  3SKK A;  4IU4 A;  4Q41 A;  3THH A;  3LP7 A;  3M1R A;  4IU5 A;  3F80 A;  1ZPG A;  1RLA A;  2EF5 A;  3E6K A;  3LHL A;  1T4R A;  1GQ7 A;  4Q3Q A;  4Q40 A;  3E6V A;  1CEV A;  1T4T A;  4HZE A;  3MMR A;  4RHI A;  1HQG A;  4MXR A;  1TBL A;  5HJ9 A;  1PQ3 A;  4MYK A;  5CEV A;  3LP4 A;  1D3V A;  1P8Q A;  3SJT A;  4GSV A;  4IE2 A;  4GWD A;  4Q3R A;  4MYF A;  4RHL A;  3MJL A;  1WVB A;  4MYL A;  1T4P A;  3THE A;  4I06 A;  4RHQ A;  4RLA A;  2ZAV A;  4Q3R C;  2RLA A;  5HJA A;  4FCI A;  4RHM A;  1XFK A;  4HXQ A;  1P8P A;  4Q3T A;  1R1O A;  1WOG A;  4IXU A;  3TH7 A;  1T4S A;  3TF3 A;  4RHK A;  4HWW A;  4Q3P A;  3THJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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