4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Arginase-2, mitochondrial
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
5CEVA 3THHA 4FCKA 1WVAA 1XFKA 4MYLA 3LHLA 3RLAA 3SL0A 2RLAA 3LP4A 4GSVA 3NIOA 2AEBA 4Q3UA 4IU5A 3THJA 5HJ9A 3E9BA 4Q3PA 3THEA 3E6VA 4IE1A 4IU4A 1ZPEA 1T5FA 4I06A 1TBLA 3SJTA 1P8RA 4Q3SA 3E8QA 4ITYA 1RLAA 4RHJA 3TH7A 1ZPGA 2EF5A 3KV2A 1T4SA 4GWCA 4IU0A 1HQFA 3MFWA 1WVBA 4G3HA 4RHKA 4Q3RA 1HQHA 3TF3A 3MFVA 4IU1A 1WOGA 1P8NA 4RLAA 3F80A 4GSZA 4RHIA 1P8SA 1TA1A 3MMRA 3GN0A 1HQ5A 3PZLA 1P8QA 4MYKA 1D3VA 2ZAVA 4GWDA 1WOIA 1TBJA 1P8OA 1TBHA 3LP7A 3MJLA 1GQ6A 4HXQA 4Q3QA 2EIVA 3GMZA 1PQ3A 4MYFA 1GQ7A 4Q41A 4CEVA 4RHQA 4IE3A 2EF4A 2A0MA 3NIQA 1P8PA 4Q3TA 3CEVA 4HWWA 4Q40A 1WOHA 4Q42A 1T4PA 3M1RA 1T4TA 3SKKA 1P8MA 4DZ4A 3SL1A 4IXUA 4Q3RC 2CEVA 1T5GA 1HQXA 4RHMA 4Q3VA 1CEVA 1T4RA 3E6KA 4RHLA 5RLAA 1R1OA 1HQGA 2PLLA 3NIPA 4FCIA 3DJ8A 3E8ZA 4IXVA 4MYNA 4GSMA 5HJAA 2PHOA 4IE2A 2PHAA 4HZEA 4MXRA
chains in the Genus database with same CATH superfamily
5CEVA 3THHA 5G10A 4FCKA 5IWGA 3SFHA 3MZ3A 1WVAA 1XFKA 4MYLA 3LHLA 3RLAA 5G1AA 3SL0A 2RLAA 5EEFA 2V5WA 4BZ7A 5EEIA 5THSA 3EZPA 3LP4A 4GSVA 3NIOA 2AEBA 4Q3UA 4QA4A 5ICNB 4IU5A 3THJA 1C3SA 1T64A 5G0YA 5EFNA 5HJ9A 3E9BA 3MZ4A 4Q3PA 3RQDA 3THEA 3E6VA 4IE1A 4IU4A 5DC6A 1ZPEA 3C0YA 3C10A 5HJAA 1T5FA 4I06A 1TBLA 4QA7A 1C3RA 5LI3A 3SJTA 1P8RA 4LY1A 4Q3SA 3E8QA 4ITYA 5EEKA 5G3WA 5DC8A 1RLAA 5THUA 3ZNRA 5G12A 2GH6A 1C3PA 4RHJA 5G1CA 5G0JA 3TH7A 3F07A 3MENA 1ZPGA 2EF5A 3KV2A 1T4SA 1VKGA 4GWCA 4IU0A 1HQFA 3Q9FA 5EEMA 4ZURA 3MFWA 3F0RA 3MAXA 5FUEA 1T69A 3Q9EA 1WVBA 4G3HA 5DC7A 3SFFA 5THVA 3Q9BA 4RHKA 4Q3RA 1HQHA 3TF3A 3MFVA 2VCGA 4IU1A 1WOGA 1P8NA 4RLAA 4BZ5A 3F80A 4GSZA 4RHIA 1P8SA 1TA1A 3MMRA 3GN0A 1HQ5A 5D1BA 5EF8A 5FCWA 3PZLA 1P8QA 3EZTA 4MYKA 4BKXB 5IX0A 1D3VA 5EENA 5THTA 2ZAVA 4GWDA 4QA2A 5G0HA 1WOIA 5EF7A 1TBJA 1P8OA 1TBHA 3LP7A 2VQWG 3MJLA 5G0IA 1GQ6A 5EFKB 5G0GA 2VQMA 4HXQA 3C0ZA 2EIVA 3GMZA 4Q3QA 1PQ3A 4ZUNA 4MYFA 1GQ7A 4Q41A 5DC5A 4QA5A 4CEVA 4RHQA 4IE3A 2EF4A 4ZUMA 2A0MA 3NIQA 1P8PA 4Q3TA 3CEVA 5D1DA 3EW8A 4HWWA 4Q40A 1WOHA 5A2SA 4QA0A 3MZ7A 4Q42A 1ZZ1A 2V5XA 5JI5A 1T4PA 3M1RA 1T4TA 3SKKA 1P8MA 4QA3A 4DZ4A 5G17A 2VQJA 1ZZ0A 3EWFA 4RN2A 3SL1A 4BZ8A 4IXUA 4Q3RC 2CEVA 1T5GA 5EFBD 4CQFA 1W22A 4BZ6A 5D1CA 1HQXA 4RHMA 2VQQA 4Q3VA 1CEVA 4QA6A 4ZUOA 4ZUPA 5G0XA 4QA1A 1T4RA 3E6KA 5EFHA 4RHLA 5RLAA 1R1OA 1HQGA 2PLLA 4LXZA 5BWZA 3Q9CA 4CBTA 3NIPA 3ZNSA 4FCIA 4CBYA 3DJ8A 3E8ZA 5EFJD 2VQOA 4IXVA 4MYNA 1ZZ3A 2VQVA 4GSMA 2PHOA 4RN0A 5G1BA 4IE2A 4A69A 4BZ9A 3F06A 2PHAA 4ZUQA 3MZ6A 4HZEA 5G13A 1T67A 4RN1A 5G11A 4MXRA 5EFGA
chains in the Genus database with same CATH topology
5CEVA 3THHA 4FCKA 1WVAA 1XFKA 4MYLA 3LHLA 3RLAA 3SL0A 2RLAA 3LP4A 4GSVA 3NIOA 2AEBA 4Q3UA 4IU5A 3THJA 5HJ9A 3E9BA 4Q3PA 3THEA 3E6VA 4IE1A 4IU4A 1ZPEA 1T5FA 4I06A 1TBLA 3SJTA 1P8RA 4Q3SA 3E8QA 4ITYA 1RLAA 4RHJA 3TH7A 1ZPGA 2EF5A 3KV2A 1T4SA 4GWCA 4IU0A 1HQFA 3MFWA 1WVBA 4G3HA 4RHKA 4Q3RA 1HQHA 3TF3A 3MFVA 4IU1A 1WOGA 1P8NA 4RLAA 3F80A 4GSZA 4RHIA 1P8SA 1TA1A 3MMRA 3GN0A 1HQ5A 3PZLA 1P8QA 4MYKA 1D3VA 2ZAVA 4GWDA 1WOIA 1TBJA 1P8OA 1TBHA 3LP7A 3MJLA 1GQ6A 4HXQA 4Q3QA 2EIVA 3GMZA 1PQ3A 4MYFA 1GQ7A 4Q41A 4CEVA 4RHQA 4IE3A 2EF4A 2A0MA 3NIQA 1P8PA 4Q3TA 3CEVA 4HWWA 4Q40A 1WOHA 4Q42A 1T4PA 3M1RA 1T4TA 3SKKA 1P8MA 4DZ4A 3SL1A 4IXUA 4Q3RC 2CEVA 1T5GA 1HQXA 4RHMA 4Q3VA 1CEVA 1T4RA 3E6KA 4RHLA 5RLAA 1R1OA 1HQGA 2PLLA 3NIPA 4FCIA 3DJ8A 3E8ZA 4IXVA 4MYNA 4GSMA 5HJAA 2PHOA 4IE2A 2PHAA 4HZEA 4MXRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CEV A;  3THH A;  4FCK A;  1WVA A;  1XFK A;  4MYL A;  3LHL A;  3RLA A;  3SL0 A;  2RLA A;  3LP4 A;  4GSV A;  3NIO A;  2AEB A;  4Q3U A;  4IU5 A;  3THJ A;  5HJ9 A;  3E9B A;  4Q3P A;  3THE A;  3E6V A;  4IE1 A;  4IU4 A;  1ZPE A;  1T5F A;  4I06 A;  1TBL A;  3SJT A;  1P8R A;  4Q3S A;  3E8Q A;  4ITY A;  1RLA A;  4RHJ A;  3TH7 A;  1ZPG A;  2EF5 A;  3KV2 A;  1T4S A;  4GWC A;  4IU0 A;  1HQF A;  3MFW A;  1WVB A;  4G3H A;  4RHK A;  4Q3R A;  1HQH A;  3TF3 A;  3MFV A;  4IU1 A;  1WOG A;  1P8N A;  4RLA A;  3F80 A;  4GSZ A;  4RHI A;  1P8S A;  1TA1 A;  3MMR A;  3GN0 A;  1HQ5 A;  3PZL A;  1P8Q A;  4MYK A;  1D3V A;  2ZAV A;  4GWD A;  1WOI A;  1TBJ A;  1P8O A;  1TBH A;  3LP7 A;  3MJL A;  1GQ6 A;  4HXQ A;  4Q3Q A;  2EIV A;  3GMZ A;  1PQ3 A;  4MYF A;  1GQ7 A;  4Q41 A;  4CEV A;  4RHQ A;  4IE3 A;  2EF4 A;  2A0M A;  3NIQ A;  1P8P A;  4Q3T A;  3CEV A;  4HWW A;  4Q40 A;  1WOH A;  4Q42 A;  1T4P A;  3M1R A;  1T4T A;  3SKK A;  1P8M A;  4DZ4 A;  3SL1 A;  4IXU A;  4Q3R C;  2CEV A;  1T5G A;  1HQX A;  4RHM A;  4Q3V A;  1CEV A;  1T4R A;  3E6K A;  4RHL A;  5RLA A;  1R1O A;  1HQG A;  2PLL A;  3NIP A;  4FCI A;  3DJ8 A;  3E8Z A;  4IXV A;  4MYN A;  4GSM A;  5HJA A;  2PHO A;  4IE2 A;  2PHA A;  4HZE A;  4MXR A; 
#chains in the Genus database with same CATH topology
 5CEV A;  3THH A;  5G10 A;  4FCK A;  5IWG A;  3SFH A;  3MZ3 A;  1WVA A;  1XFK A;  4MYL A;  3LHL A;  3RLA A;  5G1A A;  3SL0 A;  2RLA A;  5EEF A;  2V5W A;  4BZ7 A;  5EEI A;  5THS A;  3EZP A;  3LP4 A;  4GSV A;  3NIO A;  2AEB A;  4Q3U A;  4QA4 A;  5ICN B;  4IU5 A;  3THJ A;  1C3S A;  1T64 A;  5G0Y A;  5EFN A;  5HJ9 A;  3E9B A;  3MZ4 A;  4Q3P A;  3RQD A;  3THE A;  3E6V A;  4IE1 A;  4IU4 A;  5DC6 A;  1ZPE A;  3C0Y A;  3C10 A;  5HJA A;  1T5F A;  4I06 A;  1TBL A;  4QA7 A;  1C3R A;  5LI3 A;  3SJT A;  1P8R A;  4LY1 A;  4Q3S A;  3E8Q A;  4ITY A;  5EEK A;  5G3W A;  5DC8 A;  1RLA A;  5THU A;  3ZNR A;  5G12 A;  2GH6 A;  1C3P A;  4RHJ A;  5G1C A;  5G0J A;  3TH7 A;  3F07 A;  3MEN A;  1ZPG A;  2EF5 A;  3KV2 A;  1T4S A;  1VKG A;  4GWC A;  4IU0 A;  1HQF A;  3Q9F A;  5EEM A;  4ZUR A;  3MFW A;  3F0R A;  3MAX A;  5FUE A;  1T69 A;  3Q9E A;  1WVB A;  4G3H A;  5DC7 A;  3SFF A;  5THV A;  3Q9B A;  4RHK A;  4Q3R A;  1HQH A;  3TF3 A;  3MFV A;  2VCG A;  4IU1 A;  1WOG A;  1P8N A;  4RLA A;  4BZ5 A;  3F80 A;  4GSZ A;  4RHI A;  1P8S A;  1TA1 A;  3MMR A;  3GN0 A;  1HQ5 A;  5D1B A;  5EF8 A;  5FCW A;  3PZL A;  1P8Q A;  3EZT A;  4MYK A;  4BKX B;  5IX0 A;  1D3V A;  5EEN A;  5THT A;  2ZAV A;  4GWD A;  4QA2 A;  5G0H A;  1WOI A;  5EF7 A;  1TBJ A;  1P8O A;  1TBH A;  3LP7 A;  2VQW G;  3MJL A;  5G0I A;  1GQ6 A;  5EFK B;  5G0G A;  2VQM A;  4HXQ A;  3C0Z A;  2EIV A;  3GMZ A;  4Q3Q A;  1PQ3 A;  4ZUN A;  4MYF A;  1GQ7 A;  4Q41 A;  5DC5 A;  4QA5 A;  4CEV A;  4RHQ A;  4IE3 A;  2EF4 A;  4ZUM A;  2A0M A;  3NIQ A;  1P8P A;  4Q3T A;  3CEV A;  5D1D A;  3EW8 A;  4HWW A;  4Q40 A;  1WOH A;  5A2S A;  4QA0 A;  3MZ7 A;  4Q42 A;  1ZZ1 A;  2V5X A;  5JI5 A;  1T4P A;  3M1R A;  1T4T A;  3SKK A;  1P8M A;  4QA3 A;  4DZ4 A;  5G17 A;  2VQJ A;  1ZZ0 A;  3EWF A;  4RN2 A;  3SL1 A;  4BZ8 A;  4IXU A;  4Q3R C;  2CEV A;  1T5G A;  5EFB D;  4CQF A;  1W22 A;  4BZ6 A;  5D1C A;  1HQX A;  4RHM A;  2VQQ A;  4Q3V A;  1CEV A;  4QA6 A;  4ZUO A;  4ZUP A;  5G0X A;  4QA1 A;  1T4R A;  3E6K A;  5EFH A;  4RHL A;  5RLA A;  1R1O A;  1HQG A;  2PLL A;  4LXZ A;  5BWZ A;  3Q9C A;  4CBT A;  3NIP A;  3ZNS A;  4FCI A;  4CBY A;  3DJ8 A;  3E8Z A;  5EFJ D;  2VQO A;  4IXV A;  4MYN A;  1ZZ3 A;  2VQV A;  4GSM A;  2PHO A;  4RN0 A;  5G1B A;  4IE2 A;  4A69 A;  4BZ9 A;  3F06 A;  2PHA A;  4ZUQ A;  3MZ6 A;  4HZE A;  5G13 A;  1T67 A;  4RN1 A;  5G11 A;  4MXR A;  5EFG A; 
#chains in the Genus database with same CATH homology
 5CEV A;  3THH A;  4FCK A;  1WVA A;  1XFK A;  4MYL A;  3LHL A;  3RLA A;  3SL0 A;  2RLA A;  3LP4 A;  4GSV A;  3NIO A;  2AEB A;  4Q3U A;  4IU5 A;  3THJ A;  5HJ9 A;  3E9B A;  4Q3P A;  3THE A;  3E6V A;  4IE1 A;  4IU4 A;  1ZPE A;  1T5F A;  4I06 A;  1TBL A;  3SJT A;  1P8R A;  4Q3S A;  3E8Q A;  4ITY A;  1RLA A;  4RHJ A;  3TH7 A;  1ZPG A;  2EF5 A;  3KV2 A;  1T4S A;  4GWC A;  4IU0 A;  1HQF A;  3MFW A;  1WVB A;  4G3H A;  4RHK A;  4Q3R A;  1HQH A;  3TF3 A;  3MFV A;  4IU1 A;  1WOG A;  1P8N A;  4RLA A;  3F80 A;  4GSZ A;  4RHI A;  1P8S A;  1TA1 A;  3MMR A;  3GN0 A;  1HQ5 A;  3PZL A;  1P8Q A;  4MYK A;  1D3V A;  2ZAV A;  4GWD A;  1WOI A;  1TBJ A;  1P8O A;  1TBH A;  3LP7 A;  3MJL A;  1GQ6 A;  4HXQ A;  4Q3Q A;  2EIV A;  3GMZ A;  1PQ3 A;  4MYF A;  1GQ7 A;  4Q41 A;  4CEV A;  4RHQ A;  4IE3 A;  2EF4 A;  2A0M A;  3NIQ A;  1P8P A;  4Q3T A;  3CEV A;  4HWW A;  4Q40 A;  1WOH A;  4Q42 A;  1T4P A;  3M1R A;  1T4T A;  3SKK A;  1P8M A;  4DZ4 A;  3SL1 A;  4IXU A;  4Q3R C;  2CEV A;  1T5G A;  1HQX A;  4RHM A;  4Q3V A;  1CEV A;  1T4R A;  3E6K A;  4RHL A;  5RLA A;  1R1O A;  1HQG A;  2PLL A;  3NIP A;  4FCI A;  3DJ8 A;  3E8Z A;  4IXV A;  4MYN A;  4GSM A;  5HJA A;  2PHO A;  4IE2 A;  2PHA A;  4HZE A;  4MXR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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