4IXUA

Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 120
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixuA00
2EF5A 3LP7A 1P8OA 1P8NA 3LHLA 1GQ7A 4RHIA 3MMRA 4Q3QA 3SL0A 3E8ZA 3MFVA 4MXRA 2PLLA 4GWDA 4Q3TA 1WVAA 4IU4A 4IU1A 4Q3RC 1HQFA 4HZEA 4MYKA 3NIQA 4RHJA 3TF3A 3M1RA 3NIPA 4Q40A 2RLAA 3SKKA 4MYNA 1P8MA 4Q3VA 1P8RA 2ZAVA 2EF4A 4Q42A 3TH7A 4IE1A 2A0MA 4IXUA 4I06A 1HQHA 1T4TA 3LP4A 4Q3PA 3E9BA 4GSMA 3THEA 4GSZA 3SJTA 2PHAA 1WVBA 1T4SA 2PHOA 1WOHA 1R1OA 1TBHA 4MYLA 3SL1A 1TBJA 3THHA 4RHQA 5HJAA 3MJLA 4IE3A 3E6VA 3THJA 1P8SA 4HXQA 4IXVA 4RLAA 4RHMA 4GWCA 4RHLA 4Q3RA 1WOGA 1XFKA 4IU0A 2AEBA 4FCKA 3F80A 4HWWA 5RLAA 1T4RA 5HJ9A 4IU5A 1HQXA 3E6KA 1T4PA 1TA1A 1TBLA 4ITYA 3DJ8A 4Q41A 1GQ6A 2EIVA 1P8QA 3KV2A 5CEVA 3PZLA 1ZPEA 4FCIA 2CEVA 3CEVA 1D3VA 3GMZA 1PQ3A 4Q3UA 4MYFA 4RHKA 1HQGA 1CEVA 1RLAA 3GN0A 4IE2A 3E8QA 4GSVA 1P8PA 1T5GA 1T5FA 4CEVA 4Q3SA 1WOIA 4DZ4A 1ZPGA 4G3HA 1HQ5A 3NIOA 3MFWA 3RLAA
chains in the Genus database with same CATH superfamily
2EF5A 3LP7A 4RN0A 1P8OA 1P8NA 1T64A 4ZUPA 3LHLA 1GQ7A 4RHIA 3EW8A 3ZNRA 5JI5A 4ZUNA 4ZUOA 3MMRA 4Q3QA 5D1DA 3SL0A 3E8ZA 3MFVA 4MXRA 2PLLA 4GWDA 4Q3TA 5DC7A 1WVAA 5G11A 4IU4A 4IU1A 5EENA 4Q3RC 3Q9FA 1HQFA 1ZZ1A 3SFHA 4HZEA 5G0JA 4MYKA 4CQFA 3NIQA 5G10A 3Q9BA 1C3SA 1W22A 1VKGA 5G1CA 4RHJA 3TF3A 1T67A 3EWFA 3M1RA 5D1BA 5FCWA 5BWZA 3NIPA 4Q40A 4CBYA 5ICNB 5A2SA 2RLAA 3EZTA 5EEMA 5G1AA 3SKKA 2VQWG 4CBTA 4MYNA 1P8MA 4Q3VA 5EEFA 5EFNA 3MZ6A 1P8RA 2ZAVA 5D1CA 2EF4A 4Q42A 2V5WA 4RN2A 5IX0A 3TH7A 1C3PA 4IE1A 5LI3A 2A0MA 4IXUA 4I06A 1HQHA 1T4TA 5EFJD 5FUEA 3LP4A 5DC8A 5THVA 4BZ8A 5G13A 5G0HA 4Q3PA 3E9BA 4QA3A 3MAXA 4GSMA 5EFGA 5G12A 3THEA 1ZZ0A 3MZ7A 4GSZA 3SJTA 4BZ5A 2VQVA 2PHAA 1WVBA 1T4SA 2PHOA 4BZ6A 1WOHA 1R1OA 4QA2A 4QA6A 1TBHA 4RN1A 4MYLA 4ZURA 3SL1A 1TBJA 3THHA 4RHQA 5HJAA 3MJLA 1T69A 4IE3A 5EFBD 3E6VA 3F06A 3THJA 1P8SA 4HXQA 4IXVA 2VCGA 3Q9EA 4RLAA 2GH6A 3C0YA 3EZPA 4BZ7A 5THSA 4RHMA 4GWCA 3MZ4A 5THUA 3F0RA 4RHLA 5EEKA 5EF8A 4Q3RA 4QA1A 1WOGA 1XFKA 3F07A 4IU0A 5G0XA 2AEBA 5G3WA 1ZZ3A 4QA4A 4FCKA 3F80A 4HWWA 5RLAA 4BKXB 1T4RA 5HJ9A 4IU5A 4A69A 1HQXA 3E6KA 5G0YA 5G0IA 1T4PA 1TA1A 1TBLA 4ITYA 3DJ8A 4Q41A 4ZUMA 5EEIA 1GQ6A 4LY1A 5THTA 3MENA 2EIVA 4ZUQA 1P8QA 3KV2A 4BZ9A 4LXZA 5CEVA 1C3RA 3PZLA 3C10A 2VQJA 1ZPEA 4FCIA 5EF7A 2CEVA 3CEVA 5IWGA 1D3VA 3GMZA 5G0GA 1PQ3A 4Q3UA 4MYFA 4RHKA 5EFHA 1HQGA 3ZNSA 3MZ3A 1CEVA 5EFKB 1RLAA 3GN0A 4IE2A 2VQOA 4QA5A 3E8QA 4GSVA 4QA0A 1P8PA 5G17A 2VQMA 1T5GA 1T5FA 2V5XA 3RQDA 4CEVA 5DC5A 2VQQA 4QA7A 4Q3SA 1WOIA 5DC6A 3SFFA 4DZ4A 3C0ZA 1ZPGA 3Q9CA 5G1BA 4G3HA 1HQ5A 3NIOA 3MFWA 3RLAA
chains in the Genus database with same CATH topology
2EF5A 3LP7A 1P8OA 1P8NA 3LHLA 1GQ7A 4RHIA 3MMRA 4Q3QA 3SL0A 3E8ZA 3MFVA 4MXRA 2PLLA 4GWDA 4Q3TA 1WVAA 4IU4A 4IU1A 4Q3RC 1HQFA 4HZEA 4MYKA 3NIQA 4RHJA 3TF3A 3M1RA 3NIPA 4Q40A 2RLAA 3SKKA 4MYNA 1P8MA 4Q3VA 1P8RA 2ZAVA 2EF4A 4Q42A 3TH7A 4IE1A 2A0MA 4IXUA 4I06A 1HQHA 1T4TA 3LP4A 4Q3PA 3E9BA 4GSMA 3THEA 4GSZA 3SJTA 2PHAA 1WVBA 1T4SA 2PHOA 1WOHA 1R1OA 1TBHA 4MYLA 3SL1A 1TBJA 3THHA 4RHQA 5HJAA 3MJLA 4IE3A 3E6VA 3THJA 1P8SA 4HXQA 4IXVA 4RLAA 4RHMA 4GWCA 4RHLA 4Q3RA 1WOGA 1XFKA 4IU0A 2AEBA 4FCKA 3F80A 4HWWA 5RLAA 1T4RA 5HJ9A 4IU5A 1HQXA 3E6KA 1T4PA 1TA1A 1TBLA 4ITYA 3DJ8A 4Q41A 1GQ6A 2EIVA 1P8QA 3KV2A 5CEVA 3PZLA 1ZPEA 4FCIA 2CEVA 3CEVA 1D3VA 3GMZA 1PQ3A 4Q3UA 4MYFA 4RHKA 1HQGA 1CEVA 1RLAA 3GN0A 4IE2A 3E8QA 4GSVA 1P8PA 1T5GA 1T5FA 4CEVA 4Q3SA 1WOIA 4DZ4A 1ZPGA 4G3HA 1HQ5A 3NIOA 3MFWA 3RLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EF5 A;  3LP7 A;  1P8O A;  1P8N A;  3LHL A;  1GQ7 A;  4RHI A;  3MMR A;  4Q3Q A;  3SL0 A;  3E8Z A;  3MFV A;  4MXR A;  2PLL A;  4GWD A;  4Q3T A;  1WVA A;  4IU4 A;  4IU1 A;  4Q3R C;  1HQF A;  4HZE A;  4MYK A;  3NIQ A;  4RHJ A;  3TF3 A;  3M1R A;  3NIP A;  4Q40 A;  2RLA A;  3SKK A;  4MYN A;  1P8M A;  4Q3V A;  1P8R A;  2ZAV A;  2EF4 A;  4Q42 A;  3TH7 A;  4IE1 A;  2A0M A;  4IXU A;  4I06 A;  1HQH A;  1T4T A;  3LP4 A;  4Q3P A;  3E9B A;  4GSM A;  3THE A;  4GSZ A;  3SJT A;  2PHA A;  1WVB A;  1T4S A;  2PHO A;  1WOH A;  1R1O A;  1TBH A;  4MYL A;  3SL1 A;  1TBJ A;  3THH A;  4RHQ A;  5HJA A;  3MJL A;  4IE3 A;  3E6V A;  3THJ A;  1P8S A;  4HXQ A;  4IXV A;  4RLA A;  4RHM A;  4GWC A;  4RHL A;  4Q3R A;  1WOG A;  1XFK A;  4IU0 A;  2AEB A;  4FCK A;  3F80 A;  4HWW A;  5RLA A;  1T4R A;  5HJ9 A;  4IU5 A;  1HQX A;  3E6K A;  1T4P A;  1TA1 A;  1TBL A;  4ITY A;  3DJ8 A;  4Q41 A;  1GQ6 A;  2EIV A;  1P8Q A;  3KV2 A;  5CEV A;  3PZL A;  1ZPE A;  4FCI A;  2CEV A;  3CEV A;  1D3V A;  3GMZ A;  1PQ3 A;  4Q3U A;  4MYF A;  4RHK A;  1HQG A;  1CEV A;  1RLA A;  3GN0 A;  4IE2 A;  3E8Q A;  4GSV A;  1P8P A;  1T5G A;  1T5F A;  4CEV A;  4Q3S A;  1WOI A;  4DZ4 A;  1ZPG A;  4G3H A;  1HQ5 A;  3NIO A;  3MFW A;  3RLA A; 
#chains in the Genus database with same CATH topology
 2EF5 A;  3LP7 A;  4RN0 A;  1P8O A;  1P8N A;  1T64 A;  4ZUP A;  3LHL A;  1GQ7 A;  4RHI A;  3EW8 A;  3ZNR A;  5JI5 A;  4ZUN A;  4ZUO A;  3MMR A;  4Q3Q A;  5D1D A;  3SL0 A;  3E8Z A;  3MFV A;  4MXR A;  2PLL A;  4GWD A;  4Q3T A;  5DC7 A;  1WVA A;  5G11 A;  4IU4 A;  4IU1 A;  5EEN A;  4Q3R C;  3Q9F A;  1HQF A;  1ZZ1 A;  3SFH A;  4HZE A;  5G0J A;  4MYK A;  4CQF A;  3NIQ A;  5G10 A;  3Q9B A;  1C3S A;  1W22 A;  1VKG A;  5G1C A;  4RHJ A;  3TF3 A;  1T67 A;  3EWF A;  3M1R A;  5D1B A;  5FCW A;  5BWZ A;  3NIP A;  4Q40 A;  4CBY A;  5ICN B;  5A2S A;  2RLA A;  3EZT A;  5EEM A;  5G1A A;  3SKK A;  2VQW G;  4CBT A;  4MYN A;  1P8M A;  4Q3V A;  5EEF A;  5EFN A;  3MZ6 A;  1P8R A;  2ZAV A;  5D1C A;  2EF4 A;  4Q42 A;  2V5W A;  4RN2 A;  5IX0 A;  3TH7 A;  1C3P A;  4IE1 A;  5LI3 A;  2A0M A;  4IXU A;  4I06 A;  1HQH A;  1T4T A;  5EFJ D;  5FUE A;  3LP4 A;  5DC8 A;  5THV A;  4BZ8 A;  5G13 A;  5G0H A;  4Q3P A;  3E9B A;  4QA3 A;  3MAX A;  4GSM A;  5EFG A;  5G12 A;  3THE A;  1ZZ0 A;  3MZ7 A;  4GSZ A;  3SJT A;  4BZ5 A;  2VQV A;  2PHA A;  1WVB A;  1T4S A;  2PHO A;  4BZ6 A;  1WOH A;  1R1O A;  4QA2 A;  4QA6 A;  1TBH A;  4RN1 A;  4MYL A;  4ZUR A;  3SL1 A;  1TBJ A;  3THH A;  4RHQ A;  5HJA A;  3MJL A;  1T69 A;  4IE3 A;  5EFB D;  3E6V A;  3F06 A;  3THJ A;  1P8S A;  4HXQ A;  4IXV A;  2VCG A;  3Q9E A;  4RLA A;  2GH6 A;  3C0Y A;  3EZP A;  4BZ7 A;  5THS A;  4RHM A;  4GWC A;  3MZ4 A;  5THU A;  3F0R A;  4RHL A;  5EEK A;  5EF8 A;  4Q3R A;  4QA1 A;  1WOG A;  1XFK A;  3F07 A;  4IU0 A;  5G0X A;  2AEB A;  5G3W A;  1ZZ3 A;  4QA4 A;  4FCK A;  3F80 A;  4HWW A;  5RLA A;  4BKX B;  1T4R A;  5HJ9 A;  4IU5 A;  4A69 A;  1HQX A;  3E6K A;  5G0Y A;  5G0I A;  1T4P A;  1TA1 A;  1TBL A;  4ITY A;  3DJ8 A;  4Q41 A;  4ZUM A;  5EEI A;  1GQ6 A;  4LY1 A;  5THT A;  3MEN A;  2EIV A;  4ZUQ A;  1P8Q A;  3KV2 A;  4BZ9 A;  4LXZ A;  5CEV A;  1C3R A;  3PZL A;  3C10 A;  2VQJ A;  1ZPE A;  4FCI A;  5EF7 A;  2CEV A;  3CEV A;  5IWG A;  1D3V A;  3GMZ A;  5G0G A;  1PQ3 A;  4Q3U A;  4MYF A;  4RHK A;  5EFH A;  1HQG A;  3ZNS A;  3MZ3 A;  1CEV A;  5EFK B;  1RLA A;  3GN0 A;  4IE2 A;  2VQO A;  4QA5 A;  3E8Q A;  4GSV A;  4QA0 A;  1P8P A;  5G17 A;  2VQM A;  1T5G A;  1T5F A;  2V5X A;  3RQD A;  4CEV A;  5DC5 A;  2VQQ A;  4QA7 A;  4Q3S A;  1WOI A;  5DC6 A;  3SFF A;  4DZ4 A;  3C0Z A;  1ZPG A;  3Q9C A;  5G1B A;  4G3H A;  1HQ5 A;  3NIO A;  3MFW A;  3RLA A; 
#chains in the Genus database with same CATH homology
 2EF5 A;  3LP7 A;  1P8O A;  1P8N A;  3LHL A;  1GQ7 A;  4RHI A;  3MMR A;  4Q3Q A;  3SL0 A;  3E8Z A;  3MFV A;  4MXR A;  2PLL A;  4GWD A;  4Q3T A;  1WVA A;  4IU4 A;  4IU1 A;  4Q3R C;  1HQF A;  4HZE A;  4MYK A;  3NIQ A;  4RHJ A;  3TF3 A;  3M1R A;  3NIP A;  4Q40 A;  2RLA A;  3SKK A;  4MYN A;  1P8M A;  4Q3V A;  1P8R A;  2ZAV A;  2EF4 A;  4Q42 A;  3TH7 A;  4IE1 A;  2A0M A;  4IXU A;  4I06 A;  1HQH A;  1T4T A;  3LP4 A;  4Q3P A;  3E9B A;  4GSM A;  3THE A;  4GSZ A;  3SJT A;  2PHA A;  1WVB A;  1T4S A;  2PHO A;  1WOH A;  1R1O A;  1TBH A;  4MYL A;  3SL1 A;  1TBJ A;  3THH A;  4RHQ A;  5HJA A;  3MJL A;  4IE3 A;  3E6V A;  3THJ A;  1P8S A;  4HXQ A;  4IXV A;  4RLA A;  4RHM A;  4GWC A;  4RHL A;  4Q3R A;  1WOG A;  1XFK A;  4IU0 A;  2AEB A;  4FCK A;  3F80 A;  4HWW A;  5RLA A;  1T4R A;  5HJ9 A;  4IU5 A;  1HQX A;  3E6K A;  1T4P A;  1TA1 A;  1TBL A;  4ITY A;  3DJ8 A;  4Q41 A;  1GQ6 A;  2EIV A;  1P8Q A;  3KV2 A;  5CEV A;  3PZL A;  1ZPE A;  4FCI A;  2CEV A;  3CEV A;  1D3V A;  3GMZ A;  1PQ3 A;  4Q3U A;  4MYF A;  4RHK A;  1HQG A;  1CEV A;  1RLA A;  3GN0 A;  4IE2 A;  3E8Q A;  4GSV A;  1P8P A;  1T5G A;  1T5F A;  4CEV A;  4Q3S A;  1WOI A;  4DZ4 A;  1ZPG A;  4G3H A;  1HQ5 A;  3NIO A;  3MFW A;  3RLA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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