4IXVA

Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
306
structure length
306
Chain Sequence
HSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Arginase-2, mitochondrial
publication title Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction.
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 306
sequence length 306
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2013-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4ixvA00
1TBJA 4Q3TA 3GMZA 2EF5A 4IE1A 4MXRA 4Q42A 2EF4A 4GWDA 4DZ4A 3M1RA 4MYLA 5HJ9A 5HJAA 4G3HA 3SKKA 4HZEA 1WOIA 3MFVA 1RLAA 1WVBA 4RHIA 1WVAA 3LP4A 5RLAA 2PHOA 3SL1A 1T5GA 4IXUA 3MJLA 4HWWA 4HXQA 2PHAA 4IU1A 3THHA 1D3VA 3LP7A 3NIOA 1R1OA 4GSVA 1P8NA 1P8SA 1GQ7A 3F80A 4GSMA 1ZPGA 1HQFA 3THJA 4Q3RA 1WOHA 4MYFA 1PQ3A 1T4RA 1T4PA 3E6VA 4IU4A 2ZAVA 1WOGA 3CEVA 4GWCA 4IE3A 4RHKA 1T5FA 4Q3QA 4CEVA 4Q3RC 4Q3VA 4IE2A 2PLLA 3E8ZA 1TA1A 2EIVA 3KV2A 1P8MA 4FCKA 1TBHA 1P8OA 3NIQA 1P8QA 1XFKA 3LHLA 4RLAA 3MFWA 4Q40A 3E9BA 4RHQA 3TF3A 1HQ5A 4RHMA 4IU0A 1HQGA 3TH7A 2AEBA 1CEVA 3SJTA 4FCIA 1T4SA 3PZLA 4Q3UA 4IU5A 3THEA 1ZPEA 1GQ6A 2A0MA 1P8PA 2RLAA 1HQXA 1TBLA 4GSZA 5CEVA 3DJ8A 4I06A 1HQHA 4Q41A 3E8QA 4IXVA 3NIPA 4Q3SA 3MMRA 2CEVA 4MYNA 4MYKA 3E6KA 4RHJA 4ITYA 3SL0A 1T4TA 3GN0A 4Q3PA 4RHLA 1P8RA 3RLAA
chains in the Genus database with same CATH superfamily
1TBJA 4Q3TA 3GMZA 3C10A 5THTA 4QA0A 2EF5A 4RN2A 5EEIA 1T64A 3MENA 4IE1A 3EW8A 3SFFA 4MXRA 4Q42A 2EF4A 4GWDA 5DC8A 4DZ4A 3M1RA 4MYLA 2VQWG 3C0YA 2VQJA 5HJ9A 3Q9FA 5HJAA 5G1BA 4G3HA 5IWGA 3SKKA 4HZEA 4BZ9A 1WOIA 3MFVA 5EFHA 1RLAA 5D1BA 5THSA 1WVBA 5EEMA 4RHIA 1WVAA 3LP4A 5RLAA 5EEKA 1C3PA 2PHOA 3SL1A 1T5GA 4IXUA 3MJLA 3MZ6A 4CBTA 3F07A 4HWWA 4HXQA 5EFBD 4ZURA 1ZZ3A 4BKXB 2PHAA 4IU1A 2VQQA 3THHA 1D3VA 3LP7A 3NIOA 1R1OA 4GSVA 3EWFA 4ZUNA 1P8NA 1P8SA 2V5XA 5EFKB 1GQ7A 3F80A 4QA3A 5G0IA 4GSMA 1ZPGA 1HQFA 5G12A 3THJA 3F0RA 4QA1A 1T69A 5EFGA 4Q3RA 1WOHA 4MYFA 5JI5A 2VQMA 1PQ3A 4LXZA 5EF8A 1T4RA 2VQOA 4CBYA 1T4PA 3E6VA 3MZ3A 5G1CA 4RN1A 2VCGA 2V5WA 3EZPA 4IU4A 2ZAVA 1WOGA 3CEVA 4GWCA 4IE3A 4RHLA 1C3SA 4RHKA 3SFHA 1T5FA 4Q3QA 5G0HA 2VQVA 3ZNSA 4BZ5A 4ZUOA 4ZUPA 4CEVA 3Q9CA 4Q3RC 4Q3VA 4IE2A 2PLLA 5G0GA 3E8ZA 1TA1A 5IX0A 5DC6A 4BZ8A 1ZZ1A 4QA5A 1ZZ0A 4BZ7A 4CQFA 2EIVA 5G3WA 3KV2A 3RQDA 1P8MA 1TBHA 3NIQA 1P8OA 4FCKA 5EF7A 4QA4A 1P8QA 1XFKA 5G0XA 5G1AA 5G0JA 3MAXA 5THVA 5G13A 3LHLA 4RLAA 3MFWA 4Q40A 3E9BA 4RHQA 4BZ6A 5A2SA 4ZUMA 3TF3A 4QA2A 1HQ5A 3Q9EA 5BWZA 4RHMA 3EZTA 4ZUQA 4IU0A 4RN0A 1HQGA 3TH7A 2AEBA 1CEVA 1VKGA 3SJTA 4FCIA 1W22A 1T4SA 5DC7A 3PZLA 5FCWA 3Q9BA 4IU5A 4LY1A 4Q3UA 3THEA 5ICNB 1ZPEA 1GQ6A 2A0MA 1P8PA 2RLAA 1HQXA 5D1CA 5FUEA 1TBLA 3F06A 4GSZA 5CEVA 5D1DA 2GH6A 5EFNA 5EEFA 5G11A 3DJ8A 1C3RA 4I06A 3C0ZA 1HQHA 5G10A 5G17A 4Q41A 3E8QA 3MZ7A 4IXVA 3NIPA 4Q3SA 3MMRA 5EENA 2CEVA 4MYNA 4QA6A 5THUA 3ZNRA 5G0YA 1T67A 3E6KA 4MYKA 5DC5A 5EFJD 4QA7A 4RHJA 4ITYA 3SL0A 1T4TA 5LI3A 3GN0A 4Q3PA 4A69A 3MZ4A 1P8RA 3RLAA
chains in the Genus database with same CATH topology
1TBJA 4Q3TA 3GMZA 2EF5A 4IE1A 4MXRA 4Q42A 2EF4A 4GWDA 4DZ4A 3M1RA 4MYLA 5HJ9A 5HJAA 4G3HA 3SKKA 4HZEA 1WOIA 3MFVA 1RLAA 1WVBA 4RHIA 1WVAA 3LP4A 5RLAA 2PHOA 3SL1A 1T5GA 4IXUA 3MJLA 4HWWA 4HXQA 2PHAA 4IU1A 3THHA 1D3VA 3LP7A 3NIOA 1R1OA 4GSVA 1P8NA 1P8SA 1GQ7A 3F80A 4GSMA 1ZPGA 1HQFA 3THJA 4Q3RA 1WOHA 4MYFA 1PQ3A 1T4RA 1T4PA 3E6VA 4IU4A 2ZAVA 1WOGA 3CEVA 4GWCA 4IE3A 4RHKA 1T5FA 4Q3QA 4CEVA 4Q3RC 4Q3VA 4IE2A 2PLLA 3E8ZA 1TA1A 2EIVA 3KV2A 1P8MA 4FCKA 1TBHA 1P8OA 3NIQA 1P8QA 1XFKA 3LHLA 4RLAA 3MFWA 4Q40A 3E9BA 4RHQA 3TF3A 1HQ5A 4RHMA 4IU0A 1HQGA 3TH7A 2AEBA 1CEVA 3SJTA 4FCIA 1T4SA 3PZLA 4Q3UA 4IU5A 3THEA 1ZPEA 1GQ6A 2A0MA 1P8PA 2RLAA 1HQXA 1TBLA 4GSZA 5CEVA 3DJ8A 4I06A 1HQHA 4Q41A 3E8QA 4IXVA 3NIPA 4Q3SA 3MMRA 2CEVA 4MYNA 4MYKA 3E6KA 4RHJA 4ITYA 3SL0A 1T4TA 3GN0A 4Q3PA 4RHLA 1P8RA 3RLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBJ A;  4Q3T A;  3GMZ A;  2EF5 A;  4IE1 A;  4MXR A;  4Q42 A;  2EF4 A;  4GWD A;  4DZ4 A;  3M1R A;  4MYL A;  5HJ9 A;  5HJA A;  4G3H A;  3SKK A;  4HZE A;  1WOI A;  3MFV A;  1RLA A;  1WVB A;  4RHI A;  1WVA A;  3LP4 A;  5RLA A;  2PHO A;  3SL1 A;  1T5G A;  4IXU A;  3MJL A;  4HWW A;  4HXQ A;  2PHA A;  4IU1 A;  3THH A;  1D3V A;  3LP7 A;  3NIO A;  1R1O A;  4GSV A;  1P8N A;  1P8S A;  1GQ7 A;  3F80 A;  4GSM A;  1ZPG A;  1HQF A;  3THJ A;  4Q3R A;  1WOH A;  4MYF A;  1PQ3 A;  1T4R A;  1T4P A;  3E6V A;  4IU4 A;  2ZAV A;  1WOG A;  3CEV A;  4GWC A;  4IE3 A;  4RHK A;  1T5F A;  4Q3Q A;  4CEV A;  4Q3R C;  4Q3V A;  4IE2 A;  2PLL A;  3E8Z A;  1TA1 A;  2EIV A;  3KV2 A;  1P8M A;  4FCK A;  1TBH A;  1P8O A;  3NIQ A;  1P8Q A;  1XFK A;  3LHL A;  4RLA A;  3MFW A;  4Q40 A;  3E9B A;  4RHQ A;  3TF3 A;  1HQ5 A;  4RHM A;  4IU0 A;  1HQG A;  3TH7 A;  2AEB A;  1CEV A;  3SJT A;  4FCI A;  1T4S A;  3PZL A;  4Q3U A;  4IU5 A;  3THE A;  1ZPE A;  1GQ6 A;  2A0M A;  1P8P A;  2RLA A;  1HQX A;  1TBL A;  4GSZ A;  5CEV A;  3DJ8 A;  4I06 A;  1HQH A;  4Q41 A;  3E8Q A;  4IXV A;  3NIP A;  4Q3S A;  3MMR A;  2CEV A;  4MYN A;  4MYK A;  3E6K A;  4RHJ A;  4ITY A;  3SL0 A;  1T4T A;  3GN0 A;  4Q3P A;  4RHL A;  1P8R A;  3RLA A; 
#chains in the Genus database with same CATH topology
 1TBJ A;  4Q3T A;  3GMZ A;  3C10 A;  5THT A;  4QA0 A;  2EF5 A;  4RN2 A;  5EEI A;  1T64 A;  3MEN A;  4IE1 A;  3EW8 A;  3SFF A;  4MXR A;  4Q42 A;  2EF4 A;  4GWD A;  5DC8 A;  4DZ4 A;  3M1R A;  4MYL A;  2VQW G;  3C0Y A;  2VQJ A;  5HJ9 A;  3Q9F A;  5HJA A;  5G1B A;  4G3H A;  5IWG A;  3SKK A;  4HZE A;  4BZ9 A;  1WOI A;  3MFV A;  5EFH A;  1RLA A;  5D1B A;  5THS A;  1WVB A;  5EEM A;  4RHI A;  1WVA A;  3LP4 A;  5RLA A;  5EEK A;  1C3P A;  2PHO A;  3SL1 A;  1T5G A;  4IXU A;  3MJL A;  3MZ6 A;  4CBT A;  3F07 A;  4HWW A;  4HXQ A;  5EFB D;  4ZUR A;  1ZZ3 A;  4BKX B;  2PHA A;  4IU1 A;  2VQQ A;  3THH A;  1D3V A;  3LP7 A;  3NIO A;  1R1O A;  4GSV A;  3EWF A;  4ZUN A;  1P8N A;  1P8S A;  2V5X A;  5EFK B;  1GQ7 A;  3F80 A;  4QA3 A;  5G0I A;  4GSM A;  1ZPG A;  1HQF A;  5G12 A;  3THJ A;  3F0R A;  4QA1 A;  1T69 A;  5EFG A;  4Q3R A;  1WOH A;  4MYF A;  5JI5 A;  2VQM A;  1PQ3 A;  4LXZ A;  5EF8 A;  1T4R A;  2VQO A;  4CBY A;  1T4P A;  3E6V A;  3MZ3 A;  5G1C A;  4RN1 A;  2VCG A;  2V5W A;  3EZP A;  4IU4 A;  2ZAV A;  1WOG A;  3CEV A;  4GWC A;  4IE3 A;  4RHL A;  1C3S A;  4RHK A;  3SFH A;  1T5F A;  4Q3Q A;  5G0H A;  2VQV A;  3ZNS A;  4BZ5 A;  4ZUO A;  4ZUP A;  4CEV A;  3Q9C A;  4Q3R C;  4Q3V A;  4IE2 A;  2PLL A;  5G0G A;  3E8Z A;  1TA1 A;  5IX0 A;  5DC6 A;  4BZ8 A;  1ZZ1 A;  4QA5 A;  1ZZ0 A;  4BZ7 A;  4CQF A;  2EIV A;  5G3W A;  3KV2 A;  3RQD A;  1P8M A;  1TBH A;  3NIQ A;  1P8O A;  4FCK A;  5EF7 A;  4QA4 A;  1P8Q A;  1XFK A;  5G0X A;  5G1A A;  5G0J A;  3MAX A;  5THV A;  5G13 A;  3LHL A;  4RLA A;  3MFW A;  4Q40 A;  3E9B A;  4RHQ A;  4BZ6 A;  5A2S A;  4ZUM A;  3TF3 A;  4QA2 A;  1HQ5 A;  3Q9E A;  5BWZ A;  4RHM A;  3EZT A;  4ZUQ A;  4IU0 A;  4RN0 A;  1HQG A;  3TH7 A;  2AEB A;  1CEV A;  1VKG A;  3SJT A;  4FCI A;  1W22 A;  1T4S A;  5DC7 A;  3PZL A;  5FCW A;  3Q9B A;  4IU5 A;  4LY1 A;  4Q3U A;  3THE A;  5ICN B;  1ZPE A;  1GQ6 A;  2A0M A;  1P8P A;  2RLA A;  1HQX A;  5D1C A;  5FUE A;  1TBL A;  3F06 A;  4GSZ A;  5CEV A;  5D1D A;  2GH6 A;  5EFN A;  5EEF A;  5G11 A;  3DJ8 A;  1C3R A;  4I06 A;  3C0Z A;  1HQH A;  5G10 A;  5G17 A;  4Q41 A;  3E8Q A;  3MZ7 A;  4IXV A;  3NIP A;  4Q3S A;  3MMR A;  5EEN A;  2CEV A;  4MYN A;  4QA6 A;  5THU A;  3ZNR A;  5G0Y A;  1T67 A;  3E6K A;  4MYK A;  5DC5 A;  5EFJ D;  4QA7 A;  4RHJ A;  4ITY A;  3SL0 A;  1T4T A;  5LI3 A;  3GN0 A;  4Q3P A;  4A69 A;  3MZ4 A;  1P8R A;  3RLA A; 
#chains in the Genus database with same CATH homology
 1TBJ A;  4Q3T A;  3GMZ A;  2EF5 A;  4IE1 A;  4MXR A;  4Q42 A;  2EF4 A;  4GWD A;  4DZ4 A;  3M1R A;  4MYL A;  5HJ9 A;  5HJA A;  4G3H A;  3SKK A;  4HZE A;  1WOI A;  3MFV A;  1RLA A;  1WVB A;  4RHI A;  1WVA A;  3LP4 A;  5RLA A;  2PHO A;  3SL1 A;  1T5G A;  4IXU A;  3MJL A;  4HWW A;  4HXQ A;  2PHA A;  4IU1 A;  3THH A;  1D3V A;  3LP7 A;  3NIO A;  1R1O A;  4GSV A;  1P8N A;  1P8S A;  1GQ7 A;  3F80 A;  4GSM A;  1ZPG A;  1HQF A;  3THJ A;  4Q3R A;  1WOH A;  4MYF A;  1PQ3 A;  1T4R A;  1T4P A;  3E6V A;  4IU4 A;  2ZAV A;  1WOG A;  3CEV A;  4GWC A;  4IE3 A;  4RHK A;  1T5F A;  4Q3Q A;  4CEV A;  4Q3R C;  4Q3V A;  4IE2 A;  2PLL A;  3E8Z A;  1TA1 A;  2EIV A;  3KV2 A;  1P8M A;  4FCK A;  1TBH A;  1P8O A;  3NIQ A;  1P8Q A;  1XFK A;  3LHL A;  4RLA A;  3MFW A;  4Q40 A;  3E9B A;  4RHQ A;  3TF3 A;  1HQ5 A;  4RHM A;  4IU0 A;  1HQG A;  3TH7 A;  2AEB A;  1CEV A;  3SJT A;  4FCI A;  1T4S A;  3PZL A;  4Q3U A;  4IU5 A;  3THE A;  1ZPE A;  1GQ6 A;  2A0M A;  1P8P A;  2RLA A;  1HQX A;  1TBL A;  4GSZ A;  5CEV A;  3DJ8 A;  4I06 A;  1HQH A;  4Q41 A;  3E8Q A;  4IXV A;  3NIP A;  4Q3S A;  3MMR A;  2CEV A;  4MYN A;  4MYK A;  3E6K A;  4RHJ A;  4ITY A;  3SL0 A;  1T4T A;  3GN0 A;  4Q3P A;  4RHL A;  1P8R A;  3RLA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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