4Q3RA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
345
structure length
335
Chain Sequence
KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHRSGHLPFKVRNLTDQGIMSRAAHMQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 125
structure length 335
sequence length 345
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3rA00
4FCIA 3E8ZA 3PZLA 3MFVA 1P8NA 4GWDA 3SL1A 1WVAA 2ZAVA 1T5GA 4GSMA 1ZPGA 3TF3A 3NIPA 1GQ6A 4IU1A 4IE2A 1T4RA 4IU4A 3GN0A 1P8RA 3SL0A 1P8QA 1WOGA 5HJAA 5CEVA 1P8MA 3CEVA 3F80A 1WOHA 4Q42A 3SKKA 3THHA 4IE1A 4FCKA 3E9BA 4MYKA 1P8SA 4Q3RA 4IXUA 4GWCA 4HZEA 3MFWA 4CEVA 3THEA 1CEVA 3SJTA 2AEBA 4Q3RC 3NIOA 2PLLA 2EF5A 1R1OA 4Q40A 1XFKA 1ZPEA 3KV2A 4Q3PA 1RLAA 1WVBA 3E6VA 3TH7A 1HQ5A 2EIVA 1TA1A 5RLAA 4RHMA 4IXVA 1T5FA 4IE3A 3RLAA 1TBHA 2CEVA 3NIQA 1HQXA 4HXQA 4Q3SA 4Q3TA 4DZ4A 1PQ3A 4HWWA 4Q3QA 4MYLA 1GQ7A 3LHLA 1TBJA 4RHIA 1T4SA 3DJ8A 2EF4A 4RHLA 4Q3VA 5HJ9A 3M1RA 4RHJA 2PHAA 3LP7A 3THJA 2A0MA 4G3HA 4RLAA 1T4TA 4RHKA 1HQGA 3MMRA 1TBLA 4I06A 4IU0A 4MYFA 4ITYA 1T4PA 4Q41A 2RLAA 4GSVA 3LP4A 4RHQA 4Q3UA 1HQFA 2PHOA 3MJLA 1D3VA 4MYNA 3E8QA 1WOIA 1P8OA 1P8PA 4IU5A 4GSZA 1HQHA 3GMZA 4MXRA 3E6KA
chains in the Genus database with same CATH superfamily
3Q9BA 4FCIA 3E8ZA 3PZLA 3MFVA 5G0JA 1P8NA 5DC5A 3ZNSA 4GWDA 3Q9EA 3SL1A 1WVAA 5THTA 1C3RA 5JI5A 2ZAVA 4RN1A 1T5GA 4GSMA 1ZPGA 3TF3A 1VKGA 3NIPA 1GQ6A 4IU1A 4IE2A 4QA5A 5G1AA 1T4RA 4IU4A 3GN0A 1P8RA 5DC7A 3SL0A 1P8QA 1WOGA 5CEVA 4BZ7A 5HJAA 5DC8A 1T69A 5FUEA 1P8MA 3CEVA 3F80A 1WOHA 4Q42A 3SKKA 3THHA 4QA3A 5G11A 5G0HA 4ZURA 4IE1A 4FCKA 4ZUMA 3E9BA 5EFGA 1W22A 5EF8A 4MYKA 1P8SA 1T67A 4Q3RA 5G17A 4IXUA 4QA2A 1C3SA 4GWCA 3MENA 3C0YA 1ZZ3A 4LY1A 4HZEA 3MFWA 4CEVA 3THEA 4BKXB 1CEVA 5EEMA 3SJTA 3F06A 2VQOA 2GH6A 3C10A 4RN2A 2AEBA 5EFKB 5G1CA 1ZZ0A 3C0ZA 4Q3RC 3NIOA 5FCWA 2PLLA 4BZ8A 5G3WA 2EF5A 3RQDA 1R1OA 4Q40A 1XFKA 1ZPEA 2VQJA 3KV2A 4ZUQA 4Q3PA 5G0GA 1C3PA 1RLAA 1WVBA 2VQVA 3E6VA 5THVA 3TH7A 1HQ5A 5EEKA 2EIVA 5EFNA 1TA1A 5RLAA 4RHMA 4IXVA 5G10A 1T5FA 4IE3A 5G0IA 2VCGA 3EZTA 3RLAA 3SFHA 1TBHA 2CEVA 3F0RA 3MZ6A 3NIQA 1HQXA 4HXQA 1ZZ1A 4Q3SA 2V5XA 4QA7A 5G12A 3F07A 1T64A 1PQ3A 4Q3TA 4DZ4A 4QA4A 4HWWA 4Q3QA 5IX0A 4MYLA 4BZ9A 1GQ7A 3LHLA 1TBJA 4RHIA 5D1DA 1T4SA 5DC6A 2VQQA 3DJ8A 2EF4A 4RHLA 5G0XA 4Q3VA 5LI3A 5EFJD 4ZUNA 5HJ9A 3M1RA 4RHJA 2PHAA 3LP7A 5G0YA 3THJA 2A0MA 3EWFA 4QA0A 3MZ7A 4G3HA 4RLAA 5EEIA 3ZNRA 3MAXA 4CBTA 4BZ6A 2VQMA 4LXZA 5D1BA 1T4TA 4RHKA 1HQGA 3MMRA 1TBLA 3Q9CA 4I06A 4IU0A 4MYFA 4ITYA 1T4PA 3SFFA 4Q41A 2RLAA 4QA1A 3EZPA 5EEFA 5THUA 4QA6A 4GSVA 4BZ5A 5EFHA 4A69A 4ZUPA 5THSA 3LP4A 4RN0A 5ICNB 5EFBD 5G13A 4RHQA 2VQWG 4Q3UA 1HQFA 2PHOA 3MJLA 1D3VA 4MYNA 5A2SA 3E8QA 1WOIA 4ZUOA 4CQFA 1P8OA 1P8PA 3EW8A 4IU5A 3MZ3A 5IWGA 3Q9FA 1HQHA 4GSZA 5BWZA 3GMZA 4MXRA 3E6KA 3MZ4A 5D1CA 2V5WA 5EF7A 5G1BA 4CBYA 5EENA
chains in the Genus database with same CATH topology
4FCIA 3E8ZA 3PZLA 3MFVA 1P8NA 4GWDA 3SL1A 1WVAA 2ZAVA 1T5GA 4GSMA 1ZPGA 3TF3A 3NIPA 1GQ6A 4IU1A 4IE2A 1T4RA 4IU4A 3GN0A 1P8RA 3SL0A 1P8QA 1WOGA 5HJAA 5CEVA 1P8MA 3CEVA 3F80A 1WOHA 4Q42A 3SKKA 3THHA 4IE1A 4FCKA 3E9BA 4MYKA 1P8SA 4Q3RA 4IXUA 4GWCA 4HZEA 3MFWA 4CEVA 3THEA 1CEVA 3SJTA 2AEBA 4Q3RC 3NIOA 2PLLA 2EF5A 1R1OA 4Q40A 1XFKA 1ZPEA 3KV2A 4Q3PA 1RLAA 1WVBA 3E6VA 3TH7A 1HQ5A 2EIVA 1TA1A 5RLAA 4RHMA 4IXVA 1T5FA 4IE3A 3RLAA 1TBHA 2CEVA 3NIQA 1HQXA 4HXQA 4Q3SA 4Q3TA 4DZ4A 1PQ3A 4HWWA 4Q3QA 4MYLA 1GQ7A 3LHLA 1TBJA 4RHIA 1T4SA 3DJ8A 2EF4A 4RHLA 4Q3VA 5HJ9A 3M1RA 4RHJA 2PHAA 3LP7A 3THJA 2A0MA 4G3HA 4RLAA 1T4TA 4RHKA 1HQGA 3MMRA 1TBLA 4I06A 4IU0A 4MYFA 4ITYA 1T4PA 4Q41A 2RLAA 4GSVA 3LP4A 4RHQA 4Q3UA 1HQFA 2PHOA 3MJLA 1D3VA 4MYNA 3E8QA 1WOIA 1P8OA 1P8PA 4IU5A 4GSZA 1HQHA 3GMZA 4MXRA 3E6KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FCI A;  3E8Z A;  3PZL A;  3MFV A;  1P8N A;  4GWD A;  3SL1 A;  1WVA A;  2ZAV A;  1T5G A;  4GSM A;  1ZPG A;  3TF3 A;  3NIP A;  1GQ6 A;  4IU1 A;  4IE2 A;  1T4R A;  4IU4 A;  3GN0 A;  1P8R A;  3SL0 A;  1P8Q A;  1WOG A;  5HJA A;  5CEV A;  1P8M A;  3CEV A;  3F80 A;  1WOH A;  4Q42 A;  3SKK A;  3THH A;  4IE1 A;  4FCK A;  3E9B A;  4MYK A;  1P8S A;  4Q3R A;  4IXU A;  4GWC A;  4HZE A;  3MFW A;  4CEV A;  3THE A;  1CEV A;  3SJT A;  2AEB A;  4Q3R C;  3NIO A;  2PLL A;  2EF5 A;  1R1O A;  4Q40 A;  1XFK A;  1ZPE A;  3KV2 A;  4Q3P A;  1RLA A;  1WVB A;  3E6V A;  3TH7 A;  1HQ5 A;  2EIV A;  1TA1 A;  5RLA A;  4RHM A;  4IXV A;  1T5F A;  4IE3 A;  3RLA A;  1TBH A;  2CEV A;  3NIQ A;  1HQX A;  4HXQ A;  4Q3S A;  4Q3T A;  4DZ4 A;  1PQ3 A;  4HWW A;  4Q3Q A;  4MYL A;  1GQ7 A;  3LHL A;  1TBJ A;  4RHI A;  1T4S A;  3DJ8 A;  2EF4 A;  4RHL A;  4Q3V A;  5HJ9 A;  3M1R A;  4RHJ A;  2PHA A;  3LP7 A;  3THJ A;  2A0M A;  4G3H A;  4RLA A;  1T4T A;  4RHK A;  1HQG A;  3MMR A;  1TBL A;  4I06 A;  4IU0 A;  4MYF A;  4ITY A;  1T4P A;  4Q41 A;  2RLA A;  4GSV A;  3LP4 A;  4RHQ A;  4Q3U A;  1HQF A;  2PHO A;  3MJL A;  1D3V A;  4MYN A;  3E8Q A;  1WOI A;  1P8O A;  1P8P A;  4IU5 A;  4GSZ A;  1HQH A;  3GMZ A;  4MXR A;  3E6K A; 
#chains in the Genus database with same CATH topology
 3Q9B A;  4FCI A;  3E8Z A;  3PZL A;  3MFV A;  5G0J A;  1P8N A;  5DC5 A;  3ZNS A;  4GWD A;  3Q9E A;  3SL1 A;  1WVA A;  5THT A;  1C3R A;  5JI5 A;  2ZAV A;  4RN1 A;  1T5G A;  4GSM A;  1ZPG A;  3TF3 A;  1VKG A;  3NIP A;  1GQ6 A;  4IU1 A;  4IE2 A;  4QA5 A;  5G1A A;  1T4R A;  4IU4 A;  3GN0 A;  1P8R A;  5DC7 A;  3SL0 A;  1P8Q A;  1WOG A;  5CEV A;  4BZ7 A;  5HJA A;  5DC8 A;  1T69 A;  5FUE A;  1P8M A;  3CEV A;  3F80 A;  1WOH A;  4Q42 A;  3SKK A;  3THH A;  4QA3 A;  5G11 A;  5G0H A;  4ZUR A;  4IE1 A;  4FCK A;  4ZUM A;  3E9B A;  5EFG A;  1W22 A;  5EF8 A;  4MYK A;  1P8S A;  1T67 A;  4Q3R A;  5G17 A;  4IXU A;  4QA2 A;  1C3S A;  4GWC A;  3MEN A;  3C0Y A;  1ZZ3 A;  4LY1 A;  4HZE A;  3MFW A;  4CEV A;  3THE A;  4BKX B;  1CEV A;  5EEM A;  3SJT A;  3F06 A;  2VQO A;  2GH6 A;  3C10 A;  4RN2 A;  2AEB A;  5EFK B;  5G1C A;  1ZZ0 A;  3C0Z A;  4Q3R C;  3NIO A;  5FCW A;  2PLL A;  4BZ8 A;  5G3W A;  2EF5 A;  3RQD A;  1R1O A;  4Q40 A;  1XFK A;  1ZPE A;  2VQJ A;  3KV2 A;  4ZUQ A;  4Q3P A;  5G0G A;  1C3P A;  1RLA A;  1WVB A;  2VQV A;  3E6V A;  5THV A;  3TH7 A;  1HQ5 A;  5EEK A;  2EIV A;  5EFN A;  1TA1 A;  5RLA A;  4RHM A;  4IXV A;  5G10 A;  1T5F A;  4IE3 A;  5G0I A;  2VCG A;  3EZT A;  3RLA A;  3SFH A;  1TBH A;  2CEV A;  3F0R A;  3MZ6 A;  3NIQ A;  1HQX A;  4HXQ A;  1ZZ1 A;  4Q3S A;  2V5X A;  4QA7 A;  5G12 A;  3F07 A;  1T64 A;  1PQ3 A;  4Q3T A;  4DZ4 A;  4QA4 A;  4HWW A;  4Q3Q A;  5IX0 A;  4MYL A;  4BZ9 A;  1GQ7 A;  3LHL A;  1TBJ A;  4RHI A;  5D1D A;  1T4S A;  5DC6 A;  2VQQ A;  3DJ8 A;  2EF4 A;  4RHL A;  5G0X A;  4Q3V A;  5LI3 A;  5EFJ D;  4ZUN A;  5HJ9 A;  3M1R A;  4RHJ A;  2PHA A;  3LP7 A;  5G0Y A;  3THJ A;  2A0M A;  3EWF A;  4QA0 A;  3MZ7 A;  4G3H A;  4RLA A;  5EEI A;  3ZNR A;  3MAX A;  4CBT A;  4BZ6 A;  2VQM A;  4LXZ A;  5D1B A;  1T4T A;  4RHK A;  1HQG A;  3MMR A;  1TBL A;  3Q9C A;  4I06 A;  4IU0 A;  4MYF A;  4ITY A;  1T4P A;  3SFF A;  4Q41 A;  2RLA A;  4QA1 A;  3EZP A;  5EEF A;  5THU A;  4QA6 A;  4GSV A;  4BZ5 A;  5EFH A;  4A69 A;  4ZUP A;  5THS A;  3LP4 A;  4RN0 A;  5ICN B;  5EFB D;  5G13 A;  4RHQ A;  2VQW G;  4Q3U A;  1HQF A;  2PHO A;  3MJL A;  1D3V A;  4MYN A;  5A2S A;  3E8Q A;  1WOI A;  4ZUO A;  4CQF A;  1P8O A;  1P8P A;  3EW8 A;  4IU5 A;  3MZ3 A;  5IWG A;  3Q9F A;  1HQH A;  4GSZ A;  5BWZ A;  3GMZ A;  4MXR A;  3E6K A;  3MZ4 A;  5D1C A;  2V5W A;  5EF7 A;  5G1B A;  4CBY A;  5EEN A; 
#chains in the Genus database with same CATH homology
 4FCI A;  3E8Z A;  3PZL A;  3MFV A;  1P8N A;  4GWD A;  3SL1 A;  1WVA A;  2ZAV A;  1T5G A;  4GSM A;  1ZPG A;  3TF3 A;  3NIP A;  1GQ6 A;  4IU1 A;  4IE2 A;  1T4R A;  4IU4 A;  3GN0 A;  1P8R A;  3SL0 A;  1P8Q A;  1WOG A;  5HJA A;  5CEV A;  1P8M A;  3CEV A;  3F80 A;  1WOH A;  4Q42 A;  3SKK A;  3THH A;  4IE1 A;  4FCK A;  3E9B A;  4MYK A;  1P8S A;  4Q3R A;  4IXU A;  4GWC A;  4HZE A;  3MFW A;  4CEV A;  3THE A;  1CEV A;  3SJT A;  2AEB A;  4Q3R C;  3NIO A;  2PLL A;  2EF5 A;  1R1O A;  4Q40 A;  1XFK A;  1ZPE A;  3KV2 A;  4Q3P A;  1RLA A;  1WVB A;  3E6V A;  3TH7 A;  1HQ5 A;  2EIV A;  1TA1 A;  5RLA A;  4RHM A;  4IXV A;  1T5F A;  4IE3 A;  3RLA A;  1TBH A;  2CEV A;  3NIQ A;  1HQX A;  4HXQ A;  4Q3S A;  4Q3T A;  4DZ4 A;  1PQ3 A;  4HWW A;  4Q3Q A;  4MYL A;  1GQ7 A;  3LHL A;  1TBJ A;  4RHI A;  1T4S A;  3DJ8 A;  2EF4 A;  4RHL A;  4Q3V A;  5HJ9 A;  3M1R A;  4RHJ A;  2PHA A;  3LP7 A;  3THJ A;  2A0M A;  4G3H A;  4RLA A;  1T4T A;  4RHK A;  1HQG A;  3MMR A;  1TBL A;  4I06 A;  4IU0 A;  4MYF A;  4ITY A;  1T4P A;  4Q41 A;  2RLA A;  4GSV A;  3LP4 A;  4RHQ A;  4Q3U A;  1HQF A;  2PHO A;  3MJL A;  1D3V A;  4MYN A;  3E8Q A;  1WOI A;  1P8O A;  1P8P A;  4IU5 A;  4GSZ A;  1HQH A;  3GMZ A;  4MXR A;  3E6K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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