4Q3RA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
345
structure length
335
Chain Sequence
b'KLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHRSGHLPFKVRNLTDQGIMSRAAHMQT'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Arginase
publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
source organism Schistosoma mansoni
molecule tags Hydrolase/hydrolase inhibitor
total genus 125
structure length 335
sequence length 345
chains with identical sequence B
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3rA00
4IXUA 4Q3QA 4GSVA 4CEVA 4IU1A 1P8OA 4MYKA 3CEVA 4Q3SA 4MXRA 4RLAA 1T4PA 1TBLA 3KV2A 1GQ6A 1CEVA 1P8MA 2ZAVA 4I06A 4ITYA 4IU0A 4GWDA 4RHLA 5CEVA 3SL0A 4MYFA 1T5FA 4Q3UA 2A0MA 4RHMA 4Q3PA 3GN0A 4FCIA 3TF3A 1ZPEA 3MMRA 4Q42A 3GMZA 1R1OA 4IE3A 4RHJA 1P8SA 5HJAA 3THHA 2PHAA 1WVAA 3SL1A 4IE2A 1PQ3A 3E9BA 3MJLA 4FCKA 1HQ5A 1P8QA 3PZLA 1P8PA 1RLAA 2EF4A 4GSZA 1HQXA 3MFVA 1WVBA 3NIOA 4HWWA 2EIVA 4Q3RC 4Q3TA 1P8RA 2PLLA 3THJA 1ZPGA 4RHIA 4RHKA 3THEA 3RLAA 1TBJA 4DZ4A 4Q41A 4IE1A 3TH7A 3E6KA 4IXVA 1WOGA 3NIQA 1WOHA 4G3HA 4HZEA 1T5GA 3MFWA 4Q40A 1TA1A 1T4SA 2EF5A 3E6VA 4Q3RA 3F80A 1TBHA 1HQGA 3LP4A 4MYLA 1HQFA 3NIPA 2PHOA 1WOIA 1T4TA 4Q3VA 3SJTA 4IU5A 2RLAA 4RHQA 5RLAA 2AEBA 4MYNA 3E8ZA 4GSMA 1D3VA 3DJ8A 1GQ7A 3M1RA 1XFKA 2CEVA 4HXQA 1HQHA 1P8NA 5HJ9A 3LP7A 3SKKA 4IU4A 1T4RA 4GWCA 3E8QA 3LHLA
chains in the Genus database with same CATH superfamily
5EEFA 5EFKB 3EWFA 4IXUA 4Q3QA 5G0JA 5G1CA 4GSVA 4QA2A 4CEVA 4A69A 4IU1A 1P8OA 3C0ZA 4MYKA 3CEVA 4Q3SA 5G1BA 1C3RA 4BKXB 4LXZA 4MXRA 4RLAA 1T4PA 5G0GA 1TBLA 3KV2A 1GQ6A 1CEVA 1P8MA 2ZAVA 4I06A 4ITYA 4IU0A 5G13A 4BZ8A 5DC8A 3Q9BA 4GWDA 4RHLA 5CEVA 3SL0A 4MYFA 1T5FA 4Q3UA 5G1AA 2A0MA 4RHMA 4Q3PA 3GN0A 5G0XA 3ZNSA 4FCIA 3TF3A 1ZPEA 3MMRA 4QA0A 4Q42A 4RN2A 5EFBD 1W22A 3GMZA 3E8QA 5EFJD 5EFHA 2VQVA 4ZUMA 3Q9EA 4ZURA 5D1DA 5G0HA 5THSA 1R1OA 5G11A 3F0RA 4IE3A 4LY1A 1P8SA 4RHJA 3EZPA 3F07A 5THUA 3THHA 5A2SA 2PHAA 2VQQA 2VQWG 5HJAA 4ZUNA 1WVAA 1C3SA 4IE2A 1PQ3A 3EW8A 4QA7A 3SL1A 3E9BA 5ICNB 3MJLA 5DC6A 4FCKA 1HQ5A 5EF7A 5EFGA 5THVA 4ZUPA 1P8QA 4QA1A 4QA6A 4ZUOA 3PZLA 1P8PA 1RLAA 2EF4A 3MENA 3MZ3A 4BZ6A 4QA4A 4GSZA 1HQXA 3C10A 1WVBA 3MFVA 3NIOA 2VQMA 4HWWA 5G10A 5EEMA 5IX0A 2EIVA 4Q3RC 3MZ6A 4Q3TA 1P8RA 2PLLA 4BZ9A 3THJA 1ZPGA 2GH6A 5EEKA 3MZ7A 4RN0A 5EF8A 4RHIA 4RHKA 3Q9FA 3THEA 5EFNA 3RLAA 4CQFA 1TBJA 1T67A 4DZ4A 4Q41A 3EZTA 4QA3A 5G3WA 1ZZ0A 3RQDA 1C3PA 4IE1A 5D1BA 3TH7A 1T64A 3E6KA 1ZZ3A 4IXVA 1WOGA 5JI5A 3NIQA 2V5XA 1WOHA 4G3HA 4HZEA 1T5GA 3ZNRA 4CBYA 2VCGA 5LI3A 5IWGA 3MFWA 4Q40A 1T69A 5EEIA 1TA1A 1T4SA 2EF5A 3E6VA 4Q3RA 1TBHA 3F80A 1HQGA 3LP4A 4MYLA 5DC7A 5FCWA 2VQJA 1HQFA 3NIPA 2PHOA 1WOIA 4BZ7A 5D1CA 3MZ4A 4CBTA 1T4TA 4Q3VA 3SJTA 2VQOA 4IU5A 1VKGA 2RLAA 4RHQA 5RLAA 2AEBA 4MYNA 3E8ZA 4GSMA 4BZ5A 5BWZA 1D3VA 5THTA 5G0IA 3SFHA 5FUEA 5G17A 5DC5A 3DJ8A 3MAXA 5G12A 1GQ7A 3M1RA 3F06A 2V5WA 1XFKA 2CEVA 4HXQA 1HQHA 1P8NA 5G0YA 5HJ9A 3LP7A 4RN1A 4QA5A 3SKKA 5EENA 4ZUQA 4IU4A 1T4RA 1ZZ1A 3Q9CA 3SFFA 4GWCA 3C0YA 3LHLA
chains in the Genus database with same CATH topology
4IXUA 4Q3QA 4GSVA 4CEVA 4IU1A 1P8OA 4MYKA 3CEVA 4Q3SA 4MXRA 4RLAA 1T4PA 1TBLA 3KV2A 1GQ6A 1CEVA 1P8MA 2ZAVA 4I06A 4ITYA 4IU0A 4GWDA 4RHLA 5CEVA 3SL0A 4MYFA 1T5FA 4Q3UA 2A0MA 4RHMA 4Q3PA 3GN0A 4FCIA 3TF3A 1ZPEA 3MMRA 4Q42A 3GMZA 1R1OA 4IE3A 4RHJA 1P8SA 5HJAA 3THHA 2PHAA 1WVAA 3SL1A 4IE2A 1PQ3A 3E9BA 3MJLA 4FCKA 1HQ5A 1P8QA 3PZLA 1P8PA 1RLAA 2EF4A 4GSZA 1HQXA 3MFVA 1WVBA 3NIOA 4HWWA 2EIVA 4Q3RC 4Q3TA 1P8RA 2PLLA 3THJA 1ZPGA 4RHIA 4RHKA 3THEA 3RLAA 1TBJA 4DZ4A 4Q41A 4IE1A 3TH7A 3E6KA 4IXVA 1WOGA 3NIQA 1WOHA 4G3HA 4HZEA 1T5GA 3MFWA 4Q40A 1TA1A 1T4SA 2EF5A 3E6VA 4Q3RA 3F80A 1TBHA 1HQGA 3LP4A 4MYLA 1HQFA 3NIPA 2PHOA 1WOIA 1T4TA 4Q3VA 3SJTA 4IU5A 2RLAA 4RHQA 5RLAA 2AEBA 4MYNA 3E8ZA 4GSMA 1D3VA 3DJ8A 1GQ7A 3M1RA 1XFKA 2CEVA 4HXQA 1HQHA 1P8NA 5HJ9A 3LP7A 3SKKA 4IU4A 1T4RA 4GWCA 3E8QA 3LHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IXU A;  4Q3Q A;  4GSV A;  4CEV A;  4IU1 A;  1P8O A;  4MYK A;  3CEV A;  4Q3S A;  4MXR A;  4RLA A;  1T4P A;  1TBL A;  3KV2 A;  1GQ6 A;  1CEV A;  1P8M A;  2ZAV A;  4I06 A;  4ITY A;  4IU0 A;  4GWD A;  4RHL A;  5CEV A;  3SL0 A;  4MYF A;  1T5F A;  4Q3U A;  2A0M A;  4RHM A;  4Q3P A;  3GN0 A;  4FCI A;  3TF3 A;  1ZPE A;  3MMR A;  4Q42 A;  3GMZ A;  1R1O A;  4IE3 A;  4RHJ A;  1P8S A;  5HJA A;  3THH A;  2PHA A;  1WVA A;  3SL1 A;  4IE2 A;  1PQ3 A;  3E9B A;  3MJL A;  4FCK A;  1HQ5 A;  1P8Q A;  3PZL A;  1P8P A;  1RLA A;  2EF4 A;  4GSZ A;  1HQX A;  3MFV A;  1WVB A;  3NIO A;  4HWW A;  2EIV A;  4Q3R C;  4Q3T A;  1P8R A;  2PLL A;  3THJ A;  1ZPG A;  4RHI A;  4RHK A;  3THE A;  3RLA A;  1TBJ A;  4DZ4 A;  4Q41 A;  4IE1 A;  3TH7 A;  3E6K A;  4IXV A;  1WOG A;  3NIQ A;  1WOH A;  4G3H A;  4HZE A;  1T5G A;  3MFW A;  4Q40 A;  1TA1 A;  1T4S A;  2EF5 A;  3E6V A;  4Q3R A;  3F80 A;  1TBH A;  1HQG A;  3LP4 A;  4MYL A;  1HQF A;  3NIP A;  2PHO A;  1WOI A;  1T4T A;  4Q3V A;  3SJT A;  4IU5 A;  2RLA A;  4RHQ A;  5RLA A;  2AEB A;  4MYN A;  3E8Z A;  4GSM A;  1D3V A;  3DJ8 A;  1GQ7 A;  3M1R A;  1XFK A;  2CEV A;  4HXQ A;  1HQH A;  1P8N A;  5HJ9 A;  3LP7 A;  3SKK A;  4IU4 A;  1T4R A;  4GWC A;  3E8Q A;  3LHL A; 
#chains in the Genus database with same CATH topology
 5EEF A;  5EFK B;  3EWF A;  4IXU A;  4Q3Q A;  5G0J A;  5G1C A;  4GSV A;  4QA2 A;  4CEV A;  4A69 A;  4IU1 A;  1P8O A;  3C0Z A;  4MYK A;  3CEV A;  4Q3S A;  5G1B A;  1C3R A;  4BKX B;  4LXZ A;  4MXR A;  4RLA A;  1T4P A;  5G0G A;  1TBL A;  3KV2 A;  1GQ6 A;  1CEV A;  1P8M A;  2ZAV A;  4I06 A;  4ITY A;  4IU0 A;  5G13 A;  4BZ8 A;  5DC8 A;  3Q9B A;  4GWD A;  4RHL A;  5CEV A;  3SL0 A;  4MYF A;  1T5F A;  4Q3U A;  5G1A A;  2A0M A;  4RHM A;  4Q3P A;  3GN0 A;  5G0X A;  3ZNS A;  4FCI A;  3TF3 A;  1ZPE A;  3MMR A;  4QA0 A;  4Q42 A;  4RN2 A;  5EFB D;  1W22 A;  3GMZ A;  3E8Q A;  5EFJ D;  5EFH A;  2VQV A;  4ZUM A;  3Q9E A;  4ZUR A;  5D1D A;  5G0H A;  5THS A;  1R1O A;  5G11 A;  3F0R A;  4IE3 A;  4LY1 A;  1P8S A;  4RHJ A;  3EZP A;  3F07 A;  5THU A;  3THH A;  5A2S A;  2PHA A;  2VQQ A;  2VQW G;  5HJA A;  4ZUN A;  1WVA A;  1C3S A;  4IE2 A;  1PQ3 A;  3EW8 A;  4QA7 A;  3SL1 A;  3E9B A;  5ICN B;  3MJL A;  5DC6 A;  4FCK A;  1HQ5 A;  5EF7 A;  5EFG A;  5THV A;  4ZUP A;  1P8Q A;  4QA1 A;  4QA6 A;  4ZUO A;  3PZL A;  1P8P A;  1RLA A;  2EF4 A;  3MEN A;  3MZ3 A;  4BZ6 A;  4QA4 A;  4GSZ A;  1HQX A;  3C10 A;  1WVB A;  3MFV A;  3NIO A;  2VQM A;  4HWW A;  5G10 A;  5EEM A;  5IX0 A;  2EIV A;  4Q3R C;  3MZ6 A;  4Q3T A;  1P8R A;  2PLL A;  4BZ9 A;  3THJ A;  1ZPG A;  2GH6 A;  5EEK A;  3MZ7 A;  4RN0 A;  5EF8 A;  4RHI A;  4RHK A;  3Q9F A;  3THE A;  5EFN A;  3RLA A;  4CQF A;  1TBJ A;  1T67 A;  4DZ4 A;  4Q41 A;  3EZT A;  4QA3 A;  5G3W A;  1ZZ0 A;  3RQD A;  1C3P A;  4IE1 A;  5D1B A;  3TH7 A;  1T64 A;  3E6K A;  1ZZ3 A;  4IXV A;  1WOG A;  5JI5 A;  3NIQ A;  2V5X A;  1WOH A;  4G3H A;  4HZE A;  1T5G A;  3ZNR A;  4CBY A;  2VCG A;  5LI3 A;  5IWG A;  3MFW A;  4Q40 A;  1T69 A;  5EEI A;  1TA1 A;  1T4S A;  2EF5 A;  3E6V A;  4Q3R A;  1TBH A;  3F80 A;  1HQG A;  3LP4 A;  4MYL A;  5DC7 A;  5FCW A;  2VQJ A;  1HQF A;  3NIP A;  2PHO A;  1WOI A;  4BZ7 A;  5D1C A;  3MZ4 A;  4CBT A;  1T4T A;  4Q3V A;  3SJT A;  2VQO A;  4IU5 A;  1VKG A;  2RLA A;  4RHQ A;  5RLA A;  2AEB A;  4MYN A;  3E8Z A;  4GSM A;  4BZ5 A;  5BWZ A;  1D3V A;  5THT A;  5G0I A;  3SFH A;  5FUE A;  5G17 A;  5DC5 A;  3DJ8 A;  3MAX A;  5G12 A;  1GQ7 A;  3M1R A;  3F06 A;  2V5W A;  1XFK A;  2CEV A;  4HXQ A;  1HQH A;  1P8N A;  5G0Y A;  5HJ9 A;  3LP7 A;  4RN1 A;  4QA5 A;  3SKK A;  5EEN A;  4ZUQ A;  4IU4 A;  1T4R A;  1ZZ1 A;  3Q9C A;  3SFF A;  4GWC A;  3C0Y A;  3LHL A; 
#chains in the Genus database with same CATH homology
 4IXU A;  4Q3Q A;  4GSV A;  4CEV A;  4IU1 A;  1P8O A;  4MYK A;  3CEV A;  4Q3S A;  4MXR A;  4RLA A;  1T4P A;  1TBL A;  3KV2 A;  1GQ6 A;  1CEV A;  1P8M A;  2ZAV A;  4I06 A;  4ITY A;  4IU0 A;  4GWD A;  4RHL A;  5CEV A;  3SL0 A;  4MYF A;  1T5F A;  4Q3U A;  2A0M A;  4RHM A;  4Q3P A;  3GN0 A;  4FCI A;  3TF3 A;  1ZPE A;  3MMR A;  4Q42 A;  3GMZ A;  1R1O A;  4IE3 A;  4RHJ A;  1P8S A;  5HJA A;  3THH A;  2PHA A;  1WVA A;  3SL1 A;  4IE2 A;  1PQ3 A;  3E9B A;  3MJL A;  4FCK A;  1HQ5 A;  1P8Q A;  3PZL A;  1P8P A;  1RLA A;  2EF4 A;  4GSZ A;  1HQX A;  3MFV A;  1WVB A;  3NIO A;  4HWW A;  2EIV A;  4Q3R C;  4Q3T A;  1P8R A;  2PLL A;  3THJ A;  1ZPG A;  4RHI A;  4RHK A;  3THE A;  3RLA A;  1TBJ A;  4DZ4 A;  4Q41 A;  4IE1 A;  3TH7 A;  3E6K A;  4IXV A;  1WOG A;  3NIQ A;  1WOH A;  4G3H A;  4HZE A;  1T5G A;  3MFW A;  4Q40 A;  1TA1 A;  1T4S A;  2EF5 A;  3E6V A;  4Q3R A;  3F80 A;  1TBH A;  1HQG A;  3LP4 A;  4MYL A;  1HQF A;  3NIP A;  2PHO A;  1WOI A;  1T4T A;  4Q3V A;  3SJT A;  4IU5 A;  2RLA A;  4RHQ A;  5RLA A;  2AEB A;  4MYN A;  3E8Z A;  4GSM A;  1D3V A;  3DJ8 A;  1GQ7 A;  3M1R A;  1XFK A;  2CEV A;  4HXQ A;  1HQH A;  1P8N A;  5HJ9 A;  3LP7 A;  3SKK A;  4IU4 A;  1T4R A;  4GWC A;  3E8Q A;  3LHL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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