4Q3TA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor noha
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
345
structure length
336
Chain Sequence
PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 127
structure length 336
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3tA00
1HQFA 4RHIA 3MFVA 3SJTA 3MMRA 3THHA 3E8QA 4IXVA 4RLAA 4Q3VA 4IE2A 4Q3RA 2EIVA 5RLAA 3THJA 4CEVA 4IE1A 4MYKA 1T5GA 4GSVA 4HWWA 3THEA 1CEVA 3NIPA 3TF3A 4Q3UA 3RLAA 4G3HA 1WVBA 2AEBA 1P8QA 1HQHA 1P8OA 1TA1A 3CEVA 3E8ZA 3GN0A 3LHLA 3NIQA 1WOIA 1TBLA 3KV2A 3PZLA 2CEVA 1TBHA 4Q3PA 3LP4A 4HXQA 4IU5A 4IU1A 3E9BA 4MYFA 5HJAA 1P8RA 1R1OA 2EF5A 4RHMA 3MFWA 4FCKA 1HQXA 4Q3SA 1P8MA 4IU4A 4GWCA 3E6VA 3SKKA 1PQ3A 1HQ5A 1T4SA 5HJ9A 1T4RA 1ZPGA 3MJLA 4IXUA 1D3VA 2EF4A 3SL0A 1P8SA 4Q3QA 3F80A 4GWDA 2PLLA 1WOHA 2ZAVA 1HQGA 4RHQA 1P8NA 4Q3TA 3TH7A 3M1RA 1GQ6A 1T5FA 4Q42A 1TBJA 1T4PA 4GSMA 4Q3RC 4MXRA 1T4TA 1XFKA 1GQ7A 4HZEA 3GMZA 1RLAA 4MYNA 1ZPEA 4RHKA 3E6KA 4ITYA 4Q40A 4RHLA 2PHOA 4IU0A 4MYLA 5CEVA 2RLAA 1WOGA 3NIOA 1P8PA 4IE3A 4DZ4A 4Q41A 3LP7A 3DJ8A 4I06A 2PHAA 3SL1A 2A0MA 1WVAA 4RHJA 4FCIA 4GSZA
chains in the Genus database with same CATH superfamily
1HQFA 5EFKB 5G1BA 2VCGA 4RHIA 3MFVA 3EWFA 5G11A 3SJTA 3MMRA 5G17A 3THHA 4RN1A 3E8QA 5G0YA 4IXVA 4RLAA 5G0XA 5G0GA 3MZ4A 4Q3VA 4IE2A 4Q3RA 4RN0A 5G1AA 2EIVA 5RLAA 5THTA 4QA4A 5DC6A 3THJA 3MZ6A 4CEVA 5IWGA 1C3SA 1VKGA 3Q9CA 5FUEA 5G0IA 3RQDA 4IE1A 5EEIA 1T67A 4LXZA 1T5GA 2GH6A 1C3RA 4MYKA 4ZURA 3ZNSA 4GSVA 4HWWA 3THEA 3MZ3A 1CEVA 3NIPA 5D1BA 5A2SA 3TF3A 3F0RA 5G12A 4Q3UA 5EFHA 3RLAA 4G3HA 4BKXB 5EEFA 1WVBA 3F06A 2V5XA 5D1CA 2AEBA 4QA2A 1P8QA 1HQHA 1P8OA 3C0YA 1TA1A 4BZ7A 5BWZA 4QA6A 3CEVA 3E8ZA 3GN0A 3LHLA 1C3PA 5G10A 3EW8A 3NIQA 1WOIA 5D1DA 1TBLA 3KV2A 3PZLA 2CEVA 1TBHA 2VQWG 5DC7A 4Q3PA 3LP4A 4HXQA 4IU5A 4IU1A 3E9BA 4QA5A 3EZPA 4MYFA 5G1CA 2VQVA 5EF8A 4BZ9A 3C10A 5HJAA 1P8RA 1R1OA 3EZTA 4CQFA 2EF5A 4BZ8A 1W22A 1T64A 5EFJD 4BZ6A 3F07A 4RHMA 5EEMA 3MFWA 4FCKA 3MAXA 3MZ7A 1HQXA 4Q3SA 2VQOA 5DC8A 5EFNA 1P8MA 3MENA 5EFBD 5DC5A 4IU4A 4GWCA 4QA0A 5EEKA 3E6VA 3SKKA 1PQ3A 1HQ5A 1T4SA 5HJ9A 1T4RA 1ZPGA 3MJLA 4IXUA 1D3VA 4CBTA 2EF4A 1ZZ3A 3SL0A 1P8SA 4Q3QA 3F80A 4GWDA 2PLLA 1WOHA 5JI5A 2ZAVA 1HQGA 4RHQA 1P8NA 4Q3TA 1ZZ0A 3M1RA 1GQ6A 5EF7A 5G3WA 3TH7A 4CBYA 1T5FA 3Q9FA 4Q42A 1TBJA 1T4PA 4GSMA 4Q3RC 4MXRA 1T4TA 1XFKA 4ZUQA 1GQ7A 4HZEA 5THSA 3GMZA 1RLAA 4MYNA 4ZUPA 3SFHA 1ZPEA 4QA3A 5THUA 4RHKA 3E6KA 4ITYA 4Q40A 4RHLA 2PHOA 4IU0A 4MYLA 5LI3A 3Q9EA 5CEVA 3Q9BA 2RLAA 1WOGA 3NIOA 1P8PA 4IE3A 4ZUMA 4DZ4A 4Q41A 4QA1A 2VQMA 5EFGA 5THVA 4BZ5A 1T69A 3LP7A 3DJ8A 2V5WA 4I06A 5FCWA 5IX0A 1ZZ1A 5G0HA 3SFFA 5G13A 3C0ZA 4ZUNA 2PHAA 4LY1A 5G0JA 3SL1A 3ZNRA 5EENA 4ZUOA 2VQJA 4QA7A 4A69A 2A0MA 4RN2A 1WVAA 4RHJA 5ICNB 4FCIA 4GSZA 2VQQA
chains in the Genus database with same CATH topology
1HQFA 4RHIA 3MFVA 3SJTA 3MMRA 3THHA 3E8QA 4IXVA 4RLAA 4Q3VA 4IE2A 4Q3RA 2EIVA 5RLAA 3THJA 4CEVA 4IE1A 4MYKA 1T5GA 4GSVA 4HWWA 3THEA 1CEVA 3NIPA 3TF3A 4Q3UA 3RLAA 4G3HA 1WVBA 2AEBA 1P8QA 1HQHA 1P8OA 1TA1A 3CEVA 3E8ZA 3GN0A 3LHLA 3NIQA 1WOIA 1TBLA 3KV2A 3PZLA 2CEVA 1TBHA 4Q3PA 3LP4A 4HXQA 4IU5A 4IU1A 3E9BA 4MYFA 5HJAA 1P8RA 1R1OA 2EF5A 4RHMA 3MFWA 4FCKA 1HQXA 4Q3SA 1P8MA 4IU4A 4GWCA 3E6VA 3SKKA 1PQ3A 1HQ5A 1T4SA 5HJ9A 1T4RA 1ZPGA 3MJLA 4IXUA 1D3VA 2EF4A 3SL0A 1P8SA 4Q3QA 3F80A 4GWDA 2PLLA 1WOHA 2ZAVA 1HQGA 4RHQA 1P8NA 4Q3TA 3TH7A 3M1RA 1GQ6A 1T5FA 4Q42A 1TBJA 1T4PA 4GSMA 4Q3RC 4MXRA 1T4TA 1XFKA 1GQ7A 4HZEA 3GMZA 1RLAA 4MYNA 1ZPEA 4RHKA 3E6KA 4ITYA 4Q40A 4RHLA 2PHOA 4IU0A 4MYLA 5CEVA 2RLAA 1WOGA 3NIOA 1P8PA 4IE3A 4DZ4A 4Q41A 3LP7A 3DJ8A 4I06A 2PHAA 3SL1A 2A0MA 1WVAA 4RHJA 4FCIA 4GSZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQF A;  4RHI A;  3MFV A;  3SJT A;  3MMR A;  3THH A;  3E8Q A;  4IXV A;  4RLA A;  4Q3V A;  4IE2 A;  4Q3R A;  2EIV A;  5RLA A;  3THJ A;  4CEV A;  4IE1 A;  4MYK A;  1T5G A;  4GSV A;  4HWW A;  3THE A;  1CEV A;  3NIP A;  3TF3 A;  4Q3U A;  3RLA A;  4G3H A;  1WVB A;  2AEB A;  1P8Q A;  1HQH A;  1P8O A;  1TA1 A;  3CEV A;  3E8Z A;  3GN0 A;  3LHL A;  3NIQ A;  1WOI A;  1TBL A;  3KV2 A;  3PZL A;  2CEV A;  1TBH A;  4Q3P A;  3LP4 A;  4HXQ A;  4IU5 A;  4IU1 A;  3E9B A;  4MYF A;  5HJA A;  1P8R A;  1R1O A;  2EF5 A;  4RHM A;  3MFW A;  4FCK A;  1HQX A;  4Q3S A;  1P8M A;  4IU4 A;  4GWC A;  3E6V A;  3SKK A;  1PQ3 A;  1HQ5 A;  1T4S A;  5HJ9 A;  1T4R A;  1ZPG A;  3MJL A;  4IXU A;  1D3V A;  2EF4 A;  3SL0 A;  1P8S A;  4Q3Q A;  3F80 A;  4GWD A;  2PLL A;  1WOH A;  2ZAV A;  1HQG A;  4RHQ A;  1P8N A;  4Q3T A;  3TH7 A;  3M1R A;  1GQ6 A;  1T5F A;  4Q42 A;  1TBJ A;  1T4P A;  4GSM A;  4Q3R C;  4MXR A;  1T4T A;  1XFK A;  1GQ7 A;  4HZE A;  3GMZ A;  1RLA A;  4MYN A;  1ZPE A;  4RHK A;  3E6K A;  4ITY A;  4Q40 A;  4RHL A;  2PHO A;  4IU0 A;  4MYL A;  5CEV A;  2RLA A;  1WOG A;  3NIO A;  1P8P A;  4IE3 A;  4DZ4 A;  4Q41 A;  3LP7 A;  3DJ8 A;  4I06 A;  2PHA A;  3SL1 A;  2A0M A;  1WVA A;  4RHJ A;  4FCI A;  4GSZ A; 
#chains in the Genus database with same CATH topology
 1HQF A;  5EFK B;  5G1B A;  2VCG A;  4RHI A;  3MFV A;  3EWF A;  5G11 A;  3SJT A;  3MMR A;  5G17 A;  3THH A;  4RN1 A;  3E8Q A;  5G0Y A;  4IXV A;  4RLA A;  5G0X A;  5G0G A;  3MZ4 A;  4Q3V A;  4IE2 A;  4Q3R A;  4RN0 A;  5G1A A;  2EIV A;  5RLA A;  5THT A;  4QA4 A;  5DC6 A;  3THJ A;  3MZ6 A;  4CEV A;  5IWG A;  1C3S A;  1VKG A;  3Q9C A;  5FUE A;  5G0I A;  3RQD A;  4IE1 A;  5EEI A;  1T67 A;  4LXZ A;  1T5G A;  2GH6 A;  1C3R A;  4MYK A;  4ZUR A;  3ZNS A;  4GSV A;  4HWW A;  3THE A;  3MZ3 A;  1CEV A;  3NIP A;  5D1B A;  5A2S A;  3TF3 A;  3F0R A;  5G12 A;  4Q3U A;  5EFH A;  3RLA A;  4G3H A;  4BKX B;  5EEF A;  1WVB A;  3F06 A;  2V5X A;  5D1C A;  2AEB A;  4QA2 A;  1P8Q A;  1HQH A;  1P8O A;  3C0Y A;  1TA1 A;  4BZ7 A;  5BWZ A;  4QA6 A;  3CEV A;  3E8Z A;  3GN0 A;  3LHL A;  1C3P A;  5G10 A;  3EW8 A;  3NIQ A;  1WOI A;  5D1D A;  1TBL A;  3KV2 A;  3PZL A;  2CEV A;  1TBH A;  2VQW G;  5DC7 A;  4Q3P A;  3LP4 A;  4HXQ A;  4IU5 A;  4IU1 A;  3E9B A;  4QA5 A;  3EZP A;  4MYF A;  5G1C A;  2VQV A;  5EF8 A;  4BZ9 A;  3C10 A;  5HJA A;  1P8R A;  1R1O A;  3EZT A;  4CQF A;  2EF5 A;  4BZ8 A;  1W22 A;  1T64 A;  5EFJ D;  4BZ6 A;  3F07 A;  4RHM A;  5EEM A;  3MFW A;  4FCK A;  3MAX A;  3MZ7 A;  1HQX A;  4Q3S A;  2VQO A;  5DC8 A;  5EFN A;  1P8M A;  3MEN A;  5EFB D;  5DC5 A;  4IU4 A;  4GWC A;  4QA0 A;  5EEK A;  3E6V A;  3SKK A;  1PQ3 A;  1HQ5 A;  1T4S A;  5HJ9 A;  1T4R A;  1ZPG A;  3MJL A;  4IXU A;  1D3V A;  4CBT A;  2EF4 A;  1ZZ3 A;  3SL0 A;  1P8S A;  4Q3Q A;  3F80 A;  4GWD A;  2PLL A;  1WOH A;  5JI5 A;  2ZAV A;  1HQG A;  4RHQ A;  1P8N A;  4Q3T A;  1ZZ0 A;  3M1R A;  1GQ6 A;  5EF7 A;  5G3W A;  3TH7 A;  4CBY A;  1T5F A;  3Q9F A;  4Q42 A;  1TBJ A;  1T4P A;  4GSM A;  4Q3R C;  4MXR A;  1T4T A;  1XFK A;  4ZUQ A;  1GQ7 A;  4HZE A;  5THS A;  3GMZ A;  1RLA A;  4MYN A;  4ZUP A;  3SFH A;  1ZPE A;  4QA3 A;  5THU A;  4RHK A;  3E6K A;  4ITY A;  4Q40 A;  4RHL A;  2PHO A;  4IU0 A;  4MYL A;  5LI3 A;  3Q9E A;  5CEV A;  3Q9B A;  2RLA A;  1WOG A;  3NIO A;  1P8P A;  4IE3 A;  4ZUM A;  4DZ4 A;  4Q41 A;  4QA1 A;  2VQM A;  5EFG A;  5THV A;  4BZ5 A;  1T69 A;  3LP7 A;  3DJ8 A;  2V5W A;  4I06 A;  5FCW A;  5IX0 A;  1ZZ1 A;  5G0H A;  3SFF A;  5G13 A;  3C0Z A;  4ZUN A;  2PHA A;  4LY1 A;  5G0J A;  3SL1 A;  3ZNR A;  5EEN A;  4ZUO A;  2VQJ A;  4QA7 A;  4A69 A;  2A0M A;  4RN2 A;  1WVA A;  4RHJ A;  5ICN B;  4FCI A;  4GSZ A;  2VQQ A; 
#chains in the Genus database with same CATH homology
 1HQF A;  4RHI A;  3MFV A;  3SJT A;  3MMR A;  3THH A;  3E8Q A;  4IXV A;  4RLA A;  4Q3V A;  4IE2 A;  4Q3R A;  2EIV A;  5RLA A;  3THJ A;  4CEV A;  4IE1 A;  4MYK A;  1T5G A;  4GSV A;  4HWW A;  3THE A;  1CEV A;  3NIP A;  3TF3 A;  4Q3U A;  3RLA A;  4G3H A;  1WVB A;  2AEB A;  1P8Q A;  1HQH A;  1P8O A;  1TA1 A;  3CEV A;  3E8Z A;  3GN0 A;  3LHL A;  3NIQ A;  1WOI A;  1TBL A;  3KV2 A;  3PZL A;  2CEV A;  1TBH A;  4Q3P A;  3LP4 A;  4HXQ A;  4IU5 A;  4IU1 A;  3E9B A;  4MYF A;  5HJA A;  1P8R A;  1R1O A;  2EF5 A;  4RHM A;  3MFW A;  4FCK A;  1HQX A;  4Q3S A;  1P8M A;  4IU4 A;  4GWC A;  3E6V A;  3SKK A;  1PQ3 A;  1HQ5 A;  1T4S A;  5HJ9 A;  1T4R A;  1ZPG A;  3MJL A;  4IXU A;  1D3V A;  2EF4 A;  3SL0 A;  1P8S A;  4Q3Q A;  3F80 A;  4GWD A;  2PLL A;  1WOH A;  2ZAV A;  1HQG A;  4RHQ A;  1P8N A;  4Q3T A;  3TH7 A;  3M1R A;  1GQ6 A;  1T5F A;  4Q42 A;  1TBJ A;  1T4P A;  4GSM A;  4Q3R C;  4MXR A;  1T4T A;  1XFK A;  1GQ7 A;  4HZE A;  3GMZ A;  1RLA A;  4MYN A;  1ZPE A;  4RHK A;  3E6K A;  4ITY A;  4Q40 A;  4RHL A;  2PHO A;  4IU0 A;  4MYL A;  5CEV A;  2RLA A;  1WOG A;  3NIO A;  1P8P A;  4IE3 A;  4DZ4 A;  4Q41 A;  3LP7 A;  3DJ8 A;  4I06 A;  2PHA A;  3SL1 A;  2A0M A;  1WVA A;  4RHJ A;  4FCI A;  4GSZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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