4Q3UA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
345
structure length
336
Chain Sequence
PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 122
structure length 336
sequence length 345
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3uA00
1WVAA 4IE3A 2ZAVA 5HJAA 1P8OA 1HQ5A 3THEA 2RLAA 3MMRA 3E6VA 4RHQA 1RLAA 4MYNA 1P8QA 1WOHA 1T4TA 1P8PA 1P8SA 3GMZA 4IE2A 5HJ9A 3LP4A 3E8ZA 4RHJA 3E8QA 2EF4A 3PZLA 4MYFA 4Q3UA 4RHMA 4DZ4A 4GSMA 1GQ7A 1TBHA 3THJA 2PHOA 3SL0A 4GWDA 4IU5A 1D3VA 3CEVA 3E9BA 4MYLA 1CEVA 1XFKA 1T5GA 3NIOA 1R1OA 4Q40A 4IXVA 3F80A 3TH7A 1GQ6A 1TBLA 1HQGA 2EIVA 4MYKA 4IU1A 2CEVA 1WVBA 4GSVA 1PQ3A 3SL1A 4Q3TA 3SKKA 4GSZA 1T4PA 4IU0A 2PHAA 4FCIA 4Q3PA 4RHIA 4HZEA 3KV2A 4IU4A 3RLAA 3MFVA 1T4SA 3TF3A 4RHKA 4HXQA 1TA1A 1HQHA 2AEBA 1T5FA 4Q3RC 4Q41A 1P8MA 4CEVA 4MXRA 1ZPGA 2PLLA 4Q3VA 4GWCA 5RLAA 1HQXA 1P8RA 4Q3RA 5CEVA 3E6KA 3MJLA 3MFWA 2A0MA 4FCKA 3GN0A 3NIQA 3LP7A 3SJTA 1WOGA 3M1RA 2EF5A 4HWWA 1T4RA 4Q3SA 3DJ8A 4ITYA 3NIPA 4IE1A 4IXUA 4RLAA 4Q3QA 3LHLA 4RHLA 4G3HA 1WOIA 1HQFA 1TBJA 3THHA 4I06A 4Q42A 1P8NA 1ZPEA
chains in the Genus database with same CATH superfamily
5EEMA 5EENA 4CBTA 5THTA 5G0XA 3MENA 1WVAA 4QA6A 1T69A 4IE3A 2ZAVA 5EEFA 5HJAA 1P8OA 1HQ5A 1T64A 1ZZ3A 5DC8A 4BKXB 2V5WA 1T67A 2VQQA 2RLAA 4ZUOA 5FUEA 3THEA 4BZ6A 5BWZA 5LI3A 3MMRA 3ZNRA 3E6VA 4ZURA 4QA7A 5THSA 4BZ5A 4RN2A 5IWGA 4RHQA 1RLAA 4MYNA 1P8QA 1WOHA 1T4TA 1P8PA 3MZ4A 1P8SA 3GMZA 4IE2A 5FCWA 5HJ9A 3ZNSA 3LP4A 3MZ6A 3Q9EA 3E8ZA 4RHJA 3E8QA 2EF4A 3PZLA 4MYFA 2VQOA 4Q3UA 4RHMA 4RN0A 1GQ7A 1TBHA 4GSMA 5G1CA 2PHOA 5G0GA 3THJA 3MZ3A 3SL0A 2VQJA 4GWDA 3EW8A 4IU5A 3Q9CA 1D3VA 3CEVA 3E9BA 3MAXA 4MYLA 1CEVA 1XFKA 1T5GA 3NIOA 1R1OA 4Q40A 4A69A 4IXVA 3F80A 3TH7A 1GQ6A 4LXZA 1TBLA 4CBYA 1HQGA 2EIVA 4MYKA 4LY1A 5DC7A 3C10A 5EEKA 4IU1A 1C3PA 2CEVA 1WVBA 2VQVA 4GSVA 1PQ3A 3SL1A 5ICNB 4QA5A 5G13A 1C3RA 5D1CA 4ZUMA 4Q3TA 5G3WA 4ZUPA 4GSZA 5DC6A 3SKKA 1T4PA 4IU0A 5A2SA 2PHAA 4FCIA 5THUA 2GH6A 3C0YA 4Q3PA 4RHIA 5G0JA 4DZ4A 4HZEA 3KV2A 5G12A 4IU4A 5IX0A 3MFVA 3RLAA 2V5XA 1T4SA 3TF3A 4QA0A 4RHKA 4HXQA 5EFJD 5G0IA 1C3SA 1TA1A 1HQHA 2AEBA 5G10A 1T5FA 4Q3RC 5EFKB 1P8MA 4CEVA 4Q41A 4MXRA 1ZPGA 2PLLA 3EZPA 4BZ7A 4ZUQA 5DC5A 4Q3VA 5EFBD 4BZ9A 1VKGA 4GWCA 3Q9BA 4ZUNA 5G1AA 4BZ8A 5RLAA 1HQXA 1P8RA 2VQMA 4Q3RA 4QA4A 5CEVA 5G0HA 5D1DA 4QA3A 3SFFA 3E6KA 3MZ7A 3F06A 3MJLA 5EFNA 3F0RA 2VCGA 2VQWG 3MFWA 2A0MA 5EEIA 4FCKA 3Q9FA 3GN0A 3F07A 3NIQA 3LP7A 5THVA 1WOGA 3SJTA 5EFGA 3M1RA 2EF5A 4HWWA 1W22A 4QA2A 4CQFA 1ZZ0A 5G17A 1T4RA 3EZTA 4Q3SA 3DJ8A 4ITYA 3SFHA 4QA1A 3NIPA 1ZZ1A 4IE1A 4IXUA 5G0YA 4RLAA 4RN1A 4Q3QA 5EF7A 3LHLA 5EF8A 4RHLA 5G11A 4G3HA 1WOIA 5JI5A 5EFHA 5D1BA 1HQFA 1TBJA 3THHA 3EWFA 4I06A 3C0ZA 4Q42A 1P8NA 5G1BA 1ZPEA 3RQDA
chains in the Genus database with same CATH topology
1WVAA 4IE3A 2ZAVA 5HJAA 1P8OA 1HQ5A 3THEA 2RLAA 3MMRA 3E6VA 4RHQA 1RLAA 4MYNA 1P8QA 1WOHA 1T4TA 1P8PA 1P8SA 3GMZA 4IE2A 5HJ9A 3LP4A 3E8ZA 4RHJA 3E8QA 2EF4A 3PZLA 4MYFA 4Q3UA 4RHMA 4DZ4A 4GSMA 1GQ7A 1TBHA 3THJA 2PHOA 3SL0A 4GWDA 4IU5A 1D3VA 3CEVA 3E9BA 4MYLA 1CEVA 1XFKA 1T5GA 3NIOA 1R1OA 4Q40A 4IXVA 3F80A 3TH7A 1GQ6A 1TBLA 1HQGA 2EIVA 4MYKA 4IU1A 2CEVA 1WVBA 4GSVA 1PQ3A 3SL1A 4Q3TA 3SKKA 4GSZA 1T4PA 4IU0A 2PHAA 4FCIA 4Q3PA 4RHIA 4HZEA 3KV2A 4IU4A 3RLAA 3MFVA 1T4SA 3TF3A 4RHKA 4HXQA 1TA1A 1HQHA 2AEBA 1T5FA 4Q3RC 4Q41A 1P8MA 4CEVA 4MXRA 1ZPGA 2PLLA 4Q3VA 4GWCA 5RLAA 1HQXA 1P8RA 4Q3RA 5CEVA 3E6KA 3MJLA 3MFWA 2A0MA 4FCKA 3GN0A 3NIQA 3LP7A 3SJTA 1WOGA 3M1RA 2EF5A 4HWWA 1T4RA 4Q3SA 3DJ8A 4ITYA 3NIPA 4IE1A 4IXUA 4RLAA 4Q3QA 3LHLA 4RHLA 4G3HA 1WOIA 1HQFA 1TBJA 3THHA 4I06A 4Q42A 1P8NA 1ZPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WVA A;  4IE3 A;  2ZAV A;  5HJA A;  1P8O A;  1HQ5 A;  3THE A;  2RLA A;  3MMR A;  3E6V A;  4RHQ A;  1RLA A;  4MYN A;  1P8Q A;  1WOH A;  1T4T A;  1P8P A;  1P8S A;  3GMZ A;  4IE2 A;  5HJ9 A;  3LP4 A;  3E8Z A;  4RHJ A;  3E8Q A;  2EF4 A;  3PZL A;  4MYF A;  4Q3U A;  4RHM A;  4DZ4 A;  4GSM A;  1GQ7 A;  1TBH A;  3THJ A;  2PHO A;  3SL0 A;  4GWD A;  4IU5 A;  1D3V A;  3CEV A;  3E9B A;  4MYL A;  1CEV A;  1XFK A;  1T5G A;  3NIO A;  1R1O A;  4Q40 A;  4IXV A;  3F80 A;  3TH7 A;  1GQ6 A;  1TBL A;  1HQG A;  2EIV A;  4MYK A;  4IU1 A;  2CEV A;  1WVB A;  4GSV A;  1PQ3 A;  3SL1 A;  4Q3T A;  3SKK A;  4GSZ A;  1T4P A;  4IU0 A;  2PHA A;  4FCI A;  4Q3P A;  4RHI A;  4HZE A;  3KV2 A;  4IU4 A;  3RLA A;  3MFV A;  1T4S A;  3TF3 A;  4RHK A;  4HXQ A;  1TA1 A;  1HQH A;  2AEB A;  1T5F A;  4Q3R C;  4Q41 A;  1P8M A;  4CEV A;  4MXR A;  1ZPG A;  2PLL A;  4Q3V A;  4GWC A;  5RLA A;  1HQX A;  1P8R A;  4Q3R A;  5CEV A;  3E6K A;  3MJL A;  3MFW A;  2A0M A;  4FCK A;  3GN0 A;  3NIQ A;  3LP7 A;  3SJT A;  1WOG A;  3M1R A;  2EF5 A;  4HWW A;  1T4R A;  4Q3S A;  3DJ8 A;  4ITY A;  3NIP A;  4IE1 A;  4IXU A;  4RLA A;  4Q3Q A;  3LHL A;  4RHL A;  4G3H A;  1WOI A;  1HQF A;  1TBJ A;  3THH A;  4I06 A;  4Q42 A;  1P8N A;  1ZPE A; 
#chains in the Genus database with same CATH topology
 5EEM A;  5EEN A;  4CBT A;  5THT A;  5G0X A;  3MEN A;  1WVA A;  4QA6 A;  1T69 A;  4IE3 A;  2ZAV A;  5EEF A;  5HJA A;  1P8O A;  1HQ5 A;  1T64 A;  1ZZ3 A;  5DC8 A;  4BKX B;  2V5W A;  1T67 A;  2VQQ A;  2RLA A;  4ZUO A;  5FUE A;  3THE A;  4BZ6 A;  5BWZ A;  5LI3 A;  3MMR A;  3ZNR A;  3E6V A;  4ZUR A;  4QA7 A;  5THS A;  4BZ5 A;  4RN2 A;  5IWG A;  4RHQ A;  1RLA A;  4MYN A;  1P8Q A;  1WOH A;  1T4T A;  1P8P A;  3MZ4 A;  1P8S A;  3GMZ A;  4IE2 A;  5FCW A;  5HJ9 A;  3ZNS A;  3LP4 A;  3MZ6 A;  3Q9E A;  3E8Z A;  4RHJ A;  3E8Q A;  2EF4 A;  3PZL A;  4MYF A;  2VQO A;  4Q3U A;  4RHM A;  4RN0 A;  1GQ7 A;  1TBH A;  4GSM A;  5G1C A;  2PHO A;  5G0G A;  3THJ A;  3MZ3 A;  3SL0 A;  2VQJ A;  4GWD A;  3EW8 A;  4IU5 A;  3Q9C A;  1D3V A;  3CEV A;  3E9B A;  3MAX A;  4MYL A;  1CEV A;  1XFK A;  1T5G A;  3NIO A;  1R1O A;  4Q40 A;  4A69 A;  4IXV A;  3F80 A;  3TH7 A;  1GQ6 A;  4LXZ A;  1TBL A;  4CBY A;  1HQG A;  2EIV A;  4MYK A;  4LY1 A;  5DC7 A;  3C10 A;  5EEK A;  4IU1 A;  1C3P A;  2CEV A;  1WVB A;  2VQV A;  4GSV A;  1PQ3 A;  3SL1 A;  5ICN B;  4QA5 A;  5G13 A;  1C3R A;  5D1C A;  4ZUM A;  4Q3T A;  5G3W A;  4ZUP A;  4GSZ A;  5DC6 A;  3SKK A;  1T4P A;  4IU0 A;  5A2S A;  2PHA A;  4FCI A;  5THU A;  2GH6 A;  3C0Y A;  4Q3P A;  4RHI A;  5G0J A;  4DZ4 A;  4HZE A;  3KV2 A;  5G12 A;  4IU4 A;  5IX0 A;  3MFV A;  3RLA A;  2V5X A;  1T4S A;  3TF3 A;  4QA0 A;  4RHK A;  4HXQ A;  5EFJ D;  5G0I A;  1C3S A;  1TA1 A;  1HQH A;  2AEB A;  5G10 A;  1T5F A;  4Q3R C;  5EFK B;  1P8M A;  4CEV A;  4Q41 A;  4MXR A;  1ZPG A;  2PLL A;  3EZP A;  4BZ7 A;  4ZUQ A;  5DC5 A;  4Q3V A;  5EFB D;  4BZ9 A;  1VKG A;  4GWC A;  3Q9B A;  4ZUN A;  5G1A A;  4BZ8 A;  5RLA A;  1HQX A;  1P8R A;  2VQM A;  4Q3R A;  4QA4 A;  5CEV A;  5G0H A;  5D1D A;  4QA3 A;  3SFF A;  3E6K A;  3MZ7 A;  3F06 A;  3MJL A;  5EFN A;  3F0R A;  2VCG A;  2VQW G;  3MFW A;  2A0M A;  5EEI A;  4FCK A;  3Q9F A;  3GN0 A;  3F07 A;  3NIQ A;  3LP7 A;  5THV A;  1WOG A;  3SJT A;  5EFG A;  3M1R A;  2EF5 A;  4HWW A;  1W22 A;  4QA2 A;  4CQF A;  1ZZ0 A;  5G17 A;  1T4R A;  3EZT A;  4Q3S A;  3DJ8 A;  4ITY A;  3SFH A;  4QA1 A;  3NIP A;  1ZZ1 A;  4IE1 A;  4IXU A;  5G0Y A;  4RLA A;  4RN1 A;  4Q3Q A;  5EF7 A;  3LHL A;  5EF8 A;  4RHL A;  5G11 A;  4G3H A;  1WOI A;  5JI5 A;  5EFH A;  5D1B A;  1HQF A;  1TBJ A;  3THH A;  3EWF A;  4I06 A;  3C0Z A;  4Q42 A;  1P8N A;  5G1B A;  1ZPE A;  3RQD A; 
#chains in the Genus database with same CATH homology
 1WVA A;  4IE3 A;  2ZAV A;  5HJA A;  1P8O A;  1HQ5 A;  3THE A;  2RLA A;  3MMR A;  3E6V A;  4RHQ A;  1RLA A;  4MYN A;  1P8Q A;  1WOH A;  1T4T A;  1P8P A;  1P8S A;  3GMZ A;  4IE2 A;  5HJ9 A;  3LP4 A;  3E8Z A;  4RHJ A;  3E8Q A;  2EF4 A;  3PZL A;  4MYF A;  4Q3U A;  4RHM A;  4DZ4 A;  4GSM A;  1GQ7 A;  1TBH A;  3THJ A;  2PHO A;  3SL0 A;  4GWD A;  4IU5 A;  1D3V A;  3CEV A;  3E9B A;  4MYL A;  1CEV A;  1XFK A;  1T5G A;  3NIO A;  1R1O A;  4Q40 A;  4IXV A;  3F80 A;  3TH7 A;  1GQ6 A;  1TBL A;  1HQG A;  2EIV A;  4MYK A;  4IU1 A;  2CEV A;  1WVB A;  4GSV A;  1PQ3 A;  3SL1 A;  4Q3T A;  3SKK A;  4GSZ A;  1T4P A;  4IU0 A;  2PHA A;  4FCI A;  4Q3P A;  4RHI A;  4HZE A;  3KV2 A;  4IU4 A;  3RLA A;  3MFV A;  1T4S A;  3TF3 A;  4RHK A;  4HXQ A;  1TA1 A;  1HQH A;  2AEB A;  1T5F A;  4Q3R C;  4Q41 A;  1P8M A;  4CEV A;  4MXR A;  1ZPG A;  2PLL A;  4Q3V A;  4GWC A;  5RLA A;  1HQX A;  1P8R A;  4Q3R A;  5CEV A;  3E6K A;  3MJL A;  3MFW A;  2A0M A;  4FCK A;  3GN0 A;  3NIQ A;  3LP7 A;  3SJT A;  1WOG A;  3M1R A;  2EF5 A;  4HWW A;  1T4R A;  4Q3S A;  3DJ8 A;  4ITY A;  3NIP A;  4IE1 A;  4IXU A;  4RLA A;  4Q3Q A;  3LHL A;  4RHL A;  4G3H A;  1WOI A;  1HQF A;  1TBJ A;  3THH A;  4I06 A;  4Q42 A;  1P8N A;  1ZPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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