4Q3VA

Crystal structure of schistosoma mansoni arginase in complex with inhibitor bec
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
346
structure length
337
Chain Sequence
PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDCGDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSNKSTPLVIVGGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSFLVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAYFTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTAVPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVHILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Schistosoma mansoni
molecule keywords Arginase
total genus 123
structure length 337
sequence length 346
chains with identical sequence B, C, D
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2014-04-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 4q3vA00
1P8PA 4HZEA 3TH7A 1HQGA 2EF5A 1PQ3A 4GSZA 4IU0A 4ITYA 3THJA 3F80A 4Q3UA 2A0MA 4IE1A 3GN0A 4RHLA 4CEVA 3PZLA 1T5GA 3SKKA 3MFVA 4GWDA 1HQXA 3NIQA 4I06A 3SL1A 4RHJA 1TA1A 1P8OA 4HXQA 1TBJA 4Q3QA 4IU4A 4RHMA 4IXUA 2PLLA 1RLAA 3RLAA 1ZPEA 1WOIA 4Q41A 4G3HA 1T5FA 1GQ7A 4GSMA 1P8SA 1WVBA 3SL0A 1XFKA 4IU1A 2RLAA 3KV2A 3LHLA 2CEVA 3THHA 3E8ZA 1HQ5A 3GMZA 2AEBA 4Q3VA 4RLAA 4MYLA 4Q3PA 1P8RA 1P8NA 3DJ8A 4Q3SA 4RHQA 3TF3A 3NIOA 3MJLA 4RHKA 2PHOA 1CEVA 1P8QA 4HWWA 1HQHA 3NIPA 4IE2A 5HJAA 4Q40A 4MYFA 3E6KA 1R1OA 1WOHA 3SJTA 4MYNA 2PHAA 3LP4A 4Q3RC 2ZAVA 1HQFA 1ZPGA 4IE3A 3THEA 2EF4A 4GSVA 4Q3RA 2EIVA 4GWCA 4Q3TA 1D3VA 3E8QA 4DZ4A 1P8MA 5RLAA 1TBLA 1WVAA 3MFWA 5HJ9A 3E9BA 4Q42A 3E6VA 4RHIA 3LP7A 1T4PA 4IXVA 1GQ6A 1WOGA 1T4TA 4IU5A 5CEVA 4FCKA 1T4SA 1TBHA 1T4RA 4FCIA 4MXRA 3M1RA 3MMRA 4MYKA 3CEVA
chains in the Genus database with same CATH superfamily
1C3SA 1T69A 3MZ6A 1P8PA 3C0ZA 4HZEA 4LXZA 3TH7A 1HQGA 2EF5A 4QA5A 1PQ3A 4GSZA 4IU0A 4ITYA 5G0HA 4LY1A 5EFKB 3F80A 4Q3UA 3THJA 2A0MA 1VKGA 3Q9CA 5A2SA 4IE1A 3GN0A 4RHLA 2VQQA 4CEVA 3PZLA 1ZZ0A 1T5GA 3EZPA 3SKKA 4BZ7A 5D1BA 2VQMA 3MFVA 5D1CA 5G1BA 5EEIA 4GWDA 3EW8A 5FUEA 1HQXA 3NIQA 4QA6A 3MZ7A 4ZUOA 4I06A 5EF7A 3SL1A 3EZTA 4RHJA 1TA1A 5G13A 1P8OA 4HXQA 5ICNB 1TBJA 4Q3QA 3RQDA 3F0RA 5EEKA 5EEFA 4BZ5A 4IU4A 4RHMA 5FCWA 4IXUA 5BWZA 4QA3A 2VQJA 2PLLA 1RLAA 5G3WA 3RLAA 1ZPEA 1WOIA 4Q41A 4ZUQA 4CQFA 4G3HA 4QA4A 1T5FA 1W22A 3ZNSA 1GQ7A 3EWFA 3SFFA 4GSMA 5DC7A 1P8SA 2VCGA 1WVBA 3SL0A 1XFKA 4IU1A 2RLAA 3KV2A 3LHLA 2CEVA 5THSA 5G1AA 5G11A 3THHA 4RN1A 3E8ZA 1HQ5A 4ZUNA 5DC5A 3GMZA 5IWGA 3Q9EA 5EFJD 4BZ9A 2VQWG 2AEBA 4Q3VA 3ZNRA 4RLAA 4QA7A 2VQOA 4MYLA 4QA0A 5LI3A 4Q3PA 1P8RA 1P8NA 3DJ8A 4Q3SA 4RHQA 2VQVA 5D1DA 3TF3A 3NIOA 3MJLA 5EENA 4RHKA 2PHOA 1CEVA 5JI5A 1P8QA 4HWWA 5EFNA 4RN2A 1HQHA 5THUA 3NIPA 4IE2A 1ZZ1A 5HJAA 5EF8A 4Q40A 5EFGA 4MYFA 1C3PA 3E6KA 5THVA 1R1OA 4ZUMA 1WOHA 3SJTA 4MYNA 5G0XA 2PHAA 3LP4A 4Q3RC 2ZAVA 2V5WA 1HQFA 1ZPGA 3MZ3A 4IE3A 4BZ8A 3MAXA 5G12A 4ZUPA 3THEA 2EF4A 3F06A 4GSVA 5DC8A 4Q3RA 1C3RA 2EIVA 4GWCA 4Q3TA 1D3VA 3E8QA 3Q9FA 5G10A 1P8MA 4DZ4A 5RLAA 1T64A 5IX0A 2V5XA 4RN0A 4CBYA 1T67A 1TBLA 1WVAA 1ZZ3A 3MFWA 5G0YA 5HJ9A 5G0GA 5G17A 5G0IA 3E9BA 3MZ4A 4Q42A 5DC6A 5G1CA 4QA1A 4CBTA 3C0YA 3E6VA 4RHIA 3LP7A 1T4PA 3MENA 1GQ6A 1WOGA 4IXVA 4BZ6A 5THTA 1T4TA 4ZURA 4IU5A 5EEMA 5CEVA 4FCKA 1T4SA 4QA2A 3SFHA 1TBHA 1T4RA 5EFBD 4A69A 4BKXB 5EFHA 4FCIA 3F07A 4MXRA 3M1RA 3C10A 3MMRA 2GH6A 4MYKA 5G0JA 3CEVA 3Q9BA
chains in the Genus database with same CATH topology
1P8PA 4HZEA 3TH7A 1HQGA 2EF5A 1PQ3A 4GSZA 4IU0A 4ITYA 3THJA 3F80A 4Q3UA 2A0MA 4IE1A 3GN0A 4RHLA 4CEVA 3PZLA 1T5GA 3SKKA 3MFVA 4GWDA 1HQXA 3NIQA 4I06A 3SL1A 4RHJA 1TA1A 1P8OA 4HXQA 1TBJA 4Q3QA 4IU4A 4RHMA 4IXUA 2PLLA 1RLAA 3RLAA 1ZPEA 1WOIA 4Q41A 4G3HA 1T5FA 1GQ7A 4GSMA 1P8SA 1WVBA 3SL0A 1XFKA 4IU1A 2RLAA 3KV2A 3LHLA 2CEVA 3THHA 3E8ZA 1HQ5A 3GMZA 2AEBA 4Q3VA 4RLAA 4MYLA 4Q3PA 1P8RA 1P8NA 3DJ8A 4Q3SA 4RHQA 3TF3A 3NIOA 3MJLA 4RHKA 2PHOA 1CEVA 1P8QA 4HWWA 1HQHA 3NIPA 4IE2A 5HJAA 4Q40A 4MYFA 3E6KA 1R1OA 1WOHA 3SJTA 4MYNA 2PHAA 3LP4A 4Q3RC 2ZAVA 1HQFA 1ZPGA 4IE3A 3THEA 2EF4A 4GSVA 4Q3RA 2EIVA 4GWCA 4Q3TA 1D3VA 3E8QA 4DZ4A 1P8MA 5RLAA 1TBLA 1WVAA 3MFWA 5HJ9A 3E9BA 4Q42A 3E6VA 4RHIA 3LP7A 1T4PA 4IXVA 1GQ6A 1WOGA 1T4TA 4IU5A 5CEVA 4FCKA 1T4SA 1TBHA 1T4RA 4FCIA 4MXRA 3M1RA 3MMRA 4MYKA 3CEVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P8P A;  4HZE A;  3TH7 A;  1HQG A;  2EF5 A;  1PQ3 A;  4GSZ A;  4IU0 A;  4ITY A;  3THJ A;  3F80 A;  4Q3U A;  2A0M A;  4IE1 A;  3GN0 A;  4RHL A;  4CEV A;  3PZL A;  1T5G A;  3SKK A;  3MFV A;  4GWD A;  1HQX A;  3NIQ A;  4I06 A;  3SL1 A;  4RHJ A;  1TA1 A;  1P8O A;  4HXQ A;  1TBJ A;  4Q3Q A;  4IU4 A;  4RHM A;  4IXU A;  2PLL A;  1RLA A;  3RLA A;  1ZPE A;  1WOI A;  4Q41 A;  4G3H A;  1T5F A;  1GQ7 A;  4GSM A;  1P8S A;  1WVB A;  3SL0 A;  1XFK A;  4IU1 A;  2RLA A;  3KV2 A;  3LHL A;  2CEV A;  3THH A;  3E8Z A;  1HQ5 A;  3GMZ A;  2AEB A;  4Q3V A;  4RLA A;  4MYL A;  4Q3P A;  1P8R A;  1P8N A;  3DJ8 A;  4Q3S A;  4RHQ A;  3TF3 A;  3NIO A;  3MJL A;  4RHK A;  2PHO A;  1CEV A;  1P8Q A;  4HWW A;  1HQH A;  3NIP A;  4IE2 A;  5HJA A;  4Q40 A;  4MYF A;  3E6K A;  1R1O A;  1WOH A;  3SJT A;  4MYN A;  2PHA A;  3LP4 A;  4Q3R C;  2ZAV A;  1HQF A;  1ZPG A;  4IE3 A;  3THE A;  2EF4 A;  4GSV A;  4Q3R A;  2EIV A;  4GWC A;  4Q3T A;  1D3V A;  3E8Q A;  4DZ4 A;  1P8M A;  5RLA A;  1TBL A;  1WVA A;  3MFW A;  5HJ9 A;  3E9B A;  4Q42 A;  3E6V A;  4RHI A;  3LP7 A;  1T4P A;  4IXV A;  1GQ6 A;  1WOG A;  1T4T A;  4IU5 A;  5CEV A;  4FCK A;  1T4S A;  1TBH A;  1T4R A;  4FCI A;  4MXR A;  3M1R A;  3MMR A;  4MYK A;  3CEV A; 
#chains in the Genus database with same CATH topology
 1C3S A;  1T69 A;  3MZ6 A;  1P8P A;  3C0Z A;  4HZE A;  4LXZ A;  3TH7 A;  1HQG A;  2EF5 A;  4QA5 A;  1PQ3 A;  4GSZ A;  4IU0 A;  4ITY A;  5G0H A;  4LY1 A;  5EFK B;  3F80 A;  4Q3U A;  3THJ A;  2A0M A;  1VKG A;  3Q9C A;  5A2S A;  4IE1 A;  3GN0 A;  4RHL A;  2VQQ A;  4CEV A;  3PZL A;  1ZZ0 A;  1T5G A;  3EZP A;  3SKK A;  4BZ7 A;  5D1B A;  2VQM A;  3MFV A;  5D1C A;  5G1B A;  5EEI A;  4GWD A;  3EW8 A;  5FUE A;  1HQX A;  3NIQ A;  4QA6 A;  3MZ7 A;  4ZUO A;  4I06 A;  5EF7 A;  3SL1 A;  3EZT A;  4RHJ A;  1TA1 A;  5G13 A;  1P8O A;  4HXQ A;  5ICN B;  1TBJ A;  4Q3Q A;  3RQD A;  3F0R A;  5EEK A;  5EEF A;  4BZ5 A;  4IU4 A;  4RHM A;  5FCW A;  4IXU A;  5BWZ A;  4QA3 A;  2VQJ A;  2PLL A;  1RLA A;  5G3W A;  3RLA A;  1ZPE A;  1WOI A;  4Q41 A;  4ZUQ A;  4CQF A;  4G3H A;  4QA4 A;  1T5F A;  1W22 A;  3ZNS A;  1GQ7 A;  3EWF A;  3SFF A;  4GSM A;  5DC7 A;  1P8S A;  2VCG A;  1WVB A;  3SL0 A;  1XFK A;  4IU1 A;  2RLA A;  3KV2 A;  3LHL A;  2CEV A;  5THS A;  5G1A A;  5G11 A;  3THH A;  4RN1 A;  3E8Z A;  1HQ5 A;  4ZUN A;  5DC5 A;  3GMZ A;  5IWG A;  3Q9E A;  5EFJ D;  4BZ9 A;  2VQW G;  2AEB A;  4Q3V A;  3ZNR A;  4RLA A;  4QA7 A;  2VQO A;  4MYL A;  4QA0 A;  5LI3 A;  4Q3P A;  1P8R A;  1P8N A;  3DJ8 A;  4Q3S A;  4RHQ A;  2VQV A;  5D1D A;  3TF3 A;  3NIO A;  3MJL A;  5EEN A;  4RHK A;  2PHO A;  1CEV A;  5JI5 A;  1P8Q A;  4HWW A;  5EFN A;  4RN2 A;  1HQH A;  5THU A;  3NIP A;  4IE2 A;  1ZZ1 A;  5HJA A;  5EF8 A;  4Q40 A;  5EFG A;  4MYF A;  1C3P A;  3E6K A;  5THV A;  1R1O A;  4ZUM A;  1WOH A;  3SJT A;  4MYN A;  5G0X A;  2PHA A;  3LP4 A;  4Q3R C;  2ZAV A;  2V5W A;  1HQF A;  1ZPG A;  3MZ3 A;  4IE3 A;  4BZ8 A;  3MAX A;  5G12 A;  4ZUP A;  3THE A;  2EF4 A;  3F06 A;  4GSV A;  5DC8 A;  4Q3R A;  1C3R A;  2EIV A;  4GWC A;  4Q3T A;  1D3V A;  3E8Q A;  3Q9F A;  5G10 A;  1P8M A;  4DZ4 A;  5RLA A;  1T64 A;  5IX0 A;  2V5X A;  4RN0 A;  4CBY A;  1T67 A;  1TBL A;  1WVA A;  1ZZ3 A;  3MFW A;  5G0Y A;  5HJ9 A;  5G0G A;  5G17 A;  5G0I A;  3E9B A;  3MZ4 A;  4Q42 A;  5DC6 A;  5G1C A;  4QA1 A;  4CBT A;  3C0Y A;  3E6V A;  4RHI A;  3LP7 A;  1T4P A;  3MEN A;  1GQ6 A;  1WOG A;  4IXV A;  4BZ6 A;  5THT A;  1T4T A;  4ZUR A;  4IU5 A;  5EEM A;  5CEV A;  4FCK A;  1T4S A;  4QA2 A;  3SFH A;  1TBH A;  1T4R A;  5EFB D;  4A69 A;  4BKX B;  5EFH A;  4FCI A;  3F07 A;  4MXR A;  3M1R A;  3C10 A;  3MMR A;  2GH6 A;  4MYK A;  5G0J A;  3CEV A;  3Q9B A; 
#chains in the Genus database with same CATH homology
 1P8P A;  4HZE A;  3TH7 A;  1HQG A;  2EF5 A;  1PQ3 A;  4GSZ A;  4IU0 A;  4ITY A;  3THJ A;  3F80 A;  4Q3U A;  2A0M A;  4IE1 A;  3GN0 A;  4RHL A;  4CEV A;  3PZL A;  1T5G A;  3SKK A;  3MFV A;  4GWD A;  1HQX A;  3NIQ A;  4I06 A;  3SL1 A;  4RHJ A;  1TA1 A;  1P8O A;  4HXQ A;  1TBJ A;  4Q3Q A;  4IU4 A;  4RHM A;  4IXU A;  2PLL A;  1RLA A;  3RLA A;  1ZPE A;  1WOI A;  4Q41 A;  4G3H A;  1T5F A;  1GQ7 A;  4GSM A;  1P8S A;  1WVB A;  3SL0 A;  1XFK A;  4IU1 A;  2RLA A;  3KV2 A;  3LHL A;  2CEV A;  3THH A;  3E8Z A;  1HQ5 A;  3GMZ A;  2AEB A;  4Q3V A;  4RLA A;  4MYL A;  4Q3P A;  1P8R A;  1P8N A;  3DJ8 A;  4Q3S A;  4RHQ A;  3TF3 A;  3NIO A;  3MJL A;  4RHK A;  2PHO A;  1CEV A;  1P8Q A;  4HWW A;  1HQH A;  3NIP A;  4IE2 A;  5HJA A;  4Q40 A;  4MYF A;  3E6K A;  1R1O A;  1WOH A;  3SJT A;  4MYN A;  2PHA A;  3LP4 A;  4Q3R C;  2ZAV A;  1HQF A;  1ZPG A;  4IE3 A;  3THE A;  2EF4 A;  4GSV A;  4Q3R A;  2EIV A;  4GWC A;  4Q3T A;  1D3V A;  3E8Q A;  4DZ4 A;  1P8M A;  5RLA A;  1TBL A;  1WVA A;  3MFW A;  5HJ9 A;  3E9B A;  4Q42 A;  3E6V A;  4RHI A;  3LP7 A;  1T4P A;  4IXV A;  1GQ6 A;  1WOG A;  1T4T A;  4IU5 A;  5CEV A;  4FCK A;  1T4S A;  1TBH A;  1T4R A;  4FCI A;  4MXR A;  3M1R A;  3MMR A;  4MYK A;  3CEV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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