5EFG | Genus

Total Genus 138

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	138
sequence length	358
structure length	358
Chain Sequence	SPITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Danio rerio
publication title	Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. pubmed doi rcsb
molecule keywords	Hdac6 protein
total genus	138
structure length	358
sequence length	358
chains with identical sequence	D
ec nomenclature	ec 3.5.1.98: Histone deacetylase.
pdb deposition date	2015-10-23

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00850	Hist_deacetyl	Histone deacetylase domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase; Chain A	Histone deacetylase domain	5efgA00

5DC8A 1C3PA 3EZPA 1ZZ0A 5G10A 2VCGA 5G0JA 2VQMA 4QA0A 4BZ7A 1VKGA 3EW8A 5EF8A 4ZURA 3EWFA 5DC6A 5THVA 5ICNB 5EEMA 1W22A 5G12A 4RN0A 3ZNRA 4ZUQA 2V5XA 4BZ9A 1T69A 5G0HA 4BZ6A 1ZZ3A 1C3SA 4LY1A 3Q9BA 5BWZA 5EF7A 3Q9FA 4CBTA 3EZTA 5EEKA 4A69A 4QA4A 5DC7A 4BZ5A 5G0GA 2VQWG 4ZUMA 4ZUPA 5G11A 5A2SA 5G17A 5THUA 4QA6A 3SFFA 5EEIA 3F06A 3ZNSA 3MZ6A 3F0RA 3Q9CA 5EFBD 1C3RA 5G0XA 5D1DA 4ZUOA 4QA3A 5G1CA 5IX0A 3Q9EA 5THSA 5IWGA 4QA2A 5G1AA 5EEFA 4BZ8A 2VQOA 4QA7A 5G1BA 3SFHA 3MAXA 5EFJD 5FCWA 4BKXB 3C0ZA 1ZZ1A 2VQQA 3MZ4A 4CBYA 5EFKB 5EENA 5EFNA 4QA1A 3C0YA 3F07A 1T64A 5DC5A 5LI3A 4LXZA 3MZ3A 5EFHA 4CQFA 5THTA 5G13A 5JI5A 4RN2A 5D1BA 4ZUNA 3RQDA 4RN1A 1T67A 2VQVA 3MENA 2GH6A 3MZ7A 5FUEA 5G3WA 5EFGA 3C10A 5D1CA 5G0IA 5G0YA 2V5WA 4QA5A 2VQJA
chains in the Genus database with same CATH superfamily

4IE3A 3M1RA 5DC8A 1C3PA 2PHAA 1T4PA 4Q3RC 4IXVA 4Q3SA 3EZPA 1ZZ0A 4MYKA 5G10A 3E6KA 2VCGA 5G0JA 3SKKA 1T4RA 2VQMA 4Q40A 4QA0A 4BZ7A 1VKGA 3EW8A 5EF8A 4ZURA 3EWFA 4G3HA 5DC6A 1XFKA 1P8RA 1WOGA 2EIVA 5THVA 5ICNB 5EEMA 1W22A 3PZLA 4RN0A 5G12A 1D3VA 3ZNRA 5HJAA 3LP4A 3TF3A 3LP7A 4ZUQA 2V5XA 1P8NA 4BZ9A 4IE2A 1PQ3A 1T69A 4Q3QA 5G0HA 4RHLA 4BZ6A 3NIQA 4RHKA 1WVBA 1T5GA 3MMRA 3THJA 5RLAA 3GMZA 1ZZ3A 3THHA 4Q41A 1C3SA 4Q3PA 4RLAA 4LY1A 1HQHA 3GN0A 3Q9BA 3CEVA 4HXQA 4HZEA 5BWZA 5CEVA 2CEVA 3Q9FA 1HQ5A 5EF7A 4IU0A 4CBTA 1CEVA 3EZTA 5EEKA 1TBHA 4Q3UA 4IE1A 2ZAVA 4A69A 4FCKA 4QA4A 2A0MA 5DC7A 1T4SA 4BZ5A 5G0GA 1GQ7A 2VQWG 4ZUMA 4IU4A 4IU5A 4RHJA 4ZUPA 4GSVA 5G11A 5A2SA 1ZPEA 5G17A 5THUA 3E8QA 3SJTA 1P8SA 1RLAA 3NIPA 3KV2A 4QA6A 3SFFA 3TH7A 5EEIA 3F06A 4I06A 3ZNSA 3RLAA 3MZ6A 1T5FA 3F0RA 3Q9CA 5EFBD 1C3RA 1WVAA 5G0XA 5D1DA 4ZUOA 4QA3A 5G1CA 4MYFA 5IX0A 3Q9EA 5THSA 4Q42A 5IWGA 4QA2A 5G1AA 4MYNA 2RLAA 4MYLA 5EEFA 4BZ8A 4RHQA 2VQOA 4QA7A 5G1BA 3F80A 1GQ6A 3SFHA 1WOIA 3MAXA 5EFJD 2PLLA 4RHMA 3SL0A 3NIOA 4ITYA 5FCWA 4BKXB 3C0ZA 1ZZ1A 3LHLA 4IXUA 2VQQA 1P8QA 3MZ4A 4CBYA 1R1OA 5EFKB 4HWWA 4GWCA 4IU1A 5EFNA 5EENA 4DZ4A 4QA1A 3C0YA 4MXRA 4GSMA 1P8MA 4Q3RA 3F07A 1T64A 4GSZA 5DC5A 3E8ZA 4LXZA 3MZ3A 5EFHA 4CQFA 1TA1A 5LI3A 5THTA 5G13A 1T4TA 5JI5A 1P8PA 4RN2A 1HQGA 5D1BA 4ZUNA 1ZPGA 3RQDA 4RN1A 1T67A 2VQVA 3MENA 3MJLA 4Q3VA 3MFWA 2GH6A 3MFVA 4RHIA 4CEVA 1HQXA 2EF5A 3MZ7A 3SL1A 2AEBA 3E9BA 1TBJA 5FUEA 5G3WA 1WOHA 2PHOA 3C10A 3DJ8A 4Q3TA 1TBLA 4FCIA 5D1CA 5EFGA 1HQFA 1P8OA 2EF4A 3E6VA 4GWDA 5G0IA 5G0YA 2V5WA 4QA5A 3THEA 5HJ9A 2VQJA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5DC8 A;  1C3P A;  3EZP A;  1ZZ0 A;  5G10 A;  2VCG A;  5G0J A;  2VQM A;  4QA0 A;  4BZ7 A;  1VKG A;  3EW8 A;  5EF8 A;  4ZUR A;  3EWF A;  5DC6 A;  5THV A;  5ICN B;  5EEM A;  1W22 A;  5G12 A;  4RN0 A;  3ZNR A;  4ZUQ A;  2V5X A;  4BZ9 A;  1T69 A;  5G0H A;  4BZ6 A;  1ZZ3 A;  1C3S A;  4LY1 A;  3Q9B A;  5BWZ A;  5EF7 A;  3Q9F A;  4CBT A;  3EZT A;  5EEK A;  4A69 A;  4QA4 A;  5DC7 A;  4BZ5 A;  5G0G A;  2VQW G;  4ZUM A;  4ZUP A;  5G11 A;  5A2S A;  5G17 A;  5THU A;  4QA6 A;  3SFF A;  5EEI A;  3F06 A;  3ZNS A;  3MZ6 A;  3F0R A;  3Q9C A;  5EFB D;  1C3R A;  5G0X A;  5D1D A;  4ZUO A;  4QA3 A;  5G1C A;  5IX0 A;  3Q9E A;  5THS A;  5IWG A;  4QA2 A;  5G1A A;  5EEF A;  4BZ8 A;  2VQO A;  4QA7 A;  5G1B A;  3SFH A;  3MAX A;  5EFJ D;  5FCW A;  4BKX B;  3C0Z A;  1ZZ1 A;  2VQQ A;  3MZ4 A;  4CBY A;  5EFK B;  5EEN A;  5EFN A;  4QA1 A;  3C0Y A;  3F07 A;  1T64 A;  5DC5 A;  5LI3 A;  4LXZ A;  3MZ3 A;  5EFH A;  4CQF A;  5THT A;  5G13 A;  5JI5 A;  4RN2 A;  5D1B A;  4ZUN A;  3RQD A;  4RN1 A;  1T67 A;  2VQV A;  3MEN A;  2GH6 A;  3MZ7 A;  5FUE A;  5G3W A;  5EFG A;  3C10 A;  5D1C A;  5G0I A;  5G0Y A;  2V5W A;  4QA5 A;  2VQJ A; 
#chains in the Genus database with same CATH topology
 4IE3 A;  3M1R A;  5DC8 A;  1C3P A;  2PHA A;  1T4P A;  4Q3R C;  4IXV A;  4Q3S A;  3EZP A;  1ZZ0 A;  4MYK A;  5G10 A;  3E6K A;  2VCG A;  5G0J A;  3SKK A;  1T4R A;  2VQM A;  4Q40 A;  4QA0 A;  4BZ7 A;  1VKG A;  3EW8 A;  5EF8 A;  4ZUR A;  3EWF A;  4G3H A;  5DC6 A;  1XFK A;  1P8R A;  1WOG A;  2EIV A;  5THV A;  5ICN B;  5EEM A;  1W22 A;  3PZL A;  4RN0 A;  5G12 A;  1D3V A;  3ZNR A;  5HJA A;  3LP4 A;  3TF3 A;  3LP7 A;  4ZUQ A;  2V5X A;  1P8N A;  4BZ9 A;  4IE2 A;  1PQ3 A;  1T69 A;  4Q3Q A;  5G0H A;  4RHL A;  4BZ6 A;  3NIQ A;  4RHK A;  1WVB A;  1T5G A;  3MMR A;  3THJ A;  5RLA A;  3GMZ A;  1ZZ3 A;  3THH A;  4Q41 A;  1C3S A;  4Q3P A;  4RLA A;  4LY1 A;  1HQH A;  3GN0 A;  3Q9B A;  3CEV A;  4HXQ A;  4HZE A;  5BWZ A;  5CEV A;  2CEV A;  3Q9F A;  1HQ5 A;  5EF7 A;  4IU0 A;  4CBT A;  1CEV A;  3EZT A;  5EEK A;  1TBH A;  4Q3U A;  4IE1 A;  2ZAV A;  4A69 A;  4FCK A;  4QA4 A;  2A0M A;  5DC7 A;  1T4S A;  4BZ5 A;  5G0G A;  1GQ7 A;  2VQW G;  4ZUM A;  4IU4 A;  4IU5 A;  4RHJ A;  4ZUP A;  4GSV A;  5G11 A;  5A2S A;  1ZPE A;  5G17 A;  5THU A;  3E8Q A;  3SJT A;  1P8S A;  1RLA A;  3NIP A;  3KV2 A;  4QA6 A;  3SFF A;  3TH7 A;  5EEI A;  3F06 A;  4I06 A;  3ZNS A;  3RLA A;  3MZ6 A;  1T5F A;  3F0R A;  3Q9C A;  5EFB D;  1C3R A;  1WVA A;  5G0X A;  5D1D A;  4ZUO A;  4QA3 A;  5G1C A;  4MYF A;  5IX0 A;  3Q9E A;  5THS A;  4Q42 A;  5IWG A;  4QA2 A;  5G1A A;  4MYN A;  2RLA A;  4MYL A;  5EEF A;  4BZ8 A;  4RHQ A;  2VQO A;  4QA7 A;  5G1B A;  3F80 A;  1GQ6 A;  3SFH A;  1WOI A;  3MAX A;  5EFJ D;  2PLL A;  4RHM A;  3SL0 A;  3NIO A;  4ITY A;  5FCW A;  4BKX B;  3C0Z A;  1ZZ1 A;  3LHL A;  4IXU A;  2VQQ A;  1P8Q A;  3MZ4 A;  4CBY A;  1R1O A;  5EFK B;  4HWW A;  4GWC A;  4IU1 A;  5EFN A;  5EEN A;  4DZ4 A;  4QA1 A;  3C0Y A;  4MXR A;  4GSM A;  1P8M A;  4Q3R A;  3F07 A;  1T64 A;  4GSZ A;  5DC5 A;  3E8Z A;  4LXZ A;  3MZ3 A;  5EFH A;  4CQF A;  1TA1 A;  5LI3 A;  5THT A;  5G13 A;  1T4T A;  5JI5 A;  1P8P A;  4RN2 A;  1HQG A;  5D1B A;  4ZUN A;  1ZPG A;  3RQD A;  4RN1 A;  1T67 A;  2VQV A;  3MEN A;  3MJL A;  4Q3V A;  3MFW A;  2GH6 A;  3MFV A;  4RHI A;  4CEV A;  1HQX A;  2EF5 A;  3MZ7 A;  3SL1 A;  2AEB A;  3E9B A;  1TBJ A;  5FUE A;  5G3W A;  1WOH A;  2PHO A;  3C10 A;  3DJ8 A;  4Q3T A;  1TBL A;  4FCI A;  5D1C A;  5EFG A;  1HQF A;  1P8O A;  2EF4 A;  3E6V A;  4GWD A;  5G0I A;  5G0Y A;  2V5W A;  4QA5 A;  3THE A;  5HJ9 A;  2VQJ A; 
#chains in the Genus database with same CATH homology
 5DC8 A;  1C3P A;  3EZP A;  1ZZ0 A;  5G10 A;  2VCG A;  5G0J A;  2VQM A;  4QA0 A;  4BZ7 A;  1VKG A;  3EW8 A;  5EF8 A;  4ZUR A;  3EWF A;  5DC6 A;  5THV A;  5ICN B;  5EEM A;  1W22 A;  5G12 A;  4RN0 A;  3ZNR A;  4ZUQ A;  2V5X A;  4BZ9 A;  1T69 A;  5G0H A;  4BZ6 A;  1ZZ3 A;  1C3S A;  4LY1 A;  3Q9B A;  5BWZ A;  5EF7 A;  3Q9F A;  4CBT A;  3EZT A;  5EEK A;  4A69 A;  4QA4 A;  5DC7 A;  4BZ5 A;  5G0G A;  2VQW G;  4ZUM A;  4ZUP A;  5G11 A;  5A2S A;  5G17 A;  5THU A;  4QA6 A;  3SFF A;  5EEI A;  3F06 A;  3ZNS A;  3MZ6 A;  3F0R A;  3Q9C A;  5EFB D;  1C3R A;  5G0X A;  5D1D A;  4ZUO A;  4QA3 A;  5G1C A;  5IX0 A;  3Q9E A;  5THS A;  5IWG A;  4QA2 A;  5G1A A;  5EEF A;  4BZ8 A;  2VQO A;  4QA7 A;  5G1B A;  3SFH A;  3MAX A;  5EFJ D;  5FCW A;  4BKX B;  3C0Z A;  1ZZ1 A;  2VQQ A;  3MZ4 A;  4CBY A;  5EFK B;  5EEN A;  5EFN A;  4QA1 A;  3C0Y A;  3F07 A;  1T64 A;  5DC5 A;  5LI3 A;  4LXZ A;  3MZ3 A;  5EFH A;  4CQF A;  5THT A;  5G13 A;  5JI5 A;  4RN2 A;  5D1B A;  4ZUN A;  3RQD A;  4RN1 A;  1T67 A;  2VQV A;  3MEN A;  2GH6 A;  3MZ7 A;  5FUE A;  5G3W A;  5EFG A;  3C10 A;  5D1C A;  5G0I A;  5G0Y A;  2V5W A;  4QA5 A;  2VQJ A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5EFGA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations