5EFHA

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with trifluoroketone transition state analogue
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
356
structure length
356
Chain Sequence
ITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
molecule tags Hydrolase
source organism Danio rerio
molecule keywords Hdac6 protein
total genus 141
structure length 356
sequence length 356
chains with identical sequence D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5efhA00
5D1BA 5ICNB 2VCGA 1T64A 3EZPA 4ZUPA 4CQFA 5D1CA 3SFFA 5DC8A 5THSA 2VQQA 1T67A 5JI5A 4CBTA 4CBYA 5EEMA 3F0RA 4BZ5A 3EZTA 5G0YA 5G12A 4BKXB 2V5WA 3C10A 5EF8A 5THTA 4BZ8A 3Q9EA 4ZURA 4RN2A 5G1BA 5FUEA 4QA2A 3MZ6A 5G17A 5IWGA 3MENA 4BZ9A 4RN1A 1W22A 4A69A 1ZZ0A 4QA4A 3EWFA 5G0GA 3Q9BA 5EFNA 1ZZ1A 4LXZA 5G11A 5DC7A 5EF7A 5EEKA 3ZNSA 4QA5A 5THVA 4QA1A 3EW8A 1C3PA 4ZUQA 3MAXA 1VKGA 5THUA 5EEIA 3F06A 3RQDA 3MZ3A 3MZ4A 5EFHA 3F07A 4ZUOA 1C3RA 5BWZA 1T69A 4LY1A 3C0ZA 5G0IA 5IX0A 2VQJA 4QA7A 5EFJD 5EFKB 5LI3A 2GH6A 5A2SA 1C3SA 4QA6A 5EFGA 2VQVA 5G0HA 5G13A 3SFHA 5DC5A 3C0YA 4QA3A 4QA0A 3MZ7A 3Q9FA 5EEFA 5G3WA 3Q9CA 5DC6A 4ZUNA 2VQOA 3ZNRA 5EENA 5D1DA 1ZZ3A 2VQMA 5G0XA 5G10A 5FCWA 5G1AA 4BZ7A 2V5XA 2VQWG 4ZUMA 4RN0A 5EFBD 5G0JA 5G1CA 4BZ6A
chains in the Genus database with same CATH superfamily
4DZ4A 4MYFA 5D1BA 4GSMA 5ICNB 2VCGA 1T64A 1HQHA 3EZPA 4ZUPA 1T5GA 4CQFA 4Q42A 1P8RA 4IU0A 4IU4A 5D1CA 1GQ7A 4IXVA 1P8OA 1P8NA 3SFFA 5DC8A 5THSA 4RHJA 1GQ6A 2VQQA 1P8SA 4IE3A 1T67A 1P8QA 3DJ8A 1WOHA 1TBJA 4Q3TA 5JI5A 4CBTA 4IU1A 4Q3VA 3THHA 4CBYA 5EEMA 1HQFA 3F0RA 4BZ5A 1WOGA 2EF4A 4Q3RC 3EZTA 5G0YA 5G12A 4MXRA 4BKXB 5HJAA 2V5WA 1D3VA 1HQ5A 4HXQA 3THEA 1HQGA 3C10A 3TH7A 3E8QA 5EF8A 3KV2A 3MFVA 5RLAA 5THTA 4BZ8A 1TBLA 3Q9EA 2CEVA 4ZURA 4RHQA 2A0MA 4RN2A 1WVBA 4FCIA 4RHMA 5G1BA 1T4SA 5FUEA 1ZPGA 3MZ6A 3GMZA 4QA2A 5G17A 5IWGA 3MENA 4BZ9A 4RN1A 1W22A 2AEBA 4A69A 1ZZ0A 2PHAA 4QA4A 3EWFA 5G0GA 3Q9BA 3SKKA 4Q3SA 5HJ9A 4IE2A 4CEVA 1PQ3A 4GWDA 4Q3QA 4Q3UA 3PZLA 4HWWA 1RLAA 1T4TA 5EFNA 1ZZ1A 4LXZA 3E6VA 5G11A 5DC7A 5EF7A 5EEKA 3RLAA 2RLAA 1T4PA 4MYNA 3ZNSA 4QA5A 3CEVA 5THVA 4QA1A 3EW8A 1C3PA 1P8PA 4ZUQA 1TA1A 3LHLA 3MAXA 4GSZA 4RLAA 1VKGA 4IU5A 5THUA 3NIPA 5EEIA 3LP4A 3F06A 3RQDA 3MZ3A 3SJTA 3E6KA 5CEVA 3MZ4A 5EFHA 3F07A 4MYLA 4ZUOA 1C3RA 1WVAA 5BWZA 3E8ZA 4RHLA 1T69A 2EF5A 1CEVA 4HZEA 4IXUA 1ZPEA 3C0ZA 1XFKA 1WOIA 3MFWA 4LY1A 4IE1A 5G0IA 5IX0A 2VQJA 4QA7A 1HQXA 4I06A 4RHIA 5EFJD 5EFKB 1T4RA 3LP7A 4G3HA 2GH6A 5LI3A 5A2SA 1C3SA 4Q41A 4QA6A 3M1RA 4Q40A 3GN0A 5EFGA 2VQVA 4GSVA 4RHKA 5G0HA 5G13A 3SFHA 2EIVA 5DC5A 3MJLA 3C0YA 4QA3A 3NIQA 4Q3PA 4QA0A 3MZ7A 3Q9FA 5EEFA 3F80A 5G3WA 3Q9CA 1R1OA 5DC6A 4Q3RA 4GWCA 1TBHA 4ZUNA 3NIOA 2VQOA 2PLLA 3ZNRA 5EENA 5D1DA 1ZZ3A 3E9BA 2VQMA 4FCKA 5G0XA 5G10A 3SL0A 4ITYA 5FCWA 4MYKA 5G1AA 3THJA 4BZ7A 2V5XA 2PHOA 2VQWG 3MMRA 4ZUMA 3SL1A 4RN0A 5EFBD 3TF3A 1P8MA 5G0JA 2ZAVA 1T5FA 5G1CA 4BZ6A
chains in the Genus database with same CATH topology
5D1BA 5ICNB 2VCGA 1T64A 3EZPA 4ZUPA 4CQFA 5D1CA 3SFFA 5DC8A 5THSA 2VQQA 1T67A 5JI5A 4CBTA 4CBYA 5EEMA 3F0RA 4BZ5A 3EZTA 5G0YA 5G12A 4BKXB 2V5WA 3C10A 5EF8A 5THTA 4BZ8A 3Q9EA 4ZURA 4RN2A 5G1BA 5FUEA 4QA2A 3MZ6A 5G17A 5IWGA 3MENA 4BZ9A 4RN1A 1W22A 4A69A 1ZZ0A 4QA4A 3EWFA 5G0GA 3Q9BA 5EFNA 1ZZ1A 4LXZA 5G11A 5DC7A 5EF7A 5EEKA 3ZNSA 4QA5A 5THVA 4QA1A 3EW8A 1C3PA 4ZUQA 3MAXA 1VKGA 5THUA 5EEIA 3F06A 3RQDA 3MZ3A 3MZ4A 5EFHA 3F07A 4ZUOA 1C3RA 5BWZA 1T69A 4LY1A 3C0ZA 5G0IA 5IX0A 2VQJA 4QA7A 5EFJD 5EFKB 5LI3A 2GH6A 5A2SA 1C3SA 4QA6A 5EFGA 2VQVA 5G0HA 5G13A 3SFHA 5DC5A 3C0YA 4QA3A 4QA0A 3MZ7A 3Q9FA 5EEFA 5G3WA 3Q9CA 5DC6A 4ZUNA 2VQOA 3ZNRA 5EENA 5D1DA 1ZZ3A 2VQMA 5G0XA 5G10A 5FCWA 5G1AA 4BZ7A 2V5XA 2VQWG 4ZUMA 4RN0A 5EFBD 5G0JA 5G1CA 4BZ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D1B A;  5ICN B;  2VCG A;  1T64 A;  3EZP A;  4ZUP A;  4CQF A;  5D1C A;  3SFF A;  5DC8 A;  5THS A;  2VQQ A;  1T67 A;  5JI5 A;  4CBT A;  4CBY A;  5EEM A;  3F0R A;  4BZ5 A;  3EZT A;  5G0Y A;  5G12 A;  4BKX B;  2V5W A;  3C10 A;  5EF8 A;  5THT A;  4BZ8 A;  3Q9E A;  4ZUR A;  4RN2 A;  5G1B A;  5FUE A;  4QA2 A;  3MZ6 A;  5G17 A;  5IWG A;  3MEN A;  4BZ9 A;  4RN1 A;  1W22 A;  4A69 A;  1ZZ0 A;  4QA4 A;  3EWF A;  5G0G A;  3Q9B A;  5EFN A;  1ZZ1 A;  4LXZ A;  5G11 A;  5DC7 A;  5EF7 A;  5EEK A;  3ZNS A;  4QA5 A;  5THV A;  4QA1 A;  3EW8 A;  1C3P A;  4ZUQ A;  3MAX A;  1VKG A;  5THU A;  5EEI A;  3F06 A;  3RQD A;  3MZ3 A;  3MZ4 A;  5EFH A;  3F07 A;  4ZUO A;  1C3R A;  5BWZ A;  1T69 A;  4LY1 A;  3C0Z A;  5G0I A;  5IX0 A;  2VQJ A;  4QA7 A;  5EFJ D;  5EFK B;  5LI3 A;  2GH6 A;  5A2S A;  1C3S A;  4QA6 A;  5EFG A;  2VQV A;  5G0H A;  5G13 A;  3SFH A;  5DC5 A;  3C0Y A;  4QA3 A;  4QA0 A;  3MZ7 A;  3Q9F A;  5EEF A;  5G3W A;  3Q9C A;  5DC6 A;  4ZUN A;  2VQO A;  3ZNR A;  5EEN A;  5D1D A;  1ZZ3 A;  2VQM A;  5G0X A;  5G10 A;  5FCW A;  5G1A A;  4BZ7 A;  2V5X A;  2VQW G;  4ZUM A;  4RN0 A;  5EFB D;  5G0J A;  5G1C A;  4BZ6 A; 
#chains in the Genus database with same CATH topology
 4DZ4 A;  4MYF A;  5D1B A;  4GSM A;  5ICN B;  2VCG A;  1T64 A;  1HQH A;  3EZP A;  4ZUP A;  1T5G A;  4CQF A;  4Q42 A;  1P8R A;  4IU0 A;  4IU4 A;  5D1C A;  1GQ7 A;  4IXV A;  1P8O A;  1P8N A;  3SFF A;  5DC8 A;  5THS A;  4RHJ A;  1GQ6 A;  2VQQ A;  1P8S A;  4IE3 A;  1T67 A;  1P8Q A;  3DJ8 A;  1WOH A;  1TBJ A;  4Q3T A;  5JI5 A;  4CBT A;  4IU1 A;  4Q3V A;  3THH A;  4CBY A;  5EEM A;  1HQF A;  3F0R A;  4BZ5 A;  1WOG A;  2EF4 A;  4Q3R C;  3EZT A;  5G0Y A;  5G12 A;  4MXR A;  4BKX B;  5HJA A;  2V5W A;  1D3V A;  1HQ5 A;  4HXQ A;  3THE A;  1HQG A;  3C10 A;  3TH7 A;  3E8Q A;  5EF8 A;  3KV2 A;  3MFV A;  5RLA A;  5THT A;  4BZ8 A;  1TBL A;  3Q9E A;  2CEV A;  4ZUR A;  4RHQ A;  2A0M A;  4RN2 A;  1WVB A;  4FCI A;  4RHM A;  5G1B A;  1T4S A;  5FUE A;  1ZPG A;  3MZ6 A;  3GMZ A;  4QA2 A;  5G17 A;  5IWG A;  3MEN A;  4BZ9 A;  4RN1 A;  1W22 A;  2AEB A;  4A69 A;  1ZZ0 A;  2PHA A;  4QA4 A;  3EWF A;  5G0G A;  3Q9B A;  3SKK A;  4Q3S A;  5HJ9 A;  4IE2 A;  4CEV A;  1PQ3 A;  4GWD A;  4Q3Q A;  4Q3U A;  3PZL A;  4HWW A;  1RLA A;  1T4T A;  5EFN A;  1ZZ1 A;  4LXZ A;  3E6V A;  5G11 A;  5DC7 A;  5EF7 A;  5EEK A;  3RLA A;  2RLA A;  1T4P A;  4MYN A;  3ZNS A;  4QA5 A;  3CEV A;  5THV A;  4QA1 A;  3EW8 A;  1C3P A;  1P8P A;  4ZUQ A;  1TA1 A;  3LHL A;  3MAX A;  4GSZ A;  4RLA A;  1VKG A;  4IU5 A;  5THU A;  3NIP A;  5EEI A;  3LP4 A;  3F06 A;  3RQD A;  3MZ3 A;  3SJT A;  3E6K A;  5CEV A;  3MZ4 A;  5EFH A;  3F07 A;  4MYL A;  4ZUO A;  1C3R A;  1WVA A;  5BWZ A;  3E8Z A;  4RHL A;  1T69 A;  2EF5 A;  1CEV A;  4HZE A;  4IXU A;  1ZPE A;  3C0Z A;  1XFK A;  1WOI A;  3MFW A;  4LY1 A;  4IE1 A;  5G0I A;  5IX0 A;  2VQJ A;  4QA7 A;  1HQX A;  4I06 A;  4RHI A;  5EFJ D;  5EFK B;  1T4R A;  3LP7 A;  4G3H A;  2GH6 A;  5LI3 A;  5A2S A;  1C3S A;  4Q41 A;  4QA6 A;  3M1R A;  4Q40 A;  3GN0 A;  5EFG A;  2VQV A;  4GSV A;  4RHK A;  5G0H A;  5G13 A;  3SFH A;  2EIV A;  5DC5 A;  3MJL A;  3C0Y A;  4QA3 A;  3NIQ A;  4Q3P A;  4QA0 A;  3MZ7 A;  3Q9F A;  5EEF A;  3F80 A;  5G3W A;  3Q9C A;  1R1O A;  5DC6 A;  4Q3R A;  4GWC A;  1TBH A;  4ZUN A;  3NIO A;  2VQO A;  2PLL A;  3ZNR A;  5EEN A;  5D1D A;  1ZZ3 A;  3E9B A;  2VQM A;  4FCK A;  5G0X A;  5G10 A;  3SL0 A;  4ITY A;  5FCW A;  4MYK A;  5G1A A;  3THJ A;  4BZ7 A;  2V5X A;  2PHO A;  2VQW G;  3MMR A;  4ZUM A;  3SL1 A;  4RN0 A;  5EFB D;  3TF3 A;  1P8M A;  5G0J A;  2ZAV A;  1T5F A;  5G1C A;  4BZ6 A; 
#chains in the Genus database with same CATH homology
 5D1B A;  5ICN B;  2VCG A;  1T64 A;  3EZP A;  4ZUP A;  4CQF A;  5D1C A;  3SFF A;  5DC8 A;  5THS A;  2VQQ A;  1T67 A;  5JI5 A;  4CBT A;  4CBY A;  5EEM A;  3F0R A;  4BZ5 A;  3EZT A;  5G0Y A;  5G12 A;  4BKX B;  2V5W A;  3C10 A;  5EF8 A;  5THT A;  4BZ8 A;  3Q9E A;  4ZUR A;  4RN2 A;  5G1B A;  5FUE A;  4QA2 A;  3MZ6 A;  5G17 A;  5IWG A;  3MEN A;  4BZ9 A;  4RN1 A;  1W22 A;  4A69 A;  1ZZ0 A;  4QA4 A;  3EWF A;  5G0G A;  3Q9B A;  5EFN A;  1ZZ1 A;  4LXZ A;  5G11 A;  5DC7 A;  5EF7 A;  5EEK A;  3ZNS A;  4QA5 A;  5THV A;  4QA1 A;  3EW8 A;  1C3P A;  4ZUQ A;  3MAX A;  1VKG A;  5THU A;  5EEI A;  3F06 A;  3RQD A;  3MZ3 A;  3MZ4 A;  5EFH A;  3F07 A;  4ZUO A;  1C3R A;  5BWZ A;  1T69 A;  4LY1 A;  3C0Z A;  5G0I A;  5IX0 A;  2VQJ A;  4QA7 A;  5EFJ D;  5EFK B;  5LI3 A;  2GH6 A;  5A2S A;  1C3S A;  4QA6 A;  5EFG A;  2VQV A;  5G0H A;  5G13 A;  3SFH A;  5DC5 A;  3C0Y A;  4QA3 A;  4QA0 A;  3MZ7 A;  3Q9F A;  5EEF A;  5G3W A;  3Q9C A;  5DC6 A;  4ZUN A;  2VQO A;  3ZNR A;  5EEN A;  5D1D A;  1ZZ3 A;  2VQM A;  5G0X A;  5G10 A;  5FCW A;  5G1A A;  4BZ7 A;  2V5X A;  2VQW G;  4ZUM A;  4RN0 A;  5EFB D;  5G0J A;  5G1C A;  4BZ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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