5FCWA

Hdac8 complexed with a hydroxamic acid
Total Genus 130
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
365
structure length
364
Chain Sequence
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI1 (29-32)AH1 (22-29)TIV1 (32-35)TII1 (34-37)AH10 (308-323)AH2 (37-48)AH5 (108-128)3H1 (50-53)TIV3 (99-102)AH3 (64-68)AH4 (73-84)TIV2 (68-71)S3 (133-136)TI2 (90-93)TI4 (141-144)3H2 (93-96)TVIII1 (100-103)TIV4 (105-108)TI'1 (150-153)TIV8 (305-308)AH8 (237-255)AH6 (157-166)TIV5 (129-132)TVIII4 (169-172)TI5 (145-148)TI6 (166-169)AH9 (281-293)S5 (195-202)S4 (172-176)TI9 (213-216)O1 (181-183)AH7 (183-189)3H3 (220-222)S7 (259-263)TI7 (189-192)TI8 (192-195)TII2 (204-207)TVIa1 (207-210)TI13 (341-344)TVIa2 (340-343)TI10 (266-269)TII3 (222-225)S6 (226-231)TII4 (232-235)TIV7 (257-260)3H4 (337-339)TI11 (272-275)TII5 (269-272)S8 (298-301)TI12 (334-337)S1 (17-19)S2 (55-57)AH11 (359-375)TI3 (136-139)TVIII3 (153-156)O2 (351-353)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 130
structure length 364
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5fcwA00
5G0HA 4QA6A 3EW8A 5DC7A 5THUA 3MZ4A 5EENA 5G13A 5LI3A 3ZNSA 5ICNB 3EZTA 1ZZ3A 1ZZ1A 5EF7A 5DC5A 4LY1A 2VQMA 5D1CA 3F0RA 3RQDA 3EWFA 1W22A 3F06A 5G1CA 5G17A 4RN1A 5D1BA 2VQJA 5G10A 4CBTA 5EFJD 5EEMA 4ZURA 4CBYA 4ZUQA 5G0IA 5THVA 2VQWG 5FUEA 3C0ZA 5G0GA 2VQOA 4LXZA 4QA7A 5G1AA 3MZ6A 5A2SA 2V5XA 5IWGA 3Q9EA 3Q9BA 5DC8A 5G11A 1T69A 5EEKA 3MAXA 5EFBD 4BZ5A 4QA4A 5G3WA 1C3SA 3Q9CA 4BKXB 5G0YA 4ZUMA 5G1BA 4CQFA 4BZ9A 5EFHA 3MZ3A 3C10A 4QA3A 5DC6A 1C3RA 4QA2A 5G0JA 5JI5A 2VQVA 4ZUNA 3EZPA 3SFHA 5FCWA 3Q9FA 5BWZA 1C3PA 4RN0A 4ZUOA 2VQQA 4QA5A 2V5WA 4A69A 4QA1A 3MENA 4RN2A 3ZNRA 3SFFA 1T67A 5EEFA 1VKGA 5EFGA 3MZ7A 5G0XA 4BZ8A 5EFKB 5EFNA 5THTA 3C0YA 5THSA 2VCGA 3F07A 5IX0A 1ZZ0A 2GH6A 4BZ7A 5EF8A 5G12A 5D1DA 4QA0A 4ZUPA 4BZ6A 1T64A 5EEIA
chains in the Genus database with same CATH superfamily
4GWCA 5G0HA 3SL0A 3SKKA 4QA6A 3EW8A 5DC7A 5THUA 4BZ6A 4HXQA 3PZLA 4IU5A 3MFVA 3THHA 4DZ4A 3MZ4A 4Q3TA 5EENA 5G13A 5LI3A 1WOGA 3ZNSA 5ICNB 4IE3A 3EZTA 4GWDA 1ZZ3A 1ZZ1A 1XFKA 5EF7A 5EEIA 5DC5A 4LY1A 3E9BA 4RHIA 2VQMA 4IU4A 3SJTA 1T4PA 1P8OA 5D1CA 4RHMA 4RLAA 3F0RA 4CEVA 3RQDA 3EWFA 1HQ5A 3GMZA 5RLAA 1W22A 4Q3QA 1R1OA 3F06A 3MJLA 5G1CA 5G17A 4RN1A 5D1BA 4MYLA 4GSZA 1P8MA 1RLAA 4Q42A 2VQJA 4FCIA 1WVBA 5G10A 4CBTA 5EFJD 1CEVA 5EEMA 4ZURA 4IU0A 4CBYA 5G0IA 4ZUQA 5THVA 2VQWG 5FUEA 1WOHA 3C0ZA 5G0GA 3GN0A 2CEVA 2VQOA 2ZAVA 4LXZA 3LP7A 1HQXA 1P8QA 4QA7A 5G1AA 1P8PA 3MZ6A 5A2SA 2V5XA 5IWGA 5CEVA 3Q9EA 3THJA 1P8RA 4MYFA 1T4SA 2EF4A 3E6KA 3Q9BA 5DC8A 5G11A 1T69A 5EEKA 3MAXA 1GQ7A 1T5FA 4HZEA 5EFBD 4IU1A 4BZ5A 2PLLA 4QA4A 5G3WA 5HJAA 3F80A 1C3SA 1T5GA 3Q9CA 4Q3UA 4BKXB 1TBHA 3DJ8A 4RHQA 3TH7A 4Q3SA 5G0YA 4Q3RC 2PHOA 4ZUMA 5G1BA 4CQFA 2A0MA 4G3HA 1T4TA 4BZ9A 1HQFA 2EF5A 5EFHA 3MZ3A 3C10A 3CEVA 4QA3A 4MXRA 5DC6A 4ITYA 1C3RA 4GSVA 4QA2A 5G0JA 1D3VA 5JI5A 4Q41A 4Q3RA 3MFWA 2VQVA 4ZUNA 3EZPA 2AEBA 3SFHA 3TF3A 5FCWA 2RLAA 3Q9FA 1TBJA 1C3PA 5BWZA 4I06A 4RN0A 4ZUOA 2PHAA 1ZPGA 2VQQA 4FCKA 2V5WA 4MYNA 4QA5A 4IE1A 4A69A 3E6VA 4QA1A 3THEA 3MENA 4RN2A 3E8QA 4RHKA 3ZNRA 1ZPEA 1TBLA 3SFFA 1T67A 1TA1A 5EEFA 4GSMA 1WOIA 1HQHA 1VKGA 3MZ7A 3M1RA 4IXUA 5EFGA 4HWWA 5G0XA 3RLAA 4BZ8A 1P8SA 5EFKB 5EFNA 4RHLA 3LHLA 5THTA 3NIOA 1GQ6A 3C0YA 4IXVA 5THSA 2VCGA 3F07A 3LP4A 3MMRA 4MYKA 4Q3VA 5IX0A 3SL1A 3NIQA 3KV2A 1ZZ0A 2EIVA 4IE2A 2GH6A 5HJ9A 4Q40A 4BZ7A 5EF8A 1P8NA 1HQGA 3E8ZA 4Q3PA 3NIPA 4QA0A 4RHJA 5D1DA 4ZUPA 5G12A 1T64A 1WVAA 1T4RA 1PQ3A
chains in the Genus database with same CATH topology
5G0HA 4QA6A 3EW8A 5DC7A 5THUA 3MZ4A 5EENA 5G13A 5LI3A 3ZNSA 5ICNB 3EZTA 1ZZ3A 1ZZ1A 5EF7A 5DC5A 4LY1A 2VQMA 5D1CA 3F0RA 3RQDA 3EWFA 1W22A 3F06A 5G1CA 5G17A 4RN1A 5D1BA 2VQJA 5G10A 4CBTA 5EFJD 5EEMA 4ZURA 4CBYA 4ZUQA 5G0IA 5THVA 2VQWG 5FUEA 3C0ZA 5G0GA 2VQOA 4LXZA 4QA7A 5G1AA 3MZ6A 5A2SA 2V5XA 5IWGA 3Q9EA 3Q9BA 5DC8A 5G11A 1T69A 5EEKA 3MAXA 5EFBD 4BZ5A 4QA4A 5G3WA 1C3SA 3Q9CA 4BKXB 5G0YA 4ZUMA 5G1BA 4CQFA 4BZ9A 5EFHA 3MZ3A 3C10A 4QA3A 5DC6A 1C3RA 4QA2A 5G0JA 5JI5A 2VQVA 4ZUNA 3EZPA 3SFHA 5FCWA 3Q9FA 5BWZA 1C3PA 4RN0A 4ZUOA 2VQQA 4QA5A 2V5WA 4A69A 4QA1A 3MENA 4RN2A 3ZNRA 3SFFA 1T67A 5EEFA 1VKGA 5EFGA 3MZ7A 5G0XA 4BZ8A 5EFKB 5EFNA 5THTA 3C0YA 5THSA 2VCGA 3F07A 5IX0A 1ZZ0A 2GH6A 4BZ7A 5EF8A 5G12A 5D1DA 4QA0A 4ZUPA 4BZ6A 1T64A 5EEIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G0H A;  4QA6 A;  3EW8 A;  5DC7 A;  5THU A;  3MZ4 A;  5EEN A;  5G13 A;  5LI3 A;  3ZNS A;  5ICN B;  3EZT A;  1ZZ3 A;  1ZZ1 A;  5EF7 A;  5DC5 A;  4LY1 A;  2VQM A;  5D1C A;  3F0R A;  3RQD A;  3EWF A;  1W22 A;  3F06 A;  5G1C A;  5G17 A;  4RN1 A;  5D1B A;  2VQJ A;  5G10 A;  4CBT A;  5EFJ D;  5EEM A;  4ZUR A;  4CBY A;  4ZUQ A;  5G0I A;  5THV A;  2VQW G;  5FUE A;  3C0Z A;  5G0G A;  2VQO A;  4LXZ A;  4QA7 A;  5G1A A;  3MZ6 A;  5A2S A;  2V5X A;  5IWG A;  3Q9E A;  3Q9B A;  5DC8 A;  5G11 A;  1T69 A;  5EEK A;  3MAX A;  5EFB D;  4BZ5 A;  4QA4 A;  5G3W A;  1C3S A;  3Q9C A;  4BKX B;  5G0Y A;  4ZUM A;  5G1B A;  4CQF A;  4BZ9 A;  5EFH A;  3MZ3 A;  3C10 A;  4QA3 A;  5DC6 A;  1C3R A;  4QA2 A;  5G0J A;  5JI5 A;  2VQV A;  4ZUN A;  3EZP A;  3SFH A;  5FCW A;  3Q9F A;  5BWZ A;  1C3P A;  4RN0 A;  4ZUO A;  2VQQ A;  4QA5 A;  2V5W A;  4A69 A;  4QA1 A;  3MEN A;  4RN2 A;  3ZNR A;  3SFF A;  1T67 A;  5EEF A;  1VKG A;  5EFG A;  3MZ7 A;  5G0X A;  4BZ8 A;  5EFK B;  5EFN A;  5THT A;  3C0Y A;  5THS A;  2VCG A;  3F07 A;  5IX0 A;  1ZZ0 A;  2GH6 A;  4BZ7 A;  5EF8 A;  5G12 A;  5D1D A;  4QA0 A;  4ZUP A;  4BZ6 A;  1T64 A;  5EEI A; 
#chains in the Genus database with same CATH topology
 4GWC A;  5G0H A;  3SL0 A;  3SKK A;  4QA6 A;  3EW8 A;  5DC7 A;  5THU A;  4BZ6 A;  4HXQ A;  3PZL A;  4IU5 A;  3MFV A;  3THH A;  4DZ4 A;  3MZ4 A;  4Q3T A;  5EEN A;  5G13 A;  5LI3 A;  1WOG A;  3ZNS A;  5ICN B;  4IE3 A;  3EZT A;  4GWD A;  1ZZ3 A;  1ZZ1 A;  1XFK A;  5EF7 A;  5EEI A;  5DC5 A;  4LY1 A;  3E9B A;  4RHI A;  2VQM A;  4IU4 A;  3SJT A;  1T4P A;  1P8O A;  5D1C A;  4RHM A;  4RLA A;  3F0R A;  4CEV A;  3RQD A;  3EWF A;  1HQ5 A;  3GMZ A;  5RLA A;  1W22 A;  4Q3Q A;  1R1O A;  3F06 A;  3MJL A;  5G1C A;  5G17 A;  4RN1 A;  5D1B A;  4MYL A;  4GSZ A;  1P8M A;  1RLA A;  4Q42 A;  2VQJ A;  4FCI A;  1WVB A;  5G10 A;  4CBT A;  5EFJ D;  1CEV A;  5EEM A;  4ZUR A;  4IU0 A;  4CBY A;  5G0I A;  4ZUQ A;  5THV A;  2VQW G;  5FUE A;  1WOH A;  3C0Z A;  5G0G A;  3GN0 A;  2CEV A;  2VQO A;  2ZAV A;  4LXZ A;  3LP7 A;  1HQX A;  1P8Q A;  4QA7 A;  5G1A A;  1P8P A;  3MZ6 A;  5A2S A;  2V5X A;  5IWG A;  5CEV A;  3Q9E A;  3THJ A;  1P8R A;  4MYF A;  1T4S A;  2EF4 A;  3E6K A;  3Q9B A;  5DC8 A;  5G11 A;  1T69 A;  5EEK A;  3MAX A;  1GQ7 A;  1T5F A;  4HZE A;  5EFB D;  4IU1 A;  4BZ5 A;  2PLL A;  4QA4 A;  5G3W A;  5HJA A;  3F80 A;  1C3S A;  1T5G A;  3Q9C A;  4Q3U A;  4BKX B;  1TBH A;  3DJ8 A;  4RHQ A;  3TH7 A;  4Q3S A;  5G0Y A;  4Q3R C;  2PHO A;  4ZUM A;  5G1B A;  4CQF A;  2A0M A;  4G3H A;  1T4T A;  4BZ9 A;  1HQF A;  2EF5 A;  5EFH A;  3MZ3 A;  3C10 A;  3CEV A;  4QA3 A;  4MXR A;  5DC6 A;  4ITY A;  1C3R A;  4GSV A;  4QA2 A;  5G0J A;  1D3V A;  5JI5 A;  4Q41 A;  4Q3R A;  3MFW A;  2VQV A;  4ZUN A;  3EZP A;  2AEB A;  3SFH A;  3TF3 A;  5FCW A;  2RLA A;  3Q9F A;  1TBJ A;  1C3P A;  5BWZ A;  4I06 A;  4RN0 A;  4ZUO A;  2PHA A;  1ZPG A;  2VQQ A;  4FCK A;  2V5W A;  4MYN A;  4QA5 A;  4IE1 A;  4A69 A;  3E6V A;  4QA1 A;  3THE A;  3MEN A;  4RN2 A;  3E8Q A;  4RHK A;  3ZNR A;  1ZPE A;  1TBL A;  3SFF A;  1T67 A;  1TA1 A;  5EEF A;  4GSM A;  1WOI A;  1HQH A;  1VKG A;  3MZ7 A;  3M1R A;  4IXU A;  5EFG A;  4HWW A;  5G0X A;  3RLA A;  4BZ8 A;  1P8S A;  5EFK B;  5EFN A;  4RHL A;  3LHL A;  5THT A;  3NIO A;  1GQ6 A;  3C0Y A;  4IXV A;  5THS A;  2VCG A;  3F07 A;  3LP4 A;  3MMR A;  4MYK A;  4Q3V A;  5IX0 A;  3SL1 A;  3NIQ A;  3KV2 A;  1ZZ0 A;  2EIV A;  4IE2 A;  2GH6 A;  5HJ9 A;  4Q40 A;  4BZ7 A;  5EF8 A;  1P8N A;  1HQG A;  3E8Z A;  4Q3P A;  3NIP A;  4QA0 A;  4RHJ A;  5D1D A;  4ZUP A;  5G12 A;  1T64 A;  1WVA A;  1T4R A;  1PQ3 A; 
#chains in the Genus database with same CATH homology
 5G0H A;  4QA6 A;  3EW8 A;  5DC7 A;  5THU A;  3MZ4 A;  5EEN A;  5G13 A;  5LI3 A;  3ZNS A;  5ICN B;  3EZT A;  1ZZ3 A;  1ZZ1 A;  5EF7 A;  5DC5 A;  4LY1 A;  2VQM A;  5D1C A;  3F0R A;  3RQD A;  3EWF A;  1W22 A;  3F06 A;  5G1C A;  5G17 A;  4RN1 A;  5D1B A;  2VQJ A;  5G10 A;  4CBT A;  5EFJ D;  5EEM A;  4ZUR A;  4CBY A;  4ZUQ A;  5G0I A;  5THV A;  2VQW G;  5FUE A;  3C0Z A;  5G0G A;  2VQO A;  4LXZ A;  4QA7 A;  5G1A A;  3MZ6 A;  5A2S A;  2V5X A;  5IWG A;  3Q9E A;  3Q9B A;  5DC8 A;  5G11 A;  1T69 A;  5EEK A;  3MAX A;  5EFB D;  4BZ5 A;  4QA4 A;  5G3W A;  1C3S A;  3Q9C A;  4BKX B;  5G0Y A;  4ZUM A;  5G1B A;  4CQF A;  4BZ9 A;  5EFH A;  3MZ3 A;  3C10 A;  4QA3 A;  5DC6 A;  1C3R A;  4QA2 A;  5G0J A;  5JI5 A;  2VQV A;  4ZUN A;  3EZP A;  3SFH A;  5FCW A;  3Q9F A;  5BWZ A;  1C3P A;  4RN0 A;  4ZUO A;  2VQQ A;  4QA5 A;  2V5W A;  4A69 A;  4QA1 A;  3MEN A;  4RN2 A;  3ZNR A;  3SFF A;  1T67 A;  5EEF A;  1VKG A;  5EFG A;  3MZ7 A;  5G0X A;  4BZ8 A;  5EFK B;  5EFN A;  5THT A;  3C0Y A;  5THS A;  2VCG A;  3F07 A;  5IX0 A;  1ZZ0 A;  2GH6 A;  4BZ7 A;  5EF8 A;  5G12 A;  5D1D A;  4QA0 A;  4ZUP A;  4BZ6 A;  1T64 A;  5EEI A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.