5FUEA

Crystal structure of schistosoma mansoni hdac8 complexed with 3- benzamido-benzohydroxamate
Total Genus 148
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
434
structure length
398
Chain Sequence
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDSPSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDCPGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCYLNDIVLAIHRLVSSQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASPGFFPGTGTWNPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQLY

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (3-6)TVIII1 (128-131)EMPTYAH2 (23-35)AH1 (9-16)S3 (132-135)TI1 (18-21)TI2 (19-22)AH11 (343-362)AH3 (52-60)AH4 (65-78)TIV1 (60-63)TVIII3 (152-155)TI'1 (149-152)AH5 (86-95)AH6 (106-127)TII'1 (98-101)AH9 (255-273)TIV7 (300-315)AH10 (318-328)TI3 (135-138)S4 (180-184)TI4 (140-143)TIV3 (144-147)S5 (203-210)AH8 (191-197)TIV5 (222-232)O1 (189-191)3H3 (378-381)TI5 (197-200)TI6 (200-203)TII1 (212-215)3H2 (238-240)TII2 (240-243)S7 (277-281)TI8 (287-290)S6 (244-249)TIV8 (301-316)TIV9 (340-343)S2 (42-44)3H1 (38-40)S8 (333-336)TIV4 (148-151)TVIa1 (215-218)TI10 (375-378)TVIII5 (275-278)TI11 (382-385)AH7 (156-166)TII3 (250-253)TI9 (290-293)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Schistosoma mansoni
publication title Structure-Based Design and Synthesis of Novel Inhibitors Targeting Hdac8 from Schistosoma Mansoni for the Treatment of Schistosomiasis.
pubmed doi rcsb
molecule keywords HISTONE DEACETYLASE 8
total genus 148
structure length 398
sequence length 434
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2016-01-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5fueA00
4RN2A 1VKGA 5EEMA 5G1BA 5LI3A 3EZTA 4QA1A 2VQWG 5G1CA 3Q9BA 5EF7A 2VQJA 4QA0A 5A2SA 4ZUMA 3RQDA 5D1BA 5G11A 2VQMA 3SFHA 5EF8A 5EEFA 4BZ6A 1T67A 4ZUPA 5G0GA 1T64A 3MAXA 5THTA 4CQFA 3ZNSA 2VQVA 5BWZA 3C0ZA 4RN0A 1ZZ0A 1C3RA 4BKXB 5EFJD 5EFHA 5DC8A 5G0XA 3Q9EA 5D1DA 3F07A 5IWGA 5IX0A 4LXZA 5FCWA 4BZ7A 5G17A 2V5WA 5G1AA 4ZURA 2VCGA 3Q9FA 4ZUOA 5EFGA 5EEKA 4QA7A 4QA6A 5THVA 4LY1A 4QA3A 4BZ8A 5JI5A 4ZUQA 4RN1A 4CBYA 3Q9CA 5G13A 3EZPA 5G0JA 5EFKB 3EWFA 3F06A 5G0IA 5DC6A 4BZ9A 5D1CA 5THSA 3MZ3A 5DC5A 4BZ5A 3C0YA 5EFNA 5G3WA 5ICNB 1T69A 3EW8A 3MZ4A 5FUEA 5EFBD 2VQOA 3MENA 4A69A 1W22A 4ZUNA 3C10A 3MZ6A 4QA5A 5EENA 3SFFA 5THUA 4QA4A 4CBTA 3MZ7A 5G0YA 2VQQA 1ZZ1A 2GH6A 1C3SA 4QA2A 3ZNRA 5EEIA 3F0RA 5G12A 2V5XA 5G0HA 1C3PA 5G10A 5DC7A 1ZZ3A
chains in the Genus database with same CATH superfamily
4RHLA 4MYKA 4MYLA 1HQFA 4RN2A 1VKGA 5EEMA 1T4TA 4ZUNA 3EZTA 3F80A 4GSMA 4QA1A 2PHAA 5G1BA 3THEA 4RHIA 4MYFA 1ZPEA 2VQWG 1P8RA 5G1CA 3Q9BA 4IU0A 4DZ4A 4IXVA 5EF7A 1RLAA 2VQJA 3THHA 4Q3RC 4Q42A 1CEVA 4FCIA 3RLAA 4QA0A 5A2SA 3E6VA 4ZUMA 3RQDA 1P8SA 2EF4A 3NIOA 5D1BA 1P8NA 4Q3VA 5G11A 2VQMA 3SFHA 5EF8A 5EEFA 4BZ6A 3GN0A 3SL0A 1T67A 4IE1A 4ZUPA 5G0GA 1T4RA 1T64A 3MAXA 1ZPGA 5THTA 4CQFA 1HQHA 3ZNSA 4RLAA 4RHKA 2VQVA 5BWZA 1TBLA 3C0ZA 4IU1A 2PLLA 1T5GA 2PHOA 4RN0A 4ITYA 4HZEA 3SL1A 3TF3A 1ZZ0A 1C3RA 1TBJA 4GSVA 4BKXB 5EFJD 3MMRA 5DC8A 2EF5A 3E6KA 5EFHA 5G0XA 1T5FA 2A0MA 3Q9EA 3LP4A 5D1DA 1P8MA 4Q40A 4Q3RA 4Q3TA 3THJA 3F07A 5IWGA 5IX0A 4LXZA 5FCWA 4BZ7A 4RHJA 3DJ8A 4GWDA 5G17A 2V5WA 3NIQA 4ZURA 5G1AA 4RHQA 5HJ9A 3E8QA 1TBHA 2VCGA 3LP7A 4RHMA 4Q3QA 3Q9FA 4ZUOA 4Q3PA 3NIPA 1WVAA 3PZLA 5EFGA 5EEKA 4QA7A 5CEVA 4QA6A 5THVA 4LY1A 4QA3A 4Q3SA 1TA1A 1P8QA 4BZ8A 1WVBA 3E8ZA 3TH7A 3SKKA 5JI5A 4ZUQA 4HXQA 4Q3UA 3KV2A 4RN1A 4CBYA 3MFVA 5LI3A 3Q9CA 2RLAA 4FCKA 2CEVA 4IE3A 1GQ6A 3GMZA 4HWWA 5G13A 4IU4A 1D3VA 3EZPA 5G0JA 3EWFA 5EFKB 1T4PA 3F06A 5G0IA 5DC6A 4BZ9A 4I06A 5D1CA 5THSA 3MZ3A 5DC5A 1XFKA 4BZ5A 3C0YA 3MFWA 1HQXA 5EFNA 5G3WA 1R1OA 5ICNB 3LHLA 1P8PA 1T69A 5HJAA 3EW8A 3SJTA 4G3HA 3M1RA 3MZ4A 5FUEA 5EFBD 4Q41A 1GQ7A 2VQOA 4MYNA 3MENA 4A69A 4CEVA 1W22A 3E9BA 4GSZA 2AEBA 3C10A 3MZ6A 4QA5A 4MXRA 1WOIA 5EENA 3SFFA 5THUA 4QA4A 4CBTA 4IU5A 3MJLA 1T4SA 3MZ7A 1WOGA 4IE2A 5G0YA 5RLAA 1HQ5A 2VQQA 1ZZ1A 1PQ3A 2GH6A 1P8OA 1C3SA 4IXUA 4QA2A 3ZNRA 1WOHA 2EIVA 3F0RA 1HQGA 5EEIA 2V5XA 5G0HA 1C3PA 5G12A 3CEVA 4GWCA 5G10A 5DC7A 1ZZ3A 2ZAVA
chains in the Genus database with same CATH topology
4RN2A 1VKGA 5EEMA 5G1BA 5LI3A 3EZTA 4QA1A 2VQWG 5G1CA 3Q9BA 5EF7A 2VQJA 4QA0A 5A2SA 4ZUMA 3RQDA 5D1BA 5G11A 2VQMA 3SFHA 5EF8A 5EEFA 4BZ6A 1T67A 4ZUPA 5G0GA 1T64A 3MAXA 5THTA 4CQFA 3ZNSA 2VQVA 5BWZA 3C0ZA 4RN0A 1ZZ0A 1C3RA 4BKXB 5EFJD 5EFHA 5DC8A 5G0XA 3Q9EA 5D1DA 3F07A 5IWGA 5IX0A 4LXZA 5FCWA 4BZ7A 5G17A 2V5WA 5G1AA 4ZURA 2VCGA 3Q9FA 4ZUOA 5EFGA 5EEKA 4QA7A 4QA6A 5THVA 4LY1A 4QA3A 4BZ8A 5JI5A 4ZUQA 4RN1A 4CBYA 3Q9CA 5G13A 3EZPA 5G0JA 5EFKB 3EWFA 3F06A 5G0IA 5DC6A 4BZ9A 5D1CA 5THSA 3MZ3A 5DC5A 4BZ5A 3C0YA 5EFNA 5G3WA 5ICNB 1T69A 3EW8A 3MZ4A 5FUEA 5EFBD 2VQOA 3MENA 4A69A 1W22A 4ZUNA 3C10A 3MZ6A 4QA5A 5EENA 3SFFA 5THUA 4QA4A 4CBTA 3MZ7A 5G0YA 2VQQA 1ZZ1A 2GH6A 1C3SA 4QA2A 3ZNRA 5EEIA 3F0RA 5G12A 2V5XA 5G0HA 1C3PA 5G10A 5DC7A 1ZZ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RN2 A;  1VKG A;  5EEM A;  5G1B A;  5LI3 A;  3EZT A;  4QA1 A;  2VQW G;  5G1C A;  3Q9B A;  5EF7 A;  2VQJ A;  4QA0 A;  5A2S A;  4ZUM A;  3RQD A;  5D1B A;  5G11 A;  2VQM A;  3SFH A;  5EF8 A;  5EEF A;  4BZ6 A;  1T67 A;  4ZUP A;  5G0G A;  1T64 A;  3MAX A;  5THT A;  4CQF A;  3ZNS A;  2VQV A;  5BWZ A;  3C0Z A;  4RN0 A;  1ZZ0 A;  1C3R A;  4BKX B;  5EFJ D;  5EFH A;  5DC8 A;  5G0X A;  3Q9E A;  5D1D A;  3F07 A;  5IWG A;  5IX0 A;  4LXZ A;  5FCW A;  4BZ7 A;  5G17 A;  2V5W A;  5G1A A;  4ZUR A;  2VCG A;  3Q9F A;  4ZUO A;  5EFG A;  5EEK A;  4QA7 A;  4QA6 A;  5THV A;  4LY1 A;  4QA3 A;  4BZ8 A;  5JI5 A;  4ZUQ A;  4RN1 A;  4CBY A;  3Q9C A;  5G13 A;  3EZP A;  5G0J A;  5EFK B;  3EWF A;  3F06 A;  5G0I A;  5DC6 A;  4BZ9 A;  5D1C A;  5THS A;  3MZ3 A;  5DC5 A;  4BZ5 A;  3C0Y A;  5EFN A;  5G3W A;  5ICN B;  1T69 A;  3EW8 A;  3MZ4 A;  5FUE A;  5EFB D;  2VQO A;  3MEN A;  4A69 A;  1W22 A;  4ZUN A;  3C10 A;  3MZ6 A;  4QA5 A;  5EEN A;  3SFF A;  5THU A;  4QA4 A;  4CBT A;  3MZ7 A;  5G0Y A;  2VQQ A;  1ZZ1 A;  2GH6 A;  1C3S A;  4QA2 A;  3ZNR A;  5EEI A;  3F0R A;  5G12 A;  2V5X A;  5G0H A;  1C3P A;  5G10 A;  5DC7 A;  1ZZ3 A; 
#chains in the Genus database with same CATH topology
 4RHL A;  4MYK A;  4MYL A;  1HQF A;  4RN2 A;  1VKG A;  5EEM A;  1T4T A;  4ZUN A;  3EZT A;  3F80 A;  4GSM A;  4QA1 A;  2PHA A;  5G1B A;  3THE A;  4RHI A;  4MYF A;  1ZPE A;  2VQW G;  1P8R A;  5G1C A;  3Q9B A;  4IU0 A;  4DZ4 A;  4IXV A;  5EF7 A;  1RLA A;  2VQJ A;  3THH A;  4Q3R C;  4Q42 A;  1CEV A;  4FCI A;  3RLA A;  4QA0 A;  5A2S A;  3E6V A;  4ZUM A;  3RQD A;  1P8S A;  2EF4 A;  3NIO A;  5D1B A;  1P8N A;  4Q3V A;  5G11 A;  2VQM A;  3SFH A;  5EF8 A;  5EEF A;  4BZ6 A;  3GN0 A;  3SL0 A;  1T67 A;  4IE1 A;  4ZUP A;  5G0G A;  1T4R A;  1T64 A;  3MAX A;  1ZPG A;  5THT A;  4CQF A;  1HQH A;  3ZNS A;  4RLA A;  4RHK A;  2VQV A;  5BWZ A;  1TBL A;  3C0Z A;  4IU1 A;  2PLL A;  1T5G A;  2PHO A;  4RN0 A;  4ITY A;  4HZE A;  3SL1 A;  3TF3 A;  1ZZ0 A;  1C3R A;  1TBJ A;  4GSV A;  4BKX B;  5EFJ D;  3MMR A;  5DC8 A;  2EF5 A;  3E6K A;  5EFH A;  5G0X A;  1T5F A;  2A0M A;  3Q9E A;  3LP4 A;  5D1D A;  1P8M A;  4Q40 A;  4Q3R A;  4Q3T A;  3THJ A;  3F07 A;  5IWG A;  5IX0 A;  4LXZ A;  5FCW A;  4BZ7 A;  4RHJ A;  3DJ8 A;  4GWD A;  5G17 A;  2V5W A;  3NIQ A;  4ZUR A;  5G1A A;  4RHQ A;  5HJ9 A;  3E8Q A;  1TBH A;  2VCG A;  3LP7 A;  4RHM A;  4Q3Q A;  3Q9F A;  4ZUO A;  4Q3P A;  3NIP A;  1WVA A;  3PZL A;  5EFG A;  5EEK A;  4QA7 A;  5CEV A;  4QA6 A;  5THV A;  4LY1 A;  4QA3 A;  4Q3S A;  1TA1 A;  1P8Q A;  4BZ8 A;  1WVB A;  3E8Z A;  3TH7 A;  3SKK A;  5JI5 A;  4ZUQ A;  4HXQ A;  4Q3U A;  3KV2 A;  4RN1 A;  4CBY A;  3MFV A;  5LI3 A;  3Q9C A;  2RLA A;  4FCK A;  2CEV A;  4IE3 A;  1GQ6 A;  3GMZ A;  4HWW A;  5G13 A;  4IU4 A;  1D3V A;  3EZP A;  5G0J A;  3EWF A;  5EFK B;  1T4P A;  3F06 A;  5G0I A;  5DC6 A;  4BZ9 A;  4I06 A;  5D1C A;  5THS A;  3MZ3 A;  5DC5 A;  1XFK A;  4BZ5 A;  3C0Y A;  3MFW A;  1HQX A;  5EFN A;  5G3W A;  1R1O A;  5ICN B;  3LHL A;  1P8P A;  1T69 A;  5HJA A;  3EW8 A;  3SJT A;  4G3H A;  3M1R A;  3MZ4 A;  5FUE A;  5EFB D;  4Q41 A;  1GQ7 A;  2VQO A;  4MYN A;  3MEN A;  4A69 A;  4CEV A;  1W22 A;  3E9B A;  4GSZ A;  2AEB A;  3C10 A;  3MZ6 A;  4QA5 A;  4MXR A;  1WOI A;  5EEN A;  3SFF A;  5THU A;  4QA4 A;  4CBT A;  4IU5 A;  3MJL A;  1T4S A;  3MZ7 A;  1WOG A;  4IE2 A;  5G0Y A;  5RLA A;  1HQ5 A;  2VQQ A;  1ZZ1 A;  1PQ3 A;  2GH6 A;  1P8O A;  1C3S A;  4IXU A;  4QA2 A;  3ZNR A;  1WOH A;  2EIV A;  3F0R A;  1HQG A;  5EEI A;  2V5X A;  5G0H A;  1C3P A;  5G12 A;  3CEV A;  4GWC A;  5G10 A;  5DC7 A;  1ZZ3 A;  2ZAV A; 
#chains in the Genus database with same CATH homology
 4RN2 A;  1VKG A;  5EEM A;  5G1B A;  5LI3 A;  3EZT A;  4QA1 A;  2VQW G;  5G1C A;  3Q9B A;  5EF7 A;  2VQJ A;  4QA0 A;  5A2S A;  4ZUM A;  3RQD A;  5D1B A;  5G11 A;  2VQM A;  3SFH A;  5EF8 A;  5EEF A;  4BZ6 A;  1T67 A;  4ZUP A;  5G0G A;  1T64 A;  3MAX A;  5THT A;  4CQF A;  3ZNS A;  2VQV A;  5BWZ A;  3C0Z A;  4RN0 A;  1ZZ0 A;  1C3R A;  4BKX B;  5EFJ D;  5EFH A;  5DC8 A;  5G0X A;  3Q9E A;  5D1D A;  3F07 A;  5IWG A;  5IX0 A;  4LXZ A;  5FCW A;  4BZ7 A;  5G17 A;  2V5W A;  5G1A A;  4ZUR A;  2VCG A;  3Q9F A;  4ZUO A;  5EFG A;  5EEK A;  4QA7 A;  4QA6 A;  5THV A;  4LY1 A;  4QA3 A;  4BZ8 A;  5JI5 A;  4ZUQ A;  4RN1 A;  4CBY A;  3Q9C A;  5G13 A;  3EZP A;  5G0J A;  5EFK B;  3EWF A;  3F06 A;  5G0I A;  5DC6 A;  4BZ9 A;  5D1C A;  5THS A;  3MZ3 A;  5DC5 A;  4BZ5 A;  3C0Y A;  5EFN A;  5G3W A;  5ICN B;  1T69 A;  3EW8 A;  3MZ4 A;  5FUE A;  5EFB D;  2VQO A;  3MEN A;  4A69 A;  1W22 A;  4ZUN A;  3C10 A;  3MZ6 A;  4QA5 A;  5EEN A;  3SFF A;  5THU A;  4QA4 A;  4CBT A;  3MZ7 A;  5G0Y A;  2VQQ A;  1ZZ1 A;  2GH6 A;  1C3S A;  4QA2 A;  3ZNR A;  5EEI A;  3F0R A;  5G12 A;  2V5X A;  5G0H A;  1C3P A;  5G10 A;  5DC7 A;  1ZZ3 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.