5HJ9A

Crystal structure of leishmania mexicana arginase in complex with inhibitor abhpe
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
311
structure length
311
Chain Sequence
KKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLAATESHVNDTISVGCAIARCMMGETLLYTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of Leishmania mexicana arginase complexed with alpha , alpha-disubstituted boronic amino-acid inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Leishmania mexicana
molecule keywords Arginase
total genus 105
structure length 311
sequence length 311
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2016-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 5hj9A00
4Q3TA 4Q40A 1HQHA 3THEA 4HXQA 3NIQA 3SJTA 4GSZA 1P8SA 4RHQA 2PLLA 3NIOA 3LP4A 3E9BA 2A0MA 1ZPGA 1D3VA 1WOIA 4IXVA 4IU1A 4IXUA 1T4PA 3RLAA 2AEBA 3GMZA 1HQXA 1P8QA 4I06A 3THJA 1GQ7A 3TF3A 3GN0A 4HZEA 4Q3QA 1PQ3A 5HJAA 1WVAA 1GQ6A 4GSMA 4RHKA 3E6VA 4Q3SA 1P8MA 1T5FA 2ZAVA 3E8QA 4G3HA 3SL1A 1WVBA 1RLAA 1P8NA 3E8ZA 4Q42A 2RLAA 4MYFA 3F80A 5HJ9A 1T5GA 3TH7A 4GWCA 3LP7A 4GSVA 1TA1A 3MMRA 3MFWA 4RHLA 1P8RA 2CEVA 4Q3RC 4CEVA 4Q41A 1TBLA 3NIPA 3CEVA 4MYLA 3SKKA 1HQ5A 3M1RA 4ITYA 2PHOA 1TBJA 3SL0A 1TBHA 4MYNA 4IU4A 4IE3A 1HQGA 1R1OA 2PHAA 3MJLA 4RHMA 4IU5A 1XFKA 1HQFA 1CEVA 2EF4A 3MFVA 1T4SA 3THHA 4RLAA 3KV2A 4GWDA 4RHJA 4MXRA 4Q3VA 5RLAA 3LHLA 4FCIA 4Q3UA 4Q3PA 4DZ4A 4FCKA 1WOHA 4MYKA 4HWWA 4IE2A 1P8OA 5CEVA 1P8PA 1WOGA 3PZLA 1T4RA 4RHIA 3E6KA 1T4TA 4IE1A 3DJ8A 4IU0A 4Q3RA 2EF5A 1ZPEA 2EIVA
chains in the Genus database with same CATH superfamily
4Q3TA 4Q40A 1HQHA 5G11A 3THEA 1C3RA 4HXQA 4QA4A 3NIQA 3SJTA 5ICNB 3F07A 4GSZA 1P8SA 5G1CA 4RHQA 2PLLA 3NIOA 4BZ8A 2VQJA 4ZUOA 4A69A 3LP4A 3E9BA 2GH6A 3C10A 2A0MA 4ZURA 4BZ7A 1ZPGA 4ZUQA 5LI3A 2VCGA 3MZ6A 4QA0A 1D3VA 5D1CA 1WOIA 4IXVA 5G0JA 4IU1A 5D1DA 4IXUA 1T4PA 3RLAA 2AEBA 5EFJD 1HQXA 3GMZA 1P8QA 2VQMA 4I06A 5EFHA 3THJA 4BKXB 1GQ7A 3ZNRA 3TF3A 3EWFA 3GN0A 4HZEA 4Q3QA 5G0IA 3ZNSA 5EFKB 1PQ3A 5HJAA 5G10A 5EFNA 1ZZ0A 5G0YA 1WVAA 1GQ6A 5EFBD 3Q9FA 4GSMA 4RHKA 3E6VA 4Q3SA 1P8MA 1T5FA 2ZAVA 3E8QA 4G3HA 3EW8A 3SL1A 5G12A 1WVBA 1RLAA 1P8NA 1ZZ1A 4QA3A 5G0XA 3Q9BA 3E8ZA 4Q42A 5EFGA 2RLAA 1T64A 3F80A 4MYFA 5HJ9A 5THVA 5THTA 5DC5A 1T5GA 3TH7A 4GWCA 5D1BA 1W22A 4QA6A 3LP7A 4GSVA 1TA1A 4LY1A 3F06A 3MMRA 3MFWA 4RHLA 1P8RA 2CEVA 5EEIA 3EZPA 4Q3RC 4CEVA 4Q41A 1TBLA 5G1AA 3NIPA 4LXZA 4RN2A 2VQWG 2VQQA 3CEVA 3RQDA 4MYLA 3C0ZA 5G0HA 3SKKA 5G1BA 1HQ5A 5EEKA 3M1RA 4BZ9A 4ITYA 5THUA 2PHOA 1TBJA 1VKGA 3SL0A 1TBHA 4QA1A 4MYNA 5G17A 5IX0A 4QA7A 4IU4A 1ZZ3A 4ZUPA 5DC6A 5EENA 3SFHA 3MZ7A 5G13A 4IE3A 1HQGA 3EZTA 1R1OA 5G0GA 2PHAA 3MJLA 4RHMA 5EF8A 5BWZA 2V5WA 5EEMA 4IU5A 1XFKA 1HQFA 1CEVA 2EF4A 3MAXA 1T4SA 3MFVA 3MZ3A 4BZ6A 3THHA 4RLAA 5DC8A 3KV2A 4QA5A 4GWDA 4RHJA 5THSA 5FUEA 4MXRA 4Q3VA 5RLAA 3LHLA 3MZ4A 4FCIA 4Q3UA 4Q3PA 3MENA 4RN1A 3Q9CA 4DZ4A 4ZUMA 4FCKA 1WOHA 4MYKA 5IWGA 4HWWA 1C3SA 1T67A 3SFFA 4IE2A 5JI5A 4RN0A 1P8OA 3F0RA 5CEVA 1P8PA 5DC7A 1WOGA 3PZLA 5G3WA 1T4RA 4RHIA 3E6KA 4BZ5A 1T4TA 4IE1A 3DJ8A 5EEFA 4IU0A 4Q3RA 4CQFA 5FCWA 5A2SA 1T69A 2V5XA 4CBYA 4CBTA 3Q9EA 1C3PA 4QA2A 3C0YA 5EF7A 4ZUNA 2EF5A 1ZPEA 2VQVA 2VQOA 2EIVA
chains in the Genus database with same CATH topology
4Q3TA 4Q40A 1HQHA 3THEA 4HXQA 3NIQA 3SJTA 4GSZA 1P8SA 4RHQA 2PLLA 3NIOA 3LP4A 3E9BA 2A0MA 1ZPGA 1D3VA 1WOIA 4IXVA 4IU1A 4IXUA 1T4PA 3RLAA 2AEBA 3GMZA 1HQXA 1P8QA 4I06A 3THJA 1GQ7A 3TF3A 3GN0A 4HZEA 4Q3QA 1PQ3A 5HJAA 1WVAA 1GQ6A 4GSMA 4RHKA 3E6VA 4Q3SA 1P8MA 1T5FA 2ZAVA 3E8QA 4G3HA 3SL1A 1WVBA 1RLAA 1P8NA 3E8ZA 4Q42A 2RLAA 4MYFA 3F80A 5HJ9A 1T5GA 3TH7A 4GWCA 3LP7A 4GSVA 1TA1A 3MMRA 3MFWA 4RHLA 1P8RA 2CEVA 4Q3RC 4CEVA 4Q41A 1TBLA 3NIPA 3CEVA 4MYLA 3SKKA 1HQ5A 3M1RA 4ITYA 2PHOA 1TBJA 3SL0A 1TBHA 4MYNA 4IU4A 4IE3A 1HQGA 1R1OA 2PHAA 3MJLA 4RHMA 4IU5A 1XFKA 1HQFA 1CEVA 2EF4A 3MFVA 1T4SA 3THHA 4RLAA 3KV2A 4GWDA 4RHJA 4MXRA 4Q3VA 5RLAA 3LHLA 4FCIA 4Q3UA 4Q3PA 4DZ4A 4FCKA 1WOHA 4MYKA 4HWWA 4IE2A 1P8OA 5CEVA 1P8PA 1WOGA 3PZLA 1T4RA 4RHIA 3E6KA 1T4TA 4IE1A 3DJ8A 4IU0A 4Q3RA 2EF5A 1ZPEA 2EIVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Q3T A;  4Q40 A;  1HQH A;  3THE A;  4HXQ A;  3NIQ A;  3SJT A;  4GSZ A;  1P8S A;  4RHQ A;  2PLL A;  3NIO A;  3LP4 A;  3E9B A;  2A0M A;  1ZPG A;  1D3V A;  1WOI A;  4IXV A;  4IU1 A;  4IXU A;  1T4P A;  3RLA A;  2AEB A;  3GMZ A;  1HQX A;  1P8Q A;  4I06 A;  3THJ A;  1GQ7 A;  3TF3 A;  3GN0 A;  4HZE A;  4Q3Q A;  1PQ3 A;  5HJA A;  1WVA A;  1GQ6 A;  4GSM A;  4RHK A;  3E6V A;  4Q3S A;  1P8M A;  1T5F A;  2ZAV A;  3E8Q A;  4G3H A;  3SL1 A;  1WVB A;  1RLA A;  1P8N A;  3E8Z A;  4Q42 A;  2RLA A;  4MYF A;  3F80 A;  5HJ9 A;  1T5G A;  3TH7 A;  4GWC A;  3LP7 A;  4GSV A;  1TA1 A;  3MMR A;  3MFW A;  4RHL A;  1P8R A;  2CEV A;  4Q3R C;  4CEV A;  4Q41 A;  1TBL A;  3NIP A;  3CEV A;  4MYL A;  3SKK A;  1HQ5 A;  3M1R A;  4ITY A;  2PHO A;  1TBJ A;  3SL0 A;  1TBH A;  4MYN A;  4IU4 A;  4IE3 A;  1HQG A;  1R1O A;  2PHA A;  3MJL A;  4RHM A;  4IU5 A;  1XFK A;  1HQF A;  1CEV A;  2EF4 A;  3MFV A;  1T4S A;  3THH A;  4RLA A;  3KV2 A;  4GWD A;  4RHJ A;  4MXR A;  4Q3V A;  5RLA A;  3LHL A;  4FCI A;  4Q3U A;  4Q3P A;  4DZ4 A;  4FCK A;  1WOH A;  4MYK A;  4HWW A;  4IE2 A;  1P8O A;  5CEV A;  1P8P A;  1WOG A;  3PZL A;  1T4R A;  4RHI A;  3E6K A;  1T4T A;  4IE1 A;  3DJ8 A;  4IU0 A;  4Q3R A;  2EF5 A;  1ZPE A;  2EIV A; 
#chains in the Genus database with same CATH topology
 4Q3T A;  4Q40 A;  1HQH A;  5G11 A;  3THE A;  1C3R A;  4HXQ A;  4QA4 A;  3NIQ A;  3SJT A;  5ICN B;  3F07 A;  4GSZ A;  1P8S A;  5G1C A;  4RHQ A;  2PLL A;  3NIO A;  4BZ8 A;  2VQJ A;  4ZUO A;  4A69 A;  3LP4 A;  3E9B A;  2GH6 A;  3C10 A;  2A0M A;  4ZUR A;  4BZ7 A;  1ZPG A;  4ZUQ A;  5LI3 A;  2VCG A;  3MZ6 A;  4QA0 A;  1D3V A;  5D1C A;  1WOI A;  4IXV A;  5G0J A;  4IU1 A;  5D1D A;  4IXU A;  1T4P A;  3RLA A;  2AEB A;  5EFJ D;  1HQX A;  3GMZ A;  1P8Q A;  2VQM A;  4I06 A;  5EFH A;  3THJ A;  4BKX B;  1GQ7 A;  3ZNR A;  3TF3 A;  3EWF A;  3GN0 A;  4HZE A;  4Q3Q A;  5G0I A;  3ZNS A;  5EFK B;  1PQ3 A;  5HJA A;  5G10 A;  5EFN A;  1ZZ0 A;  5G0Y A;  1WVA A;  1GQ6 A;  5EFB D;  3Q9F A;  4GSM A;  4RHK A;  3E6V A;  4Q3S A;  1P8M A;  1T5F A;  2ZAV A;  3E8Q A;  4G3H A;  3EW8 A;  3SL1 A;  5G12 A;  1WVB A;  1RLA A;  1P8N A;  1ZZ1 A;  4QA3 A;  5G0X A;  3Q9B A;  3E8Z A;  4Q42 A;  5EFG A;  2RLA A;  1T64 A;  3F80 A;  4MYF A;  5HJ9 A;  5THV A;  5THT A;  5DC5 A;  1T5G A;  3TH7 A;  4GWC A;  5D1B A;  1W22 A;  4QA6 A;  3LP7 A;  4GSV A;  1TA1 A;  4LY1 A;  3F06 A;  3MMR A;  3MFW A;  4RHL A;  1P8R A;  2CEV A;  5EEI A;  3EZP A;  4Q3R C;  4CEV A;  4Q41 A;  1TBL A;  5G1A A;  3NIP A;  4LXZ A;  4RN2 A;  2VQW G;  2VQQ A;  3CEV A;  3RQD A;  4MYL A;  3C0Z A;  5G0H A;  3SKK A;  5G1B A;  1HQ5 A;  5EEK A;  3M1R A;  4BZ9 A;  4ITY A;  5THU A;  2PHO A;  1TBJ A;  1VKG A;  3SL0 A;  1TBH A;  4QA1 A;  4MYN A;  5G17 A;  5IX0 A;  4QA7 A;  4IU4 A;  1ZZ3 A;  4ZUP A;  5DC6 A;  5EEN A;  3SFH A;  3MZ7 A;  5G13 A;  4IE3 A;  1HQG A;  3EZT A;  1R1O A;  5G0G A;  2PHA A;  3MJL A;  4RHM A;  5EF8 A;  5BWZ A;  2V5W A;  5EEM A;  4IU5 A;  1XFK A;  1HQF A;  1CEV A;  2EF4 A;  3MAX A;  1T4S A;  3MFV A;  3MZ3 A;  4BZ6 A;  3THH A;  4RLA A;  5DC8 A;  3KV2 A;  4QA5 A;  4GWD A;  4RHJ A;  5THS A;  5FUE A;  4MXR A;  4Q3V A;  5RLA A;  3LHL A;  3MZ4 A;  4FCI A;  4Q3U A;  4Q3P A;  3MEN A;  4RN1 A;  3Q9C A;  4DZ4 A;  4ZUM A;  4FCK A;  1WOH A;  4MYK A;  5IWG A;  4HWW A;  1C3S A;  1T67 A;  3SFF A;  4IE2 A;  5JI5 A;  4RN0 A;  1P8O A;  3F0R A;  5CEV A;  1P8P A;  5DC7 A;  1WOG A;  3PZL A;  5G3W A;  1T4R A;  4RHI A;  3E6K A;  4BZ5 A;  1T4T A;  4IE1 A;  3DJ8 A;  5EEF A;  4IU0 A;  4Q3R A;  4CQF A;  5FCW A;  5A2S A;  1T69 A;  2V5X A;  4CBY A;  4CBT A;  3Q9E A;  1C3P A;  4QA2 A;  3C0Y A;  5EF7 A;  4ZUN A;  2EF5 A;  1ZPE A;  2VQV A;  2VQO A;  2EIV A; 
#chains in the Genus database with same CATH homology
 4Q3T A;  4Q40 A;  1HQH A;  3THE A;  4HXQ A;  3NIQ A;  3SJT A;  4GSZ A;  1P8S A;  4RHQ A;  2PLL A;  3NIO A;  3LP4 A;  3E9B A;  2A0M A;  1ZPG A;  1D3V A;  1WOI A;  4IXV A;  4IU1 A;  4IXU A;  1T4P A;  3RLA A;  2AEB A;  3GMZ A;  1HQX A;  1P8Q A;  4I06 A;  3THJ A;  1GQ7 A;  3TF3 A;  3GN0 A;  4HZE A;  4Q3Q A;  1PQ3 A;  5HJA A;  1WVA A;  1GQ6 A;  4GSM A;  4RHK A;  3E6V A;  4Q3S A;  1P8M A;  1T5F A;  2ZAV A;  3E8Q A;  4G3H A;  3SL1 A;  1WVB A;  1RLA A;  1P8N A;  3E8Z A;  4Q42 A;  2RLA A;  4MYF A;  3F80 A;  5HJ9 A;  1T5G A;  3TH7 A;  4GWC A;  3LP7 A;  4GSV A;  1TA1 A;  3MMR A;  3MFW A;  4RHL A;  1P8R A;  2CEV A;  4Q3R C;  4CEV A;  4Q41 A;  1TBL A;  3NIP A;  3CEV A;  4MYL A;  3SKK A;  1HQ5 A;  3M1R A;  4ITY A;  2PHO A;  1TBJ A;  3SL0 A;  1TBH A;  4MYN A;  4IU4 A;  4IE3 A;  1HQG A;  1R1O A;  2PHA A;  3MJL A;  4RHM A;  4IU5 A;  1XFK A;  1HQF A;  1CEV A;  2EF4 A;  3MFV A;  1T4S A;  3THH A;  4RLA A;  3KV2 A;  4GWD A;  4RHJ A;  4MXR A;  4Q3V A;  5RLA A;  3LHL A;  4FCI A;  4Q3U A;  4Q3P A;  4DZ4 A;  4FCK A;  1WOH A;  4MYK A;  4HWW A;  4IE2 A;  1P8O A;  5CEV A;  1P8P A;  1WOG A;  3PZL A;  1T4R A;  4RHI A;  3E6K A;  1T4T A;  4IE1 A;  3DJ8 A;  4IU0 A;  4Q3R A;  2EF5 A;  1ZPE A;  2EIV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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