5HJAA

Crystal structure of leishmania mexicana arginase in complex with inhibitor abhdp
Total Genus 117
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
117
sequence length
310
structure length
303
Chain Sequence
KKMSIVLAPFSGGQPHSGVELGPDYLLKQGLQQDMEKLGWDTRLERVFDGKVVEARKASDNGDRIGRVKRPRLTAECTEKIYKCVRRVAEQGRFPLTIGGDHSIALGTVAGVLSVHPDAGVIWVDAHADINTMSGTVSGNLHGCPLSILLGLDRENIPECFSWVPQVLKPNKIAYIGLRAVDDEEKKILHDLNIAAFSMHHVDRYGIDKVVSMAIEAVSPKGTEPVMVSYDVDTIDPLYVPATGTPVRGGLSFREALFLCERIAECGRLVALDVVECNPLLNDTISVGCAIARCMMGETLLYT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of Leishmania mexicana arginase complexed with alpha , alpha-disubstituted boronic amino-acid inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Leishmania mexicana
molecule keywords Arginase
total genus 117
structure length 303
sequence length 310
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 2016-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 5hjaA00
1WVBA 1P8OA 4GSZA 1HQXA 2ZAVA 4Q3SA 4HXQA 3NIQA 4RHLA 1P8QA 4RLAA 1T4SA 5RLAA 2AEBA 3LP4A 4Q3UA 1WOHA 4Q3RA 3THEA 3SKKA 4Q3RC 3MMRA 4GWCA 4IU1A 1GQ6A 1P8PA 4RHMA 3PZLA 3M1RA 4RHQA 1P8RA 3E8ZA 2CEVA 3THHA 4IU5A 1WVAA 1HQFA 4Q3VA 4MYLA 3LP7A 1WOGA 3TH7A 3SL1A 4IE3A 4Q41A 1TBLA 4IU0A 1ZPGA 2RLAA 4Q3PA 4FCKA 4RHJA 3TF3A 3NIPA 2PHOA 1ZPEA 4I06A 4MYNA 3SL0A 3RLAA 4G3HA 1HQGA 4Q40A 5HJAA 3E6KA 3SJTA 1P8MA 1HQHA 1R1OA 1CEVA 1TBHA 4IXUA 3DJ8A 1TBJA 4FCIA 4IXVA 3THJA 2EIVA 1TA1A 1T4PA 3KV2A 1WOIA 1T5GA 1T5FA 4MYKA 4GSVA 3NIOA 4IE2A 4Q42A 1PQ3A 4HZEA 3E9BA 3E8QA 5CEVA 3GMZA 1D3VA 4RHKA 4MXRA 4MYFA 4Q3TA 4HWWA 4IE1A 2PHAA 3MFVA 3MFWA 4CEVA 1T4RA 3GN0A 1P8SA 3MJLA 2EF4A 1GQ7A 2A0MA 3E6VA 4Q3QA 1T4TA 2PLLA 5HJ9A 3F80A 4GWDA 1HQ5A 2EF5A 3CEVA 4DZ4A 1P8NA 1RLAA 4GSMA 1XFKA 3LHLA 4IU4A 4ITYA 4RHIA
chains in the Genus database with same CATH superfamily
5D1CA 1WVBA 1P8OA 3EZPA 4GSZA 1HQXA 3Q9CA 4QA4A 5DC8A 2ZAVA 5G1BA 5EEKA 4Q3SA 2VCGA 4HXQA 3NIQA 4RHLA 1P8QA 5THUA 4CQFA 4BZ6A 1T64A 2GH6A 5EFNA 2VQVA 5A2SA 4QA6A 4RLAA 1T4SA 5RLAA 3F0RA 2V5XA 2AEBA 3LP4A 4Q3UA 1WOHA 4Q3RA 3THEA 3SKKA 1T67A 5DC6A 4Q3RC 3MMRA 5G0HA 4GWCA 5D1DA 1ZZ0A 4ZUOA 5FUEA 4IU1A 1GQ6A 1P8PA 5G3WA 1C3SA 3MAXA 3MZ3A 4RHMA 5G0GA 3PZLA 3M1RA 5G13A 5THSA 4QA2A 4RHQA 1P8RA 3E8ZA 2CEVA 3THHA 4IU5A 1WVAA 3C0ZA 1HQFA 3Q9BA 3Q9FA 3SFFA 4Q3VA 5EFKB 3Q9EA 3EWFA 4MYLA 5EENA 3LP7A 4ZURA 1WOGA 3TH7A 3SL1A 5G0JA 4IE3A 4Q41A 2VQMA 4A69A 1TBLA 4RN2A 4IU0A 1ZPGA 2RLAA 5G0YA 4Q3PA 5DC5A 5EF8A 4FCKA 4RHJA 4BKXB 3TF3A 1W22A 3MZ4A 5EFJD 3NIPA 2PHOA 1ZPEA 4I06A 5G1CA 4ZUNA 4MYNA 3SL0A 3RLAA 4G3HA 3ZNSA 1HQGA 4Q40A 5HJAA 3E6KA 3SJTA 5IWGA 2V5WA 5EFHA 1P8MA 1HQHA 1CEVA 1R1OA 1TBHA 4IXUA 1C3RA 3DJ8A 4BZ9A 1TBJA 4FCIA 4ZUQA 4IXVA 3MENA 3EW8A 3THJA 5G17A 5BWZA 1C3PA 3F07A 4CBTA 5DC7A 5EFBD 2EIVA 4LXZA 3C0YA 5EEMA 1TA1A 1T4PA 4BZ5A 3KV2A 1T69A 5EEFA 4ZUPA 1WOIA 1T5GA 5G1AA 1T5FA 2VQQA 4LY1A 4RN1A 5G12A 4MYKA 4GSVA 3EZTA 3MZ7A 3NIOA 4IE2A 4Q42A 1ZZ3A 4CBYA 2VQOA 5G0IA 1VKGA 4QA3A 5EEIA 5G11A 3MZ6A 3SFHA 2VQJA 1PQ3A 4HZEA 4QA7A 3E9BA 5ICNB 5EFGA 3E8QA 3F06A 1ZZ1A 5CEVA 3GMZA 1D3VA 4RHKA 4MXRA 4MYFA 4Q3TA 4HWWA 4QA1A 4IE1A 4QA0A 2PHAA 4ZUMA 3MFVA 3MFWA 5FCWA 1T4RA 3GN0A 1P8SA 3MJLA 2EF4A 4CEVA 5JI5A 5G0XA 1GQ7A 2A0MA 3E6VA 4Q3QA 1T4TA 5THTA 2PLLA 5G10A 5HJ9A 4RN0A 3F80A 4GWDA 5IX0A 3RQDA 1HQ5A 4QA5A 2EF5A 3CEVA 4BZ8A 4DZ4A 1P8NA 1RLAA 4GSMA 5THVA 1XFKA 3LHLA 3C10A 4IU4A 5D1BA 5EF7A 3ZNRA 2VQWG 4ITYA 4RHIA 4BZ7A 5LI3A
chains in the Genus database with same CATH topology
1WVBA 1P8OA 4GSZA 1HQXA 2ZAVA 4Q3SA 4HXQA 3NIQA 4RHLA 1P8QA 4RLAA 1T4SA 5RLAA 2AEBA 3LP4A 4Q3UA 1WOHA 4Q3RA 3THEA 3SKKA 4Q3RC 3MMRA 4GWCA 4IU1A 1GQ6A 1P8PA 4RHMA 3PZLA 3M1RA 4RHQA 1P8RA 3E8ZA 2CEVA 3THHA 4IU5A 1WVAA 1HQFA 4Q3VA 4MYLA 3LP7A 1WOGA 3TH7A 3SL1A 4IE3A 4Q41A 1TBLA 4IU0A 1ZPGA 2RLAA 4Q3PA 4FCKA 4RHJA 3TF3A 3NIPA 2PHOA 1ZPEA 4I06A 4MYNA 3SL0A 3RLAA 4G3HA 1HQGA 4Q40A 5HJAA 3E6KA 3SJTA 1P8MA 1HQHA 1R1OA 1CEVA 1TBHA 4IXUA 3DJ8A 1TBJA 4FCIA 4IXVA 3THJA 2EIVA 1TA1A 1T4PA 3KV2A 1WOIA 1T5GA 1T5FA 4MYKA 4GSVA 3NIOA 4IE2A 4Q42A 1PQ3A 4HZEA 3E9BA 3E8QA 5CEVA 3GMZA 1D3VA 4RHKA 4MXRA 4MYFA 4Q3TA 4HWWA 4IE1A 2PHAA 3MFVA 3MFWA 4CEVA 1T4RA 3GN0A 1P8SA 3MJLA 2EF4A 1GQ7A 2A0MA 3E6VA 4Q3QA 1T4TA 2PLLA 5HJ9A 3F80A 4GWDA 1HQ5A 2EF5A 3CEVA 4DZ4A 1P8NA 1RLAA 4GSMA 1XFKA 3LHLA 4IU4A 4ITYA 4RHIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WVB A;  1P8O A;  4GSZ A;  1HQX A;  2ZAV A;  4Q3S A;  4HXQ A;  3NIQ A;  4RHL A;  1P8Q A;  4RLA A;  1T4S A;  5RLA A;  2AEB A;  3LP4 A;  4Q3U A;  1WOH A;  4Q3R A;  3THE A;  3SKK A;  4Q3R C;  3MMR A;  4GWC A;  4IU1 A;  1GQ6 A;  1P8P A;  4RHM A;  3PZL A;  3M1R A;  4RHQ A;  1P8R A;  3E8Z A;  2CEV A;  3THH A;  4IU5 A;  1WVA A;  1HQF A;  4Q3V A;  4MYL A;  3LP7 A;  1WOG A;  3TH7 A;  3SL1 A;  4IE3 A;  4Q41 A;  1TBL A;  4IU0 A;  1ZPG A;  2RLA A;  4Q3P A;  4FCK A;  4RHJ A;  3TF3 A;  3NIP A;  2PHO A;  1ZPE A;  4I06 A;  4MYN A;  3SL0 A;  3RLA A;  4G3H A;  1HQG A;  4Q40 A;  5HJA A;  3E6K A;  3SJT A;  1P8M A;  1HQH A;  1R1O A;  1CEV A;  1TBH A;  4IXU A;  3DJ8 A;  1TBJ A;  4FCI A;  4IXV A;  3THJ A;  2EIV A;  1TA1 A;  1T4P A;  3KV2 A;  1WOI A;  1T5G A;  1T5F A;  4MYK A;  4GSV A;  3NIO A;  4IE2 A;  4Q42 A;  1PQ3 A;  4HZE A;  3E9B A;  3E8Q A;  5CEV A;  3GMZ A;  1D3V A;  4RHK A;  4MXR A;  4MYF A;  4Q3T A;  4HWW A;  4IE1 A;  2PHA A;  3MFV A;  3MFW A;  4CEV A;  1T4R A;  3GN0 A;  1P8S A;  3MJL A;  2EF4 A;  1GQ7 A;  2A0M A;  3E6V A;  4Q3Q A;  1T4T A;  2PLL A;  5HJ9 A;  3F80 A;  4GWD A;  1HQ5 A;  2EF5 A;  3CEV A;  4DZ4 A;  1P8N A;  1RLA A;  4GSM A;  1XFK A;  3LHL A;  4IU4 A;  4ITY A;  4RHI A; 
#chains in the Genus database with same CATH topology
 5D1C A;  1WVB A;  1P8O A;  3EZP A;  4GSZ A;  1HQX A;  3Q9C A;  4QA4 A;  5DC8 A;  2ZAV A;  5G1B A;  5EEK A;  4Q3S A;  2VCG A;  4HXQ A;  3NIQ A;  4RHL A;  1P8Q A;  5THU A;  4CQF A;  4BZ6 A;  1T64 A;  2GH6 A;  5EFN A;  2VQV A;  5A2S A;  4QA6 A;  4RLA A;  1T4S A;  5RLA A;  3F0R A;  2V5X A;  2AEB A;  3LP4 A;  4Q3U A;  1WOH A;  4Q3R A;  3THE A;  3SKK A;  1T67 A;  5DC6 A;  4Q3R C;  3MMR A;  5G0H A;  4GWC A;  5D1D A;  1ZZ0 A;  4ZUO A;  5FUE A;  4IU1 A;  1GQ6 A;  1P8P A;  5G3W A;  1C3S A;  3MAX A;  3MZ3 A;  4RHM A;  5G0G A;  3PZL A;  3M1R A;  5G13 A;  5THS A;  4QA2 A;  4RHQ A;  1P8R A;  3E8Z A;  2CEV A;  3THH A;  4IU5 A;  1WVA A;  3C0Z A;  1HQF A;  3Q9B A;  3Q9F A;  3SFF A;  4Q3V A;  5EFK B;  3Q9E A;  3EWF A;  4MYL A;  5EEN A;  3LP7 A;  4ZUR A;  1WOG A;  3TH7 A;  3SL1 A;  5G0J A;  4IE3 A;  4Q41 A;  2VQM A;  4A69 A;  1TBL A;  4RN2 A;  4IU0 A;  1ZPG A;  2RLA A;  5G0Y A;  4Q3P A;  5DC5 A;  5EF8 A;  4FCK A;  4RHJ A;  4BKX B;  3TF3 A;  1W22 A;  3MZ4 A;  5EFJ D;  3NIP A;  2PHO A;  1ZPE A;  4I06 A;  5G1C A;  4ZUN A;  4MYN A;  3SL0 A;  3RLA A;  4G3H A;  3ZNS A;  1HQG A;  4Q40 A;  5HJA A;  3E6K A;  3SJT A;  5IWG A;  2V5W A;  5EFH A;  1P8M A;  1HQH A;  1CEV A;  1R1O A;  1TBH A;  4IXU A;  1C3R A;  3DJ8 A;  4BZ9 A;  1TBJ A;  4FCI A;  4ZUQ A;  4IXV A;  3MEN A;  3EW8 A;  3THJ A;  5G17 A;  5BWZ A;  1C3P A;  3F07 A;  4CBT A;  5DC7 A;  5EFB D;  2EIV A;  4LXZ A;  3C0Y A;  5EEM A;  1TA1 A;  1T4P A;  4BZ5 A;  3KV2 A;  1T69 A;  5EEF A;  4ZUP A;  1WOI A;  1T5G A;  5G1A A;  1T5F A;  2VQQ A;  4LY1 A;  4RN1 A;  5G12 A;  4MYK A;  4GSV A;  3EZT A;  3MZ7 A;  3NIO A;  4IE2 A;  4Q42 A;  1ZZ3 A;  4CBY A;  2VQO A;  5G0I A;  1VKG A;  4QA3 A;  5EEI A;  5G11 A;  3MZ6 A;  3SFH A;  2VQJ A;  1PQ3 A;  4HZE A;  4QA7 A;  3E9B A;  5ICN B;  5EFG A;  3E8Q A;  3F06 A;  1ZZ1 A;  5CEV A;  3GMZ A;  1D3V A;  4RHK A;  4MXR A;  4MYF A;  4Q3T A;  4HWW A;  4QA1 A;  4IE1 A;  4QA0 A;  2PHA A;  4ZUM A;  3MFV A;  3MFW A;  5FCW A;  1T4R A;  3GN0 A;  1P8S A;  3MJL A;  2EF4 A;  4CEV A;  5JI5 A;  5G0X A;  1GQ7 A;  2A0M A;  3E6V A;  4Q3Q A;  1T4T A;  5THT A;  2PLL A;  5G10 A;  5HJ9 A;  4RN0 A;  3F80 A;  4GWD A;  5IX0 A;  3RQD A;  1HQ5 A;  4QA5 A;  2EF5 A;  3CEV A;  4BZ8 A;  4DZ4 A;  1P8N A;  1RLA A;  4GSM A;  5THV A;  1XFK A;  3LHL A;  3C10 A;  4IU4 A;  5D1B A;  5EF7 A;  3ZNR A;  2VQW G;  4ITY A;  4RHI A;  4BZ7 A;  5LI3 A; 
#chains in the Genus database with same CATH homology
 1WVB A;  1P8O A;  4GSZ A;  1HQX A;  2ZAV A;  4Q3S A;  4HXQ A;  3NIQ A;  4RHL A;  1P8Q A;  4RLA A;  1T4S A;  5RLA A;  2AEB A;  3LP4 A;  4Q3U A;  1WOH A;  4Q3R A;  3THE A;  3SKK A;  4Q3R C;  3MMR A;  4GWC A;  4IU1 A;  1GQ6 A;  1P8P A;  4RHM A;  3PZL A;  3M1R A;  4RHQ A;  1P8R A;  3E8Z A;  2CEV A;  3THH A;  4IU5 A;  1WVA A;  1HQF A;  4Q3V A;  4MYL A;  3LP7 A;  1WOG A;  3TH7 A;  3SL1 A;  4IE3 A;  4Q41 A;  1TBL A;  4IU0 A;  1ZPG A;  2RLA A;  4Q3P A;  4FCK A;  4RHJ A;  3TF3 A;  3NIP A;  2PHO A;  1ZPE A;  4I06 A;  4MYN A;  3SL0 A;  3RLA A;  4G3H A;  1HQG A;  4Q40 A;  5HJA A;  3E6K A;  3SJT A;  1P8M A;  1HQH A;  1R1O A;  1CEV A;  1TBH A;  4IXU A;  3DJ8 A;  1TBJ A;  4FCI A;  4IXV A;  3THJ A;  2EIV A;  1TA1 A;  1T4P A;  3KV2 A;  1WOI A;  1T5G A;  1T5F A;  4MYK A;  4GSV A;  3NIO A;  4IE2 A;  4Q42 A;  1PQ3 A;  4HZE A;  3E9B A;  3E8Q A;  5CEV A;  3GMZ A;  1D3V A;  4RHK A;  4MXR A;  4MYF A;  4Q3T A;  4HWW A;  4IE1 A;  2PHA A;  3MFV A;  3MFW A;  4CEV A;  1T4R A;  3GN0 A;  1P8S A;  3MJL A;  2EF4 A;  1GQ7 A;  2A0M A;  3E6V A;  4Q3Q A;  1T4T A;  2PLL A;  5HJ9 A;  3F80 A;  4GWD A;  1HQ5 A;  2EF5 A;  3CEV A;  4DZ4 A;  1P8N A;  1RLA A;  4GSM A;  1XFK A;  3LHL A;  4IU4 A;  4ITY A;  4RHI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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