5RLAA

Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function
Total Genus 107

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
314
structure length
314
Chain Sequence
KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDNSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL
5010015020025030030025020015010050
020406080100Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (7-12)S3 (93-97)O1 (13-15)TIV2 (63-66)TIV6 (135-138)TI1 (16-19)S8 (270-276)AH1 (27-34)S2 (46-52)EMPTYTIV3 (64-67)TIV1 (58-61)AH3 (70-90)AH8 (254-267)AH4 (102-114)S4 (119-123)TI2 (115-118)S7 (227-232)S5 (174-179)3H2 (140-142)TIV5 (131-134)TI3 (132-135)3H3 (144-147)TII2 (159-162)TI4 (162-165)3H4 (150-152)TII1 (152-155)TIV7 (154-157)TIV8 (160-163)TI5 (170-173)O2 (242-244)AH6 (200-206)3H5 (233-235)AH9 (286-304)TI6 (237-240)TI8 (279-282)TI9 (280-283)AH2 (36-42)3H1 (24-26)TIV4 (67-70)AH7 (208-221)TVIII1 (283-286)AH5 (184-193)S6 (196-199)TIV11 (244-247)Updating...
connected with : NaN
publication title Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rattus norvegicus
molecule keywords ARGINASE
total genus 107
structure length 314
sequence length 314
chains with identical sequence B, C
ec nomenclature ec 3.5.3.1: Arginase.
pdb deposition date 1997-05-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00491 Arginase Arginase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.10 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Ureohydrolase domain 5rlaA00
1CEVA 3SKKA 2PHAA 4MYFA 4Q42A 4Q41A 3RLAA 3SL0A 2PHOA 4IE3A 4RHJA 4IU5A 4IXVA 3THHA 4HZEA 4Q40A 5RLAA 3E6VA 1ZPGA 2AEBA 4MXRA 3MFVA 3GMZA 1GQ6A 4GSMA 1P8PA 4Q3QA 3KV2A 1WOHA 1WVBA 3M1RA 3THJA 1T5GA 3F80A 1HQ5A 2RLAA 3MMRA 3NIQA 4DZ4A 3TF3A 2PLLA 1PQ3A 1R1OA 2CEVA 4MYKA 4RHQA 4GWCA 3NIPA 4Q3RA 3CEVA 3E9BA 3PZLA 1T5FA 1TBJA 3NIOA 1HQXA 4IE2A 4Q3PA 3LHLA 4FCIA 3DJ8A 4MYNA 4Q3SA 4FCKA 3MJLA 4IU0A 1P8QA 5HJ9A 2EF4A 2EF5A 4RHIA 3LP4A 4GSZA 1HQFA 4IU4A 1XFKA 3MFWA 1WVAA 4Q3RC 4G3HA 4RHKA 1TBHA 1TBLA 1T4SA 1TA1A 4CEVA 1T4RA 3E8ZA 1P8NA 3SJTA 3TH7A 4RLAA 1T4TA 1P8RA 1WOIA 3E8QA 2ZAVA 4ITYA 3E6KA 1D3VA 1HQHA 4GWDA 4IE1A 5HJAA 3GN0A 2A0MA 4RHMA 4MYLA 1WOGA 4Q3UA 1RLAA 1ZPEA 1P8MA 4IXUA 4Q3TA 4GSVA 4Q3VA 3SL1A 4IU1A 4I06A 4RHLA 1P8SA 3LP7A 2EIVA 4HXQA 3THEA 5CEVA 1HQGA 1T4PA 1GQ7A 4HWWA 1P8OA
chains in the Genus database with same CATH superfamily
1CEVA 3C10A 3SFHA 3SKKA 1W22A 5D1BA 2PHAA 4MYFA 4Q42A 5G1CA 4LY1A 4Q41A 3RLAA 3C0ZA 3SL0A 4CBYA 5G1AA 2PHOA 4IE3A 5EFNA 4RHJA 4IU5A 1T67A 3C0YA 4IXVA 5JI5A 3THHA 4HZEA 4Q40A 5RLAA 5G0HA 3E6VA 1ZPGA 2AEBA 3F07A 4MXRA 3MFVA 3GMZA 1GQ6A 3MZ7A 1P8PA 4GSMA 4ZUQA 3EZPA 5EFKB 4Q3QA 5EEKA 5THTA 3KV2A 4QA0A 4RN1A 2VQWG 1WOHA 1WVBA 3M1RA 3SFFA 3THJA 5G0IA 1T5GA 3F80A 1HQ5A 2RLAA 5FCWA 5G17A 2VQQA 3MMRA 3MAXA 3Q9FA 3NIQA 1T64A 3F06A 4DZ4A 3TF3A 1C3PA 2PLLA 1PQ3A 1R1OA 4QA4A 5EFHA 4LXZA 2CEVA 5D1DA 5EEIA 4MYKA 4RHQA 1C3SA 4GWCA 4BZ8A 3NIPA 4Q3RA 3CEVA 3E9BA 3PZLA 1T5FA 1TBJA 3NIOA 1HQXA 4IE2A 3EWFA 4Q3PA 3ZNRA 3LHLA 4FCIA 4CQFA 3DJ8A 4MYNA 5A2SA 4Q3SA 3EZTA 4FCKA 3MJLA 4ZUPA 4IU0A 1P8QA 5G0GA 5IWGA 5HJ9A 2EF4A 2EF5A 5G3WA 4RHIA 4ZUMA 3LP4A 4GSZA 1HQFA 4IU4A 5LI3A 5EENA 1XFKA 3MFWA 1WVAA 4Q3RC 4G3HA 4BZ7A 4RHKA 1TBHA 3MZ6A 5EEMA 1TBLA 1T4SA 4QA1A 1TA1A 2GH6A 1T4RA 3E8ZA 1P8NA 3EW8A 3Q9CA 5EF8A 3RQDA 4RLAA 2VQMA 3SJTA 1T4TA 4ZUOA 5THUA 3TH7A 1P8RA 1WOIA 3E8QA 4BZ6A 5G10A 3F0RA 2ZAVA 4ITYA 5G11A 3E6KA 4ZURA 5DC6A 3ZNSA 1D3VA 1HQHA 5EFGA 4GWDA 4IE1A 5HJAA 3GN0A 3Q9EA 2A0MA 4CBTA 4RHMA 1ZZ1A 4MYLA 5G13A 1ZZ0A 5DC7A 5DC5A 1WOGA 4Q3UA 1RLAA 5EFBD 2VQVA 3MZ3A 1ZPEA 2VCGA 2VQJA 4BKXB 5BWZA 1P8MA 4QA3A 4IXUA 3MENA 4Q3TA 5FUEA 4QA5A 5G12A 4GSVA 1VKGA 4Q3VA 5G0YA 1C3RA 4CEVA 1ZZ3A 4BZ9A 5DC8A 5EF7A 5G1BA 4RN0A 3SL1A 3Q9BA 4IU1A 2V5XA 4QA2A 4RN2A 4QA6A 4A69A 4ZUNA 4I06A 5ICNB 5G0JA 4RHLA 5D1CA 4QA7A 3MZ4A 4BZ5A 5EFJD 5THSA 1P8SA 3LP7A 5EEFA 2EIVA 2V5WA 4HXQA 3THEA 5IX0A 5CEVA 5THVA 2VQOA 1HQGA 1T4PA 1GQ7A 5G0XA 4HWWA 1T69A 1P8OA
chains in the Genus database with same CATH topology
1CEVA 3SKKA 2PHAA 4MYFA 4Q42A 4Q41A 3RLAA 3SL0A 2PHOA 4IE3A 4RHJA 4IU5A 4IXVA 3THHA 4HZEA 4Q40A 5RLAA 3E6VA 1ZPGA 2AEBA 4MXRA 3MFVA 3GMZA 1GQ6A 4GSMA 1P8PA 4Q3QA 3KV2A 1WOHA 1WVBA 3M1RA 3THJA 1T5GA 3F80A 1HQ5A 2RLAA 3MMRA 3NIQA 4DZ4A 3TF3A 2PLLA 1PQ3A 1R1OA 2CEVA 4MYKA 4RHQA 4GWCA 3NIPA 4Q3RA 3CEVA 3E9BA 3PZLA 1T5FA 1TBJA 3NIOA 1HQXA 4IE2A 4Q3PA 3LHLA 4FCIA 3DJ8A 4MYNA 4Q3SA 4FCKA 3MJLA 4IU0A 1P8QA 5HJ9A 2EF4A 2EF5A 4RHIA 3LP4A 4GSZA 1HQFA 4IU4A 1XFKA 3MFWA 1WVAA 4Q3RC 4G3HA 4RHKA 1TBHA 1TBLA 1T4SA 1TA1A 4CEVA 1T4RA 3E8ZA 1P8NA 3SJTA 3TH7A 4RLAA 1T4TA 1P8RA 1WOIA 3E8QA 2ZAVA 4ITYA 3E6KA 1D3VA 1HQHA 4GWDA 4IE1A 5HJAA 3GN0A 2A0MA 4RHMA 4MYLA 1WOGA 4Q3UA 1RLAA 1ZPEA 1P8MA 4IXUA 4Q3TA 4GSVA 4Q3VA 3SL1A 4IU1A 4I06A 4RHLA 1P8SA 3LP7A 2EIVA 4HXQA 3THEA 5CEVA 1HQGA 1T4PA 1GQ7A 4HWWA 1P8OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CEV A;  3SKK A;  2PHA A;  4MYF A;  4Q42 A;  4Q41 A;  3RLA A;  3SL0 A;  2PHO A;  4IE3 A;  4RHJ A;  4IU5 A;  4IXV A;  3THH A;  4HZE A;  4Q40 A;  5RLA A;  3E6V A;  1ZPG A;  2AEB A;  4MXR A;  3MFV A;  3GMZ A;  1GQ6 A;  4GSM A;  1P8P A;  4Q3Q A;  3KV2 A;  1WOH A;  1WVB A;  3M1R A;  3THJ A;  1T5G A;  3F80 A;  1HQ5 A;  2RLA A;  3MMR A;  3NIQ A;  4DZ4 A;  3TF3 A;  2PLL A;  1PQ3 A;  1R1O A;  2CEV A;  4MYK A;  4RHQ A;  4GWC A;  3NIP A;  4Q3R A;  3CEV A;  3E9B A;  3PZL A;  1T5F A;  1TBJ A;  3NIO A;  1HQX A;  4IE2 A;  4Q3P A;  3LHL A;  4FCI A;  3DJ8 A;  4MYN A;  4Q3S A;  4FCK A;  3MJL A;  4IU0 A;  1P8Q A;  5HJ9 A;  2EF4 A;  2EF5 A;  4RHI A;  3LP4 A;  4GSZ A;  1HQF A;  4IU4 A;  1XFK A;  3MFW A;  1WVA A;  4Q3R C;  4G3H A;  4RHK A;  1TBH A;  1TBL A;  1T4S A;  1TA1 A;  4CEV A;  1T4R A;  3E8Z A;  1P8N A;  3SJT A;  3TH7 A;  4RLA A;  1T4T A;  1P8R A;  1WOI A;  3E8Q A;  2ZAV A;  4ITY A;  3E6K A;  1D3V A;  1HQH A;  4GWD A;  4IE1 A;  5HJA A;  3GN0 A;  2A0M A;  4RHM A;  4MYL A;  1WOG A;  4Q3U A;  1RLA A;  1ZPE A;  1P8M A;  4IXU A;  4Q3T A;  4GSV A;  4Q3V A;  3SL1 A;  4IU1 A;  4I06 A;  4RHL A;  1P8S A;  3LP7 A;  2EIV A;  4HXQ A;  3THE A;  5CEV A;  1HQG A;  1T4P A;  1GQ7 A;  4HWW A;  1P8O A; 
#chains in the Genus database with same CATH topology
 1CEV A;  3C10 A;  3SFH A;  3SKK A;  1W22 A;  5D1B A;  2PHA A;  4MYF A;  4Q42 A;  5G1C A;  4LY1 A;  4Q41 A;  3RLA A;  3C0Z A;  3SL0 A;  4CBY A;  5G1A A;  2PHO A;  4IE3 A;  5EFN A;  4RHJ A;  4IU5 A;  1T67 A;  3C0Y A;  4IXV A;  5JI5 A;  3THH A;  4HZE A;  4Q40 A;  5RLA A;  5G0H A;  3E6V A;  1ZPG A;  2AEB A;  3F07 A;  4MXR A;  3MFV A;  3GMZ A;  1GQ6 A;  3MZ7 A;  1P8P A;  4GSM A;  4ZUQ A;  3EZP A;  5EFK B;  4Q3Q A;  5EEK A;  5THT A;  3KV2 A;  4QA0 A;  4RN1 A;  2VQW G;  1WOH A;  1WVB A;  3M1R A;  3SFF A;  3THJ A;  5G0I A;  1T5G A;  3F80 A;  1HQ5 A;  2RLA A;  5FCW A;  5G17 A;  2VQQ A;  3MMR A;  3MAX A;  3Q9F A;  3NIQ A;  1T64 A;  3F06 A;  4DZ4 A;  3TF3 A;  1C3P A;  2PLL A;  1PQ3 A;  1R1O A;  4QA4 A;  5EFH A;  4LXZ A;  2CEV A;  5D1D A;  5EEI A;  4MYK A;  4RHQ A;  1C3S A;  4GWC A;  4BZ8 A;  3NIP A;  4Q3R A;  3CEV A;  3E9B A;  3PZL A;  1T5F A;  1TBJ A;  3NIO A;  1HQX A;  4IE2 A;  3EWF A;  4Q3P A;  3ZNR A;  3LHL A;  4FCI A;  4CQF A;  3DJ8 A;  4MYN A;  5A2S A;  4Q3S A;  3EZT A;  4FCK A;  3MJL A;  4ZUP A;  4IU0 A;  1P8Q A;  5G0G A;  5IWG A;  5HJ9 A;  2EF4 A;  2EF5 A;  5G3W A;  4RHI A;  4ZUM A;  3LP4 A;  4GSZ A;  1HQF A;  4IU4 A;  5LI3 A;  5EEN A;  1XFK A;  3MFW A;  1WVA A;  4Q3R C;  4G3H A;  4BZ7 A;  4RHK A;  1TBH A;  3MZ6 A;  5EEM A;  1TBL A;  1T4S A;  4QA1 A;  1TA1 A;  2GH6 A;  1T4R A;  3E8Z A;  1P8N A;  3EW8 A;  3Q9C A;  5EF8 A;  3RQD A;  4RLA A;  2VQM A;  3SJT A;  1T4T A;  4ZUO A;  5THU A;  3TH7 A;  1P8R A;  1WOI A;  3E8Q A;  4BZ6 A;  5G10 A;  3F0R A;  2ZAV A;  4ITY A;  5G11 A;  3E6K A;  4ZUR A;  5DC6 A;  3ZNS A;  1D3V A;  1HQH A;  5EFG A;  4GWD A;  4IE1 A;  5HJA A;  3GN0 A;  3Q9E A;  2A0M A;  4CBT A;  4RHM A;  1ZZ1 A;  4MYL A;  5G13 A;  1ZZ0 A;  5DC7 A;  5DC5 A;  1WOG A;  4Q3U A;  1RLA A;  5EFB D;  2VQV A;  3MZ3 A;  1ZPE A;  2VCG A;  2VQJ A;  4BKX B;  5BWZ A;  1P8M A;  4QA3 A;  4IXU A;  3MEN A;  4Q3T A;  5FUE A;  4QA5 A;  5G12 A;  4GSV A;  1VKG A;  4Q3V A;  5G0Y A;  1C3R A;  4CEV A;  1ZZ3 A;  4BZ9 A;  5DC8 A;  5EF7 A;  5G1B A;  4RN0 A;  3SL1 A;  3Q9B A;  4IU1 A;  2V5X A;  4QA2 A;  4RN2 A;  4QA6 A;  4A69 A;  4ZUN A;  4I06 A;  5ICN B;  5G0J A;  4RHL A;  5D1C A;  4QA7 A;  3MZ4 A;  4BZ5 A;  5EFJ D;  5THS A;  1P8S A;  3LP7 A;  5EEF A;  2EIV A;  2V5W A;  4HXQ A;  3THE A;  5IX0 A;  5CEV A;  5THV A;  2VQO A;  1HQG A;  1T4P A;  1GQ7 A;  5G0X A;  4HWW A;  1T69 A;  1P8O A; 
#chains in the Genus database with same CATH homology
 1CEV A;  3SKK A;  2PHA A;  4MYF A;  4Q42 A;  4Q41 A;  3RLA A;  3SL0 A;  2PHO A;  4IE3 A;  4RHJ A;  4IU5 A;  4IXV A;  3THH A;  4HZE A;  4Q40 A;  5RLA A;  3E6V A;  1ZPG A;  2AEB A;  4MXR A;  3MFV A;  3GMZ A;  1GQ6 A;  4GSM A;  1P8P A;  4Q3Q A;  3KV2 A;  1WOH A;  1WVB A;  3M1R A;  3THJ A;  1T5G A;  3F80 A;  1HQ5 A;  2RLA A;  3MMR A;  3NIQ A;  4DZ4 A;  3TF3 A;  2PLL A;  1PQ3 A;  1R1O A;  2CEV A;  4MYK A;  4RHQ A;  4GWC A;  3NIP A;  4Q3R A;  3CEV A;  3E9B A;  3PZL A;  1T5F A;  1TBJ A;  3NIO A;  1HQX A;  4IE2 A;  4Q3P A;  3LHL A;  4FCI A;  3DJ8 A;  4MYN A;  4Q3S A;  4FCK A;  3MJL A;  4IU0 A;  1P8Q A;  5HJ9 A;  2EF4 A;  2EF5 A;  4RHI A;  3LP4 A;  4GSZ A;  1HQF A;  4IU4 A;  1XFK A;  3MFW A;  1WVA A;  4Q3R C;  4G3H A;  4RHK A;  1TBH A;  1TBL A;  1T4S A;  1TA1 A;  4CEV A;  1T4R A;  3E8Z A;  1P8N A;  3SJT A;  3TH7 A;  4RLA A;  1T4T A;  1P8R A;  1WOI A;  3E8Q A;  2ZAV A;  4ITY A;  3E6K A;  1D3V A;  1HQH A;  4GWD A;  4IE1 A;  5HJA A;  3GN0 A;  2A0M A;  4RHM A;  4MYL A;  1WOG A;  4Q3U A;  1RLA A;  1ZPE A;  1P8M A;  4IXU A;  4Q3T A;  4GSV A;  4Q3V A;  3SL1 A;  4IU1 A;  4I06 A;  4RHL A;  1P8S A;  3LP7 A;  2EIV A;  4HXQ A;  3THE A;  5CEV A;  1HQG A;  1T4P A;  1GQ7 A;  4HWW A;  1P8O A; 
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