5THTA

Crystal structure of g303a hdac8 in complex with m344
Total Genus 129
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
366
structure length
361
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGAGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVIE
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI1 (31-34)TIV1 (32-35)AH2 (37-48)TII1 (34-37)AH10 (308-323)TIV8 (305-308)3H1 (50-53)TVIII1 (100-103)TIV4 (145-148)AH3 (64-68)AH4 (73-84)TIV2 (68-71)TI2 (90-93)TVIII2 (131-134)TIV3 (99-102)O1 (103-105)AH5 (108-128)TI3 (136-139)TII2 (105-108)S8 (297-301)AH8 (237-255)TIV5 (166-169)S3 (133-136)S4 (172-176)TVIII3 (153-156)AH6 (157-166)O2 (181-183)AH7 (183-189)TI5 (192-195)TVIII4 (169-172)TVIa1 (207-210)S5 (195-202)TII3 (204-207)TI6 (213-216)3H3 (220-222)TII4 (222-225)S6 (226-231)TI8 (334-337)S7 (259-263)TI7 (266-269)TIV7 (272-275)AH9 (281-293)3H4 (337-339)AH1 (22-29)S2 (55-57)3H2 (93-96)TI'1 (150-153)TII5 (269-272)O3 (302-304)AH11 (359-377)S1 (17-19)TI9 (341-344)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 129
structure length 361
sequence length 366
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thtA00
1ZZ0A 5EEFA 1ZZ1A 3Q9BA 5A2SA 4CBYA 4RN2A 2V5WA 2VQQA 4CBTA 4ZUMA 4QA4A 5D1CA 2VCGA 5LI3A 4QA1A 5FUEA 4BZ5A 4QA2A 3RQDA 4ZUOA 3MZ3A 5EFHA 5EFKB 3EZPA 4QA3A 3F06A 5G0YA 3MZ6A 4RN0A 3MZ7A 3C10A 5G1AA 4BZ6A 5BWZA 5EFBD 1T64A 5THVA 4QA7A 5EFGA 4ZURA 4BZ9A 4BZ8A 5EFNA 5FCWA 5G12A 4RN1A 3F0RA 3SFFA 4BKXB 5DC8A 5IX0A 1ZZ3A 1VKGA 3EWFA 5G0JA 5DC5A 5G11A 3EW8A 2VQWG 5EF7A 4QA6A 2VQJA 1C3SA 5G0GA 1C3RA 5G1BA 1W22A 3C0ZA 3Q9CA 3C0YA 4QA0A 5DC6A 5EF8A 4ZUPA 4LXZA 4ZUQA 5G3WA 5G17A 3Q9FA 5D1DA 5DC7A 3ZNSA 5G13A 4CQFA 4A69A 5G1CA 5THTA 3MENA 5ICNB 3MAXA 2GH6A 5EEMA 1C3PA 1T67A 5G0IA 3SFHA 3ZNRA 5IWGA 5D1BA 5EFJD 5G0XA 1T69A 5JI5A 3MZ4A 5G10A 2VQMA 3EZTA 5THSA 4BZ7A 5EEIA 4LY1A 2VQVA 3Q9EA 4ZUNA 5G0HA 5THUA 2VQOA 5EENA 5EEKA 2V5XA 3F07A 4QA5A
chains in the Genus database with same CATH superfamily
1ZZ0A 1GQ6A 1WOHA 1ZZ1A 3Q9BA 5EEFA 4Q3SA 2EIVA 5A2SA 1T4RA 3RLAA 4CBYA 3NIOA 3PZLA 4RN2A 3SKKA 1TBJA 2V5WA 2VQQA 1XFKA 5G0YA 4CBTA 4ZUMA 4FCKA 3E8QA 4GWDA 1WOIA 4QA4A 1P8PA 4GSZA 5D1CA 3E6VA 1CEVA 2VCGA 5LI3A 1TA1A 5CEVA 1P8NA 4QA1A 5FUEA 1R1OA 4IU4A 4Q42A 4QA2A 4BZ5A 3LP4A 3RQDA 4ZUOA 3MZ3A 5EFHA 5EFKB 1T4TA 1TBHA 1D3VA 3F06A 3EZPA 4IE2A 1WVAA 3MZ6A 4QA3A 2PLLA 3MZ7A 3C10A 4Q3UA 4RN0A 2EF4A 5G1AA 4BZ6A 2PHAA 3NIQA 5BWZA 5EFBD 1T64A 1ZPEA 4Q3QA 5THVA 4QA7A 5EFGA 4ZURA 4BZ9A 1HQ5A 3E8ZA 4BZ8A 1T4PA 2CEVA 4IXVA 4GWCA 4HZEA 5EFNA 3LHLA 1GQ7A 2A0MA 5FCWA 5G12A 4RN1A 3THJA 3DJ8A 3F0RA 3SFFA 4BKXB 4ITYA 4IE3A 3GMZA 4RHLA 3MMRA 5DC8A 1ZZ3A 5IX0A 4IU0A 1VKGA 3EWFA 4RHJA 5G0JA 1HQFA 1PQ3A 4HWWA 5DC5A 4MXRA 3EW8A 2VQWG 5G11A 3MFVA 1ZPGA 4RHKA 5EF7A 2RLAA 4QA6A 2AEBA 4Q3TA 2VQJA 1C3SA 5G0GA 1C3RA 1HQGA 5G1BA 1W22A 3C0ZA 4MYFA 3Q9CA 1TBLA 3C0YA 3M1RA 3MFWA 4QA0A 5DC6A 5EF8A 4ZUPA 4RHQA 4LXZA 4ZUQA 3GN0A 5G3WA 3F80A 4G3HA 5G17A 4IE1A 3TH7A 3Q9FA 3CEVA 4RLAA 3SL1A 1P8QA 4MYNA 1HQXA 3SJTA 5D1DA 3TF3A 5DC7A 3ZNSA 5G13A 4CQFA 4A69A 5G1CA 1P8SA 5THTA 3MENA 5ICNB 3MAXA 2GH6A 5EEMA 1C3PA 1HQHA 1T67A 2PHOA 3NIPA 4IXUA 4IU5A 5G0IA 3THHA 5HJ9A 3SFHA 5HJAA 3KV2A 1P8RA 4Q3RC 3ZNRA 4MYKA 1P8MA 5IWGA 3LP7A 1T5FA 5D1BA 4RHIA 3MJLA 3E6KA 5EFJD 5G0XA 1T69A 4Q3VA 5JI5A 3MZ4A 2ZAVA 4Q3PA 5G10A 1WVBA 2VQMA 3EZTA 4I06A 5THSA 3THEA 4RHMA 1RLAA 4BZ7A 1WOGA 1P8OA 4GSVA 3E9BA 4IU1A 5EEIA 1T4SA 4FCIA 2EF5A 2VQVA 3Q9EA 4GSMA 4LY1A 4ZUNA 4Q41A 5G0HA 5THUA 4MYLA 4DZ4A 4CEVA 2VQOA 4HXQA 5RLAA 3SL0A 4Q3RA 5EENA 1T5GA 5EEKA 2V5XA 3F07A 4Q40A 4QA5A
chains in the Genus database with same CATH topology
1ZZ0A 5EEFA 1ZZ1A 3Q9BA 5A2SA 4CBYA 4RN2A 2V5WA 2VQQA 4CBTA 4ZUMA 4QA4A 5D1CA 2VCGA 5LI3A 4QA1A 5FUEA 4BZ5A 4QA2A 3RQDA 4ZUOA 3MZ3A 5EFHA 5EFKB 3EZPA 4QA3A 3F06A 5G0YA 3MZ6A 4RN0A 3MZ7A 3C10A 5G1AA 4BZ6A 5BWZA 5EFBD 1T64A 5THVA 4QA7A 5EFGA 4ZURA 4BZ9A 4BZ8A 5EFNA 5FCWA 5G12A 4RN1A 3F0RA 3SFFA 4BKXB 5DC8A 5IX0A 1ZZ3A 1VKGA 3EWFA 5G0JA 5DC5A 5G11A 3EW8A 2VQWG 5EF7A 4QA6A 2VQJA 1C3SA 5G0GA 1C3RA 5G1BA 1W22A 3C0ZA 3Q9CA 3C0YA 4QA0A 5DC6A 5EF8A 4ZUPA 4LXZA 4ZUQA 5G3WA 5G17A 3Q9FA 5D1DA 5DC7A 3ZNSA 5G13A 4CQFA 4A69A 5G1CA 5THTA 3MENA 5ICNB 3MAXA 2GH6A 5EEMA 1C3PA 1T67A 5G0IA 3SFHA 3ZNRA 5IWGA 5D1BA 5EFJD 5G0XA 1T69A 5JI5A 3MZ4A 5G10A 2VQMA 3EZTA 5THSA 4BZ7A 5EEIA 4LY1A 2VQVA 3Q9EA 4ZUNA 5G0HA 5THUA 2VQOA 5EENA 5EEKA 2V5XA 3F07A 4QA5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZZ0 A;  5EEF A;  1ZZ1 A;  3Q9B A;  5A2S A;  4CBY A;  4RN2 A;  2V5W A;  2VQQ A;  4CBT A;  4ZUM A;  4QA4 A;  5D1C A;  2VCG A;  5LI3 A;  4QA1 A;  5FUE A;  4BZ5 A;  4QA2 A;  3RQD A;  4ZUO A;  3MZ3 A;  5EFH A;  5EFK B;  3EZP A;  4QA3 A;  3F06 A;  5G0Y A;  3MZ6 A;  4RN0 A;  3MZ7 A;  3C10 A;  5G1A A;  4BZ6 A;  5BWZ A;  5EFB D;  1T64 A;  5THV A;  4QA7 A;  5EFG A;  4ZUR A;  4BZ9 A;  4BZ8 A;  5EFN A;  5FCW A;  5G12 A;  4RN1 A;  3F0R A;  3SFF A;  4BKX B;  5DC8 A;  5IX0 A;  1ZZ3 A;  1VKG A;  3EWF A;  5G0J A;  5DC5 A;  5G11 A;  3EW8 A;  2VQW G;  5EF7 A;  4QA6 A;  2VQJ A;  1C3S A;  5G0G A;  1C3R A;  5G1B A;  1W22 A;  3C0Z A;  3Q9C A;  3C0Y A;  4QA0 A;  5DC6 A;  5EF8 A;  4ZUP A;  4LXZ A;  4ZUQ A;  5G3W A;  5G17 A;  3Q9F A;  5D1D A;  5DC7 A;  3ZNS A;  5G13 A;  4CQF A;  4A69 A;  5G1C A;  5THT A;  3MEN A;  5ICN B;  3MAX A;  2GH6 A;  5EEM A;  1C3P A;  1T67 A;  5G0I A;  3SFH A;  3ZNR A;  5IWG A;  5D1B A;  5EFJ D;  5G0X A;  1T69 A;  5JI5 A;  3MZ4 A;  5G10 A;  2VQM A;  3EZT A;  5THS A;  4BZ7 A;  5EEI A;  4LY1 A;  2VQV A;  3Q9E A;  4ZUN A;  5G0H A;  5THU A;  2VQO A;  5EEN A;  5EEK A;  2V5X A;  3F07 A;  4QA5 A; 
#chains in the Genus database with same CATH topology
 1ZZ0 A;  1GQ6 A;  1WOH A;  1ZZ1 A;  3Q9B A;  5EEF A;  4Q3S A;  2EIV A;  5A2S A;  1T4R A;  3RLA A;  4CBY A;  3NIO A;  3PZL A;  4RN2 A;  3SKK A;  1TBJ A;  2V5W A;  2VQQ A;  1XFK A;  5G0Y A;  4CBT A;  4ZUM A;  4FCK A;  3E8Q A;  4GWD A;  1WOI A;  4QA4 A;  1P8P A;  4GSZ A;  5D1C A;  3E6V A;  1CEV A;  2VCG A;  5LI3 A;  1TA1 A;  5CEV A;  1P8N A;  4QA1 A;  5FUE A;  1R1O A;  4IU4 A;  4Q42 A;  4QA2 A;  4BZ5 A;  3LP4 A;  3RQD A;  4ZUO A;  3MZ3 A;  5EFH A;  5EFK B;  1T4T A;  1TBH A;  1D3V A;  3F06 A;  3EZP A;  4IE2 A;  1WVA A;  3MZ6 A;  4QA3 A;  2PLL A;  3MZ7 A;  3C10 A;  4Q3U A;  4RN0 A;  2EF4 A;  5G1A A;  4BZ6 A;  2PHA A;  3NIQ A;  5BWZ A;  5EFB D;  1T64 A;  1ZPE A;  4Q3Q A;  5THV A;  4QA7 A;  5EFG A;  4ZUR A;  4BZ9 A;  1HQ5 A;  3E8Z A;  4BZ8 A;  1T4P A;  2CEV A;  4IXV A;  4GWC A;  4HZE A;  5EFN A;  3LHL A;  1GQ7 A;  2A0M A;  5FCW A;  5G12 A;  4RN1 A;  3THJ A;  3DJ8 A;  3F0R A;  3SFF A;  4BKX B;  4ITY A;  4IE3 A;  3GMZ A;  4RHL A;  3MMR A;  5DC8 A;  1ZZ3 A;  5IX0 A;  4IU0 A;  1VKG A;  3EWF A;  4RHJ A;  5G0J A;  1HQF A;  1PQ3 A;  4HWW A;  5DC5 A;  4MXR A;  3EW8 A;  2VQW G;  5G11 A;  3MFV A;  1ZPG A;  4RHK A;  5EF7 A;  2RLA A;  4QA6 A;  2AEB A;  4Q3T A;  2VQJ A;  1C3S A;  5G0G A;  1C3R A;  1HQG A;  5G1B A;  1W22 A;  3C0Z A;  4MYF A;  3Q9C A;  1TBL A;  3C0Y A;  3M1R A;  3MFW A;  4QA0 A;  5DC6 A;  5EF8 A;  4ZUP A;  4RHQ A;  4LXZ A;  4ZUQ A;  3GN0 A;  5G3W A;  3F80 A;  4G3H A;  5G17 A;  4IE1 A;  3TH7 A;  3Q9F A;  3CEV A;  4RLA A;  3SL1 A;  1P8Q A;  4MYN A;  1HQX A;  3SJT A;  5D1D A;  3TF3 A;  5DC7 A;  3ZNS A;  5G13 A;  4CQF A;  4A69 A;  5G1C A;  1P8S A;  5THT A;  3MEN A;  5ICN B;  3MAX A;  2GH6 A;  5EEM A;  1C3P A;  1HQH A;  1T67 A;  2PHO A;  3NIP A;  4IXU A;  4IU5 A;  5G0I A;  3THH A;  5HJ9 A;  3SFH A;  5HJA A;  3KV2 A;  1P8R A;  4Q3R C;  3ZNR A;  4MYK A;  1P8M A;  5IWG A;  3LP7 A;  1T5F A;  5D1B A;  4RHI A;  3MJL A;  3E6K A;  5EFJ D;  5G0X A;  1T69 A;  4Q3V A;  5JI5 A;  3MZ4 A;  2ZAV A;  4Q3P A;  5G10 A;  1WVB A;  2VQM A;  3EZT A;  4I06 A;  5THS A;  3THE A;  4RHM A;  1RLA A;  4BZ7 A;  1WOG A;  1P8O A;  4GSV A;  3E9B A;  4IU1 A;  5EEI A;  1T4S A;  4FCI A;  2EF5 A;  2VQV A;  3Q9E A;  4GSM A;  4LY1 A;  4ZUN A;  4Q41 A;  5G0H A;  5THU A;  4MYL A;  4DZ4 A;  4CEV A;  2VQO A;  4HXQ A;  5RLA A;  3SL0 A;  4Q3R A;  5EEN A;  1T5G A;  5EEK A;  2V5X A;  3F07 A;  4Q40 A;  4QA5 A; 
#chains in the Genus database with same CATH homology
 1ZZ0 A;  5EEF A;  1ZZ1 A;  3Q9B A;  5A2S A;  4CBY A;  4RN2 A;  2V5W A;  2VQQ A;  4CBT A;  4ZUM A;  4QA4 A;  5D1C A;  2VCG A;  5LI3 A;  4QA1 A;  5FUE A;  4BZ5 A;  4QA2 A;  3RQD A;  4ZUO A;  3MZ3 A;  5EFH A;  5EFK B;  3EZP A;  4QA3 A;  3F06 A;  5G0Y A;  3MZ6 A;  4RN0 A;  3MZ7 A;  3C10 A;  5G1A A;  4BZ6 A;  5BWZ A;  5EFB D;  1T64 A;  5THV A;  4QA7 A;  5EFG A;  4ZUR A;  4BZ9 A;  4BZ8 A;  5EFN A;  5FCW A;  5G12 A;  4RN1 A;  3F0R A;  3SFF A;  4BKX B;  5DC8 A;  5IX0 A;  1ZZ3 A;  1VKG A;  3EWF A;  5G0J A;  5DC5 A;  5G11 A;  3EW8 A;  2VQW G;  5EF7 A;  4QA6 A;  2VQJ A;  1C3S A;  5G0G A;  1C3R A;  5G1B A;  1W22 A;  3C0Z A;  3Q9C A;  3C0Y A;  4QA0 A;  5DC6 A;  5EF8 A;  4ZUP A;  4LXZ A;  4ZUQ A;  5G3W A;  5G17 A;  3Q9F A;  5D1D A;  5DC7 A;  3ZNS A;  5G13 A;  4CQF A;  4A69 A;  5G1C A;  5THT A;  3MEN A;  5ICN B;  3MAX A;  2GH6 A;  5EEM A;  1C3P A;  1T67 A;  5G0I A;  3SFH A;  3ZNR A;  5IWG A;  5D1B A;  5EFJ D;  5G0X A;  1T69 A;  5JI5 A;  3MZ4 A;  5G10 A;  2VQM A;  3EZT A;  5THS A;  4BZ7 A;  5EEI A;  4LY1 A;  2VQV A;  3Q9E A;  4ZUN A;  5G0H A;  5THU A;  2VQO A;  5EEN A;  5EEK A;  2V5X A;  3F07 A;  4QA5 A; 
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