5THUA

Crystal structure of g304a hdac8 in complex with m344
Total Genus 134
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
365
structure length
358
Chain Sequence
LVPVYIYSPEYVSMCDSKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGAGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
5010015020025030035035030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (17-19)TVIII2 (131-134)AH1 (22-30)TIV1 (30-35)AH10 (308-323)AH2 (37-48)TII1 (34-37)TIV5 (305-308)TI2 (99-102)3H2 (93-96)3H1 (50-53)TI4 (141-144)S2 (55-57)S3 (133-136)TVIII1 (100-103)AH5 (108-128)TI3 (136-139)TII2 (105-108)TI5 (145-148)TIV4 (272-275)S8 (298-301)AH8 (237-255)TVIII3 (153-156)TIV2 (166-169)TI'1 (150-153)TII5 (232-235)EMPTYS4 (172-176)AH6 (157-166)AH9 (281-294)O1 (181-183)TI6 (189-192)TVIa1 (207-210)TVIII4 (169-172)S5 (195-202)TI7 (213-216)AH7 (183-189)TIV3 (192-195)TI9 (334-337)3H3 (220-222)TII4 (222-225)S6 (226-231)TI8 (266-269)3H4 (337-340)TIV7 (341-344)TIV6 (340-343)AH3 (64-69)AH4 (73-83)TI1 (90-93)S7 (259-263)TII3 (204-207)TII6 (269-272)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 134
structure length 358
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thuA00
3MZ6A 5D1BA 4RN2A 3C10A 4CBTA 4CQFA 2V5WA 5IX0A 4BKXB 4ZUMA 1T69A 1T67A 4BZ7A 5G10A 5G3WA 2VQOA 5EF7A 5EEIA 3MZ3A 2VQMA 3Q9EA 3C0YA 4ZUOA 5THTA 3SFHA 5DC8A 5LI3A 1C3SA 3RQDA 3F06A 3ZNSA 5IWGA 3F0RA 4QA2A 5ICNB 5EFKB 5EENA 5G12A 4BZ8A 5DC5A 5JI5A 3EWFA 5DC7A 5EFBD 4QA3A 1W22A 5EFJD 5G0HA 1ZZ3A 3EZPA 3SFFA 3MAXA 4QA0A 5DC6A 5G0IA 4RN0A 5G0JA 4ZUNA 5G1BA 1ZZ0A 4LY1A 5BWZA 1VKGA 5G17A 5THSA 2VCGA 1ZZ1A 5G0GA 4ZURA 5G1AA 5THUA 3F07A 5FCWA 5EEMA 5FUEA 4A69A 5G0XA 3Q9CA 4LXZA 5EFHA 5EFNA 4QA5A 2VQQA 5EEFA 3MZ7A 4BZ9A 1C3RA 3MENA 3EW8A 5A2SA 5EEKA 2VQWG 3C0ZA 4RN1A 5G1CA 5EFGA 2VQJA 5D1DA 3Q9FA 1T64A 2VQVA 4BZ5A 5G13A 4QA4A 2GH6A 3ZNRA 5D1CA 3MZ4A 4ZUPA 4QA1A 4QA6A 5EF8A 5THVA 4BZ6A 4QA7A 2V5XA 4ZUQA 5G11A 1C3PA 3Q9BA 3EZTA 4CBYA 5G0YA
chains in the Genus database with same CATH superfamily
3MZ6A 4RHQA 4IU5A 5D1BA 4RN2A 4CEVA 1HQ5A 3C10A 4G3HA 4DZ4A 4CBTA 4CQFA 1WVAA 2V5WA 4Q3QA 5IX0A 4BKXB 2EF5A 4ZUMA 3MFVA 1T69A 3SKKA 3E9BA 4HZEA 4Q3RC 5HJAA 4MYLA 1T67A 4MYFA 4IE3A 4RHIA 1HQGA 2PLLA 4BZ7A 5G10A 3MMRA 5G3WA 2VQOA 4MXRA 3SL1A 5EF7A 5EEIA 3SL0A 1WOGA 3MZ3A 3TH7A 2VQMA 3Q9EA 4GSZA 3C0YA 4ZUOA 5THTA 3SFHA 5DC8A 5LI3A 1C3SA 4RHLA 3RQDA 2EF4A 4Q3UA 3F06A 1RLAA 4HXQA 2ZAVA 3ZNSA 5IWGA 3F0RA 4QA2A 5ICNB 4IU1A 3THJA 4GWCA 5EFKB 5EENA 1HQHA 5HJ9A 1ZPGA 4HWWA 5G12A 4Q3PA 4BZ8A 5DC5A 3THEA 5JI5A 4MYKA 3EWFA 4IXVA 4RHMA 5DC7A 1HQXA 3LP7A 5EFBD 2PHOA 1T4TA 1TBJA 1P8NA 4QA3A 1W22A 5EFJD 5G0HA 1PQ3A 1ZZ3A 3CEVA 3EZPA 4IE1A 1D3VA 3KV2A 3SFFA 3MAXA 4QA0A 5DC6A 2EIVA 5G0IA 4Q41A 1GQ7A 4RN0A 5G0JA 4ZUNA 1P8PA 5G1BA 1ZZ0A 4LY1A 4RHKA 4IE2A 2RLAA 4FCKA 5BWZA 1P8OA 1VKGA 4Q3VA 3M1RA 5G17A 2VCGA 1ZZ1A 5G0GA 5THSA 2CEVA 4ZURA 5G1AA 5THUA 3F07A 5FCWA 5EEMA 5FUEA 1P8MA 4Q3SA 1WVBA 3SJTA 3NIQA 4A69A 3MFWA 4Q42A 4RLAA 3Q9CA 5G0XA 3LHLA 4LXZA 5EFHA 5EFNA 3THHA 4I06A 1T4RA 1ZPEA 4QA5A 1XFKA 2VQQA 4RHJA 5CEVA 5EEFA 3MZ7A 1CEVA 3DJ8A 4BZ9A 1T4SA 3E6VA 1C3RA 1R1OA 2A0MA 3MENA 4GWDA 4IU4A 3EW8A 5A2SA 4MYNA 5EEKA 2VQWG 3C0ZA 1WOHA 1P8QA 3TF3A 3GMZA 3LP4A 2AEBA 4RN1A 5G1CA 1HQFA 1P8RA 2VQJA 4ITYA 5D1DA 3F80A 5EFGA 1TA1A 3Q9FA 1T64A 2VQVA 4BZ5A 5G13A 4QA4A 3MJLA 3NIOA 4Q3TA 4IU0A 4Q3RA 2GH6A 3ZNRA 1WOIA 5D1CA 3RLAA 3MZ4A 4GSMA 3E6KA 4ZUPA 3NIPA 1P8SA 4QA1A 3GN0A 4QA6A 4FCIA 5EF8A 5THVA 4BZ6A 4QA7A 4GSVA 5RLAA 1T4PA 1TBLA 2V5XA 2PHAA 3E8QA 1T5FA 3E8ZA 4ZUQA 5G11A 4IXUA 1GQ6A 1TBHA 1C3PA 1T5GA 4Q40A 3Q9BA 3EZTA 4CBYA 3PZLA 5G0YA
chains in the Genus database with same CATH topology
3MZ6A 5D1BA 4RN2A 3C10A 4CBTA 4CQFA 2V5WA 5IX0A 4BKXB 4ZUMA 1T69A 1T67A 4BZ7A 5G10A 5G3WA 2VQOA 5EF7A 5EEIA 3MZ3A 2VQMA 3Q9EA 3C0YA 4ZUOA 5THTA 3SFHA 5DC8A 5LI3A 1C3SA 3RQDA 3F06A 3ZNSA 5IWGA 3F0RA 4QA2A 5ICNB 5EFKB 5EENA 5G12A 4BZ8A 5DC5A 5JI5A 3EWFA 5DC7A 5EFBD 4QA3A 1W22A 5EFJD 5G0HA 1ZZ3A 3EZPA 3SFFA 3MAXA 4QA0A 5DC6A 5G0IA 4RN0A 5G0JA 4ZUNA 5G1BA 1ZZ0A 4LY1A 5BWZA 1VKGA 5G17A 5THSA 2VCGA 1ZZ1A 5G0GA 4ZURA 5G1AA 5THUA 3F07A 5FCWA 5EEMA 5FUEA 4A69A 5G0XA 3Q9CA 4LXZA 5EFHA 5EFNA 4QA5A 2VQQA 5EEFA 3MZ7A 4BZ9A 1C3RA 3MENA 3EW8A 5A2SA 5EEKA 2VQWG 3C0ZA 4RN1A 5G1CA 5EFGA 2VQJA 5D1DA 3Q9FA 1T64A 2VQVA 4BZ5A 5G13A 4QA4A 2GH6A 3ZNRA 5D1CA 3MZ4A 4ZUPA 4QA1A 4QA6A 5EF8A 5THVA 4BZ6A 4QA7A 2V5XA 4ZUQA 5G11A 1C3PA 3Q9BA 3EZTA 4CBYA 5G0YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MZ6 A;  5D1B A;  4RN2 A;  3C10 A;  4CBT A;  4CQF A;  2V5W A;  5IX0 A;  4BKX B;  4ZUM A;  1T69 A;  1T67 A;  4BZ7 A;  5G10 A;  5G3W A;  2VQO A;  5EF7 A;  5EEI A;  3MZ3 A;  2VQM A;  3Q9E A;  3C0Y A;  4ZUO A;  5THT A;  3SFH A;  5DC8 A;  5LI3 A;  1C3S A;  3RQD A;  3F06 A;  3ZNS A;  5IWG A;  3F0R A;  4QA2 A;  5ICN B;  5EFK B;  5EEN A;  5G12 A;  4BZ8 A;  5DC5 A;  5JI5 A;  3EWF A;  5DC7 A;  5EFB D;  4QA3 A;  1W22 A;  5EFJ D;  5G0H A;  1ZZ3 A;  3EZP A;  3SFF A;  3MAX A;  4QA0 A;  5DC6 A;  5G0I A;  4RN0 A;  5G0J A;  4ZUN A;  5G1B A;  1ZZ0 A;  4LY1 A;  5BWZ A;  1VKG A;  5G17 A;  5THS A;  2VCG A;  1ZZ1 A;  5G0G A;  4ZUR A;  5G1A A;  5THU A;  3F07 A;  5FCW A;  5EEM A;  5FUE A;  4A69 A;  5G0X A;  3Q9C A;  4LXZ A;  5EFH A;  5EFN A;  4QA5 A;  2VQQ A;  5EEF A;  3MZ7 A;  4BZ9 A;  1C3R A;  3MEN A;  3EW8 A;  5A2S A;  5EEK A;  2VQW G;  3C0Z A;  4RN1 A;  5G1C A;  5EFG A;  2VQJ A;  5D1D A;  3Q9F A;  1T64 A;  2VQV A;  4BZ5 A;  5G13 A;  4QA4 A;  2GH6 A;  3ZNR A;  5D1C A;  3MZ4 A;  4ZUP A;  4QA1 A;  4QA6 A;  5EF8 A;  5THV A;  4BZ6 A;  4QA7 A;  2V5X A;  4ZUQ A;  5G11 A;  1C3P A;  3Q9B A;  3EZT A;  4CBY A;  5G0Y A; 
#chains in the Genus database with same CATH topology
 3MZ6 A;  4RHQ A;  4IU5 A;  5D1B A;  4RN2 A;  4CEV A;  1HQ5 A;  3C10 A;  4G3H A;  4DZ4 A;  4CBT A;  4CQF A;  1WVA A;  2V5W A;  4Q3Q A;  5IX0 A;  4BKX B;  2EF5 A;  4ZUM A;  3MFV A;  1T69 A;  3SKK A;  3E9B A;  4HZE A;  4Q3R C;  5HJA A;  4MYL A;  1T67 A;  4MYF A;  4IE3 A;  4RHI A;  1HQG A;  2PLL A;  4BZ7 A;  5G10 A;  3MMR A;  5G3W A;  2VQO A;  4MXR A;  3SL1 A;  5EF7 A;  5EEI A;  3SL0 A;  1WOG A;  3MZ3 A;  3TH7 A;  2VQM A;  3Q9E A;  4GSZ A;  3C0Y A;  4ZUO A;  5THT A;  3SFH A;  5DC8 A;  5LI3 A;  1C3S A;  4RHL A;  3RQD A;  2EF4 A;  4Q3U A;  3F06 A;  1RLA A;  4HXQ A;  2ZAV A;  3ZNS A;  5IWG A;  3F0R A;  4QA2 A;  5ICN B;  4IU1 A;  3THJ A;  4GWC A;  5EFK B;  5EEN A;  1HQH A;  5HJ9 A;  1ZPG A;  4HWW A;  5G12 A;  4Q3P A;  4BZ8 A;  5DC5 A;  3THE A;  5JI5 A;  4MYK A;  3EWF A;  4IXV A;  4RHM A;  5DC7 A;  1HQX A;  3LP7 A;  5EFB D;  2PHO A;  1T4T A;  1TBJ A;  1P8N A;  4QA3 A;  1W22 A;  5EFJ D;  5G0H A;  1PQ3 A;  1ZZ3 A;  3CEV A;  3EZP A;  4IE1 A;  1D3V A;  3KV2 A;  3SFF A;  3MAX A;  4QA0 A;  5DC6 A;  2EIV A;  5G0I A;  4Q41 A;  1GQ7 A;  4RN0 A;  5G0J A;  4ZUN A;  1P8P A;  5G1B A;  1ZZ0 A;  4LY1 A;  4RHK A;  4IE2 A;  2RLA A;  4FCK A;  5BWZ A;  1P8O A;  1VKG A;  4Q3V A;  3M1R A;  5G17 A;  2VCG A;  1ZZ1 A;  5G0G A;  5THS A;  2CEV A;  4ZUR A;  5G1A A;  5THU A;  3F07 A;  5FCW A;  5EEM A;  5FUE A;  1P8M A;  4Q3S A;  1WVB A;  3SJT A;  3NIQ A;  4A69 A;  3MFW A;  4Q42 A;  4RLA A;  3Q9C A;  5G0X A;  3LHL A;  4LXZ A;  5EFH A;  5EFN A;  3THH A;  4I06 A;  1T4R A;  1ZPE A;  4QA5 A;  1XFK A;  2VQQ A;  4RHJ A;  5CEV A;  5EEF A;  3MZ7 A;  1CEV A;  3DJ8 A;  4BZ9 A;  1T4S A;  3E6V A;  1C3R A;  1R1O A;  2A0M A;  3MEN A;  4GWD A;  4IU4 A;  3EW8 A;  5A2S A;  4MYN A;  5EEK A;  2VQW G;  3C0Z A;  1WOH A;  1P8Q A;  3TF3 A;  3GMZ A;  3LP4 A;  2AEB A;  4RN1 A;  5G1C A;  1HQF A;  1P8R A;  2VQJ A;  4ITY A;  5D1D A;  3F80 A;  5EFG A;  1TA1 A;  3Q9F A;  1T64 A;  2VQV A;  4BZ5 A;  5G13 A;  4QA4 A;  3MJL A;  3NIO A;  4Q3T A;  4IU0 A;  4Q3R A;  2GH6 A;  3ZNR A;  1WOI A;  5D1C A;  3RLA A;  3MZ4 A;  4GSM A;  3E6K A;  4ZUP A;  3NIP A;  1P8S A;  4QA1 A;  3GN0 A;  4QA6 A;  4FCI A;  5EF8 A;  5THV A;  4BZ6 A;  4QA7 A;  4GSV A;  5RLA A;  1T4P A;  1TBL A;  2V5X A;  2PHA A;  3E8Q A;  1T5F A;  3E8Z A;  4ZUQ A;  5G11 A;  4IXU A;  1GQ6 A;  1TBH A;  1C3P A;  1T5G A;  4Q40 A;  3Q9B A;  3EZT A;  4CBY A;  3PZL A;  5G0Y A; 
#chains in the Genus database with same CATH homology
 3MZ6 A;  5D1B A;  4RN2 A;  3C10 A;  4CBT A;  4CQF A;  2V5W A;  5IX0 A;  4BKX B;  4ZUM A;  1T69 A;  1T67 A;  4BZ7 A;  5G10 A;  5G3W A;  2VQO A;  5EF7 A;  5EEI A;  3MZ3 A;  2VQM A;  3Q9E A;  3C0Y A;  4ZUO A;  5THT A;  3SFH A;  5DC8 A;  5LI3 A;  1C3S A;  3RQD A;  3F06 A;  3ZNS A;  5IWG A;  3F0R A;  4QA2 A;  5ICN B;  5EFK B;  5EEN A;  5G12 A;  4BZ8 A;  5DC5 A;  5JI5 A;  3EWF A;  5DC7 A;  5EFB D;  4QA3 A;  1W22 A;  5EFJ D;  5G0H A;  1ZZ3 A;  3EZP A;  3SFF A;  3MAX A;  4QA0 A;  5DC6 A;  5G0I A;  4RN0 A;  5G0J A;  4ZUN A;  5G1B A;  1ZZ0 A;  4LY1 A;  5BWZ A;  1VKG A;  5G17 A;  5THS A;  2VCG A;  1ZZ1 A;  5G0G A;  4ZUR A;  5G1A A;  5THU A;  3F07 A;  5FCW A;  5EEM A;  5FUE A;  4A69 A;  5G0X A;  3Q9C A;  4LXZ A;  5EFH A;  5EFN A;  4QA5 A;  2VQQ A;  5EEF A;  3MZ7 A;  4BZ9 A;  1C3R A;  3MEN A;  3EW8 A;  5A2S A;  5EEK A;  2VQW G;  3C0Z A;  4RN1 A;  5G1C A;  5EFG A;  2VQJ A;  5D1D A;  3Q9F A;  1T64 A;  2VQV A;  4BZ5 A;  5G13 A;  4QA4 A;  2GH6 A;  3ZNR A;  5D1C A;  3MZ4 A;  4ZUP A;  4QA1 A;  4QA6 A;  5EF8 A;  5THV A;  4BZ6 A;  4QA7 A;  2V5X A;  4ZUQ A;  5G11 A;  1C3P A;  3Q9B A;  3EZT A;  4CBY A;  5G0Y A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.