5THVA

Crystal structure of g305a hdac8 in complex with m344
Total Genus 132

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
362
structure length
349
Chain Sequence
VPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLTEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGAYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHV
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (22-31)TII1 (34-37)TVIII1 (32-35)S8 (297-301)AH2 (37-48)3H2 (93-96)3H1 (50-53)TI1 (136-139)AH5 (108-128)S2 (55-57)EMPTYAH4 (73-84)TI6 (266-269)TII2 (105-108)TIV5 (272-275)AH9 (281-293)TIV2 (149-152)AH6 (157-166)TIV1 (131-134)TI2 (141-144)TIV3 (166-169)TII5 (232-235)TI3 (145-148)TVIII3 (169-172)TI'1 (150-153)AH8 (237-255)TVIII2 (153-156)AH7 (183-189)S4 (172-176)S5 (195-202)TI4 (189-192)TIV4 (192-195)TII3 (204-207)3H3 (220-222)TI5 (213-216)TII4 (222-225)S6 (226-231)S7 (259-263)TII6 (269-272)3H4 (337-339)TI7 (334-337)TVIa2 (340-343)TI8 (341-344)AH3 (64-69)S3 (133-136)TVIa1 (207-210)AH10 (308-323)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 132
structure length 349
sequence length 362
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thvA00
3C0YA 4ZUMA 3C0ZA 4QA7A 4BZ5A 4QA1A 1ZZ3A 3MZ6A 4BZ6A 5EEIA 5THUA 3EW8A 3EWFA 4BZ7A 3F07A 5EFBD 3MZ7A 4QA0A 1C3RA 5DC8A 4QA3A 5EF8A 5ICNB 5EFJD 4BZ9A 5G17A 5THSA 5G0XA 3ZNSA 5BWZA 5G10A 5FCWA 4A69A 3C10A 5G1AA 5G0JA 3Q9BA 4CBYA 3MAXA 5G13A 5EEFA 3EZTA 5JI5A 5D1CA 4RN1A 3SFHA 5G11A 4RN2A 2VQQA 5EENA 5G1CA 2VQMA 3Q9CA 5DC5A 5G0GA 4CQFA 4BZ8A 5EEKA 3Q9EA 4QA2A 5THTA 3F06A 3RQDA 2VQWG 2VQJA 5DC7A 4QA6A 1T69A 5G0IA 1ZZ0A 5DC6A 4ZUOA 5LI3A 4LXZA 3F0RA 5IWGA 5A2SA 1T64A 5D1BA 3MENA 1ZZ1A 4CBTA 2V5XA 4BKXB 1VKGA 5G3WA 4ZUQA 1C3SA 5THVA 1C3PA 5EFGA 5G12A 4LY1A 5G1BA 4QA4A 3EZPA 2GH6A 3Q9FA 5G0YA 4QA5A 2VQVA 3MZ4A 5D1DA 5EEMA 5EF7A 5EFNA 5FUEA 4ZUNA 2V5WA 5EFKB 4RN0A 4ZUPA 4ZURA 5IX0A 5G0HA 2VCGA 5EFHA 3MZ3A 2VQOA 1W22A 3SFFA 3ZNRA 1T67A
chains in the Genus database with same CATH superfamily
3C0YA 4ZUMA 5CEVA 3E8ZA 3NIOA 4Q42A 3C0ZA 2PHAA 4QA7A 4BZ5A 4MYLA 2AEBA 4IU4A 4QA1A 1ZZ3A 3MZ6A 4IXUA 4IXVA 3TH7A 4BZ6A 5EEIA 5THUA 3EW8A 3SL1A 3EWFA 4BZ7A 4RHLA 1T5FA 3M1RA 4IE2A 3F07A 3E8QA 4GSVA 5EFBD 3MZ7A 4GSMA 4GWDA 5HJ9A 4QA0A 1GQ7A 1C3RA 3SKKA 5DC8A 4FCKA 4QA3A 3GMZA 4HXQA 1HQXA 5EF8A 3RLAA 5ICNB 1P8RA 4GSZA 5EFJD 4BZ9A 5G17A 5THSA 5HJAA 5G0XA 3ZNSA 5BWZA 4ITYA 5G10A 5FCWA 4A69A 3C10A 5G1AA 5G0JA 3Q9BA 1TBHA 4CBYA 3PZLA 3MAXA 4GWCA 4Q3VA 3LP7A 1HQ5A 3SL0A 5G13A 2RLAA 3E6VA 1WOGA 4MYKA 5EEFA 3EZTA 5JI5A 4CEVA 4IE1A 2EIVA 2EF4A 4RHJA 5D1CA 4RN1A 3SFHA 5G11A 3DJ8A 3GN0A 4IE3A 3F80A 4RN2A 2VQQA 5EENA 4IU0A 4RHIA 5G1CA 2VQMA 3Q9CA 5DC5A 5G0GA 2PLLA 3MFVA 3KV2A 4Q40A 4CQFA 4BZ8A 1ZPGA 3MJLA 3THEA 5EEKA 1T4PA 3LP4A 3Q9EA 1WVBA 4QA2A 5THTA 3THHA 3F06A 3RQDA 1HQHA 2VQWG 2VQJA 5DC7A 4QA6A 1T69A 5G0IA 1ZZ0A 5DC6A 4ZUOA 5LI3A 4LXZA 3F0RA 5IWGA 5A2SA 4MYNA 1T64A 5D1BA 1P8MA 4Q3RC 1ZPEA 4FCIA 2A0MA 1GQ6A 1T5GA 1ZZ1A 3MENA 4Q3QA 4Q3RA 3CEVA 4Q3TA 3SJTA 4CBTA 1HQGA 2V5XA 2CEVA 5RLAA 1R1OA 1RLAA 1CEVA 1TA1A 1VKGA 4MYFA 1WOHA 4Q3PA 4RLAA 5G3WA 4BKXB 4RHMA 1HQFA 1C3SA 2EF5A 2ZAVA 4I06A 4Q3SA 5THVA 3NIQA 3NIPA 1C3PA 4Q3UA 3MFWA 4HZEA 5EFGA 5G12A 3LHLA 1T4RA 4LY1A 5G1BA 1PQ3A 1P8PA 4MXRA 4QA4A 3EZPA 2GH6A 3Q9FA 3E6KA 1D3VA 1TBLA 4RHKA 4QA5A 5G0YA 3THJA 2VQVA 4IU1A 3MZ4A 4HWWA 3MMRA 4IU5A 5D1DA 1P8SA 5EEMA 4RHQA 1WVAA 2PHOA 4DZ4A 5EF7A 1P8OA 4ZUQA 1P8QA 1T4SA 5EFNA 5FUEA 4ZUNA 2V5WA 5EFKB 4RN0A 4G3HA 4ZUPA 4ZURA 1T4TA 1P8NA 1XFKA 4Q41A 3E9BA 5IX0A 5G0HA 2VCGA 5EFHA 3MZ3A 2VQOA 1W22A 3SFFA 1WOIA 3TF3A 3ZNRA 1T67A 1TBJA
chains in the Genus database with same CATH topology
3C0YA 4ZUMA 3C0ZA 4QA7A 4BZ5A 4QA1A 1ZZ3A 3MZ6A 4BZ6A 5EEIA 5THUA 3EW8A 3EWFA 4BZ7A 3F07A 5EFBD 3MZ7A 4QA0A 1C3RA 5DC8A 4QA3A 5EF8A 5ICNB 5EFJD 4BZ9A 5G17A 5THSA 5G0XA 3ZNSA 5BWZA 5G10A 5FCWA 4A69A 3C10A 5G1AA 5G0JA 3Q9BA 4CBYA 3MAXA 5G13A 5EEFA 3EZTA 5JI5A 5D1CA 4RN1A 3SFHA 5G11A 4RN2A 2VQQA 5EENA 5G1CA 2VQMA 3Q9CA 5DC5A 5G0GA 4CQFA 4BZ8A 5EEKA 3Q9EA 4QA2A 5THTA 3F06A 3RQDA 2VQWG 2VQJA 5DC7A 4QA6A 1T69A 5G0IA 1ZZ0A 5DC6A 4ZUOA 5LI3A 4LXZA 3F0RA 5IWGA 5A2SA 1T64A 5D1BA 3MENA 1ZZ1A 4CBTA 2V5XA 4BKXB 1VKGA 5G3WA 4ZUQA 1C3SA 5THVA 1C3PA 5EFGA 5G12A 4LY1A 5G1BA 4QA4A 3EZPA 2GH6A 3Q9FA 5G0YA 4QA5A 2VQVA 3MZ4A 5D1DA 5EEMA 5EF7A 5EFNA 5FUEA 4ZUNA 2V5WA 5EFKB 4RN0A 4ZUPA 4ZURA 5IX0A 5G0HA 2VCGA 5EFHA 3MZ3A 2VQOA 1W22A 3SFFA 3ZNRA 1T67A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C0Y A;  4ZUM A;  3C0Z A;  4QA7 A;  4BZ5 A;  4QA1 A;  1ZZ3 A;  3MZ6 A;  4BZ6 A;  5EEI A;  5THU A;  3EW8 A;  3EWF A;  4BZ7 A;  3F07 A;  5EFB D;  3MZ7 A;  4QA0 A;  1C3R A;  5DC8 A;  4QA3 A;  5EF8 A;  5ICN B;  5EFJ D;  4BZ9 A;  5G17 A;  5THS A;  5G0X A;  3ZNS A;  5BWZ A;  5G10 A;  5FCW A;  4A69 A;  3C10 A;  5G1A A;  5G0J A;  3Q9B A;  4CBY A;  3MAX A;  5G13 A;  5EEF A;  3EZT A;  5JI5 A;  5D1C A;  4RN1 A;  3SFH A;  5G11 A;  4RN2 A;  2VQQ A;  5EEN A;  5G1C A;  2VQM A;  3Q9C A;  5DC5 A;  5G0G A;  4CQF A;  4BZ8 A;  5EEK A;  3Q9E A;  4QA2 A;  5THT A;  3F06 A;  3RQD A;  2VQW G;  2VQJ A;  5DC7 A;  4QA6 A;  1T69 A;  5G0I A;  1ZZ0 A;  5DC6 A;  4ZUO A;  5LI3 A;  4LXZ A;  3F0R A;  5IWG A;  5A2S A;  1T64 A;  5D1B A;  3MEN A;  1ZZ1 A;  4CBT A;  2V5X A;  4BKX B;  1VKG A;  5G3W A;  4ZUQ A;  1C3S A;  5THV A;  1C3P A;  5EFG A;  5G12 A;  4LY1 A;  5G1B A;  4QA4 A;  3EZP A;  2GH6 A;  3Q9F A;  5G0Y A;  4QA5 A;  2VQV A;  3MZ4 A;  5D1D A;  5EEM A;  5EF7 A;  5EFN A;  5FUE A;  4ZUN A;  2V5W A;  5EFK B;  4RN0 A;  4ZUP A;  4ZUR A;  5IX0 A;  5G0H A;  2VCG A;  5EFH A;  3MZ3 A;  2VQO A;  1W22 A;  3SFF A;  3ZNR A;  1T67 A; 
#chains in the Genus database with same CATH topology
 3C0Y A;  4ZUM A;  5CEV A;  3E8Z A;  3NIO A;  4Q42 A;  3C0Z A;  2PHA A;  4QA7 A;  4BZ5 A;  4MYL A;  2AEB A;  4IU4 A;  4QA1 A;  1ZZ3 A;  3MZ6 A;  4IXU A;  4IXV A;  3TH7 A;  4BZ6 A;  5EEI A;  5THU A;  3EW8 A;  3SL1 A;  3EWF A;  4BZ7 A;  4RHL A;  1T5F A;  3M1R A;  4IE2 A;  3F07 A;  3E8Q A;  4GSV A;  5EFB D;  3MZ7 A;  4GSM A;  4GWD A;  5HJ9 A;  4QA0 A;  1GQ7 A;  1C3R A;  3SKK A;  5DC8 A;  4FCK A;  4QA3 A;  3GMZ A;  4HXQ A;  1HQX A;  5EF8 A;  3RLA A;  5ICN B;  1P8R A;  4GSZ A;  5EFJ D;  4BZ9 A;  5G17 A;  5THS A;  5HJA A;  5G0X A;  3ZNS A;  5BWZ A;  4ITY A;  5G10 A;  5FCW A;  4A69 A;  3C10 A;  5G1A A;  5G0J A;  3Q9B A;  1TBH A;  4CBY A;  3PZL A;  3MAX A;  4GWC A;  4Q3V A;  3LP7 A;  1HQ5 A;  3SL0 A;  5G13 A;  2RLA A;  3E6V A;  1WOG A;  4MYK A;  5EEF A;  3EZT A;  5JI5 A;  4CEV A;  4IE1 A;  2EIV A;  2EF4 A;  4RHJ A;  5D1C A;  4RN1 A;  3SFH A;  5G11 A;  3DJ8 A;  3GN0 A;  4IE3 A;  3F80 A;  4RN2 A;  2VQQ A;  5EEN A;  4IU0 A;  4RHI A;  5G1C A;  2VQM A;  3Q9C A;  5DC5 A;  5G0G A;  2PLL A;  3MFV A;  3KV2 A;  4Q40 A;  4CQF A;  4BZ8 A;  1ZPG A;  3MJL A;  3THE A;  5EEK A;  1T4P A;  3LP4 A;  3Q9E A;  1WVB A;  4QA2 A;  5THT A;  3THH A;  3F06 A;  3RQD A;  1HQH A;  2VQW G;  2VQJ A;  5DC7 A;  4QA6 A;  1T69 A;  5G0I A;  1ZZ0 A;  5DC6 A;  4ZUO A;  5LI3 A;  4LXZ A;  3F0R A;  5IWG A;  5A2S A;  4MYN A;  1T64 A;  5D1B A;  1P8M A;  4Q3R C;  1ZPE A;  4FCI A;  2A0M A;  1GQ6 A;  1T5G A;  1ZZ1 A;  3MEN A;  4Q3Q A;  4Q3R A;  3CEV A;  4Q3T A;  3SJT A;  4CBT A;  1HQG A;  2V5X A;  2CEV A;  5RLA A;  1R1O A;  1RLA A;  1CEV A;  1TA1 A;  1VKG A;  4MYF A;  1WOH A;  4Q3P A;  4RLA A;  5G3W A;  4BKX B;  4RHM A;  1HQF A;  1C3S A;  2EF5 A;  2ZAV A;  4I06 A;  4Q3S A;  5THV A;  3NIQ A;  3NIP A;  1C3P A;  4Q3U A;  3MFW A;  4HZE A;  5EFG A;  5G12 A;  3LHL A;  1T4R A;  4LY1 A;  5G1B A;  1PQ3 A;  1P8P A;  4MXR A;  4QA4 A;  3EZP A;  2GH6 A;  3Q9F A;  3E6K A;  1D3V A;  1TBL A;  4RHK A;  4QA5 A;  5G0Y A;  3THJ A;  2VQV A;  4IU1 A;  3MZ4 A;  4HWW A;  3MMR A;  4IU5 A;  5D1D A;  1P8S A;  5EEM A;  4RHQ A;  1WVA A;  2PHO A;  4DZ4 A;  5EF7 A;  1P8O A;  4ZUQ A;  1P8Q A;  1T4S A;  5EFN A;  5FUE A;  4ZUN A;  2V5W A;  5EFK B;  4RN0 A;  4G3H A;  4ZUP A;  4ZUR A;  1T4T A;  1P8N A;  1XFK A;  4Q41 A;  3E9B A;  5IX0 A;  5G0H A;  2VCG A;  5EFH A;  3MZ3 A;  2VQO A;  1W22 A;  3SFF A;  1WOI A;  3TF3 A;  3ZNR A;  1T67 A;  1TBJ A; 
#chains in the Genus database with same CATH homology
 3C0Y A;  4ZUM A;  3C0Z A;  4QA7 A;  4BZ5 A;  4QA1 A;  1ZZ3 A;  3MZ6 A;  4BZ6 A;  5EEI A;  5THU A;  3EW8 A;  3EWF A;  4BZ7 A;  3F07 A;  5EFB D;  3MZ7 A;  4QA0 A;  1C3R A;  5DC8 A;  4QA3 A;  5EF8 A;  5ICN B;  5EFJ D;  4BZ9 A;  5G17 A;  5THS A;  5G0X A;  3ZNS A;  5BWZ A;  5G10 A;  5FCW A;  4A69 A;  3C10 A;  5G1A A;  5G0J A;  3Q9B A;  4CBY A;  3MAX A;  5G13 A;  5EEF A;  3EZT A;  5JI5 A;  5D1C A;  4RN1 A;  3SFH A;  5G11 A;  4RN2 A;  2VQQ A;  5EEN A;  5G1C A;  2VQM A;  3Q9C A;  5DC5 A;  5G0G A;  4CQF A;  4BZ8 A;  5EEK A;  3Q9E A;  4QA2 A;  5THT A;  3F06 A;  3RQD A;  2VQW G;  2VQJ A;  5DC7 A;  4QA6 A;  1T69 A;  5G0I A;  1ZZ0 A;  5DC6 A;  4ZUO A;  5LI3 A;  4LXZ A;  3F0R A;  5IWG A;  5A2S A;  1T64 A;  5D1B A;  3MEN A;  1ZZ1 A;  4CBT A;  2V5X A;  4BKX B;  1VKG A;  5G3W A;  4ZUQ A;  1C3S A;  5THV A;  1C3P A;  5EFG A;  5G12 A;  4LY1 A;  5G1B A;  4QA4 A;  3EZP A;  2GH6 A;  3Q9F A;  5G0Y A;  4QA5 A;  2VQV A;  3MZ4 A;  5D1D A;  5EEM A;  5EF7 A;  5EFN A;  5FUE A;  4ZUN A;  2V5W A;  5EFK B;  4RN0 A;  4ZUP A;  4ZUR A;  5IX0 A;  5G0H A;  2VCG A;  5EFH A;  3MZ3 A;  2VQO A;  1W22 A;  3SFF A;  3ZNR A;  1T67 A; 
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